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Heart drug shows promise in preventing preeclampsia in High-Risk pregnancies

NCT ID NCT03944512

First seen Jan 10, 2026 · Last updated May 20, 2026 · Updated 11 times

Summary

This study tested whether taking pravastatin, a common cholesterol medication, early in pregnancy could prevent preeclampsia in women at high risk due to a previous severe case. The trial aimed to enroll 1,550 women but was terminated early with only 102 participants. Researchers tracked rates of preeclampsia, fetal loss, and maternal death, along with long-term health of mothers and children.

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Contacts and locations

Locations

  • Brown University

    Providence, Rhode Island, 02905, United States

  • Case Western Reserve-Metro Health

    Cleveland, Ohio, 44109, United States

  • Columbia University

    New York, New York, 10032, United States

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Magee Women's Hospital of UPMC

    Pittsburgh, Pennsylvania, 15213, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Ohio State University Hospital

    Columbus, Ohio, 43210, United States

  • University of Alabama - Birmingham

    Birmingham, Alabama, 35233, United States

  • University of North Carolina - Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

  • University of Texas - Houston

    Houston, Texas, 77030, United States

  • University of Texas Medical Branch

    Galveston, Texas, 77555, United States

  • University of Utah Medical Center

    Salt Lake City, Utah, 84132, United States

Conditions

Explore the condition pages connected to this study.