Scientists hunt for hidden genes behind family blood cancer clusters

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: On referral, persons \>= 11 months will be included only because of personal history, and persons \>=18 years can also be included because of personal or family history of the parameters listed below: * A medical history of hematologic/ lymphoproliferative malignancy of an unusual type, pattern, or number or * Known or suspected factor(s) predisposing to hematologic malignancy, either genetic and/or congenital factors (birth defects, metabolic phenotype, chromosomal anomalies or Mendelian traits associated with tumors), environmental exposure (medications, occupation, radiation, diet, infectious agents, etc.), or unusual demographic features (very young age of onset, multiple tumors, etc.) Personal and family medical history must be verified through questionnaires, interviews, and review of pathology slides and medical records. For familial neoplasms, two or more living affected cases among family members are generally required, although in selected instances exceptions may be made, e.g., for WM, one case plus a living 1st degree relative with an autoimmune condition will qualify a family for further investigations. Disease-specific considerations. Familial aggregation of any hematologic cancer(s) is eligible for study. Disease-specific procedures are outlined in appendices: 1. Chronic lymphocytic leukemia (CLL) 2. Waldenstrom macroglobulinemia (WM) 3. Non-Hodgkin lymphoma (NHL) 4. Hodgkin lymphoma (HL) 5. Mixed/miscellaneous hematologic and lymphoproliferative diseases Ability of subject or Legally Authorized Representative (LAR) to understand, and the willingness to sign, a written informed consent document. EXCLUSION CRITERIA: * Referred individuals for whom reported diagnoses cannot be verified; * Referred individuals who decline informed consent.