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New depression drug tested for long-term safety in 1,000 patients

NCT ID NCT06029439

Disease control Sponsor: Neumora Therapeutics, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 2 times

Summary

This study looks at the long-term safety and effectiveness of an experimental drug called NMRA-335140 for people with major depressive disorder. About 1,000 adults who completed earlier studies of this drug will take it for 52 weeks. Researchers will track side effects and changes in depression symptoms to see if the drug remains safe and helpful over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

904 people

The number who actually took part.

Started

Nov 2023

Finished

Aug 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: Rollover participants are eligible for the study if the following inclusion criteria are met: * Completed a previous NMRA-335140 Phase 3 MDD study (example: NMRA-335140-301, NMRA-335140-302, or NMRA-335140-303) according to the completion definition in the parent study protocol. * Signed an informed consent form (ICF) for this study. * Willing to comply with the contraception requirements described in the inclusion criteria of the parent study protocol. * Willing to comply with the concomitant medication/therapy restrictions described in the exclusion criteria of the parent study protocol. Key Exclusion Criteria: Rollover participants are excluded from the study if any of the following exclusion criteria are met: * Diagnosed with another Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) disorder that would have been exclusionary in the parent study (eg, personality disorder, bipolar 1 or 2, schizophrenia, any other psychotic disorder, or moderate or severe substance or alcohol use disorder \[excluding nicotine\]). * Considered to be at significant risk of suicide in the judgment of the Investigator. This includes participants who are actively suicidal (eg, any suicide attempts during the parent study) or are at serious suicidal risk as indicated by any current suicidal intent, including a plan, as assessed by the C-SSRS ("Since Last Visit" version, score of "YES" on suicidal ideation Item 4 or 5) and/or based on clinical evaluation by the Investigator; or are homicidal, in the opinion of the Investigator. * Non-adherent with study medication (took ≤70% of study drug over any 2-week visit interval) or procedures during the parent study. * Experienced treatment emergent adverse events (TEAEs) considered related to the study medication from the parent study and judged by the Investigator to be clinically significant to render the participant ineligible for enrollment. * Have an abnormality on ocular examination that would prohibit continued study participation as determined by the Investigator. * Use of disallowed concomitant medication or therapy that would have been exclusionary in the parent study, may compromise the safety of the participant, and/or confound the interpretation of protocol assessments. * Considered by the Investigator to be inappropriate for any other reason.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major depressive disorder

