Disease by developmental or physiological process

Atransferrinemia is a rare inherited condition in which the body cannot make enough transferrin, a protein that moves iron through the blood. Without it, iron builds up in organs and red blood cells cannot form properly. Researchers are testing intravenous infusions of apotransfe…

This early-phase trial tests whether a bone marrow transplant from a partially matched relative can safely cure chronic granulomatous disease (CGD), a condition that causes severe infections and inflammation. Four people aged 4 to 65 with CGD and no perfect donor will receive che…

Rett syndrome is a rare genetic disorder that mostly affects girls and stems from mutations in the MECP2 gene. This trial tests GCB-002, an experimental gene therapy given as a single injection into the spinal fluid, in 6 to 9 girls aged 2 to 10 who have a confirmed MECP2 mutatio…

Researchers are following 64 people with cerebral adrenoleukodystrophy (CALD) for 15 years after they received a one-time gene therapy called eli-cel in earlier studies. The therapy uses the patient's own stem cells, modified to carry a working copy of the gene that is faulty in …

This early-stage trial is testing a new vaccine called HydroVax-001B WNV to see if it is safe and triggers an immune response against West Nile virus, a mosquito-borne disease. About 30 healthy adults aged 18 to 49 will receive either the vaccine or a placebo. The study will comp…

This study looks at how well a pneumonia vaccine (PCV20) works in people who have recovered from B-cell lymphoma and were treated with anti-CD20 therapy. Researchers want to see if a single dose or a boosted dose is safer and more effective at preventing pneumococcal infections. …

This study tests a new medicine, maridebart cafraglutide, for adults with obstructive sleep apnea who are overweight or obese and already use a CPAP machine. The goal is to see if the drug can reduce breathing pauses during sleep and help with weight loss over 52 weeks. About 250…

This study looked at whether adding the drug cidofovir to usual care helps people who develop painful bladder bleeding from the BK virus after a stem cell transplant. About 27 participants received either cidofovir or standard supportive care. The goal was to see if symptoms impr…

This study tests an experimental drug called ALN-APP in 200 adults with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain. The drug is given via spinal injection and aims to slow disease progression and reduce new brain bleeds. Participants will be …

This study is a long-term extension of earlier trials testing the drug riliprubart in adults with CIDP, a condition where the immune system attacks the nerves, causing weakness and numbness. About 300 participants who completed a prior riliprubart study will continue receiving th…

This study tests an experimental drug, GSK4532990, in 284 adults with nonalcoholic steatohepatitis (NASH) and advanced liver scarring. The goal is to see if the drug can improve liver fibrosis and inflammation compared to a placebo over 52 weeks. Participants must have a liver bi…

This early-stage trial tests a drug called NIO752 in 38 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. The drug is given as one or two injections into the spinal fluid to see if it can lower levels of tau protein, a key marker of Alzheimer's damage.…

This study tests a device called the iLet Bionic Pancreas, which automatically adjusts insulin delivery based on continuous glucose monitor readings, in people with cystic fibrosis-related diabetes. About 150 participants aged 14 and older will either use the bionic pancreas or t…

This Phase II trial tests whether combining lenvatinib and everolimus can shrink or slow advanced carcinoid tumors that cannot be removed by surgery. The study enrolls 36 adults with confirmed unresectable carcinoid tumors. Both drugs are taken orally and work by blocking enzymes…

This study tests an experimental drug called BAY 3401016 in 60 adults aged 18 to 45 with Alport syndrome, a rare genetic condition that damages kidneys, hearing, and eyes. The drug works by blocking a protein thought to cause kidney injury, with the goal of slowing the loss of ki…

This study tests a new medicine called bimekizumab against an existing one (ustekinumab) for children and teens aged 6 to 17 with moderate to severe plaque psoriasis. The goal is to see if bimekizumab works better at clearing skin symptoms. About 168 participants will receive inj…

This study tests a higher dose of the drug aflibercept (8 mg) given as an eye injection every 4 weeks to people with wet age-related macular degeneration (nAMD) or diabetic macular edema (DME). The goal is to see if this dosing schedule is safe and works well for those who have a…

This study looks at how well a new insulin called icodec controls blood sugar in adults with type 2 diabetes who are switching from their current daily insulin. About 214 participants in Italy will use icodec as prescribed by their doctor for 22 to 30 weeks. Researchers will meas…

This study tests a new gene therapy called LY3884961 in 32 people with moderate to severe Parkinson's disease who have a specific genetic change (GBA1 mutation). The treatment is given as a single injection into the fluid around the brain and spinal cord. The main goal is to chec…

This phase 2 trial is testing whether a combination of two drugs, enfortumab vedotin and pembrolizumab, can shrink tumors in people with advanced melanoma that has worsened after standard therapy. The study will enroll 60 adults with unresectable stage III or IV melanoma. Researc…

This study tests whether offering rewards (contingency management) can help people who use methamphetamine reduce their use after a traumatic injury. Twenty adults admitted to the hospital with a positive meth test will receive urine tests and rewards for negative results, starti…

This study tests a 9-session program called MILAP for young married women (ages 15-24) in Nepal who have experienced intimate partner violence. The program involves the woman, her husband, and her mother-in-law, aiming to reduce depression, violence, and PTSD. 900 participants wi…

This study tests whether the Ask Me 3® educational program, which encourages patients to ask three key questions during doctor visits, can improve blood sugar control in adults with type 2 diabetes. Participants are randomly assigned to receive the program plus standard care or s…

This study tests whether benfotiamine, a form of vitamin B1, can safely slow memory and thinking decline in people with early Alzheimer's. About 406 adults aged 50-89 with mild symptoms will take the drug or a placebo for up to 72 weeks. Researchers will measure changes in cognit…

This study tests a new treatment called cipaglucosidase alfa/miglustat in children (0 to under 18 years) with late-onset Pompe disease. The goal is to see if it is safe and how well it works. Participants either have never had enzyme therapy before or have been on it for at least…

This early-phase study tests a single injection of a gene therapy called V001-BCMA for people with autoimmune diseases like lupus that have not responded to standard treatments. The therapy targets and modifies specific immune cells to reduce disease activity. The main goal is to…

This study explores whether eating alkalizing fruits and vegetables, delivered to your home, can help manage metabolic acidosis in people with chronic kidney disease. The usual treatment, sodium bicarbonate, often causes side effects and doesn't always work. The trial will see if…

Researchers compare two biologic drugs, ustekinumab and infliximab, in adults with moderate to severe ulcerative colitis who have not previously tried biologic therapy. The trial measures how well each drug reduces inflammation, controls symptoms, and improves quality of life, wh…

This early-phase trial tests a personalized RNA nanoparticle vaccine made from a patient's own tumor. The goal is to help anti-PD-1 immunotherapy work better in people with advanced melanoma or soft tissue sarcoma whose cancer has progressed on standard treatment. Up to 18 partic…

This study tests whether Empagliflozin (Jardiance), a drug used for diabetes and heart failure, can help adults born with heart defects who now have a weakened heart. Forty participants will receive either the drug or a placebo for one year. Researchers will measure changes in he…

Researchers test whether intentionally removing, treating, and replanting a severely loose lower front tooth works better than splinting alone. Fifty adults with advanced periodontitis and at least 50% bone loss around the tooth join the study. Half receive replantation plus spli…

This study tests whether triheptanoin, a special oil, can reduce major clinical events (like severe low blood sugar or heart problems) in children with long-chain fatty acid oxidation disorders (LC-FAOD), a rare condition where the body can't break down certain fats for energy. A…

This early-phase study tests whether a type of brain stimulation called rTMS can help older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. Participants receive 50 sessions of stimulation over one week. Researchers will measure changes in thi…

This trial tests whether adjusting the number of non-opioid pain pills or adding gabapentin can reduce opioid use after hand, wrist, or elbow surgery. Participants are randomly assigned to one of three pain medication regimens and report their pain levels and any need for extra p…

This phase 3 trial compares two drugs for primary progressive multiple sclerosis (PPMS), a form of MS that steadily worsens. About 985 adults with PPMS will receive either daily oral fenebrutinib or intravenous ocrelizumab (plus matching placebos) to see which better delays disab…

This study tests a new medicine called PYC-001, given as an injection into the eye, for people with a genetic condition that damages the optic nerve (OPA1 optic atrophy). The main goal is to check if the treatment is safe and tolerable. About 18 adults will receive a single dose,…

This study tests whether tranexamic acid, a drug that helps blood clot, can reduce blood loss during planned hip replacement surgery. About 1000 adults having elective hip replacement will receive the drug directly into the joint during surgery. The goal is to see if it lowers th…

Researchers are following people with chronic kidney disease who received up to four injections of REACT, a therapy made from their own kidney cells, in earlier studies. The goal is to track long-term safety and see how long any effects on kidney function last. About 50 participa…

This Phase 3 study compares fenebrutinib, an experimental oral drug, to teriflunomide, an approved MS therapy, in 751 adults with relapsing multiple sclerosis. The goal is to see if fenebrutinib better reduces relapse rates and delays disability progression. Participants take eit…

This study tests a drug called selumetinib in children and young adults (ages 3-18) with neurofibromatosis type 1 (NF1) who have nerve tumors that cannot be removed by surgery. The goal is to see if the drug can shrink or slow the growth of these tumors. Participants take the dru…

This study tests a new medicine called ALN-6400 for people with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and frequent nosebleeds. First, healthy volunteers will receive a single dose to check safety. Then, HHT patients will recei…

This study tests a new drug called ARV-806 in adults with advanced solid tumors that have a specific KRAS G12D mutation. The drug aims to break down the mutated protein that helps tumors grow. The trial has two parts: first, finding a safe dose in small groups, then testing that …

This study tests whether cannabidiol (CBD) can reduce alcohol cravings and drinking in people with alcohol use disorder. Thirty-six participants will receive both CBD and a placebo at different times to compare effects. The goal is to see if CBD can help control alcohol use, but …

This study tests an experimental drug called BI 764524, given as an eye injection, in 190 adults with moderate to severe diabetic retinopathy. Participants receive different numbers of injections over a year, and doctors compare eye damage improvements against a sham procedure or…

This early study is testing a new device called the ReNew Hip Implant in 15 people aged 14 to 64 with hip cartilage damage from conditions like osteoarthritis or hip impingement. The implant is surgically placed to repair the cartilage. Researchers are checking if it is safe and …

This phase 2 trial tests whether adding an experimental pill (GB1211) to the immunotherapy drug pembrolizumab (Keytruda) works better than Keytruda alone for people with advanced melanoma or head and neck cancer. The study will enroll 92 participants and measure how many patients…

This early study is testing a new device called the DurAVR™ THV System, which is a replacement heart valve placed through a small tube in the leg (TAVI procedure). The study includes 40 people with severe aortic stenosis or a failed surgical valve. The main goal is to see if the …

This study gives the drug metreleptin to 29 people with partial lipodystrophy, a rare condition that causes high blood fats and diabetes. Participants have already shown improvement from the drug in earlier studies. The goal is to keep providing the treatment and check its long-t…

