Scientists spy on Lungs' first response to fake infection
NCT ID NCT02392442
First seen Jun 26, 2026 · Last updated Sep 17, 2026 · Updated 9 times
Summary
This study looks at how healthy lungs respond to a substance called endotoxin, which mimics a bacterial infection. Researchers will collect lung cells and fluid from 58 healthy, non-smoking adults using a thin tube inserted into the airways. The goal is to understand inflammation and the role of microRNA molecules in the lung's defense.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Endotoxin
- What this could lead to
- If successful, this could improve understanding of how the lungs fight infection and how microRNA influences inflammation.
- What could go wrong
- This is an early-stage study in healthy volunteers, not patients. It aims to understand basic biology, not test a treatment, so direct benefits are unlikely.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 58 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2015
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA: 1. Healthy 18 to 45 year old, nonsmoking subjects based on screening examination and laboratory tests. 2. No significant active medical problems. This would include but not be limited to any cardiac disorder (e.g. arrhythmia, valvular heart disease), pulmonary disease (e.g. asthma requiring chronic medications, chronic bronchitis, emphysema), neurologic disorder (e.g. epilepsy), kidney disease (e.g. nephritis, nephrosis), rheumatologic disorder (e.g. inflammatory arthritis), endocrine disorder (e.g. diabetes, thyroid disease), liver disease (e.g. hepatitis), gastrointestinal disorder (e.g. inflammatory bowel disease) or infectious disease (e.g. human immunodeficiency virus). 3. No concurrent medications including aspirin or non-steroidal anti-inflammatory drugs or have not taken these for at least 7 days prior to study participation. 4. Previous smokers would have to have abstained from cigarettes for at least one year and have no greater than a 10-pack year smoking history. If you use a hookah, e-cigarette, or vaping more than once a week, you must abstain for at least 6 weeks prior to participating in the study. 5. Females must be practicing active method of birth control or abstinence of sexual activity. 6. Must be willing to have samples stored EXCLUSION CRITERIA: 1. Any serious active medical problem as defined above 2. Pregnancy and/or lactation 3. BMI \>30
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States