KIDNEY CANCER

This study looks at whether removing the kidney after successful immunotherapy can help patients with metastatic kidney cancer stop all treatment and stay cancer-free. About 60 adults whose tumors have shrunk significantly with immunotherapy will be randomly assigned to either ha…

This early-phase trial tests a new treatment called VET3-TGI, a virus designed to infect and kill cancer cells. It is given alone or with an immunotherapy drug (atezolizumab) to about 60 adults with advanced solid tumors that have not responded to standard treatments. The main go…

This study tests whether the drug casdatifan, alone or with zimberelimab, can safely shrink kidney tumors before surgery. It is for adults with a specific type of kidney cancer (clear cell renal cell carcinoma) that is large or has spread. The goal is to see if the treatment redu…

This study looks at how older adults (70+) with advanced kidney cancer handle a combination of two drugs, cabozantinib and nivolumab. The goal is to see what doses work best and how often side effects cause treatment breaks. About 50 participants will be followed for a year to tr…

This study tests the drug olaparib (a pill) in 20 people with advanced kidney cancer that has spread. To join, your tumor must have a specific gene mutation (like BAP-1 or BRCA). The goal is to see if the drug can shrink or stop tumor growth for at least 6 months. Participants mu…

This early-phase trial tests whether adding a new drug (HC-7366) to standard immunotherapy can help control advanced clear cell kidney cancer. About 35 adults with stage IV disease will receive the combination. The main goal is to check safety and side effects.

This study tests an experimental oral drug called Alintegimod (7HP349) combined with two immunotherapy drugs (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if…

This study tests whether giving two drugs (pembrolizumab and axitinib) before surgery can shrink tumor clots in the main vein (inferior vena cava) for people with kidney cancer. About 17 adults with clear cell kidney cancer and a vein clot will receive the drugs for 12 weeks, the…

This study tests whether a combination of three drugs (sasanlimab, palbociclib, and axitinib) can shrink tumors in people with advanced kidney cancer that has spread. About 25 adults with clear cell or translocation renal cell carcinoma will receive the drugs and be monitored for…

This study tests a new treatment called EBNK-001, which uses donor immune cells (natural killer cells) to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive these cells alon…

This study tests a personalized cancer vaccine made from patients' own tumor cells. The goal is to train the immune system to fight metastatic cancers like melanoma, breast, lung, and colorectal cancer. Participants receive eight injections over 16 weeks. The study is for adults …

This study is for people with kidney cancer that has spread to other parts of the body. It compares two approaches: having surgery to remove the kidney tumor after initial immunotherapy, versus not having surgery at all. The goal is to see if delayed surgery helps patients live l…

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study tests whether non-steroidal anti-inflammatory drugs (NSAIDs) can effectively control pain after robotic kidney surgery for cancer, reducing the need for stronger opioid painkillers. About 110 adults undergoing this surgery will be randomly assigned to receive either NS…

This study tests if fecal microbiota transplantation (FMT) can help people with diarrhea and colitis caused by immune checkpoint inhibitors, a type of cancer immunotherapy. About 20 adults with melanoma or kidney cancer will receive either FMT capsules or placebo capsules alongsi…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used in future research to better understand how cancers grow and respond to treatment. No new treatments are being tested; the goal…

This study looks at 200 people with advanced kidney cancer to see if measuring drug levels in the blood can help doctors choose the right dose, reduce side effects, and improve survival. Researchers will also check how genes and immune responses affect treatment success. The goal…

This study collects tumor samples from 2,000 people with various cancers to learn how to predict who will respond to immunotherapy. Participants donate tissue during a routine biopsy. The goal is to understand tumor biology and improve future treatment decisions, not to test a ne…

This study looks at how well different imaging methods can measure the stiffness of kidney tumors and healthy kidney tissue. The goal is to create more realistic 3D printed models for surgeons to practice on before surgery. About 50 adults scheduled for kidney tumor removal will …

This study looks at a rare inherited condition called Birt-Hogg-Dube (BHD) syndrome, which raises the risk of kidney cancer. Researchers want to learn more about the genes involved, how kidney tumors grow, and the overall risk for people with BHD. Up to 950 people with known or s…

This study is developing an AI method to track the movement of tumors and nearby organs during radiation therapy without using physical markers. Researchers will use data from 300 patients receiving radiation for various cancers or heart arrhythmias to train and test the system. …

This study will follow 50 adults with localized kidney cancer who have laparoscopic nephrectomy as an outpatient procedure. Researchers will track any complications that happen within the first month after surgery, such as pain, infection, or bleeding. The goal is to better under…

This study tests whether visual decision-support tools help surgeons better discuss risks and benefits of surgery with patients who have prostate or kidney cancer. About 20 urologists and 200 patient visits will be studied, comparing conversations before and after the tools are i…

This study is building a huge French database of 30,000 kidney cancer patients. Researchers will collect medical information and biological samples over time to better understand the disease and improve care. The goal is to create a powerful research tool, not to test a new treat…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study aims to find the genetic changes that cause hereditary leiomyomatosis renal cell cancer (HLRCC), a condition that can lead to kidney cancer, skin bumps, and uterine tumors. Researchers will study people with known or suspected HLRCC and their family members to understa…

This study aims to learn more about kidney and urinary tract cancers that run in families. Researchers will follow up to 5,000 people with or at risk for these inherited conditions, collecting blood, tissue, and urine samples over time. The goal is to identify new genes linked to…

This study looks at whether a blood test that detects tiny bits of tumor DNA can help monitor kidney cancer after surgery. Researchers will follow 450 people with newly diagnosed kidney cancer who have surgery to remove the tumor. The goal is to see if this test can predict cance…

This study tests a small implantable device that releases tiny amounts of 19 different cancer drugs directly into a kidney tumor. The goal is to see if the device is safe and can help doctors figure out which drug works best for each patient. About 20 adults with kidney cancer wh…

This study looks at whether giving cancer patients more personalized help (high-intensity navigation) makes them more likely to join a clinical trial compared to standard help (low-intensity navigation). About 90 adults with prostate or kidney cancer will take part. The goal is t…

This study looks at how kidney and bladder cancers use nutrients like sugar and fat to grow. About 600 adults having surgery or a biopsy will receive a special nutrient tracer through an IV. Blood and tissue samples are then analyzed to see how the cancer uses these fuels. Partic…

This study collects blood, urine, saliva, and tissue samples from people who have or may have cancer, as well as their blood relatives. The goal is to help researchers learn more about the genetic and molecular causes of cancer. No direct treatment is given, but the samples may l…