This study tests whether adding tocilizumab (a drug used for arthritis) to standard immunotherapy can reduce severe side effects in people with advanced melanoma, lung cancer, or bladder cancer. About 35 participants will receive all three drugs. The goal is to see if the combina…

Researchers are testing whether natural killer (NK) cells from a universal donor can be safely given with standard chemotherapy drugs and an immune-targeting antibody to children and young adults with neuroblastoma that has returned or stopped responding. The NK cells are modifie…

This study tests AIDANET, an automated insulin delivery algorithm, in 40 adults with type 1 diabetes. Participants will use the system in three modes: fully automatic (no meal announcements), hybrid (with meal announcements), or a mix. The goal is to see which mode keeps blood su…

This study compares two ways to remove infection at the tip of a tooth root: using a rotary bur (a small drill) or a piezoelectric unit (a vibrating tool). 124 adults with root infections will have surgery and then be followed for 12 months to see which method leads to better bon…

This study tested a new device called the ACURATE neo2, which replaces a narrowed heart valve without open-heart surgery. About 1,900 people with severe aortic stenosis received either the new device or a standard one. The goal was to see if the new device is safe and works as we…

This study looks at whether the MCV test (which measures red blood cell size) is as good as or better than the standard ferritin test for guiding phlebotomy (blood removal) therapy in people with hereditary hemochromatosis, a condition causing too much iron absorption. About 622 …

This study tests whether offering small monetary rewards can help people with opioid and stimulant use disorders stay in treatment and avoid drug use. Fifty-six adults starting medication for opioid use disorder at a family medicine clinic will earn incentives for attending appoi…

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to high blood fats and diabetes. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…

This phase II trial tests whether intensive blood pressure management (targeting systolic BP below 120 mmHg) is better than standard care (below 140 mmHg) for patients with advanced kidney or thyroid cancer starting anti-angiogenic TKI therapy. The study enrolls 61 participants a…

This study tests a high-dose stem cell transplant for people with chronic granulomatous disease (CGD), a condition that weakens the immune system. Participants receive donor stem cells along with drugs to prevent rejection and graft-versus-host disease. The goal is to improve tra…

Fanconi anemia is a genetic condition that can damage bone marrow and lead to low blood cell counts, causing anemia, bleeding, or infections. Researchers are testing whether a daily pill called eltrombopag can improve blood counts in people with this condition. The trial enrolls …

This early-stage study tests an experimental drug called ALN-4324 in two groups: healthy overweight volunteers and overweight patients with type 2 diabetes. The goal is to check the drug's safety and how well it controls blood sugar. Participants receive either the drug or a plac…

This trial tests whether a dietary supplement called protocatechuic acid (PCA) can improve health markers in people undergoing revision surgery for a knee prosthetic joint infection. Participants take PCA before and after surgery, and researchers measure changes in immune and met…

This study looks at how well a new once-weekly insulin, called insulin icodec, works for people with type 2 diabetes who are switching from a daily insulin. Researchers will track blood sugar control, treatment satisfaction, and how well patients stick to the new regimen over abo…

Steroid injections for knee arthritis can temporarily raise blood sugar in people with type 2 diabetes. This trial tests whether giving a short course of NPH insulin right after the injection can prevent those high blood sugar episodes. Adults with type 2 diabetes and knee osteoa…

This study looks at the long-term safety and effectiveness of balinatunfib, an oral tablet, in adults with Crohn's disease or ulcerative colitis. Participants have already completed a one-year treatment in a previous study. The trial will last up to 107 weeks and includes both do…

Researchers are testing a cream called delgocitinib on facial vitiligo, a condition where skin loses its color in patches. Twelve adults with non-segmental vitiligo on the face will apply the cream twice daily for 24 weeks. The trial measures changes in the size and severity of w…

This study looks at whether a toothpaste with a special gum-health ingredient can improve gum health in people with gingivitis. 150 adults will use the test toothpaste for 13 weeks, then switch to a regular fluoride toothpaste for 4 weeks. Researchers will measure gum inflammatio…

This study is testing whether a new gel applied daily for up to 52 weeks is safe for people with acne. About 400 participants will use the gel on their face and upper body and visit the clinic regularly for checkups. The main goal is to track any side effects, not to measure how …

This early-phase study tests whether 30 minutes of moderate exercise (like walking or cycling) right before standard immunotherapy can improve treatment for certain skin cancers (melanoma, squamous cell carcinoma, Merkel cell carcinoma). About 22 adults will exercise before each …

This phase 2 trial compares two ways of taking the targeted drugs dabrafenib and trametinib for advanced BRAF-mutant melanoma: continuously versus with planned breaks. About 280 people with stage III or IV melanoma that cannot be surgically removed are participating. The goal is …

Researchers test whether giving mitomycin plus carboplatin before surgery helps people with BRCA1 or BRCA2 mutations and locally advanced triple-negative breast cancer. The trial compares this combination, followed by paclitaxel, against standard chemotherapy. About 30 adults wit…

This study tests a new drug called tulisokibart in 147 people with moderate to severe hidradenitis suppurativa, a chronic skin condition causing painful lumps. Participants are randomly assigned to receive either the drug or a placebo, and researchers will check if the drug reduc…

This international registry study looks at a small device called a transcatheter pulmonary flow restrictor, which doctors implant in the lung arteries of young children with congenital or acquired heart disease. The goal is to see whether the device safely and effectively control…

This study is for people with PMM2-CDG, a rare genetic disorder, who have already taken the experimental drug GLM101 in a previous trial. The goal is to see if GLM101 is safe and effective over a longer period. Participants will receive weekly infusions of GLM101 at the same dose…

This early-stage trial tests a therapeutic vaccine called ISA104 in 24 people with chronic hepatitis B who are already on antiviral drugs. The goal is to see if the vaccine is safe and can boost the immune system to better fight the virus. Participants will receive either ISA104 …

Researchers are studying lebrikizumab, an approved injectable drug for atopic dermatitis, to understand how it changes skin biology over time. The trial enrolls 48 people with moderate-to-severe atopic dermatitis who have not done well on topical treatments. Participants receive …

This phase II trial tests two drugs—olaparib and pembrolizumab—together in 12 people with advanced uveal melanoma, a rare eye cancer that has spread. The goal is to see if the combination can shrink tumors or slow the disease. The study is active but no longer recruiting, and res…

This study looks at whether doctors can safely stop standard anti-PD-1 immunotherapy early in people with advanced melanoma that cannot be surgically removed. By using PET/CT scans and tumor biopsies as guides, the goal is to reduce treatment side effects and burden without harmi…

This study is testing three long-acting antibodies, alone or in combination, in 645 people with ulcerative colitis. The goal is to see if they are safe and can improve bowel inflammation over 48 weeks. Participants are joining from a previous study and may have already seen some …

This trial tests whether a multilingual interactive voice response (IVR) system can help adults with type 2 diabetes and low health literacy adjust their insulin doses. Participants use a feature phone to report blood sugar levels and receive algorithm-guided dose recommendations…

This study tests a drug called selumetinib in adults with neurofibromatosis type 1 (NF1) who have nerve tumors that cannot be removed by surgery. The goal is to see if the drug can shrink these tumors or slow their growth. Participants take the drug twice daily and are monitored …

This early-phase trial tested the safety and best dose of two drugs—riluzole and sorafenib—given together to people with advanced solid tumors or melanoma that had spread and stopped responding to standard treatments. The goal was to find the highest safe dose and see if the comb…

This study compares two ways of managing gout: a supported self-management approach where patients monitor their own urate levels with a finger-prick test and adjust medication via a smartphone app, versus usual care where a doctor manages treatment. The goal is to see if the sel…

Researchers are testing two doses of an experimental eye implant called EC-104 against the standard Ozurdex implant in adults with diabetic macular edema. The trial enrolls people whose swelling did not improve enough with anti-VEGF injections but who have tolerated steroid eye t…

This study tests a new gene therapy for people with chronic granulomatous disease (CGD), a genetic disorder that weakens the immune system and makes them prone to serious infections. The treatment takes the patient's own blood stem cells, adds a missing gene in the lab, and puts …

This Phase III trial tests whether giving radiation in three smaller doses (FSRS) works better than a single large dose (SRS) for cancer that has spread to the brain. About 269 adults with lung, breast, melanoma, kidney, or gastrointestinal cancers will be randomly assigned to on…

This early study tests whether QLS-111 eye drops can improve blood flow to the back of the eye in people with non-proliferative diabetic retinopathy or certain types of glaucoma. Fourteen participants will use the drops twice daily for two weeks. The main goal is to measure chang…

Researchers are testing an experimental antibody called ONC-392 in people with advanced solid tumors, including non-small cell lung cancer and melanoma. The trial gives ONC-392 alone or with pembrolizumab, an approved immunotherapy, to see what doses are safe and how the body pro…

This study tests a program called 'Type 1 Doing Well' for youth aged 10–13 with type 1 diabetes and their parents. The program uses a smartphone app, goal-setting, and family meetings to build on the teen's diabetes strengths. Researchers want to see if it improves blood sugar co…

This early-stage study is testing a new drug called RO7121932 in 129 people with multiple sclerosis (MS). The goal is to check if the drug is safe and how the body handles it when given as a single or multiple doses, either through a vein or under the skin. Participants are not o…

This study tests whether a drug that blocks alpha-1 receptors can help people with alcohol use disorder drink less and feel less craving. About 184 adults who want to cut back or quit drinking will take the drug or a placebo and report their drinking and cravings. The goal is to …

This Phase 3 trial tests whether the drug Afimkibart can help people with moderate-to-severe ulcerative colitis achieve remission. About 400 adults who have not responded well to other treatments will receive either Afimkibart or a placebo. The study measures remission at 12 and …

This phase II trial tested a combination of three drugs—pembrolizumab (Keytruda), dabrafenib (Tafinlar), and trametinib (Mekinist)—in 16 people with advanced melanoma that could not be removed by surgery. The goal was to see if a shorter course of targeted therapy, followed by im…

This study tests a non-invasive device that uses ultrasound to stimulate the spleen and reduce inflammation in people with moderate to severe rheumatoid arthritis. About 60 adults who haven't responded well to standard medications will use the device at home for 12 weeks, with so…

This phase 2 study tests acalabrutinib, a targeted drug, in 107 people with Waldenström macroglobulinemia, a rare blood cancer. The goal is to see how well the drug shrinks tumors and controls the disease. Participants either had prior treatment or are new to therapy and cannot t…

This phase II trial tests whether adding a growth factor (GM-CSF) to the immunotherapy drug ipilimumab helps people with advanced melanoma live longer. About 245 patients with stage III or IV melanoma that cannot be surgically removed are randomly assigned to get ipilimumab alone…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

Researchers at Stanford University are testing whether a program that combines weekly healthy food deliveries with group lifestyle coaching helps Latino patients with type 2 diabetes. The study enrolls adults who receive care at partner clinics, have type 2 diabetes, and report f…

This study tests an experimental drug called RO7126209 (Trontinemab) in people with early to moderate Alzheimer's disease. The drug is given by IV infusion and aims to reduce amyloid plaques in the brain, a hallmark of Alzheimer's. About 241 participants will receive either the d…

This phase II trial tests whether combining two drugs, atezolizumab and bevacizumab, can shrink rare solid tumors like appendix cancer, anal cancer, and mesothelioma. About 133 participants with various rare cancers will receive the drugs intravenously. The goal is to see if the …

Researchers are testing whether Chronocort, a modified-release hydrocortisone taken twice daily, controls hormones as well as standard glucocorticoid therapy in people aged 16 and over with congenital adrenal hyperplasia. The trial assigns participants to either Chronocort or the…

This study tests the safety and dosing of ocrelizumab in 23 children and teens (ages 10–18) with relapsing-remitting multiple sclerosis over 2 years. The goal is to find the best dose for a future larger study. Participants receive the drug and are monitored for side effects and …

This trial tests two treatments for dry socket, a painful complication after tooth extraction. One is Alvogyl, a standard medicated dressing. The other is platelet-rich fibrin (PRF), made from the patient's own blood, which may help tissue heal. About 102 adults with dry socket w…

This phase II trial is testing the drug dinaciclib in 72 people with stage IV melanoma that has spread. The drug works by blocking enzymes that help cancer cells grow. Researchers are looking at side effects and whether it helps patients live longer or slows tumor growth.

