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New study tests better ways to clean teeth during root canal retreatment

NCT ID NCT07150585

Symptom relief Sponsor: Ege University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 15, 2026 · Updated 2 times

Summary

This study looks at three different methods to activate cleaning fluids during root canal retreatment: ultrasonic, sonic, and laser. The goal is to see which one causes the least pain and helps the infection heal best. Seventy-five adults with previously treated teeth that still have small infections are taking part. Pain is measured over a week, and healing is checked with X-rays up to two years later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could identify the best irrigation activation method to reduce pain and improve healing after root canal retreatment.
What could go wrong
This is a small, early-stage study with only 75 participants, so results may not apply to all patients. The outcomes rely on subjective pain reports and radiographic healing, which can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

75 people

The number who actually took part.

Started

Aug 2024

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy patients * Patients between 18 and 65 years of age * Patients with previously root canal-treated teeth who are asymptomatic * Patients with maxillary anterior teeth presenting with periapical lesions measuring between 2-5 mm * Teeth with completed root development and healthy periodontal status * Patients who agreed to participate in the study Exclusion Criteria: * Patients with any systemic disease * Pregnant patients * Patients with allergies to the materials used during the procedure * Patients with previously root canal-treated teeth who are symptomatic * Teeth in the maxillary anterior region with periapical lesions smaller than 2 mm or larger than 5.1 mm * Teeth with open apices * Teeth with advanced periodontal disease and mobility * Patients who did not consent to participate in the study

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asymptomatic apical periodontitis Retreatment

Contacts and locations

Locations

  • Ege University, Department of Endodontics

    Izmır, Bornova, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.