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Could a quick insulin shot stop Steroid-Induced blood sugar spikes?

NCT ID NCT07757464

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 11, 2026 · Last updated Sep 16, 2026 · Updated 3 times

Summary

Steroid injections for knee arthritis can temporarily raise blood sugar in people with type 2 diabetes. This trial tests whether giving a short course of NPH insulin right after the injection can prevent those high blood sugar episodes. Adults with type 2 diabetes and knee osteoarthritis will be randomly assigned to receive either the pre-emptive insulin or their usual diabetes care. Both groups will wear continuous glucose monitors to track blood sugar levels for 72 hours after the injection, and the study will also check for low blood sugar and other side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NPH insulin (a type of intermediate-acting insulin) given as a short course of injections after a knee steroid injection
What this could lead to
If it works, this could offer a simple way to prevent steroid-related blood sugar spikes in people with type 2 diabetes, making joint pain relief safer and more comfortable.
What could go wrong
This is an early-phase trial with a modest number of participants, so results may not apply to everyone. NPH insulin can cause low blood sugar, and the added injections may be burdensome.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 125 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 40 to 80 years at consent. * Documented diagnosis of type 2 diabetes for at least 6 months. * HbA1c from 6.5% through 9.0% measured within 30 days before randomisation. * Symptomatic osteoarthritis of one knee for which the treating clinician has independently determined that an intra-articular corticosteroid injection is clinically indicated. * Planned administration of one intra-articular injection of triamcinolone acetonide crystalline suspension 40 mg into the index knee. * Diabetes managed without insulin, sulfonylureas or meglitinides. * Permitted glucose-lowering medications at stable doses for at least 30 days before randomisation. * Estimated glomerular filtration rate at least 45 mL/min/1.73 m² within 60 days before randomisation. * Capillary glucose from 90 through 250 mg/dL immediately before the injection. * Ability and willingness to perform scheduled capillary glucose testing, administer or receive subcutaneous insulin if assigned, follow hypoglycaemia instructions and remain contactable through day 7. * Ability to wear the study continuous glucose monitoring device and provide informed consent. Exclusion Criteria: * Type 1 diabetes, latent autoimmune diabetes in adults, pancreatogenic diabetes or another specific diabetes type requiring insulin. * Current basal, prandial, premixed or pump insulin treatment. * Current sulfonylurea or meglitinide treatment. * HbA1c below 6.5% or above 9.0%. * Capillary glucose below 90 mg/dL or above 250 mg/dL immediately before injection. * Fasting glucose above 250 mg/dL, random glucose above 300 mg/dL, clinically significant ketonaemia or hyperglycaemia requiring immediate treatment during screening. * Estimated glomerular filtration rate below 45 mL/min/1.73 m². * Severe hepatic impairment or another condition expected to materially alter insulin clearance or hypoglycaemia risk. * Level 3 hypoglycaemia requiring third-party assistance during the previous 6 months. * Documented impaired awareness of hypoglycaemia. * Pregnancy, planned pregnancy during study participation or breastfeeding. * Oral, intravenous or intramuscular corticosteroid use within 30 days before the study injection. * Any intra-articular, epidural, periarticular or soft-tissue corticosteroid injection within 30 days before the study injection. * Planned additional systemic or injected corticosteroid exposure before the day-7 assessment. * Acute febrile illness, active systemic infection or acute deterioration in health at screening or injection. * Suspected septic arthritis, infection over the injection site, prosthetic index knee, uncontrolled bleeding disorder or another contraindication to knee injection. * Known allergy or clinically significant hypersensitivity to triamcinolone acetonide, human NPH insulin, insulin aspart, protamine, lidocaine or required excipients. * Known allergy to continuous glucose monitoring adhesive or a skin condition preventing sensor use. * Cognitive, visual, physical or social limitation that would prevent safe glucose testing, insulin administration, hypoglycaemia treatment or study contact. * Participation in another interventional study likely to affect glucose or corticosteroid response. * Any condition that, in the investigator's documented judgement, makes participation unsafe for a reason not otherwise captured above.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Shifa International hospital

    Lahore, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.