This study tests whether cognitive behavioral therapy for insomnia (CBT-I) can help lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will receive either CBT-I or a patient education program. The main goal is to see if improv…

This study tests a new device called the Navitor TAVI system to replace a stiff, narrowed heart valve without open-heart surgery. It includes 1,500 people with severe aortic stenosis who are at low or intermediate risk for surgery. The goal is to see if the device is safe and eff…

This study follows 300 people with blocked leg arteries who received a treatment using a balloon coated with paclitaxel and vitamin E. The goal is to see if the balloon keeps the artery open and prevents the need for repeat procedures over one year. Participants are adults with m…

This trial is testing whether adding hydroxychloroquine to two targeted cancer drugs (dabrafenib and trametinib) can help children and young adults with certain brain tumors that have come back or not responded to treatment. The study includes patients with specific genetic chang…

This early-phase trial is testing a personalized cell therapy called lifileucel in 10 people with melanoma that has spread to the brain and is no longer responding to standard immunotherapy. Doctors remove a piece of the tumor, grow the patient's own immune cells in the lab, and …

Researchers are testing whether a structured primary care program can help adults aged 40 to 90 with higher heart or diabetes risk reach recommended prevention targets. The program trains doctors and nurses, uses routine data to flag at-risk patients before visits, and provides d…

This early-stage trial tests a DNA vaccine called INO-8000, given with an immune booster, to see if it can help people with chronic hepatitis C fight the virus. The study involves 33 participants and focuses on safety and finding the best dose. The vaccine is delivered through in…

This study looks at two different sedative medicines given to children on breathing machines in the ICU. The goal is to see which one causes less confusion (delirium) and helps the brain recover better. About 372 children up to age 11 will take part. The results could change how …

This early-phase trial tests a new treatment for people with advanced melanoma that has stopped responding to standard immunotherapy. The treatment uses a patient's own immune cells (TILs) that have been engineered to produce a protein called IL15, combined with a drug called ace…

This study tests two approaches—lifestyle medicine consultations and cognitive behavioral therapy (CBT)—to reduce cardiovascular risk in autistic individuals aged 9 to 26 who have a high body mass index. Participants are randomly assigned to receive lifestyle coaching, CBT sessio…

This early-phase study tests a new drug, RO7247669, that targets two immune system checkpoints (PD-1 and LAG-3) to help the body fight cancer. About 170 adults with advanced solid tumors (including melanoma, lung cancer, and esophageal cancer) who have run out of standard options…

This Phase 2 study tests a new injectable drug called maridebart cafraglutide in 409 adults with type 2 diabetes. The main goal is to see if it improves blood sugar control compared to a placebo. Researchers will also check if it helps with weight loss. The trial is active but no…

This study tests whether the drug zanubrutinib can help people with primary membranous nephropathy, a kidney disease that causes protein leakage. About 178 participants will receive either zanubrutinib or the standard drug tacrolimus. The goal is to see if zanubrutinib reduces pr…

This study tests an experimental drug called SAR441566 in about 204 adults with moderate-to-severe ulcerative colitis, a chronic bowel disease causing inflammation and symptoms like diarrhea and bleeding. Participants will receive either the drug or a placebo for up to 52 weeks t…

This early-phase trial is testing an experimental drug called TTX-080, which blocks a protein (HLA-G) that tumors use to hide from the immune system. The study will give TTX-080 alone or combined with other cancer drugs (pembrolizumab, cetuximab, or FOLFIRI plus cetuximab) to abo…

Researchers are testing whether deucravacitinib, a daily oral drug, can reduce joint swelling, tenderness, and skin symptoms in people with active psoriatic arthritis. The trial enrolls adults who have not taken biologic drugs for their arthritis or who previously received a TNF …

This study tests an experimental oral drug called GS-5290 (tilpisertib fosmecarbil) in 176 adults with moderate to severe ulcerative colitis. Participants are randomly assigned to receive either the drug or a placebo for 12 weeks. The main goal is to see if the drug can improve s…

This Phase 2 study tests an experimental drug called ALG-000184 against a standard hepatitis B medication (tenofovir) in 200 adults with chronic hepatitis B. Participants take one pill daily for 48 weeks. The main goal is to see if the new drug can lower hepatitis B virus levels …

This study tests whether adding hydroxychloroquine (a malaria drug) to standard immunotherapy (nivolumab with or without ipilimumab) can help shrink advanced melanoma tumors. About 41 adults with stage III or IV melanoma that cannot be removed by surgery are participating. The go…

This study is testing two simple tools to help women with type 2 diabetes better manage their condition and understand reproductive health risks. The tools include a personalized medication list for patients and an alert for doctors during checkups. Researchers will track blood s…

This study tests an experimental drug called TransCon IL-2 β/γ, which aims to boost the immune system to fight cancer. It is given alone or with other treatments like pembrolizumab (Keytruda) or chemotherapy. The trial includes 320 adults with advanced solid tumors that have not …

This Phase 2 trial tests whether adding TQ-A3334 tablets to standard nucleoside analog drugs can better control chronic hepatitis B. About 116 adults with the infection will receive either the combination or a placebo plus standard drugs. The main goal is to see if the combinatio…

This study tests a drug called bimekizumab in teenagers (ages 9 to 17) with moderate to severe hidradenitis suppurativa, a painful skin condition that causes boils. The goal is to see how the drug moves through the body and if it is safe. About 40 participants will receive the dr…

This early-phase trial is testing a new treatment called CC-97540, a type of CAR T cell therapy, in 12 people with severe ANCA-associated vasculitis that has not responded to standard treatments. The therapy is designed to target and destroy certain immune cells that drive the di…

This early-phase study is testing a new drug called JZP815 in people with advanced or spreading solid tumors that have specific changes in the MAPK pathway. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. About 332 adults who h…

This study tests the safety of an antibiotic called Vabomere in children aged 3 months to 12 years who have complicated urinary tract infections, including kidney infections. The children receive the medicine through an IV while in the hospital. Researchers monitor for side effec…

This trial tests whether trained village health workers, using a smartphone app, can provide effective type 2 diabetes care in rural Lesotho. 252 adults with diabetes will either receive community-based care (lifestyle advice, metformin, statins) or be referred to a clinic. The g…

This study tests two methods for adjusting basal insulin in people with type 2 diabetes who fast during Ramadan. One method follows standard guidelines, while the other uses a personalized carbohydrate fasting test. The goal is to see which approach better controls blood sugar an…

This study tracks 132 people with PNH who are taking Fabhalta to see how safe it is and what side effects occur. Researchers will monitor infections and check for serious red blood cell breakdown if the drug is stopped. The goal is to better understand the drug's risks in everyda…

This trial tests whether a toothpaste containing arginine can alter the bacteria living below the gumline in people with gum disease who are already receiving ongoing dental care. Participants will brush twice daily for six months with either an arginine toothpaste or a standard …

Researchers are studying how the length of bypassed intestine during gastric bypass affects weight loss, complications, and metabolic changes in people with severe obesity. Participants will have different lengths of intestine bypassed and will provide blood and stool samples bef…

Researchers compare a very low calorie ketogenic diet with a Mediterranean-style low-calorie diet in 40 adults who have type 2 diabetes, obesity, and non-alcoholic fatty liver disease. Participants follow one of the two diets for several weeks. The study measures changes in weigh…

This study tests whether adding olaparib to the standard chemotherapy temozolomide helps control advanced pheochromocytoma or paraganglioma—rare neuroendocrine tumors that have spread or can't be removed surgically. About 46 adults with these cancers will be randomly assigned to …

This study looks at people with severe aortic stenosis (a narrowed heart valve) who don't yet have symptoms. Doctors usually wait until symptoms appear before replacing the valve, but by then the heart may already be damaged. The researchers use MRI scans to find hidden scarring …

This long-term study tests the safety and effectiveness of bitopertin (DISC-1459) in people with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP), rare conditions that cause severe pain from sunlight exposure. About 230 participants who previously took bitoper…

This early-phase trial tested two oral drugs, cediranib and selumetinib, in 19 people with advanced solid tumors (including melanoma) that had stopped responding to standard treatments. Cediranib works by cutting off blood supply to tumors, while selumetinib blocks a key growth s…

This small pilot study at Yale tests whether semaglutide (a drug used for diabetes and weight loss) can help people who have had bariatric surgery and now struggle with alcohol use disorder. Ten adults will take the drug for three months and be followed for three more months to s…

This trial investigates whether drinking a beverage made from 30 different organic vegetables daily for four weeks can improve gut microbiome diversity, reduce inflammation, and ease PTSD symptoms in adults diagnosed with PTSD. Participants are randomly assigned to receive either…

This early-phase trial tests VX-264, a therapy made from stem cells that produce insulin, in 7 people with long-standing type 1 diabetes. The goal is to see if it is safe and can help control blood sugar. If successful, it may reduce or replace the need for insulin injections.

