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Gut health fix for aching knees? probiotic trial launches

NCT ID NCT06459700

Symptom relief Sponsor: Lund University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Sep 09, 2026 · Updated 4 times

Summary

This study tests whether taking probiotic supplements for 6 months can reduce pain, improve knee function, and boost quality of life in women aged 45-70 with knee osteoarthritis. Researchers will compare the probiotic group to a placebo group to see if the gut bacteria help lower inflammation and ease symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
probiotic supplements
What this could lead to
If it works, this could point toward a simple, safe way to reduce pain and improve daily life for people with knee osteoarthritis.
What could go wrong
This is a small, early-stage trial with only 86 women. The results may not apply to everyone, and probiotics may not work better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 86 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2024

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 70 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Females aged 45-70 years 2. Clinical diagnosis of knee OA 3. Mild to moderate knee joint pain (Visual Analog Scale (VAS) 3-7)) during the last 3 months 4. Able to perform walking and stair tests 5. No use of other supplements/food products containing probiotics and/or supplements targeting OA symptoms (e.g., glucosamine, turmeric) 6. Able to write and understand Swedish. Exclusion Criteria: 1. Rheumatoid arthritis or other active generalised inflammatory comorbidities affecting the gastrointestinal tract (IBD, celiac disease) 2. Performed a total knee replacement on the affected knee or on waiting list for joint replacement 3. Other concomitant injuries or surgeries overriding the OA knee symptoms 4. Other concomitant injuries or diseases where physical activity is a contra indication 5. Malabsorption disorders, presence of renal and/or hepatic failure 6. Use of corticosteroids with doses above 10 mg/day and/or Intra-articular injections during the previous 6 months 7. Heavy use of alcohol (\>10 standard units a week), or recreational drug use 8. BMI ≥30 Kg/m2 9. Antibiotic treatment during the previous 2 months 10. clinical depression diagnosis 11. Pregnancy/breast feeding 12. Smoking or other nicotine containing products during the previous 6months 13. Performed a gastric bypass 14. Immunosuppressive treatment or impaired immune system 15. Chronic or acute diarrhoea 16. Blood/plasma donation/transfusion during the 3months or during the study 17. Non-controlled diabetes 18. Allergy with regards to any of the study product ingredients.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

Contacts and locations

Locations

  • MoReLab, Lund University

    Lund, 22100, Sweden

More trials for these conditions

Other studies related to the condition(s) this trial covers.