Gel that promises faster healing after tooth extraction falls short in early trial
NCT ID NCT07421934
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a gel made from hyaluronic acid and amino acids (Gumblast) to see if it helps surgical wounds in the mouth heal better. It involved 28 adults who needed at least two teeth extracted, with one socket treated with the gel and the other left to heal normally. The trial was terminated early, so we don't have clear results on whether the gel improved healing or reduced complications.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hyaluronic acid gel with amino acids (Gumblast)
- What this could lead to
- If it worked, this gel could help mouth wounds heal faster after dental surgery.
- What could go wrong
- The trial was terminated early with only 28 participants, so we don't have reliable evidence it works. Risks were considered minimal but unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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28 people
The number who actually took part.
- Started
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Oct 2024
- Finished
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Dec 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients requiring extractive surgery in at least two different sites , with a good state of oral and systemic health. * Subjects capable of complying with the study protocol procedures. * Provision of a signed Informed Consent form. Exclusion Criteria: * Patients with a history of alcoholism. * Smokers of more than 10 cigarettes per day. * Patients who have undergone radiotherapy, chemotherapy, or immunosuppressive therapy within the last five years. * Patients who have undergone antibiotic therapy within the last two months. * Patients on bisphosphonate therapy. * Patients with poor oral hygiene, an acute infection at the treatment site, or any contraindications to extractive surgery. * Allergies to local anesthetics. * Pregnancy and breastfeeding.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dipartimento Multidisciplinare di Specialità Medico-Chirurgiche e Odontoiatriche - Via Luigi De Crecchio,6 , 80138 NAPOLI
Naples, 80138, Italy