This study tests a cancer pill called venetoclax in 14 Japanese adults with a rare blood cancer (Waldenström macroglobulinemia) that has come back or not responded to treatment. Participants take the drug by mouth daily, with doses slowly increased. The main goal is to see how ma…

This study tests a drug called BBP-418 (Ribitol) in 81 people aged 12 to 60 with limb girdle muscular dystrophy type 2I (LGMD2I), a genetic condition that causes progressive muscle weakness. Participants receive either the drug or a placebo for 36 months to see if it slows the di…

This study is for people with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP), rare conditions that cause severe pain and skin reactions to sunlight. The purpose is to check the long-term safety of an oral medication called dersimelagon. About 301 participant…

This Phase 3 trial tests a gene therapy called DTX301 for people with late-onset OTC deficiency, a rare genetic disorder that causes dangerous ammonia buildup. The study involves 37 participants and compares the gene therapy to a placebo. The goal is to see if the treatment can h…

This study follows 17 people with Pompe disease who have already taken part in earlier trials of avalglucosidase alfa (Nexviadyme). It aims to check the drug's long-term safety and effectiveness by giving it every two weeks as an IV infusion. The study will continue until the dru…

This study tests whether delivering healthy food boxes, remote health monitoring, and one-on-one coaching can help low-income Black adults with type 2 diabetes better control their blood sugar. The trial enrolls 304 participants in the Deep South and tracks changes in HbA1c level…

This study offers kidney transplant patients with antibody-mediated rejection (AMR) the chance to receive felzartamab for up to 4 more years. AMR occurs when the immune system attacks the new kidney. The main goal is to check long-term safety and monitor kidney health through bio…

This study looks at whether semaglutide, a medicine for type 2 diabetes, can slow or prevent diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo injection once a week, in addition to their usual diabetes medicatio…

People with MEN1 syndrome inherit a high risk of developing multiple pancreatic neuroendocrine tumors. Surgery is the only curative option but causes major complications. Researchers are testing high-dose, high-precision MR-guided radiotherapy to see if it can shrink these tumors…

This early-phase trial tests two drugs together—MK-2206 and hydroxychloroquine—in people with advanced solid tumors, melanoma, kidney, or prostate cancer. The goal is to find the safest dose and see how the combination affects cancer cell growth. About 62 participants will take b…

This early-stage study tests a new drug called RO7812653 in 50 people with early Alzheimer's disease. The main goal is to check if the drug is safe and how the body handles it. Participants receive a single dose injected into the spine and are closely monitored for side effects.

This study tests whether a newer type of dialysis filter (medium cut-off membrane) can reduce inflammation and improve heart function better than the standard filter in people with end-stage kidney disease. Thirty adults on maintenance hemodialysis will use each filter for three …

This study tests whether infusions of cord blood stem cells can help people with moderate to critical COVID-19 pneumonia. The trial includes 65 adults with COVID-19-related acute respiratory distress syndrome (ARDS). Researchers will compare stem cell treatment plus standard care…

This Phase 3 study tests whether a daily pill combining obicetrapib and ezetimibe, or obicetrapib alone, can lower LDL (bad) cholesterol more than placebo in 300 people with type 2 diabetes or metabolic syndrome. Participants continue their standard cholesterol medications. The m…

This study tests an experimental oral medication, KAI-7535, taken once daily to help people with obesity or overweight lose weight. About 320 adults with at least one weight-related condition (like high blood pressure or sleep apnea) will receive either the drug or a placebo for …

This study looks at the long-term safety and effectiveness of a drug called sonelokimab for people with psoriatic arthritis. About 1560 adults who finished an earlier study will receive the drug as a shot under the skin. Researchers will track side effects and how well the drug c…

Researchers are studying whether daily injections of vosoritide can safely improve long-term growth in children with hypochondroplasia, a genetic condition that causes short stature. The trial enrolls about 140 children who have already taken vosoritide in earlier studies and who…

This study observes how well insulin icodec controls blood sugar in 245 people with type 1 diabetes who have never used it before. Participants take the insulin as prescribed by their doctor, and researchers track changes in HbA1c and treatment satisfaction over about 22 to 30 we…

This study tests whether adding a person's own bone marrow stem cells to their islet transplant can help the islets survive longer and work better. It includes 42 adults with chronic pancreatitis who are already scheduled for pancreas removal and islet auto-transplant. Participan…

Researchers are testing tividenofusp alfa (DNL310), an experimental enzyme replacement therapy, against the standard treatment idursulfase in children and young adults with mucopolysaccharidosis type II (MPS II). The study includes participants with and without brain involvement,…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This study tests a gene therapy for people with X-linked chronic granulomatous disease (X-CGD), a genetic condition that weakens the immune system and leads to severe infections. Researchers take the patient's own stem cells, add a working copy of the faulty gene, and return the …

This study looks at whether eating 2 cups of frozen raspberries daily for 8 weeks can improve blood sugar, cholesterol, and gut health in overweight or obese adults with early signs of metabolic syndrome. Researchers want to see if the berries' natural compounds help by changing …

This phase 3 trial tests whether the immunotherapy drug ipilimumab is better than high-dose interferon alfa-2b at preventing melanoma from coming back in patients whose cancer was removed by surgery. Over 1,600 people with high-risk stage III or IV melanoma took part. The study m…

This study tests a vaccine called AADvac1, which targets tau tangles in the brain, a hallmark of Alzheimer's. It will be given alone or with another drug (donanemab) to 450 adults aged 50-80 with very early Alzheimer's. The goal is to see if this approach can reduce tau buildup a…

This Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…

This study tests whether a probiotic called Lactobacillus plantarum can improve social interactions, reduce inflammation, and enhance quality of life in adults with autism spectrum disorder. Twelve participants take the probiotic for 8 weeks, with assessments including blood test…

This study tests a personalized approach to dosing two immunotherapy drugs (ipilimumab and nivolumab) for people with advanced melanoma. Instead of giving everyone four doses, doctors will check after two doses: patients who show early benefit may stop, while those who don't can …

This study tests the long-term safety and effects of JR-141, an enzyme replacement therapy, in people with mucopolysaccharidosis II (MPS II), a rare genetic disorder. Participants who completed an earlier JR-141 trial receive the drug again by IV infusion. Researchers track side …

This Phase 2 trial tests two experimental injections, HRS-7249 and SHR-1918, in 108 adults with severely high triglycerides who are at high risk of acute pancreatitis. The study aims to see if these drugs can safely lower fat levels in the blood and reduce the chance of a pancrea…

This UK trial tests whether cladribine tablets, taken for just 8-10 days a year over two years, can slow the loss of hand function in people with advanced multiple sclerosis (MS). The study includes 204 participants with significant disability (EDSS 6.5-8.5). Half receive cladrib…

This study tests whether giving buprenorphine (a medication for opioid addiction) through telemedicine works as well as in-person care. Fifty adults with opioid use disorder will be randomly assigned to either remote or in-person treatment. The main goal is to see how long people…

This early-stage trial is testing a combination of two experimental drugs, APG777 and APG990, in 86 adults with moderate-to-severe atopic dermatitis (eczema). The main goal is to check safety and how the drugs move through the body, comparing them to the existing treatment Dupixe…

This trial tests whether an 8-week home-based program called FEED@Home can reduce hospital readmissions for people with advanced dementia who have feeding difficulties. The program involves speech therapists and nurses guiding family caregivers through teleconsultations and home …

This trial tests an experimental enzyme replacement called GC1130A in children with Sanfilippo syndrome type A, a rare genetic disease that damages the brain. The enzyme is given through a small device placed under the scalp that delivers it directly into the fluid around the bra…

This early-phase study tests a single injection of ICM-203, a gene therapy that delivers a gene to promote cartilage growth and reduce inflammation in the knee. About 18 adults with mild to moderate knee osteoarthritis will receive escalating doses to check safety and whether it …

This study tests whether adding a mild expiratory resistance to the breathing circuit can improve ventilation and sleep in people with obstructive sleep apnea who also have expiratory flow limitation, a condition where exhaling is partially blocked. Researchers will compare real …

This study tests a drug called daratumumab in 40 people with a rare kidney condition called PGNMID, where abnormal proteins damage the kidneys. Participants receive weekly injections for 8 weeks, then every two weeks for another 8 weeks. The goal is to see if the drug can reduce …

This phase 2 trial is testing whether adding a personalized mRNA cancer vaccine (mRNA-4157) to the immunotherapy drug pembrolizumab can better prevent melanoma from coming back after surgery compared to pembrolizumab alone. The study involves 267 people with high-risk melanoma th…

This Phase 3 trial is evaluating how safe solriamfetol is when taken daily over a long period by children and adolescents with ADHD. Participants who completed earlier studies will receive the medication and be monitored for side effects. The goal is to see if this treatment rema…

This study tests whether taking 50 grams of blueberry powder daily for 8 weeks can improve gut bacteria and metabolic health in overweight or obese adults. Researchers will measure changes in blood sugar, cholesterol, and gut microbes. The goal is to see if blueberries can help m…

This early-phase trial tests a single dose of YTB323, a CAR-T cell therapy, in 28 adults with non-active progressive multiple sclerosis. The study aims to check safety and track disability changes over time. Participants must be 18–60 and able to undergo lumbar punctures and MRIs…

This trial tests whether extra support from peer recovery specialists can help young adults aged 18 to 25 stay in outpatient substance use treatment. Participants receive four weekly sessions plus monthly check-ins focused on motivation and skills to improve attendance. Researche…

Researchers test whether an AI algorithm called AK-AVS can spot moderate-to-severe aortic stenosis, a narrowing of the heart's aortic valve, in older adults who have not been diagnosed. The study reviews about 4,000 routine electrocardiograms (ECGs) already collected during prima…

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder that can cause dangerous blood clots. Researchers want to know how often PNH appears in people under 50 who have had a stroke, mini-stroke, or brain vein clot with no clear cause. The study will screen 200 partici…

Researchers are testing whether a brain imaging measurement can predict how strongly the body reacts to low blood sugar. The study enrolls healthy adults aged 18 to 40 with a body mass index between 20 and 30. Participants undergo two procedures: a brain scan to measure glial ace…

Researchers at Mayo Clinic are testing whether advanced PET and MRI brain scans can measure inflammation in people with multiple sclerosis and other inflammatory demyelinating diseases. The study includes about 200 participants, both patients and healthy controls. Participants re…

Functional somatic disorders cause persistent physical symptoms that doctors cannot explain by other diseases. The DISTRESS trial evaluates a new clinic where internal medicine doctors, trained to recognize these disorders, examine patients and provide guidance to their general p…

This study tests whether a new type of PET scan (18F-MFBG) can detect neuroblastoma tumors as accurately as the current standard scan (123I-MIBG). About 84 children and adults with newly diagnosed, high-risk neuroblastoma will receive both scans to compare results. If the new sca…

This study tests a new way to screen for type 2 diabetes by measuring sugar levels in fingernails. Researchers will compare results from 100 adults (half with known diabetes, half without) to standard blood tests. The goal is to see if this simple, non-invasive method can accurat…

This study tests whether special lights and cameras can help find early signs of mouth cancer in people at high risk. About 338 participants with precancerous spots or conditions like Fanconi anemia will have their mouths examined with fluorescence imaging, which makes abnormal c…

Researchers are building deep learning models that analyze digital images of kidney biopsy tissue to classify kidney diseases such as IgA nephropathy and membranous nephropathy. The study uses pathology images and clinical data from thousands of patients who had kidney biopsies a…

This study is testing whether two simple, non-invasive tests—a breath test (FeNO) and a blood test (eosinophil count)—can accurately diagnose asthma in children aged 6 to 17. Currently, diagnosing asthma often requires complex hospital-based breathing tests. The researchers aim t…

