Probiotics and brushing: a tiny study on gum health in teens with braces ends early
NCT ID NCT04634201
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether taking probiotic tablets (Lactobacillus reuteri) twice a day, along with regular tooth brushing, could reduce gum inflammation in teenagers with braces. Only 3 participants were enrolled before the study was terminated early, so no meaningful results were obtained. The idea was that probiotics might help balance the mouth's bacteria and lower the risk of gingivitis.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Oral probiotics (Lactobacillus reuteri)
- What this could lead to
- If it worked, this could point toward a simple way to reduce gum inflammation in teens with braces.
- What could go wrong
- The study was terminated early with only 3 participants, so no reliable conclusions can be drawn. Probiotics may not help everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
3 people
The number who actually took part.
- Started
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Mar 2022
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
12 to 16 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * adolescents aged 12 to 16 benefiting from social security coverage * in good general health in brushing and taking treatments * Have FODs * who consent to the study and whose parents have given their consent * suitable for orthodontic treatment in view of his oral state Exclusion Criteria: * inability to obtain informed consent * use of another probiotic or toothpaste / antiseptic mouthwash ≤ 1 month before inclusion * allergy or hypersensibiliity to the active substance or to any of the excipients listed in the Gum® PerioBalance® user guide) * no history of antibiotic therapy, antiseptic mouthwash ≤ 1 month before inclusion * medical contraindication (immunosuppression, pathology requiring prophylactic antibiotic therapy before dental care) * physiological, pathological condition, medication or behavior that may have repercussions on the oral cavity (eg: pregnancy, diabetes, antiepileptics, tobacco) * oral state requiring other priority care (untreated cavities, untreated active periodontitis, progressive recession)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hop Salengro - Chu Lille
Lille, 59037, France
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Other studies related to the condition(s) this trial covers.
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