Can retelling and deep breathing ease trauma in terminal cancer?
NCT ID NCT03652298
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tested a neuroscience-based technique combining memory structuring and deep vagal breathing to reduce PTSD symptoms in people with advanced, incurable cancer and their partners. The study enrolled 19 patients who had just received a terminal diagnosis. The approach aimed to help them process the traumatic news by organizing memories and using paced breathing to calm the nervous system. The trial was terminated early, so firm conclusions cannot be drawn.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Memory structuring intervention plus vagal breathing
- What this could lead to
- If it works, this could point toward a non-drug technique to reduce PTSD symptoms in people with advanced cancer.
- What could go wrong
- The trial was terminated early with only 19 participants, so results are very limited. It is unclear if the approach is effective or safe in this setting.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
19 people
The number who actually took part.
- Started
-
Jul 2018
- Finished
-
Jun 2020
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Men or women aged over 18 years old; * Who received in the last 7 days the diagnosis of metastatic incurable bladder, prostate, kidney, colorectal or sarcoma cancer (including recurrence) during the announcement visit; * Whose life expectancy is estimated ≥ 6 months by their treating oncologist; * Who have a WHO performance score \< 3 (to be coherent with the life expectancy); * Who have an albumin level \> 30g/liter (patients with an acceptable state of nutrition); * Who gave their signed consent to participate in the study; * Who are covered by a social insurance. Exclusion Criteria: * Patients diagnosed with cerebral metastases; * Patients with locally advanced cancer without metastases; * Patients with an advanced or metastatic cancer amenable to curative intent treatment; * Patients suffering from a psychological vulnerability that might alter their reasoning or judgment capacities; * Patients with a psychological or physical incapacity to answer the questionnaires, attested by the medical staff; * Patients under custodial sentence or under tutelage or protection of vulnerable adults
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Advanced sarcoma are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Centre Oscar Lambret
Lille, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Radioactive missile aims at prostate cancer that spread
- New PET tracer targets ACP3 to spot prostate cancer
- Dutch bladder cancer cohort aims to map survival and recurrence
- Can a One-Week radiation course match four weeks for prostate cancer?
- Can a new PET tracer spot hidden prostate cancer spread?
- Can a gel cushion shield the rectum during prostate radiation?