Researchers at Beijing Anzhen Hospital are studying whether a computer model that combines two types of heart scans can predict 12-month survival in people with light-chain cardiac amyloidosis, a condition where abnormal proteins stiffen the heart. The study enrolls 49 patients w…

Researchers are comparing the SavvyCheck Vaginal Yeast Test, a rapid swab test women use themselves, against standard vaginal yeast culture done in a lab. The study enrolls women with symptoms such as vaginal itching, discharge, soreness, or burning. The goal is to measure how ac…

Researchers at a Turkish hospital are studying how errors in bone density scans (DXA) affect doctors' decisions about osteoporosis. They will review scans from 530 adults, identify common positioning mistakes, correct them, and compare the original and corrected results. The goal…

Researchers are testing whether artificial intelligence can combine ultrasound images with routine health data to track changes in a person's physiology over time. The study enrolls adults with heart, lung, kidney, or blood vessel conditions, as well as healthy volunteers. The go…

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. About 43 participants from Washington, D.C. will take surveys, attend cooking classes led by a chef, and track their eating habits. The…

This study tests whether adding a communication skills video and a substance use module to standard couples HIV testing can help male couples reduce drug use and risky sex. About 484 male couples are randomly assigned to receive standard testing alone or with one or both extra mo…

Women who develop gestational diabetes are far more likely than other women to develop type 2 diabetes within a few years after giving birth. This trial tests whether a smartphone app that delivers personalized coaching on diet, exercise, sleep, and mental well-being can help pre…

Removing an impacted lower wisdom tooth can leave a painful complication called dry socket, where the protective blood clot in the empty socket breaks down. This trial compares two liquids used to rinse the socket right after extraction: normal saline and chlorhexidine, an antise…

This trial tests a school-based program called HENKA, designed to promote emotional well-being and prevent mental health problems in adolescents aged 12 to 16. The program includes eight classroom sessions on skills like self-esteem, emotional regulation, and mindfulness, taught …

This study tests whether curcumin, a compound found in turmeric, can prevent stomach cancer in people with chronic atrophic gastritis or gastric intestinal metaplasia. About 50 participants will receive either curcumin or a placebo for a period, and researchers will measure chang…

This study looks at how to best help HIV clinics in Vietnam offer a short alcohol counseling program to patients who drink heavily. The goal is to reduce risky drinking and lower the chance of spreading HIV. Over 3,200 people living with HIV and clinic staff are taking part to se…

Researchers at Cornell University are testing whether a produce prescription program helps adults who have diet-related conditions and trouble affording food. Participants receive weekly boxes of fresh local produce for 8 to 24 weeks and attend eight nutrition education classes. …

This study tests an experimental drug called LMN-201 to see if it can prevent C. difficile infection from coming back after standard antibiotic treatment. About 375 adults with a recent C. diff infection will receive either LMN-201 or a placebo. The main goal is to see if more pe…

Researchers are testing whether ParentText, a WhatsApp-based parenting programme, can be delivered through government health services in South Africa's Western Cape. The programme has two five-lesson modules: one on improving caregiver-child relationships and one on keeping child…

Researchers test whether flecainide, an antiarrhythmic drug, can prevent atrial arrhythmias in adults who have a patent foramen ovale (PFO) closed after a cryptogenic stroke. Participants receive flecainide or standard care for 3 to 6 months. An insertable cardiac monitor records…

Researchers are testing whether a detailed functional exam plus motivational interviewing helps physically inactive 40-year-olds become more active. Half of the 250 participants receive a full functional profile with advice and goal-setting support; the other half get standard me…

Researchers are testing a 12-month physical activity program for adolescents with overweight. The program includes weekly 90-minute sessions with strength, endurance, and coordination training, plus a small-group session with peers. The study measures changes in fitness, strength…

This study tests whether a disposable device called the Zero Degree Knee positioner helps people regain full knee extension faster after total knee replacement surgery. About 154 adults aged 40-80 with knee osteoarthritis will be randomly assigned to use the device at home or fol…

Researchers are comparing two ways to perform total knee replacement in patients with obesity and knee arthritis. One method uses custom-made guides based on each patient's knee scans, while the other uses standard surgical tools. The trial measures how well the knee aligns, how …

This study looks at whether weekly phone counseling can help identify and treat depression in women with ovarian, peritoneal, or fallopian tube cancer. About 409 participants will either receive phone counseling or standard care with resource lists. The goal is to see which appro…

This study tests a small device called Cerogrin that gently stimulates a nerve in the ear, aiming to improve thinking and memory in people with vascular dementia or mild cognitive impairment. Twenty-four participants will use the device at home for 30 minutes daily over four week…

Researchers compare whether adding omega-3 or resveratrol supplements to standard non-surgical gum treatment improves periodontal health in healthy non-smokers with periodontitis. The study looks back at records from 60 patients split into three groups: those who took resveratrol…

This study is testing whether an online course can help people with multiple sclerosis, long COVID, fibromyalgia, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health. The goal is to …

This study tests whether two special diets—a modified Paleolithic elimination diet and a time-restricted ketogenic diet—can improve quality of life, fatigue, and mood in 162 people with relapsing-remitting multiple sclerosis. Participants are assigned to one of the diets or stand…

Researchers are testing whether a daily oral supplement regimen improves skin, hair, sleep, energy, cognition and sexual wellbeing in healthy adults aged 35 to 65. Participants take either the active supplement or a placebo for 12 weeks. The study measures skin elasticity, firmne…

This study tests whether 3D printed custom foot orthotics work as well as traditionally made ones for people with plantar fasciitis. About 30 adults with the condition will wear one type of insert for 8 weeks and report on comfort, fit, and pain relief. The goal is to see if the …

Guillain-Barré syndrome can leave people with weak arms and hands, making daily tasks hard. This trial tests whether adding robot-assisted arm training to usual therapy helps adults in the sub-acute phase of recovery. Participants use the Armeo Power 2 exoskeleton for 20 sessions…

Researchers are testing whether a suture-based closure device helps patients recover faster after heart procedures that use a large tube placed in the femoral vein. The trial enrolls adults undergoing procedures such as atrial fibrillation ablation, leadless pacemaker insertion, …

This study tests a virtual behavioral therapy (Functional Behavioral Training) for children aged 2-12 with genetic syndromes like Fragile X, Angelman, or Rett syndrome who have challenging behaviors. The therapy teaches parents how to identify what triggers problem behaviors and …

Researchers at Cambridge Health Alliance are adapting a mental health screening and support program for racially, ethnically, and linguistically diverse youth aged 12 to 17 in the Denver Health area. The program includes screening, feedback, a single session intervention, and res…

Researchers are testing FX201, an experimental gene therapy, in adults aged 30 to 80 with painful knee osteoarthritis. Participants receive a single injection of FX201 into the affected knee. The study first checks safety at increasing doses, then gives more people the same dose …

This study tests if giving the drug dinutuximab over 4 hours or less is safe and practical for children with high-risk neuroblastoma. Currently, standard infusions take 10-20 hours and require a hospital stay. The goal is to see if a shorter infusion can be used in an outpatient …

This study tests a computer-based memory strategy program called E-MinD Life in 60 older adults, including healthy individuals, those with memory complaints, and those with mild cognitive impairment. The program teaches memory strategies through daily activities over 9 weeks. The…

Researchers are testing whether a low-level laser therapy device called Luminance RED can reduce pain and discomfort from recurrent canker sores. Adults who get canker sores at least once a month use the device at home and report daily pain and how hard it is to eat, drink, and b…

People on hemodialysis receive needle sticks through a fistula or graft several times a week, and the pain and anxiety can build over time. This trial tests whether slow, deep breathing combined with lemongrass aromatherapy reduces pain and anxiety during needle insertion. Resear…

This study tests whether a 10-week telehealth program that combines gentle exercise with mindfulness can help people with knee osteoarthritis feel less pain and move better. Researchers will compare the mindful exercise group to an exercise-only group. All sessions happen remotel…

Researchers are testing whether a Joovv Mini infrared light device changes mood, sleep, and activity levels during winter months. Participants include US-based adults with a history of mental health issues such as depression who live in colder regions. They will use the device an…

This study was designed to see if giving nitrous oxide (laughing gas) helps pregnant women feel less pain when a balloon is placed to start labor. It planned to compare nitrous oxide with plain oxygen. However, the study was withdrawn before any participants were enrolled, so no …

This study adapts Project YES+, a behavioral program, to improve mental health and reduce HIV-related stigma for adolescent and young men who have sex with men living with HIV in Vietnam. Eighty participants aged 16-24 will receive individual and group sessions with peer mentors.…

Researchers test whether repeated cold exposure using a water-perfused cooling suit can reduce liver fat and improve liver health in adults with metabolic dysfunction-associated steatohepatitis (MASH). Eleven participants wear the suit for about two hours daily over three months.…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

Researchers are testing a personalized, non-drug treatment for adults with ongoing depression, anxiety, trauma-related symptoms, sleep problems, attention difficulties, or substance-use concerns. Instead of assigning treatment by diagnosis alone, the study selects approaches base…

This study tests whether a therapist-guided virtual reality (VR) program can help adolescents in psychiatric hospitals improve how they regulate their emotions. Participants, aged 11 to 18, are randomly assigned to either personalized VR exposure sessions or a VR relaxation contr…

Researchers are observing people with knee osteoarthritis who receive an injection of Arthrosamid, a hydrogel, into the affected knee. The study follows about 200 adults over the long term to track side effects and changes in pain, stiffness, and physical function. Because it is …

This trial compares two final rinses used during two-visit root canal treatment for adults with symptomatic irreversible pulpitis, a painful tooth infection. Participants receive either a dexamethasone solution or normal saline as the last rinse inside the root canal. Researchers…

This study looks at whether a 6-month thermal spa treatment program can meaningfully reduce pain and improve daily function in people with knee osteoarthritis. Researchers will compare results from 76 participants aged 50-80 who receive the spa therapy against an external group r…

This study tests a cognitive behavioral therapy (CBT) group designed specifically for women Veterans who have alcohol use disorder. About 162 women will take part, and the therapy focuses on changing drinking habits and related behaviors. The goal is to see if this female-only ap…

This study tests whether masupirdine, a daily tablet, can safely reduce agitation in people with Alzheimer's dementia. About 375 participants will receive either masupirdine or a placebo. The main goal is to see if the drug improves agitation symptoms, which can include aggressio…

This study compares robotic-assisted total knee replacement to the standard manual procedure in 86 adults aged 40-85 with severe knee arthritis. Participants will receive the same knee implant, but one group's surgery is guided by a robotic system. Researchers will measure pain, …

This study tests a new type of cycling called eccentric cycling for people with multiple sclerosis. Researchers want to see if it improves muscle strength, walking ability, fatigue, and quality of life better than standard cycling. Sixty adults with MS who can walk independently …

