KIDNEY CANCER

This early-phase study tests a personalized cancer vaccine (NeoVax) combined with the drug ipilimumab for people with high-risk kidney cancer. The vaccine is custom-made for each patient based on their tumor's unique features. The main goal is to check safety and find the right d…

This early-phase study tests a new gene therapy for people with advanced kidney cancer. Doctors take a patient's own white blood cells, modify them in the lab to better attack cancer, and return them to the patient. The main goals are to check safety and see if tumors shrink. The…

This early-stage study tests an experimental drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal is to find a safe dose and see how the body handles the drugs. Participants must …

This study planned to test a material called PuraBond that helps stop bleeding during robotic kidney cancer surgery. It was designed for adults having a partial nephrectomy, where only the tumor is removed. The study was withdrawn before any participants were enrolled, so no resu…

This study looks at 180 adults with metastatic kidney cancer to find the best order of two drugs from a set of three: everolimus, bevacizumab, and pazopanib. Participants start on one drug and may switch to another later. The goal is to see which sequence works best and is safest…

This study tests a drug called 177Lu-PSMA-617, which delivers radiation directly to cancer cells, in 24 people with advanced clear cell kidney cancer that has spread. The goal is to see if it shrinks tumors and how safe it is. Participants must have a specific marker (PSMA) on th…

This study tests whether giving two drugs—lenvatinib and pembrolizumab—before surgery can shrink tumors in people with advanced kidney cancer that hasn't spread to other organs. About 18 participants will receive the combination for 12 weeks, then have surgery. The main goal is t…

This study tests a new device that uses focused ultrasound (histotripsy) to break apart kidney tumors without any cuts or needles. About 67 adults with a single small kidney tumor (3 cm or less) will receive this non-invasive treatment. The goal is to see if the tumor is complete…

This study compares two ways to remove kidney tumors using robotic surgery: one with stitches to close the wound and one without. The goal is to see if skipping stitches is just as safe and effective, while reducing surgery time. About 248 adults with early-stage kidney cancer wi…

This study tests a combination of two drugs—nivolumab and a radioactive antibody called 177Lu-girentuximab—for people with advanced clear cell kidney cancer that has a specific protein (CAIX). The goal is to see if the combination is safe and can shrink tumors. About 9 participan…

This study tests a new robotic surgery system (Medtronic Hugo™) in 144 adults needing urologic procedures like prostate, bladder, or kidney surgery. The goal is to see if the robot helps surgeons complete the operation without switching to other methods, and to track any serious …

This study looks at ways to reduce the need for blood transfusions during surgery for advanced kidney cancer. About 240 adults with large kidney tumors will be enrolled. The goal is to see if special blood-saving techniques can lower the number of transfusions needed, which may l…

This study aimed to see if adding the diabetes drug acarbose to standard immunotherapy was safe and could help control advanced kidney cancer. It planned to enroll people with metastatic renal cell carcinoma. However, the study was withdrawn before any participants were enrolled.

This study collects fresh tumor samples from 416 adults with various cancers (bladder, kidney, colorectal, head and neck, liver, lung, skin, endometrial) to develop and train a live tumor diagnostic platform. The goal is to see how accurately the platform can predict whether a pa…

This study looks at four different tools to help people who have had cancer improve their diet and physical activity. About 353 cancer survivors will try these tools to see which ones work best. The goal is to find simple ways to help survivors follow healthy lifestyle guidelines…

This study is testing a new system that combines aging, mental health, and social needs checks for cancer patients aged 65 and older. The goal is to help doctors provide care that fits each patient's life. About 35 people with different cancers will try it during their first visi…

This study collects DNA from over 21,000 New York cancer patients to look for inherited gene changes linked to several cancer types. It is an exploratory project that does not offer treatment but aims to find clues for future research. Participants include people with breast, col…

This study looks at how robotic surgery for prostate, bladder, or kidney cancer affects patients' finances. About 120 adults who had surgery in the last year will fill out questionnaires about money worries, medical costs, and travel expenses. The goal is to understand which pati…

This study looks at whether a 12-week survivorship program can be added to the usual follow-up care for men with advanced prostate, kidney, bladder, testicular, or penile cancer. Researchers will ask 72 men about their experience to see if the program is practical and helpful. Th…

This study is looking at two substances in the blood, called MMP2 and MMP9, to see if they can help predict how well certain drugs work in people with kidney cancer that has spread. The researchers will measure these markers in 50 patients and track their cancer progression. The …