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Brain scans reveal Serotonin's role in food avoidance in anorexia

NCT ID NCT05155280

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Saint Etienne Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how serotonin, a brain chemical, affects circuits involved in avoiding food in people with anorexia nervosa. Researchers used PET and fMRI scans to compare brain activity between 30 women with anorexia and 27 healthy women. The goal was to understand the brain differences behind food avoidance, but the study was ended early.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

57 people

The number who actually took part.

Started

Dec 2021

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 35 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Common Criteria for inclusion : * Signature of written consent * Subject affiliated or entitled to a social security scheme Inclusion Criteria: Patients with restrictive anorexia nervosa (30 subjects). * Anorexia nervosa common features : fear of weight gain, dysmorphophobia, BMI \< 17.5 kg/ m², amenorrhea * Absence of food compulsions and purges * Subgroup 1 (15 subjects) : STAI Y2 anxiety score \> 61 * Subgroup 2 (15 subjects) : STAI Y2 anxiety score \< 51 Inclusion criteria - Female control subjects (15 subjects) * BMI between 18.5 and 25 kg/ m² * Absence of a psychological profile of eating disorder or other psychiatric disorders. Exclusion Criteria: * Subjects with an oral contraception and breastfeeding woman * Subject with heart failure * Subject treated during the last three months with neuroleptics, and antiparkinsonian drugs, monoamine oxidase (MAO)-A or monoamine oxidase (MOA)-B inhibitors, tricyclic antidepressants, 5HT reuptake inhibitors, thymo regulators (lithium), antiepileptic dugs, codeine derivatives, morphinics, tramadol-containing products (Topalgic, …),dopaminergic drugs. * Subjects with suspected pregnancy; Test β human chorionic gonadotropin (HCG) positive prior to examination. * Subjects for whom MRI is contraindicated (pacemaker, intracerebral clips, prosthesis made of ferromagnetic material or claustrophobia). * Subjects unable to sign written consent for participation in the study. * Subject deprived of liberty by a judicial or administrative decision

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Conditions

The condition(s) this trial relates to.

anorexia nervosa Feeding and Eating Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anorexia nervosa

Contacts and locations

Locations

  • CHU de Saint-Etienne

    Saint-Etienne, 42055, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.