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New study aims to catch pancreatic cancer sooner in diabetics

NCT ID NCT04662879

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 09, 2026 · Updated 3 times

Summary

This large study is testing whether a risk-scoring tool (called ENDPAC) can identify people with new-onset diabetes who are at higher risk for pancreatic cancer. About 8,800 participants aged 50-85 will have their medical records checked for age, weight changes, and blood sugar trends. Those flagged as high risk will get a CT or MRI scan to look for early signs of pancreatic cancer. The goal is to see if this approach can detect the cancer earlier than usual.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a screening method that catches pancreatic cancer earlier in people with new-onset diabetes, potentially improving survival.
What could go wrong
This is an observational study, not a treatment trial. The algorithm may not prove accurate enough for widespread use, and early detection does not guarantee better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

8,869 people

The number who actually took part.

Started

Oct 2021

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient must have given institutional consent for minimal risk studies. * Patient must be ≥50 and ≤85 years of age at the time of diagnosis \[index date Parameters of Diabetes Mellitus (PDM)\]. * Patient must have index weight and left-window weight values available in electronic medical record (EMR). * Patient must have hyperglycemia and/or diabetes as one of the following (all glycemic parameters, except for HbA1c, must be measured in an outpatient setting): A. Glycated hemoglobin (HbA1c) ≥ 6.5% OR B. Any (2) PDMs on consecutive (≤90 days between PDMs) or simultaneous testing: * Fasting Blood Glucose (FBG) ≥126 mg/dl * Glycated hemoglobin (HbA1c) ≥ 6.5% * Random Blood Glucose (RBG) ≥200 mg/dl * 2 hour Post Glucose (PG) ≥ 200mg (11.1 mmol/L) during oral glucose tolerance test (OGTT) OR C. Any one (1) PDM present followed by an anti- diabetes medication ≤90 days after the index PDM date * Patient must have ≥1 glycemic parameter measured in the past 91-548 days prior to the index PDM date (Left Window) without meeting inclusion criteria A, B, or C. * For Intervention Sites, patients must meet inclusion criteria A, B, or C ≤90 days prior to enrollment. Exclusion Criteria: * Patient has declined institutional consent for minimal risk studies. * Patient must not have any known past history of hyperglycemia and/or diabetes as defined by inclusion criteria A, B, or C \*Transient diabetes (e.g. gestational and steroid-induced) is not an exclusion. * Patient must not be on ongoing active treatment for cancer, and/or carry a current diagnosis of any cancer (except non-melanoma skin cancer). Non-invasive cancer of any organ (carcinoma-in-situ/high grade dysplasia) is not an exclusion. \*Ongoing work up for suspicion of pancreatic cancer is not an exclusion. * Patient must not have had a definitive diagnosis of pancreatic cancer prior to index PDM date. * Patient must not be on any anti-diabetes medications prior to index PDM date. * Patient must not be on chronic or acute use of steroid medications ≤90 days prior to the index PDM date. \*Allowed: Nasal, topical steroids, oral budesonide, ophthalmic * Patient must not have had an intra-articular steroid injection ≤ 7 days prior to the index PDM date. * Patient must have values available in the EMR to calculate the ENDPAC score.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Kaiser Permanente Southern California, Kaiser Permanente Research

    Pasadena, California, 91101, United States

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Other studies related to the condition(s) this trial covers.