Contacts and locations

Locations

  • Neumora Investigator Site

    Phoenix, Arizona, 85012, United States

  • Neumora Investigator Site

    Bentonville, Arkansas, 72712, United States

  • Neumora Investigator Site

    Rogers, Arkansas, 72758, United States

  • Neumora Investigator Site

    Cerritos, California, 90703, United States

  • Neumora Investigator Site

    Encino, California, 91316, United States

  • Neumora Investigator Site

    Garden Grove, California, 92845, United States

  • Neumora Investigator Site

    Glendale, California, 91206, United States

  • Neumora Investigator Site

    Imperial, California, 92251, United States

  • Neumora Investigator Site

    Irvine, California, 92614, United States

  • Neumora Investigator Site

    Lafayette, California, 94549, United States

  • Neumora Investigator Site

    Los Angeles, California, 90015, United States

  • Neumora Investigator Site

    Newport Beach, California, 92660, United States

  • Neumora Investigator Site

    Oceanside, California, 92056, United States

  • Neumora Investigator Site

    Orange, California, 92868, United States

  • Neumora Investigator Site

    Riverside, California, 92506, United States

  • Neumora Investigator Site

    San Diego, California, 92103, United States

  • Neumora Investigator Site

    San Francisco, California, 94107, United States

  • Neumora Investigator Site

    San Jose, California, 95124, United States

  • Neumora Investigator Site

    Santa Ana, California, 92704, United States

  • Neumora Investigator Site

    Sherman Oaks, California, 91403, United States

  • Neumora Investigator Site

    Temecula, California, 92591, United States

  • Neumora Investigator Site

    Torrance, California, 90504, United States

  • Neumora Investigator Site

    Colorado Springs, Colorado, 80910, United States

  • Neumora Investigator Site

    New Haven, Connecticut, 06520, United States

  • Neumora Investigator Site

    Norwalk, Connecticut, 06851, United States

  • Neumora Investigator Site

    Bradenton, Florida, 34205, United States

  • Neumora Investigator Site

    Brandon, Florida, 33511, United States

  • Neumora Investigator Site

    Gainesville, Florida, 32607, United States

  • Neumora Investigator Site

    Hallandale, Florida, 33009, United States

  • Neumora Investigator Site

    Hialeah, Florida, 33012, United States

  • Neumora Investigator Site

    Hialeah, Florida, 33016, United States

  • Neumora Investigator Site

    Hollywood, Florida, 33024, United States

  • Neumora Investigator Site

    Jacksonville, Florida, 32256, United States

  • Neumora Investigator Site

    Lauderhill, Florida, 33319, United States

  • Neumora Investigator Site

    Maitland, Florida, 32751, United States

  • Neumora Investigator Site

    Miami, Florida, 33122, United States

  • Neumora Investigator Site

    Miami, Florida, 33126, United States

  • Neumora Investigator Site

    Miami, Florida, 33133, United States

  • Neumora Investigator Site

    Miami, Florida, 33137, United States

  • Neumora Investigator Site

    Miami, Florida, 33143, United States

  • Neumora Investigator Site

    Miami, Florida, 33165, United States

  • Neumora Investigator Site

    Miami, Florida, 33174, United States

  • Neumora Investigator Site

    Miami Beach, Florida, 33140, United States

  • Neumora Investigator Site

    Miami Springs, Florida, 33166, United States

  • Neumora Investigator Site

    Orlando, Florida, 32803, United States

  • Neumora Investigator Site

    Orlando, Florida, 32807, United States

  • Neumora Investigator Site

    Pembroke Pines, Florida, 33024, United States

  • Neumora Investigator Site

    Pompano Beach, Florida, 33060, United States

  • Neumora Investigator Site

    Saint Augustine, Florida, 32086, United States

  • Neumora Investigator Site

    Tampa, Florida, 33607, United States

  • Neumora Investigator Site

    Tampa, Florida, 33613, United States

  • Neumora Investigator Site

    Atlanta, Georgia, 30318, United States

  • Neumora Investigator Site

    Atlanta, Georgia, 30328, United States

  • Neumora Investigator Site

    Atlanta, Georgia, 30338, United States

  • Neumora Investigator Site

    Decatur, Georgia, 30030, United States

  • Neumora Investigator Site

    Marietta, Georgia, 30060, United States

  • Neumora Investigator Site

    Savannah, Georgia, 31405, United States

  • Neumora Investigator Site

    Chicago, Illinois, 60634, United States

  • Neumora Investigator Site

