LYMPHOMA

This study tests adding a new drug called capivasertib to a standard treatment for adults with certain types of leukemia or lymphoma that have come back or not responded to treatment. The standard treatment includes venetoclax and low-intensity chemotherapy. The study has three p…

This study tests a new way to make special immune cells (T cells) that can attack cancer cells infected with the Epstein-Barr virus (EBV). The cells are grown faster in the lab and given to patients with Hodgkin or non-Hodgkin lymphoma, or related diseases that have come back or …

This study tests a new oral drug called AZD3470 in people with certain blood cancers, including Hodgkin and non-Hodgkin lymphoma. The goal is to see if the drug is safe and works, either alone or with other cancer treatments. About 161 adults and adolescents will take part in thi…

This study tests a combination of five drugs (venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide, called ViPOR) in people with B-cell lymphoma that has returned or not improved after prior treatment. The goal is to see if this drug mix is safe and can control the c…

This study tests a new drug called glofitamab against standard treatments for mantle cell lymphoma that has returned or stopped responding to therapy. About 182 adults will be randomly assigned to receive glofitamab alone or one of two standard drug combinations. The main goal is…

This study tests whether a cord blood transplant, used as a first or second transplant, can help children and young adults (up to age 26) with blood cancers like leukemia and lymphoma. About 71 participants will receive the transplant to see if it keeps them cancer-free for at le…

This study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in adults with blood cancers who are at high risk of rejecting a stem cell transplant. Participants receive the drug before standard transplant preparation to reduce DSA levels enough to al…

This study tests whether the drug mosunetuzumab, given alone or with a BTK inhibitor (like ibrutinib), can clear tiny amounts of leftover leukemia cells in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 40 adults who are already on or ha…

This study tests pembrolizumab, an immunotherapy that helps the immune system fight cancer, in children aged 6 months to 18 years with advanced melanoma, solid tumors, or lymphoma that has spread, returned, or not responded to treatment. The goal is to see if the drug can shrink …

This study tests a new drug called OSE-279 that blocks PD-1, a protein that can stop the immune system from attacking cancer. It is for people with advanced solid tumors or lymphomas that have not responded to other treatments. The study has three parts: first finding a safe dose…

This study tests the drug pembrolizumab in Japanese children with solid tumors or lymphomas, and in Japanese adults with advanced Merkel cell skin cancer. The main goals are to check the drug's safety, how the body processes it, and whether tumors shrink. About 20 participants wi…

This early-stage trial tests an experimental drug called TLN-254 in about 50 adults with T-cell lymphoma that has returned or not responded to prior therapy. The main goal is to see if the drug can shrink tumors or make them disappear. Researchers will also monitor side effects a…

This study tests a new drug, duvelisib, against two standard chemotherapy drugs (gemcitabine or bendamustine) in people with a rare type of T-cell lymphoma that has returned or not responded to prior treatment. The main goal is to see if duvelisib can delay cancer growth longer t…

This study tests the safety and effectiveness of ponatinib in children aged 1 to under 18 with advanced leukemias, lymphomas, or solid tumors that have come back or not responded to other treatments. The goal is to see if the drug can shrink or control the cancer. About 70 childr…

This early-stage trial is testing a new drug called TLN-121, alone or with other treatments, in about 180 people whose Non-Hodgkin Lymphoma has returned or not responded to prior therapies. The main goals are to check the drug's safety and how the body processes it, while also lo…

This study tests a new combination of drugs (bendamustine, rituximab, cytarabine, and zanubrutinib) as initial treatment for mantle cell lymphoma, followed by a maintenance phase with or without an additional drug (sonrotoclax). The goal is to see if this approach leads to a comp…

This study tests whether a non-invasive procedure called remote ischemic preconditioning (RIPC) can prevent heart damage in lymphoma patients receiving anthracycline chemotherapy. About 608 adults with lymphoma or breast cancer will be randomly assigned to receive either RIPC or …

This study tests whether adding a short course of radiation to the drug glofitamab can help people with a fast-growing type of lymphoma (DLBCL) that has come back or not responded to prior treatment. It focuses on patients with a high tumor burden, who typically do not respond as…

This study tests if the antiviral drug remdesivir can safely treat RSV (a common respiratory virus) in 60 adults whose immune systems are weakened by cancer treatments or autoimmune therapies. Participants must have a confirmed RSV infection with symptoms. The main goal is to see…

This study tests whether combining rituximab (an antibody) with venetoclax (a targeted pill) can effectively treat marginal zone lymphoma that hasn't been treated before. About 33 adults with measurable disease will receive the drug combo, and researchers will measure how many ac…

