KIDNEY CANCER

This study is testing a personalized cancer vaccine made from a patient's own tumor cells. The cells are modified in a lab to train the immune system to attack the cancer, then injected back into the patient. The trial is for adults with advanced cancers that have spread and who …

This study is testing a new oral drug called Alintegimod, given alongside standard immunotherapy drugs (ipilimumab and nivolumab), for people with advanced cancers that have spread. The main goals are to find a safe dose and see if the combination helps control the cancer. It is …

This study is testing a new type of immune cell therapy called EBNK-001 for people with advanced solid tumors that have stopped responding to standard treatments. Participants receive 'off-the-shelf' natural killer (NK) cells from a donor after a short course of chemotherapy, wit…

This study is looking at how well older adults (70+) with advanced kidney cancer tolerate and respond to a standard two-drug treatment (cabozantinib and nivolumab). Researchers will closely monitor 50 patients' treatment patterns, side effects, and quality of life over time. The …

This study is testing a new combination of three drugs to see if they can safely control advanced kidney cancer that has spread. The trial will enroll about 25 adults with specific types of advanced kidney cancer who have not yet received treatment for their metastatic disease. R…

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This study is testing whether removing the kidney after successful immunotherapy treatment can help control metastatic kidney cancer long-term. Researchers want to see if patients who have surgery and then stop immunotherapy can stay cancer-free as well as those who continue taki…

This study aims to develop and test a new diagnostic tool that uses artificial intelligence (AI) to analyze small pieces of a patient's tumor. The goal is to predict whether a patient will respond to certain immunotherapy cancer drugs before they start treatment. Researchers will…

This study is testing if a 'stool transplant' (taking capsules containing processed stool from a healthy donor) can help cancer patients who develop severe diarrhea and colon inflammation from their immunotherapy drugs. Twenty patients with melanoma or kidney cancer will receive …

This study is testing if common anti-inflammatory painkillers (like ibuprofen) can effectively manage pain after robotic kidney cancer surgery, with the goal of reducing the need for stronger opioid medications. It will involve 110 adults undergoing this specific surgery at the U…

This study aims to understand how kidney and bladder cancers use different nutrients from the blood to grow and survive. Researchers will give some participants a safe, specially labeled nutrient during their scheduled surgery or biopsy to track how the tumor uses it. The goal is…

This study aims to create a large collection of blood samples from cancer patients and people at high risk for cancer. Researchers will use these samples to build a research library for future studies on 'liquid biopsies'—blood tests that can detect cancer DNA. The goal is to hel…

This study aims to understand the genetic causes of a rare, inherited condition called Hereditary Leiomyomatosis Renal Cell Cancer (HLRCC). Researchers are recruiting families affected by HLRCC to learn which gene changes cause the disease and how it leads to kidney tumors, skin …

This study collects tumor tissue samples from cancer patients to research whether laboratory tests can predict which patients will respond to immunotherapy drugs. Researchers will analyze how live tumor samples react to immunotherapy treatments in the lab, then compare those resu…

This study is testing a new type of blood test to see if it can detect the return of kidney cancer earlier than current standard scans. It will follow 450 patients who are having surgery for newly diagnosed kidney cancer. Researchers will track changes in genetic markers in the b…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to learn more about inherited kidney and urinary tract cancers by observing families who have them. Researchers will collect health information and genetic samples from up to 5,000 participants over time. The goal is to understand how these diseases develop, how t…

This study collects blood, urine, and tissue samples from people with or suspected of having cancers of the kidney, bladder, prostate, and other urinary system cancers. The samples are stored in a tissue bank and used for research to understand the genetic causes of these cancers…

This study aims to better understand Birt-Hogg-Dubé (BHD) syndrome, a rare inherited condition. Researchers want to learn how the gene that causes BHD increases a person's risk for developing kidney tumors, lung cysts, and skin growths. The study is enrolling about 950 people wit…

This study aims to find out if a high-support patient navigation program helps more people with prostate or kidney cancer join clinical trials compared to a low-support program. Patient navigators help participants overcome barriers to healthcare access. About 90 eligible patient…

This study is testing whether visual tools help surgeons explain prostate and kidney cancer surgery options more clearly to patients. Researchers will record conversations between 20 surgeons and 200 patients before and after surgeons use the visual aids. They'll measure if discu…

This study is creating a large national database to collect detailed information from 30,000 kidney cancer patients in France. The goal is to gather real-world data on treatments, outcomes, and patient experiences to help researchers better understand the disease. It does not tes…