    Warrenville, Illinois, 60555, United States

  • Neumora Investigator Site

    Marrero, Louisiana, 70072, United States

  • Neumora Investigator Site

    New Orleans, Louisiana, 70115, United States

  • Neumora Investigator Site

    Baltimore, Maryland, 21208, United States

  • Neumora Investigator Site

    Boston, Massachusetts, 02116, United States

  • Neumora Investigator Site

    Boston, Massachusetts, 02131, United States

  • Neumora Investigator Site

    Watertown, Massachusetts, 02472, United States

  • Neumora Investigator Site

    Mankato, Minnesota, 56001, United States

  • Neumora Investigator Site

    Flowood, Mississippi, 39232, United States

  • Neumora Investigator Site

    Saint Charles, Missouri, 63304, United States

  • Neumora Investigator Site

    St Louis, Missouri, 63141, United States

  • Neumora Investigator Site

    Las Vegas, Nevada, 89102, United States

  • Neumora Investigator Site

    Berlin, New Jersey, 08009, United States

  • Neumora Investigator Site

    Toms River, New Jersey, 08755, United States

  • Neumora Investigator Site

    Albuquerque, New Mexico, 87109, United States

  • Neumora Investigator Site

    Brooklyn, New York, 11224, United States

  • Neumora Investigator Site

    Buffalo, New York, 14215, United States

  • Neumora Investigator Site

    Cedarhurst, New York, 11516, United States

  • Neumora Investigator Site

    Inwood, New York, 11096, United States

  • Neumora Investigator Site

    New York, New York, 10017, United States

  • Neumora Investigator Site

    New York, New York, 10029, United States

  • Neumora Investigator Site

    New York, New York, 10036, United States

  • Neumora Investigator Site

    Staten Island, New York, 10310, United States

  • Neumora Investigator Site

    Staten Island, New York, 10314, United States

  • Neumora Investigator Site

    The Bronx, New York, 10461, United States

  • Neumora Investigator Site

    Charlotte, North Carolina, 28211, United States

  • Neumora Investigator Site

    Monroe, North Carolina, 28112, United States

  • Neumora Investigator Site

    Columbus, Ohio, 43210, United States

  • Neumora Investigator Site

    Dayton, Ohio, 45417, United States

  • Neumora Investigator Site

    North Canton, Ohio, 44720, United States

  • Neumora Investigator Site

    Edmond, Oklahoma, 73013, United States

  • Neumora Investigator Site

    Oklahoma City, Oklahoma, 73118, United States

  • Neumora Investigator Site

    Allentown, Pennsylvania, 18104, United States

  • Neumora Investigator Site

    Media, Pennsylvania, 19063, United States

  • Neumora Investigator Site

    Philadelphia, Pennsylvania, 19104, United States

  • Neumora Investigator Site

    Memphis, Tennessee, 38119, United States

  • Neumora Investigator Site

    Austin, Texas, 78737, United States

  • Neumora Investigator Site

    Dallas, Texas, 75243, United States

  • Neumora Investigator Site

    DeSoto, Texas, 75115, United States

  • Neumora Investigator Site

    Fort Worth, Texas, 76104, United States

  • Neumora Investigator Site

    Houston, Texas, 77030, United States

  • Neumora Investigator Site

    Houston, Texas, 77090, United States

  • Neumora Investigator Site

    Wichita Falls, Texas, 76309, United States

  • Neumora Investigator Site

    Bellevue, Washington, 98007, United States

  • Neumora Investigator Site

    Curitiba, Paraná, 80240280, Brazil

  • Neumora Investigator Site

    Botafogo - Rio de Janeiro, Rio de Janeiro, 22270-060, Brazil

  • Neumora Investigator Site

    Porto Alegre, Rio Grande do Sul, 90610-001, Brazil

  • Neumora Investigator Site

    Santa Cecília, São Paulo, 01228-000, Brazil

  • Neumora Investigator Site

    São Bernardo do Campo, São Paulo, 09726150, Brazil

  • Neumora Investigator Site

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Neumora Investigator Site

    São Paulo, 01236030, Brazil

  • Neumora Investigator Site

    Cherven Bryag, Pleven, 5980, Bulgaria

  • Neumora Investigator Site

    Sofia, Sofia-Grad, 1408, Bulgaria

  • Neumora Investigator Site

    Sofia, Sofia-Grad, 1463, Bulgaria

  • Neumora Investigator Site

    Sofia, Sofia-Grad, 1680, Bulgaria

  • Neumora Investigator Site

    Varosha, Targovishte, 7700, Bulgaria

  • Neumora Investigator Site

    Kardzhali, 6600, Bulgaria

  • Neumora Investigator Site

    Pleven, 5800, Bulgaria

  • Neumora Investigator Site

    Varna, 9020, Bulgaria

  • Neumora Investigator Site

    Kelowna, British Columbia, V1Y 1Z9, Canada

  • Neumora Investigator Site