This study tests alectinib, a drug already approved for some lung cancers, in patients with rare cancers that have an ALK gene change. About 30 adults and children with ALK-positive cancers will receive alectinib to see if it shrinks tumors or stops them from growing. The goal is…

This study tests whether the drug mosunetuzumab, given alone or with zanubrutinib, can shrink or eliminate tumors in people recently diagnosed with follicular lymphoma who have not yet had treatment. About 152 adults with advanced or bulky disease will receive the drugs and be mo…

This study tests a new drug called valemetostat combined with two standard drugs (rituximab and lenalidomide) in people with follicular lymphoma that has returned or not responded to prior treatment. The main goals are to find a safe dose and to see how well the combination works…

This study tests a mix of six drugs (ViPOR-P) in people with B-cell lymphoma that came back or didn't respond to prior treatment. The goal is to see if the combination is safe and can shrink tumors. Up to 55 adults will receive up to six 21-day cycles of oral pills and IV infusio…

This study tests the drug ruxolitinib in people with T or NK cell lymphoma that has come back or not responded to treatment. Ruxolitinib blocks a protein that helps these cancer cells survive, which may shrink the tumors. About 83 adults will take part to see if the drug can cont…

This study tests a one-time infusion of specially engineered immune cells (lisocabtagene maraleucel) as the first treatment for primary central nervous system lymphoma in 65 adults who are not eligible for a stem cell transplant. The goal is to see if this therapy can control the…

This study tests a new form of the chemotherapy drug carmustine (called VI-0609) that doesn't contain ethanol, compared to the standard version (BiCNU) which does. Both are used as part of the BEAM conditioning regimen before a stem cell transplant in adults with Hodgkin or non-H…

This study is testing an experimental drug called NUC-7738, given alone or with another drug (pembrolizumab), in people with advanced solid tumors or lymphoma that have not responded to other treatments. The goal is to find the safest dose and see if it can shrink tumors or slow …

This study tests whether the drug nivolumab can slow or stop the growth of certain cancers linked to the Epstein-Barr virus. About 40 people aged 12 and older whose cancers did not respond to standard treatments will receive nivolumab every two weeks. The goal is to see if the dr…

This study tests whether combining two drugs, mosunetuzumab and zanubrutinib, can safely control marginal zone lymphoma that has returned or not responded to prior treatment. About 36 adults with this slow-growing blood cancer will receive the combination. The goal is to see if t…

This study tests whether the drug epcoritamab can help people with follicular lymphoma whose cancer did not completely go away after standard first treatment. About 35 adults with advanced-stage disease will receive epcoritamab as a second-line therapy. The main goal is to see ho…

This study looks at how well umbilical cord blood stem cells from unrelated donors can restore blood cell counts in people with serious blood cancers, immune deficiencies, or genetic disorders. Researchers will track how often the transplant succeeds, how long it takes for blood …

This study tests a radioactive drug (lutetium Lu 177 edotreotide) in children aged 2 to 17 with cancers that have a specific marker (SSTR-positive). The goal is to find the best dose and see if it is safe. About 20 children whose cancer has not responded to prior treatment will t…

This study tests a combination of three drugs—epcoritamab, zanubrutinib, and rituximab—in people with follicular lymphoma or marginal zone lymphoma that has come back or not responded to prior treatment. The goal is to see how well the combo works at shrinking tumors and to check…

This study tests whether a very low dose of radiation (4 Gy) can control marginal zone lymphoma, a slow-growing blood cancer. About 50 adults with early-stage disease will first receive the low dose; if the tumor shrinks enough, no further radiation is given. The goal is to reduc…

This early-stage study is testing an experimental drug called LB1410 in people with advanced solid tumors or lymphoma that hasn't responded to standard treatments. The drug is a bispecific antibody designed to block two proteins (PD-1 and TIM-3) that can help cancer hide from the…

This study tests whether the drug loncastuximab tesirine can help people with large B-cell lymphoma who had only a partial response to CAR T-cell therapy achieve a complete remission. About 30 adults whose lymphoma returned or didn't fully respond after CAR T will receive the stu…

This study tests whether fecal microbiota transplantation (FMT) can reduce gut-related side effects from antibiotics in lymphoma patients receiving standard CAR-T cell therapy. About 40 adults with B-cell lymphoma will get FMT alongside their treatment. The goal is to see if it's…

This study tests a new treatment called CD70-CAR T cells for children and young adults up to age 21 with blood cancers like leukemia, lymphoma, or MDS that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to…