This study aims to develop and test a shortened version of Mindfulness-Based Cognitive Therapy (MBCT) to improve mood in older African American/Black women who have had breast cancer and now have mild to moderate depression. About 23 participants will attend group sessions and re…

This trial tests a wearable device that uses mild electrical pulses to stimulate the leg muscles of people with multiple sclerosis who have foot drop. The goal is to see if using the device for several months improves walking quality, physical activity, and participation in daily…

This study adapts Written Exposure Therapy (WET), a brief 5-session treatment, for adolescents aged 12-18 with PTSD. Researchers will first gather feedback from experts and teens, then test the adapted therapy against the standard 12-16 session treatment in 48 teens. The goal is …

This pilot study tests MPowerHub, a smartphone app that helps adults with type 2 diabetes make sense of data from continuous glucose monitors and activity trackers. The app shows combined trends and prompts daily questions about diet, sleep, stress, and medication. Researchers wa…

Researchers are testing whether limiting eating to a 10-hour window each day can improve quality of life, ADHD symptoms, sleep, and gut health in adults with ADHD who have disrupted body clocks. The trial enrolls 60 adults aged 18 to 65 who usually eat over more than 14 hours a d…

People with rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis often struggle to stay in work. This trial tests a 6-month vocational rehabilitation program called WORK-ON, which includes a coordinating occupational therapist, group sessions with peers, and ind…

Researchers are testing whether a virtual walking program can reduce chronic pain and psychological distress in people with severe mobility impairment, mostly from spinal cord injuries or polio. Participants wear a head-mounted display and use a controller to guide an avatar thro…

Researchers are testing a virtual reality therapy for young people with depression and anxiety. The therapy adapts acceptance and commitment therapy to teach skills for viewing thoughts and emotions as temporary events. Up to 75 young people aged 12 to 25 will receive the clinici…

This study tests whether adding shock wave therapy to a knee strengthening exercise program reduces pain and improves function more than exercise alone in people with knee osteoarthritis. Forty patients with moderate knee pain will be randomly assigned to either exercise only or …

This study tests whether giving haloperidol alone or with chlorpromazine can safely calm severe agitation and confusion (delirium) in 70 advanced cancer patients in a palliative care unit. The main goal is to see if the drugs improve sedation scores within 24 hours. It is a phase…

Researchers are testing whether occupational therapy that uses virtual reality can improve cognitive skills, daily performance, and motivation in children with autism. The study includes 32 children aged 6 to 12 with autism level 1. Half receive virtual reality-supported cognitiv…

After hip replacement through a front incision, many people feel numbness, tingling, or burning in the thigh because a nearby nerve gets irritated. This trial tests whether a handheld massage gun, used at home twice a day for six weeks, can ease those symptoms faster than gentle …

This study looks at three different methods to activate cleaning fluids during root canal retreatment: ultrasonic, sonic, and laser. The goal is to see which one causes the least pain and helps the infection heal best. Seventy-five adults with previously treated teeth that still …

Researchers at the University of Illinois at Chicago are studying which parts of a yoga practice affect anxiety, mood, and thinking in highly anxious college women. About 60 participants complete four sessions that include yoga postures, breathwork, meditation, or watching a yoga…

This study tests a smartphone app called MS CATCH that lets people with multiple sclerosis regularly report their mood to their neurologist. The goal is to improve how doctors screen and treat depression in MS. About 100 adults with MS and mild-to-moderate depression are taking p…

This study looks at whether people with melanoma prefer getting their cancer medicine as a shot under the skin or through an IV. About 100 patients will try both ways and say which they like better. The goal is to make treatment more convenient and comfortable for patients.

Researchers are testing a new medical device called Bocaliner in people who have painful mouth sores caused by chemotherapy or radiation. The device is held in the mouth after using medicated mouthwashes, gels, or rinses, with the goal of keeping those treatments in contact with …

This study tests a new program that combines mindful eating with motivational interviewing to help people with overweight reduce binge eating. One hundred participants will either receive the full program (counseling plus daily meditation) or just daily meditation. The main goal …

This study looks at whether treating insomnia can help people with Crohn's disease feel better, including reducing pain and inflammation. About 83 adults with mild to moderate Crohn's and insomnia will receive a remote sleep treatment. The main goal is to see if the approach is p…

This Phase 3 trial tests whether catechins (compounds found in green tea) given as a pill or spray can prevent or treat skin damage caused by radiation therapy. About 162 cancer patients will receive either catechins or a placebo, alongside standard care. The goal is to see if th…

This study tests whether adding mental health care to standard diabetes treatment improves mood and blood sugar control in adults with type 1 diabetes. Eighty participants will be randomly assigned to usual care or a collaborative care model that includes a behavioral health cons…

Researchers are studying whether a pre-made plantar insole, designed by shoe size and gender, helps adults with plantar fasciitis that has lasted at least six months and resisted other treatments. About 25 people will wear the insole during everyday walking for one year. The team…

This trial tests a six-month program where a coordinating rheumatology nurse helps people with inflammatory arthritis set goals and plan actions to manage their condition. Participants also get access to physiotherapy, occupational therapy, and social work support as needed. The …

This study at Johns Hopkins tests whether using personalized mobile health assessments can improve cognitive-behavioral therapy (CBT) for children aged 8-17 with obsessive-compulsive disorder (OCD). 30 participants will receive either standard CBT or CBT guided by their own sympt…

This study tests whether a smartphone app that uses augmented reality (AR) can help people quit smoking when used alongside standard quitline counseling. The app shows smoking-related cues to help users manage cravings. The trial will enroll 3,600 adult daily smokers and measure …

Researchers are testing a virtual stress-management program for people who care for a spouse or partner with a solid tumor cancer while also holding a job. The program teaches skills such as paced respiration, relaxation, and coping with work and caregiving demands across eight s…

This early-stage study tests whether LCFA-01, a natural gel containing oleic acid, is safe and comfortable when placed in the vagina. Thirty healthy women aged 18-40 will use the gel and be monitored for side effects, discomfort, and how much of the product enters the bloodstream…

This study tests whether a mobile app called PTSD Coach, with or without brief clinician support, can reduce PTSD, anxiety, depression, and sleep problems in World Trade Center responders living in Florida. About 120 English- or Spanish-speaking responders will be randomly assign…

This study looks at whether doing heated or non-heated yoga can reduce symptoms of depression. Researchers will enroll 120 adults with moderate depression. Participants will practice yoga and report their mood changes over time.

This study tests whether a 12-week web-based support program can improve wellbeing in adults who survived a cardiac arrest 1 to 3 months earlier. The program includes educational modules, videos, breathing exercises, and a chat forum. Researchers will compare 120 participants who…

Researchers are testing whether a six-week group talk therapy program eases depression in Ugandan villages. The trial enrolls about 1,200 people aged 15 and older with at least moderate depressive symptoms across 100 villages in Luuka and Buikwe districts. Villages are randomly a…

Researchers are comparing two common surgical approaches during total hip replacement: removing the acetabular labrum (a ring of cartilage around the hip socket) or leaving it in place. The trial enrolls 200 adults with hip osteoarthritis who are scheduled for a primary unilatera…

Researchers in Greece are testing a nine-session group program called TRANSFORM for people who have finished treatment for blood cancers such as leukemia, lymphoma, and myeloma. The program combines teaching, reflection, coping exercises, and mindfulness to see whether it can spa…

This pilot study tests whether taking a seaweed supplement called fucoidan for 8 to 16 weeks can reduce fatigue and inflammation in cancer survivors. Researchers will enroll 40 adults who have completed cancer treatment within the last 10 years and still feel tired. The main goal…

Researchers are testing whether semaglutide, a drug used for diabetes and weight loss, is safe and tolerable in adults with cocaine use disorder. The trial includes 40 people who use cocaine often, some of whom also have HIV. Participants receive weekly injections of semaglutide …

This study tests a proprietary amino acid drink given twice daily for up to 4 days to older adults (60+) hospitalized with infections who have delirium. 20 participants get the drink, 20 get standard care, and 20 non-delirious controls are observed. The goal is to see if the drin…

This study tested two ways to teach people with gingivitis (early gum disease) how to clean their teeth better. One group watched a video, the other practiced on a dental model. After one month, both groups showed improved gum health and awareness, with no major difference betwee…

Researchers are adapting a mobile health program that pairs the PositiveLinks app with video counseling from a community health worker. The study enrolls 60 people in Florida who have HIV and mild to moderate anxiety or depression. Participants receive either the enhanced counsel…

This trial tests whether a wearable sensor that monitors home exercises helps people recover after total knee replacement. Researchers randomly assign 250 adults to either use the sensor or receive standard unsupervised home exercises. The study compares knee function, pain, and …

This study tests a program called FOREST that teaches positive emotion skills to staff working in gun violence prevention. The goal is to reduce burnout, anxiety, and depression, and improve well-being and job retention. One hundred employees from UCAN in Chicago will take part o…

This study combines virtual reality with a gentle electrical pulse on the ear (called taVNS) to help people with chronic shoulder pain who are waiting for surgery. The goal is to see if this drug-free approach can reduce pain, anxiety, and depression. Only 10 people will take par…

Researchers test an 8-week online precision nursing education program for young colorectal cancer survivors. The program includes Qigong exercise and mindfulness training delivered through an e-flipped classroom model. The study measures changes in depression symptoms and mindful…

This study tests whether olanzapine, a medication typically used for mental health conditions, can reduce opioid cravings and misuse in adults with cancer who are on long-term opioid pain therapy. About 87 participants will receive either olanzapine or a placebo to see if it help…

This study tests an experimental drug called APG777 in 470 adults with moderate-to-severe atopic dermatitis (eczema) that hasn't improved with creams. The goal is to see if the drug safely reduces skin redness, itching, and rash. Participants receive either APG777 or a placebo fo…

This pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease. Ten participants will work one-on-one with a coach in nine virtual sessions to learn problem-solving strategies and memory a…

Researchers at Baylor College of Medicine are testing whether a supplement combination called GlyNAC can improve brain energy use and reduce inflammation in people with Alzheimer's disease. The trial enrolls 52 adults aged 55 to 85 who have progressive memory loss and amyloid pla…

Researchers are comparing three ways to treat shoulder stiffness: physical therapy alone, the ERMI Shoulder Flexionater stretch device alone, and the device plus physical therapy. The trial includes people with frozen shoulder (adhesive capsulitis), people with stiffness after sh…

Researchers are testing an experimental eye drop called TJO-087 in adults with dry eye syndrome. The trial enrolls about 90 people who have dry eye symptoms and signs of corneal damage. Participants receive either TJO-087 or a placebo drop for 3 months. The main measure is whethe…

This study tests whether using a portable oxygen concentrator (a lightweight, battery-powered device) during walking or exercise helps people with interstitial lung disease (ILD) or COPD feel less breathless and be more active in their daily lives. Twenty-four participants will t…

Depression is common among cancer survivors, but many don't get help. This pilot study tests a text-based referral platform that sends tailored messages and a video to encourage survivors to take up a mental health referral. The study will enroll 60 cancer survivors with depressi…

