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New root canal dressings aim to cut pain and speed healing

NCT ID NCT07641933

Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares three different root canal dressings used between visits in retreatment cases. The goal is to see which one best reduces inflammation, shrinks infection-related lesions, and lowers pain. Sixty adults with previously treated but still infected lower first molars will be randomly assigned to one of the three dressings.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
calcium silicate or calcium hydroxide mixed with sodium hypochlorite
What this could lead to
If it works, this could point toward a better root canal dressing that reduces pain and speeds healing after retreatment.
What could go wrong
This is a small, early-phase trial with only 60 people, so results may not apply to everyone. The treatments are already used in dentistry, so no major new risks are expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age: 21-45 years. 2. Medically free patients. (ASA Class 1) 3. Gender: males and females 4. Patients who are cooperative at operation and in attendance at scheduled follow-up visits. 5. Restorable root canal treated permanent lower first molars with periapical lesions. 6. Small (\<5 mm) or medium periapical lesion size (5-10 mm) Exclusion Criteria: 1. Patients with a history of allergic reactions to any of the study materials. 2. Teeth that become non-restorable after complete caries excavation. 3. Teeth that have mobility or deep periodontal pockets. 4. Teeth with internal or external resorption.

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Conditions

The condition(s) this trial relates to.

periapical periodontitis suppurative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asa physical status I Intervention studies Intracanal medication Periapical abscess Retreatment

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ain Shams University

    RECRUITING

    Cairo, Egypt

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