This early study tests if a mild electrical pulse to a nerve in the ear can help protect the heart in people receiving chemotherapy for breast cancer or lymphoma. Researchers will check heart function and inflammation markers in 104 adults who recently started chemo. The goal is …

This early-phase study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy is safe and effective for people newly diagnosed with primary central nervous system lymphoma, a rare brain cancer. About 15 participants will receive the combination and be …

This early-stage trial tests a new treatment for people with certain blood cancers (like Hodgkin lymphoma) that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells, which are modified in the lab to better attack cancer cells. The m…

This study tests new drug combinations to prevent graft-versus-host disease (GVHD) in people with blood cancers who receive stem cells from an unrelated donor. About 358 participants will get either the standard GVHD prevention drugs or a new mix, and researchers will compare whi…

This study tests whether adding the drug eliglustat to standard CD30-targeted immunotherapy can improve outcomes for people with CD30-positive lymphoma. About 40 adults who have already tried at least one other treatment will receive either a CAR-T cell therapy or an antibody-dru…

This study tests an experimental drug called MDX2003 in about 180 adults with B-cell lymphomas (like diffuse large B-cell lymphoma or follicular lymphoma) that have returned or not improved after at least two prior treatments. The main goals are to find the safest dose and to see…

This study tests whether adding two targeted drugs, glofitamab and polatuzumab, to standard chemotherapy (R-CHP) can improve outcomes for people with high-risk diffuse large B-cell lymphoma. About 41 adults with untreated disease will receive the combination. The main goal is to …

This early-stage study tests a new drug called glofitamab combined with two chemotherapy drugs (gemcitabine and oxaliplatin) in about 50 US adults with diffuse large B-cell lymphoma that has returned or stopped responding to prior treatment. The main goals are to check safety and…

This study tests a drug called repotrectinib in children and young adults (up to age 25) with advanced solid tumors or lymphomas that have specific genetic changes (ALK, ROS1, or NTRK1-3). The first part finds the safest dose, and the second part checks how well the drug shrinks …

This program provides access to a cancer treatment called tisagenlecleucel (Kymriah) for people with lymphoma, leukemia, or other conditions where standard treatments have failed. It is for patients who cannot join a clinical trial and have no other good options. The goal is to o…

This study tests a drug called odronextamab in 35 adults with untreated, low-tumor follicular lymphoma. The goal is to see if the drug can shrink or eliminate tumors. Participants receive the drug as an infusion, and researchers will monitor how well it works and any side effects…

This study tests whether a prebiotic (resistant starch) can improve gut microbiome diversity in 30 people with multiple myeloma or lymphoma undergoing autologous stem cell transplant. Participants take the prebiotic or a placebo for about 10 days before and until engraftment. The…

This study looks at whether lower doses of two common blood thinner pills (apixaban and rivaroxaban) work as well as standard daily injections to prevent dangerous blood clots in people with blood cancers like lymphoma, leukemia, and multiple myeloma. About 100 participants will …

This study is testing a new two-drug combination (ZG005 and gecacitinib) for people with lymphoma that has returned or hasn't responded to previous treatments. The first part aims to find a safe and effective dose, while the second part will measure how well the combination works…

This study tests a new type of PET scan that targets a protein called CD70, which is found on some cancer cells. The goal is to see if this scan can better detect kidney cancer, lymphoma, and nasopharyngeal cancer compared to standard scans. About 300 adults with known or suspect…

This study looks at three types of scans—MRI, PET/MR, and PET/CT—to see which one works best for finding tumors in children and young adults with cancer. About 100 participants with solid tumors will be enrolled. The goal is to improve how doctors diagnose and monitor these cance…

This study tests a new ultrasound method called super-resolution ultrasound (SRUS) to see if it can better tell the difference between benign (harmless) and malignant (cancerous) lymph nodes. About 779 adults with abnormal lymph nodes will get this special ultrasound before a bio…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study will collect MRI scans from 3000 adults with brain tumors (like gliomas or metastases) to train an AI system. The goal is to help doctors identify tumor types more accurately without surgery. If successful, it could reduce the number of biopsies needed.