    Hamilton, Ontario, L8S 1B7, Canada

  • Neumora Investigator Site

    Markham, Ontario, L3R 1A3, Canada

  • Neumora Investigator Site

    Mississauga, Ontario, L5L 1W8, Canada

  • Neumora Investigator Site

    Toronto, Ontario, M5S 1M2, Canada

  • Neumora Investigator Site

    Santiago, Santiago Metropolitan, 7500710, Chile

  • Neumora Investigator Site

    Santiago, Santiago Metropolitan, 7560356, Chile

  • Neumora Investigator Site

    Santiago, Santiago Metropolitan, 7561282, Chile

  • Neumora Investigator Site

    Santiago, Santiago Metropolitan, 8330034, Chile

  • Neumora Investigator Site

    Antofagasta, 1270244, Chile

  • Neumora Investigator Site

    Pilsen, Plzeň, 301 00, Czechia

  • Neumora Investigator Site

    Prague, Prague, 186 00, Czechia

  • Neumora Investigator Site

    Kladno, South Bohemian, 272 01, Czechia

  • Neumora Investigator Site

    Kladno, 272 01, Czechia

  • Neumora Investigator Site

    Prague, 109 00, Czechia

  • Neumora Investigator Site

    Helsinki, Etelä-Suomen Lääni, 00100, Finland

  • Neumora Investigator Site

    Turku, Etelä-Suomen Lääni, 20520, Finland

  • Neumora Investigator Site

    Oulu, Oulun Lääni, 90100, Finland

  • Neumora Investigator Site

    Clermont-Ferrand, Auvergne-Rhône-Alpes, 63000, France

  • Neumora Investigator Site

    Douai, Hauts-de-France, 59500, France

  • Neumora Investigator Site

    Montpellier, Hérault, 34295, France

  • Neumora Investigator Site

    La Roche-sur-Yon, Vendée, 85000, France

  • Neumora Investigator Site

    Poitiers, Vienne, 86000, France

  • Neumora Investigator Site

    Berlin, 10117, Germany

  • Neumora Investigator Site

    Berlin, 10629, Germany

  • Neumora Investigator Site

    Berlin, 13187, Germany

  • Neumora Investigator Site

    Hamburg, 20253, Germany

  • Neumora Investigator Site

    Suchy Las, Greater Poland Voivodeship, 62-002, Poland

  • Neumora Investigator Site

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-133, Poland

  • Neumora Investigator Site

    Wroclaw, Lower Silesian Voivodeship, 50-414, Poland

  • Neumora Investigator Site

    Lublin, Lublin Voivodeship, 20-109, Poland

  • Neumora Investigator Site

    Lublin, Lublin Voivodeship, 20-582, Poland

  • Neumora Investigator Site

    Białystok, Podkarpackie Voivodeship, 15-879, Poland

  • Neumora Investigator Site

    Gdansk, Pomeranian Voivodeship, 80-438, Poland

  • Neumora Investigator Site

    Lund, Skåne County, 222 22, Sweden

  • Neumora Investigator Site

    Stockholm, Stolkholm Ian, 113 29, Sweden

  • Neumora Investigator Site #1

    Little Rock, Arkansas, 72211, United States

  • Neumora Investigator Site #1

    Long Beach, California, 90807, United States

  • Neumora Investigator Site #1

    Orange, California, 92868, United States

  • Neumora Investigator Site #1

    Miami Lakes, Florida, 33016, United States

  • Neumora Investigator Site #1

    Orlando, Florida, 32801, United States

  • Neumora Investigator Site #1

    Pompano Beach, Florida, 33060, United States

  • Neumora Investigator Site #1

    Tampa, Florida, 33613, United States

  • Neumora Investigator Site #1

    Atlanta, Georgia, 30328, United States

  • Neumora Investigator Site #1

    Houston, Texas, 77030, United States

  • Neumora Investigator Site #1

    Everett, Washington, 98201, United States

  • Neumora Investigator Site #1

    Berlin, 10117, Germany

  • Neumora Investigator Site #2

    Miami Lakes, Florida, 33016, United States

  • Neumora Investigator site

    Huntsville, Alabama, 35801, United States

  • Neumora Investigator site

    Little Rock, Arkansas, 72211, United States

  • Neumora Investigator site

    Bellflower, California, 90706, United States

  • Neumora Investigator site

    Long Beach, California, 90807, United States

  • Neumora Investigator site

    Miami, Florida, 33183, United States

  • Neumora Investigator site

    Miami Lakes, Florida, 33014, United States

  • Neumora Investigator site

    Orlando, Florida, 32801, United States

  • Neumora Investigator site

    Towson, Maryland, 21204, United States

  • Neumora Investigator site

    Methuen, Massachusetts, 01844, United States

  • Neumora Investigator site

    Springfield, Massachusetts, 01103, United States

  • Neumora Investigator site

    Bloomfield Township, Michigan, 48302, United States

  • Neumora Investigator site

    Princeton, New Jersey, 08540, United States

  • Neumora Investigator site

    Austin, Texas, 78759, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.