Atypical Werner syndrome

MONDO:0019321

A heterogeneous group of cases that are clinically diagnosed as Werner syndrome (WS) but do not carry WRN gene mutations. Similar to classical WS caused by WRN mutations, patients generally exhibit an aged appearance and common age-related disorders at earlier ages compared to the general population.

Also known as: atypical progeroid syndrome

1 clinical trial for this condition and its sub-types, 0 tagged with Atypical Werner syndrome itself.

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Where it sits in the disease tree

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↑ Disorder of development or morphogenesis (5170) ↑ Laminopathy (25)

Including sub-types (1) Tagged with Atypical Werner syndrome (0)

Trials to join now! 1

Scientists hunt for 'Modifier Genes' that could explain why some LMNA patients fare better than others

Knowledge-focused Recruiting now

This study aims to identify genetic factors that affect how severe muscle and heart problems become in people with LMNA gene mutations. Researchers will collect skin and muscle samples from 40 participants and use advanced DNA and RNA analysis to look for protective or aggravatin…

Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused

Last updated Jun 27, 2026 09:10 UTC

Atypical Werner syndrome

Where it sits in the disease tree

Scientists hunt for 'Modifier Genes' that could explain why some LMNA patients fare better than others