This study tests whether the drug mogamulizumab can prevent adult T-cell leukemia/lymphoma (ATL) in people infected with HTLV-1 who have early cell changes. About 134 participants will receive a limited course of the drug to reduce their viral load. The goal is to stop cancer bef…

This study looks at whether offering blood transfusions at home for people with advanced blood cancers who are in hospice care can improve their quality of life and mood. About 700 adults with relapsed or hard-to-treat blood cancers will take part. The goal is to see if this prog…

This study tests whether personalized diet advice from a registered dietitian can reduce fatigue and improve sleep and quality of life in lymphoma survivors. About 100 adults with persistent tiredness will receive 8 counseling sessions over 3 months by phone or video. The goal is…

This study looks at whether adding a special palliative care program (called PEACE) to usual cancer care can help adults with lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly assigned to either get PEACE plus standard …

This study tests a smartphone app that connects young adults (ages 18-40) who have finished treatment for certain cancers (lymphoma, breast, testicular, or sarcoma) with trained peer navigators. The goal is to see if this digital support program is feasible and helps participants…

This study is testing a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage common symptoms like pain, fatigue, and emotional distress, and encourages participants to stay engaged with their follow-up medical care. Abo…

This study tests a home-based rehabilitation program for 40 adults with lymphoma or myeloma who are about to receive CAR-T cell therapy. The program includes personalized exercise and nutrition plans, monitored remotely via a web portal and smart technology. The goal is to see if…

This study tests whether a simple card game, called the Go Wish Game, can help people with advanced blood cancers or solid tumors talk about their end-of-life wishes with their doctors. About 75 adults with a life expectancy of more than 3 months will play the game and then compl…

This study tests a drug called eflapegrastim in 40 children with solid tumors or lymphoma who are receiving chemotherapy. The goal is to see if it safely helps their white blood cell counts recover faster, reducing the risk of serious infections. Participants will be monitored fo…

This early-phase trial is testing whether eating magnesium-rich foods and applying magnesium lotion can help lymphoma patients keep their magnesium levels in a healthy range. About 60 adults with lymphoma will try this approach for up to 12 weeks. Researchers will also check for …

This study tests whether a one-day hospital visit that includes medical, psychological, and social support can improve the quality of life for teens and young adults (ages 15-25) who have just finished cancer treatment. About 214 participants will be randomly assigned to receive …

This study tests whether a 12-week program of short, frequent activity breaks can help newly diagnosed lymphoma patients on chemotherapy. Researchers want to see if reducing long periods of sitting can improve heart health and lessen drug side effects. The study involves 24 adult…

This study looks at whether a 12-week home exercise program with remote coaching and monitoring can improve heart and lung fitness and daily activity levels in people who have finished treatment for lymphoma. About 80 participants will be randomly assigned to either home-based or…

This study tests whether adding a non-opioid painkiller (ketorolac) to standard opioid pain medicine can reduce the amount of opioids needed after preventive thigh bone surgery. The surgery is for patients with cancer that has spread to the thigh bone but who do not have a broken…

This study tests a smartphone app called ASSIST that uses artificial intelligence to help people with breast cancer, lymphoma, or colorectal cancer manage symptoms during treatment. About 60 adults starting or recently starting systemic therapy will either use the app for 12 week…

This study tests a program called GEM-S, which combines a geriatric check-up with survivorship health education, to see if it helps older cancer survivors with daily activities, memory, and mental well-being. About 668 participants will be split into two groups: one gets GEM-S, t…

This study tests a program called UPLYFT for lymphoma survivors who worry about their cancer returning. The program provides information and tools to improve quality of life and reduce anxiety. About 74 survivors who finished treatment within the last 3 to 24 months will particip…

This study tests an 8-week virtual rehabilitation program (CaRE@Home) for adults who have finished treatment for breast, colorectal, head and neck cancer, or lymphoma. The goal is to see if the program reduces disability and improves physical function, anxiety, and quality of lif…

This study is creating a large registry of lymphoma patients in Malawi to collect detailed information about the disease and its treatment. Researchers will enroll 800 people with suspected lymphoma, perform biopsies, and follow their health over time. The goal is to better under…

This study is for people newly diagnosed with a type of lymphoma called DLBCL. Researchers want to see if a blood test that tracks tumor DNA can help decide who can safely stop chemotherapy early. About 40 participants will get standard treatment, and those whose blood test shows…

This study is developing and testing a communication training program called Hematolo-GIST for doctors who treat large B-cell lymphoma. The goal is to help doctors talk with patients about their diagnosis and plan future care. About 48 people (doctors and patients) will take part…

This study tests a decision-support tool called PRIME for adults aged 60 and older with blood cancers like lymphoma, leukemia, or multiple myeloma. The tool helps patients clarify their personal values and shares that information with their doctors. The goal is to see if using PR…

This study follows 475 women with breast cancer or lymphoma to see how cancer treatments impact their sexual health and ability to have children. Participants will fill out questionnaires and may also choose to give blood samples to measure ovary function. The goal is to better u…