This study compares two 12-week exercise programs—eccentric training and heavy-slow resistance training—in 30 adults aged 18–50 with patellar tendinopathy (knee pain lasting over 3 months). Researchers measure changes in tendon thickness, stiffness, strength, and pain to see whic…

This study compares cognitive behavioral therapy (CBT) with online expert coaching to usual care for children aged 6-14 with autism who struggle with anxiety, irritability, or emotional outbursts. About 100 children and 50 therapists will take part. The goal is to see if the coac…

Researchers at Evanston Hospital are testing whether a single intramuscular dose of ketamine can quickly reduce suicidal distress in adults who arrive at the emergency department and are waiting for psychiatric admission. The pilot study enrolls 8 patients who receive the injecti…

This study tests a new, non-invasive brain stimulation method using low-intensity ultrasound waves aimed at specific brain areas linked to depression. Researchers will personalize the treatment for each of the 30 participants based on their brain scans. The goal is to see if this…

This study looks at whether terpenes—natural compounds found in plants—can reduce pain when taken alone or with THC. Researchers will test 45 adults who use cannabis regularly to measure pain relief and any feelings of being high or drug liking. The goal is to find safer ways to …

This study is testing a new behavioral program for pregnant women with ADHD. The program teaches skills to manage ADHD symptoms during pregnancy and after the baby is born. Ten participants will work with a therapist in an OB care setting. The goal is to see if the program is acc…

This study tests whether taking probiotic supplements for 6 months can reduce pain, improve knee function, and boost quality of life in women aged 45-70 with knee osteoarthritis. Researchers will compare the probiotic group to a placebo group to see if the gut bacteria help lower…

This study tests whether an online problem-solving therapy, matched to a person's specific symptoms using machine learning, can reduce depression and anxiety better than usual care. About 380 adults with moderate symptoms will take part. The goal is to create a precise, scalable …

This study explores whether a photography-based program can help children aged 8-12 with ADHD better recognize and express emotions, and improve attention and impulsivity. Sixty children will take photos and learn photography skills as a tool to boost emotional well-being. The go…

This study compares high-effort versus low-effort resistance exercise sessions to see which better controls blood sugar in people with prediabetes or type 2 diabetes. Fifteen participants will complete both types of sessions plus a no-exercise control day, with blood sugar monito…

Researchers are running an international registry to follow adults who had an ischemic stroke or transient ischemic attack and also have a patent foramen ovale, a small opening between the upper chambers of the heart. The registry collects real-world information on how these pati…

This study looks at a special training program called Fundamentals of Communication in Surgery (FCS) for surgeons and surgery trainees. The goal is to see if the training helps surgeons communicate better with patients and each other. About 600 people will take part, and research…

This study tests a new interview tool called the Opioid Timeline Follow-Back (OpiTLFB) to better track nonmedical opioid use, including fentanyl. Thirty adults who use opioids at least once a week will fill out a calendar and answer questions about their drug use over the past 30…

This natural history study follows 259 children, adolescents, and adults with Neurofibromatosis Type 1 (NF1) for up to 10 years. Researchers will track tumor growth, monitor quality of life, and perform genetic testing to better understand how the disease changes over time. The g…

Researchers at UC San Diego want to know whether doing a mental task changes breathing differently in people who take opioid pain medicine every day, people with obstructive sleep apnea, and healthy adults. The study compares three groups of 40 adults in total. Each participant v…

This study follows 126 melanoma survivors who are receiving immunotherapy after surgery. Researchers will track side effects and quality of life for up to 24 months. They will also collect blood samples to look for markers that might predict who gets side effects. The goal is to …

This study looks at whether transcranial magnetic stimulation (TMS) can change how people with opioid use disorder and healthy volunteers make risky or uncertain decisions. Participants will have MRI scans and computer tasks, and some will receive real or sham TMS. The goal is to…

This study looks at people with late-onset Pompe disease to measure antibodies against a virus used in gene therapy and against the standard enzyme replacement therapy. It also checks for biomarkers in blood and urine. About 119 teenagers and adults will give samples over 2 years…

This study reviews medical records of 72 American Indian patients treated with immunotherapy for cancers like lung cancer, melanoma, and kidney cancer. Researchers compare their outcomes—such as how long the cancer is controlled and side effects—to those of White patients. The go…

This study follows over 64,000 adults who grew up on farms to see if early exposure to pesticides and other agricultural factors is linked to cancer. Participants fill out an online questionnaire and may provide biological samples. Researchers will track their health over many ye…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study develops and tests a decision-making program designed specifically for African American adult daughters who make healthcare choices for their parents with dementia. The program focuses on communication, problem-solving, and understanding the healthcare system, all whil…

This early-phase trial tested a special PET/CT imaging agent, Zirconium Zr 89 Crefmirlimab Berdoxam, to see if it can measure immune activity in tumors of patients with advanced melanoma. Six adults on immunotherapy plus hydroxychloroquine received scans before and after starting…

The SHAKTI study is a 5-year observational project that will follow 6,000 people of Asian or Pacific Islander descent, aged 10 and older, with depression or related mood disorders. Researchers will collect a wide range of data—including lifestyle, clinical history, blood and stoo…

The Austrian LEAD study follows a large group of people to understand how lung, heart, and metabolic health change over time. Researchers measure lung function with spirometry and track body composition and metabolic markers. By observing this group, they aim to learn how these c…

Researchers at Semmelweis University are studying whether bacteria that cause gum disease also show up in damaged blood vessels. They will compare samples from the mouth and from diseased artery sites in 100 people who need surgery for aortic aneurysm or carotid artery narrowing.…

Infective endocarditis is an infection of the heart's inner lining or valves. About half of patients need surgery during their hospital stay, while others receive antibiotics alone. Researchers are following 1,046 adults with confirmed endocarditis for up to 24 months to compare …

Researchers at the University of Management and Technology Sialkot are studying how motor coordination relates to postural stability in children with autism spectrum disorder. The study includes 30 children aged 5 to 12 who can stand and walk without help. Parents answer a questi…

Researchers in Argentina are developing and testing a self-administered questionnaire to measure how hereditary transthyretin amyloidosis affects patients' physical, emotional, and social quality of life. The study includes input from neurologists, a cardiologist, a psychologist,…

This study tests whether giving smokers and former smokers a personalized risk report (based on clinical and genetic factors) helps doctors order lung cancer screening and helps patients follow through. About 915 participants will be randomly assigned to usual care or one of two …

This study was designed to see if giving pregnant women nutrition advice based on their unique biology, lifestyle, and health could improve their health and their baby's health. It planned to enroll women less than 20 weeks pregnant, excluding those with high-risk conditions. How…

Researchers are studying how advanced and metastatic melanoma is diagnosed and treated in everyday Spanish clinics. The study follows about 400 adults with stage III, metastatic, or unresectable melanoma from their first diagnosis. No experimental treatment is given; instead, the…

This study surveys over 21,000 nurses at Mayo Clinic to measure levels of moral distress, moral injury, and post-traumatic stress. Participants fill out questionnaires about their experiences and well-being. The goal is to understand how these issues vary by work setting, special…

This study checks if a Turkish version of a questionnaire about managing low blood sugar (hypoglycemia) is accurate and reliable. Researchers will ask 200 adults with type 2 diabetes who have had low blood sugar to fill out the questionnaire. The goal is to make sure the scale wo…

This study tests whether a simple educational guide can help postpartum patients who had high blood pressure during pregnancy become more active in their own care. Researchers will give the tool to some mothers shortly after delivery and compare their engagement scores with those…

This early-stage study looks at how taking a new tablet called CX11 with or without food changes the amount of drug in the blood. It involves 32 healthy adults and does not aim to treat any disease. The results will help researchers decide how to give the drug in future studies f…

This study collects and analyzes blood, DNA, and tissue samples from 315 adults with pulmonary fibrosis, their relatives, and healthy volunteers. The goal is to learn more about the disease's causes, not to test a new treatment. Researchers hope the findings will guide future the…

This study uses MRI scans to look at the brains of children and adults with conditions like ADHD, autism, schizophrenia, and endocrine disorders, as well as healthy volunteers. Researchers aim to compare brain anatomy and function across different groups and ages. The goal is to …

This study looks at how healthy lungs respond to a substance called endotoxin, which mimics a bacterial infection. Researchers will collect lung cells and fluid from 58 healthy, non-smoking adults using a thin tube inserted into the airways. The goal is to understand inflammation…

This study aims to identify genetic, biochemical, and clinical factors linked to disease severity in people with Gaucher disease and other lysosomal storage disorders. Researchers will evaluate up to 1,000 participants, including patients, carriers, and healthy controls, to bette…

This study is looking at how nerve pain (neuropathic pain) affects the ability to care for oneself and overall quality of life in people with type 2 diabetes. Researchers will measure pain levels and quality of life in 128 adults with type 2 diabetes. The goal is to better unders…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…

This long-term study looks at people and families with a higher chance of developing blood or lymph node cancers like leukemia or lymphoma. Researchers collect medical histories, genetic samples, and sometimes perform exams to find inherited genes or environmental triggers. The g…

This pilot study looks at biomarkers in the blood of people with fragile sarcolemmal muscular dystrophy, a condition that makes muscle membranes weak. Researchers will collect blood samples at rest and after exercise during four 5-day hospital stays. The goal is to better underst…

This long-term study follows over 3,700 adults in Baltimore to understand why some people age healthier than others. Researchers are looking at how race, income, and neighborhood affect risks for diseases like diabetes, heart disease, and memory loss. Participants visit mobile he…

This study looks at people and families who have a high risk of cancer to learn what genes and environmental factors might increase that risk. Over 5,000 participants are followed over time with questionnaires, medical records, and optional genetic testing. No treatment is given,…

This observational study follows adults with morbid obesity who undergo bariatric surgery to see if substantial weight loss changes the alignment of their hips, knees, and ankles. Researchers measure leg alignment using standing X-rays before surgery and at 3, 6, and 12 months af…

This study aims to test a new assessment tool called the ANA, which uses surveys and computer tasks to measure three key brain functions related to addiction. Researchers will study 1,400 adults with alcohol use disorder to see how these brain functions relate to drinking behavio…

Researchers at Ain Shams University are examining kidney biopsy tissue from 30 adults with lupus nephritis to see whether a protein called TGF-beta is present and how it relates to kidney scarring, disease activity, and chronic damage. Participants undergo a standard ultrasound-g…

This study looks at whether special mouth and throat exercises can improve sleep apnea by strengthening the muscles that keep the airway open. Thirty adults with sleep apnea will use myofunctional therapy devices for three months. Researchers will measure muscle pressure in the t…

Researchers are studying how people with relapsing multiple sclerosis use ofatumumab in everyday practice in Germany and Japan. The study looks at insurance claims from about 5,000 adults to see how many stay on the treatment and how regularly they take it. It also tracks how oft…

This pilot study is testing a device called LabClasp that measures blood sugar without needles. Researchers want to see if regular, non-invasive glucose checks can help predict gestational diabetes and preeclampsia in pregnant women. The study plans to enroll 100 women with at le…

This study follows 500 obese adults to see how different factors like diet, exercise, stress, and sleep affect weight loss. Researchers collect blood tests, measurements, and questionnaires at the start and during follow-up. The goal is to find patterns that could lead to more pe…

Primary biliary cholangitis is a rare liver disease that slowly damages the bile ducts and can lead to cirrhosis or a liver transplant. Researchers are studying anonymised health records from about 3,000 adults in four Spanish databases to estimate how many people have the diseas…

Researchers are checking whether tests of muscle strength, walking, balance, and fine motor skills give consistent results in people with polyneuropathy. About 520 adults with various forms of nerve damage, plus healthy volunteers, take part. Participants complete physical tests,…

This study collects health information and test results from 317 people at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. Researchers aim to build a database to find better ways to detect the disease early or prevent it. No …

This study follows 25 people with spinocerebellar ataxia type 7 (SCA7) for up to 5 years to learn how the disease changes vision, coordination, and thinking. Participants will have yearly eye exams, brain scans, and neurological tests. No treatment is given; the goal is to gather…

This study tests whether a brief information session can help people with risky alcohol use feel more comfortable seeking help. Many avoid help due to shame or fear of consequences, even though effective treatments exist. Researchers will measure changes in participants' willingn…

This 10-year study follows 1,500 young people aged 10-24 to learn what makes some more resilient to depression and anxiety than others. Researchers will track lifestyle, brain scans, and mental health over time. No treatments or interventions are given—the goal is simply to obser…

This study aimed to evaluate how community cancer centers test for biomarkers in common solid cancers like breast, lung, and colorectal cancer. Researchers planned to survey pathology practices to see if they follow guidelines for key tests and how quickly results are reported. T…

This study follows 2,500 people aged 10 and older with depression or bipolar depression over 10 years. Researchers collect data on symptoms, brain scans, genetics, and lifestyle to find patterns that predict how someone will respond to different treatments. No experimental drugs …

This study follows 817 military personnel who served in Iraq to see how war affects mental health, thinking skills, and daily life over time. Participants complete surveys and in-person tests on mood, stress, and memory. The goal is to learn how conditions like PTSD develop and c…

This study investigates how the brain processes anticipation of rewards in people with bulimia nervosa. Researchers will use brain scans (fMRI) and daily-life surveys to compare 100 participants—those with bulimia and healthy controls. The goal is to identify neural and psycholog…

This study looked at whether people who donate a kidney have a higher chance of developing gout later in life compared to similar healthy people who did not donate. Researchers reviewed health records from 50,000 donors and matched non-donors in Canada over many years. The goal i…

This study follows children and adults with medullary thyroid cancer (MTC), often linked to a genetic condition called MEN2. Researchers will track how the cancer grows and affects health over time using regular check-ups, blood tests, and imaging. No treatment is given, but part…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study investigates why brown fat, which burns calories to generate heat, stops working when it's warm. Researchers will use cold vests on 8 healthy and obese adults to see how genes and proteins change. The goal is to find new targets for treating obesity and related metabol…

Researchers are testing a coaching program to help primary care clinics in rural West Virginia screen and treat opioid use disorder, HIV, and hepatitis C. The program includes group priority-setting, rapid-cycle improvement coaching, and provider training. Twenty clinics will tak…

This study looks at whether a 12-session parenting program can change brain activity in mothers recovering from opioid use disorder. Researchers will use EEG to measure brain responses to baby faces and cries before and after the program. The goal is to see if supporting the moth…

This study tests whether an AI chatbot can help people with hip or knee osteoarthritis feel less conflicted and anxious about their treatment choices. About 100 adults with osteoarthritis will chat with the AI before seeing their surgeon. Researchers will measure changes in decis…

Researchers at Karolinska Institutet are surveying adults in Sweden who have Chiari malformation type 1, a condition where part of the brain pushes into the spinal canal. The study asks how these patients rate their health-related quality of life compared with the general Swedish…

This study is a health check for students at Constructor University Bremen and employees at HAW-Hamburg. Researchers will use surveys and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects wellbeing and find ways to suppor…

This study follows 285 older adults with Alzheimer's or mild cognitive impairment to learn how they make decisions about aging in place or moving to long-term care. Researchers will track planning and preferences over time. No treatment or intervention is being tested.

This study trains police officers and first responders to better communicate with people who have aphasia, a condition that affects speech and understanding. 75 participants from the Madison Police Department will take part for up to 6 months. The goal is to see if training impro…

Researchers are reviewing medical records from a large hospital network in Buenos Aires to understand what happens to adults with severely weakened immune systems after they catch RSV, influenza, or SARS-CoV-2. The study covers 350 patients and looks at how sick they were at diag…

This study follows 110 people with brain metastases who are receiving either focused or whole-brain radiation. Researchers use advanced MRI scans and memory tests before treatment and for two years after to see if the scans can predict thinking and memory problems. The goal is to…

This study tests whether brain wave (EEG) measurements can predict who will get better from a non-invasive magnetic stimulation treatment for depression called rTMS. Researchers will treat 30 adults with depression using rTMS and compare their EEG patterns before and after treatm…

Researchers are testing a transition program for 17-year-olds with type 1 diabetes, asthma, or obesity who are preparing to move from pediatric to adult healthcare. The program includes a consultation with the teen and family, a solo visit where the teen completes a readiness che…

This study looks at whether a high-fiber, plant-based diet and regular exercise can change the gut microbiome in people with melanoma who are receiving immunotherapy. Researchers want to see if these lifestyle changes are feasible and if they might affect how well the treatment w…

This study uses a noninvasive brain stimulation technique called TMS, combined with brain scans, to understand working memory problems in people with early psychosis. Twenty participants will receive both active and placebo TMS to see how it affects brain activity and memory perf…

This early study at Mayo Clinic tests whether using a device that massages the legs at night can help the brain clear waste products better in people with obstructive sleep apnea. The study involves 12 adults aged 50 and older who already use CPAP therapy. Researchers will measur…

This study aims to understand how genes affect obesity, diabetes, and heart disease in people of African ancestry. Researchers will collect blood samples and health information from 1,100 adults, including African Americans, Afro-Caribbeans, and migrants from sub-Saharan Africa. …

Researchers are building a registry to follow adults with recurrent pericarditis, a condition where inflammation around the heart keeps coming back. The registry collects information over time on how often flare-ups happen, what treatments patients receive, and whether they are h…

Researchers are running a long-term observational study to see whether changes in clinical measurements over time can predict meaningful patient outcomes better than a single snapshot. The study will enroll about 1,000 adults and follow them, collecting routine clinical data, lab…

Researchers are examining how the body's natural day-and-night rhythms behave in people treated in the intensive care unit. The study uses routine data already collected during and after ICU stays, including heart rate, temperature, blood pressure, blood sugar, and insulin. The t…

This observational study will enroll 100,000 people over age 45 to track early signs of Alzheimer's and Parkinson's using smartphone-based tests, genetic data, and brain scans. Researchers aim to develop better ways to identify who is at risk before symptoms worsen. Participants …

Researchers at Sahlgrenska University Hospital are collecting cerebrospinal fluid through lumbar puncture from people with alcohol use disorder and from healthy volunteers across different ages. They will measure molecules such as dopamine and test how the fluid affects nerve cel…

This study looks at children having surgery to remove a common neck lump called a thyroglossal duct cyst. Some kids will have a small drain placed during surgery, and some will not. The goal is to see if using a drain reduces problems like infection, fluid buildup, or the need fo…

Researchers are collecting blood and skin samples from people with ALS, people with MS, and healthy volunteers. They turn skin cells into stem cells and grow them into 3D organoids that mimic the brain and spinal cord. The goal is to see whether secretions from human amniotic mes…

This study aims to validate a new questionnaire that measures emotional wellbeing and patient perceptions after total knee replacement surgery for knee arthritis. Researchers will enroll 167 adults who had knee replacement within the last 3 months. The goal is to ensure the quest…

This completed study tested different messages to see which ones make adults more willing to get the HPV vaccine, which prevents certain cancers. Over 5,300 adults aged 18-45 were randomly assigned to read one of five theory-based messages or a control message. The goal was to fi…

This study aims to find blood-based biomarkers that signal the presence and size of plexiform neurofibromas in people with Neurofibromatosis type 1 (NF1). Researchers will collect blood samples and use whole-body MRI to compare biomarker levels in 200 participants with different …

This large study is looking at the genes of over 9,000 people with diabetes and kidney disease, along with their family members. The goal is to find which genes make some people more likely to get diabetic kidney disease. By understanding the genetic roots, researchers hope to de…

This study follows 207 people with primary hyperoxaluria type 1 (PH1), a rare kidney disease, to see how the condition progresses over time. Researchers are also checking the long-term safety and real-world effectiveness of the drug lumasiran. Participants are not given any new t…

This study will test whether using essential oils (by smelling, applying to skin, or swallowing capsules) can improve immune health in healthy adults aged 18 to 45. Forty participants will use either the oils or a placebo for 30 days. Researchers will measure changes in blood, sa…

This study is testing a new video game designed to help teenagers with congenital heart disease learn how to manage their own healthcare. The game teaches skills like talking to doctors, understanding medical information, and keeping track of appointments and medications. About 1…

This pilot study is testing whether it's possible to run a larger study that focuses on heart disease in women. Researchers will gather information from 176 women aged 25-55 in Ontario who have had certain female-specific health issues like pre-eclampsia, gestational diabetes, or…

Researchers are studying whether a mother's weight and blood sugar during pregnancy affect the makeup of her breast milk, and whether those differences influence how her baby grows. The study will follow pregnant women with a range of body sizes, including those with gestational …

This study looks at how daily cannabis smoking changes pain sensitivity and the risk of abuse in healthy adults who already use cannabis. Researchers will measure pain tolerance and withdrawal symptoms over 16 days in a controlled hospital setting. The goal is to understand if ca…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure a fungal marker called BDG in blood and urine, and track lung health over three years. The goal is to better understan…

This large study is testing whether a risk-scoring tool (called ENDPAC) can identify people with new-onset diabetes who are at higher risk for pancreatic cancer. About 8,800 participants aged 50-85 will have their medical records checked for age, weight changes, and blood sugar t…

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

This study tests whether platelet-rich plasma (PRP) injections into the knee can change certain proteins in the blood of people with knee osteoarthritis. About 60 participants aged 18-70 will receive either PRP or a saltwater placebo, and researchers will compare protein levels t…

This study compares two different radioactive tracers used in PET scans to measure tau tangles in the brain, a hallmark of Alzheimer's disease. Researchers will scan over 800 participants with either Flortaucipir or MK-6240 to see how well they work over time. The goal is to harm…

This pilot study tests a program that screens older dialysis patients for common age-related problems like falls, memory trouble, and medication issues. A geriatrics team then gives personalized recommendations to the dialysis clinic. The goal is to see if this approach is practi…