This study looks at whether a blood test that finds cell-free DNA (tiny bits of genetic material floating in the blood) can help doctors detect lymphoma and see how well treatment is working. About 517 adults with a type of lymphoma called DLBCL will give blood samples before and…

This study is a registry that collects information from 1,000 patients with blood diseases who receive stem cell transplants at a hospital on the Qinghai-Tibet Plateau. Researchers will track their health, treatments, and costs over time to learn how high altitude affects recover…

This study watches how older patients (60+) with certain blood cancers handle standard CAR T therapy and how it changes their quality of life. No extra treatment is given—just regular care and check-ins. The goal is to see if patients can complete all planned visits before their …

This study looks at lymphoma patients who also develop a serious immune condition called HLH. Researchers will collect data from 2,000 participants to see which treatments and factors help patients live longer. The goal is to find better ways to treat this rare complication.

This study looks at whether using a simple early warning score (based on vital signs like heart rate and oxygen levels) can help doctors identify blood cancer patients who are getting sicker and need intensive care. The goal is to see if moving these patients to the ICU sooner ca…

This study looks at the genetic makeup of tumors from 40 adults with advanced solid tumors or lymphoma. The goal is to use this information to better match patients with early phase clinical trials. Participants provide a tissue sample from a past surgery or biopsy, but no new tr…

This study tests whether an AI-powered chatbot can help people with blood cancers (like leukemia, lymphoma, or multiple myeloma) better understand clinical trials and feel more willing to join one. About 196 participants will receive either standard education or AI-assisted educa…

This study aims to uncover the genetic roots of lymphomas, leukemias, multiple myeloma, and similar diseases by collecting DNA and blood samples from people who have these conditions and their family members. Researchers will analyze the samples to find genes that increase the ri…

This study tests whether a smartwatch and artificial intelligence can detect early signs of heart problems in people who have had lymphoma or sarcoma. About 250 participants will use a mobile device to record their heart's electrical activity, which an AI will analyze to find hid…

This study tracks thinking and memory changes in children and young adults (ages 5-35) with hard-to-treat blood cancers who receive CAR T-cell therapy. Participants take computer and paper tests at home or at the hospital to measure memory, attention, and reasoning over up to 3 y…

This study is testing whether a new lab platform can quickly suggest personalized cancer treatments for 210 patients in Florida whose cancer has come back or not responded to standard therapy. The platform combines drug sensitivity testing and genetic profiling to recommend optio…

This study is testing whether an AI tool can create a personalized list of questions for people with lymphoma or multiple myeloma to use during their doctor appointments. About 40 participants will use the AI-generated list and then report how confident they felt communicating an…

This study collects blood or cheek swab samples from people with cancer who are already in treatment at the National Cancer Institute. Researchers will analyze the DNA to find genetic differences that may affect how the body processes cancer drugs and whether side effects occur. …

This study collects blood, bone marrow, and tissue samples from up to 15,000 people with blood cancers or related disorders. The samples are stored and used for future research to better understand these diseases. Participants do not receive any treatment as part of this study. T…

This study follows 100 adults with blood cancers who receive whole brain radiation therapy to see how it affects their memory and thinking skills. Researchers will test cognitive function over time using standard assessments. The goal is to better understand the side effects of t…

This study looks at how well vaccines work in adults with certain blood cancers like chronic lymphocytic leukemia (CLL) or non-Hodgkin lymphomas. Participants will receive one or more vaccines (e.g., COVID-19, hepatitis B, shingles) and give blood samples to measure their immune …

This study is creating a large database of people in China with various blood diseases, such as leukemia, multiple myeloma, and hemophilia. Researchers will collect information from medical records and follow participants over time to learn about disease patterns, treatments, and…

This study is testing whether a specially designed video game can help young people (ages 15-39) who have had a stem cell transplant for leukemia or lymphoma improve their health habits. Researchers will collect feedback from 40 participants to see if the game is easy and enjoyab…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured. T…

This study looks at how services from a non-profit cancer advocacy organization affect people with blood cancers like leukemia and lymphoma. Researchers will track 400 patients over time to see if the group's programs improve access to care, quality of life, and reduce financial …

This study enrolls 88 adults receiving a stem cell transplant for blood cancers. Researchers collect DNA from blood, skin, hair, and cheek cells before and after transplant to see which source gives the most reliable genetic information for adjusting drug doses. The goal is to im…

This study is testing a new way to predict which patients with B-cell lymphoma will respond to CAR T cell therapy. Researchers will combine blood tests, scans, and immune system measurements to create a personalized risk profile. The goal is to see if this tool can be completed s…

This study enrolls people with cancer who are already participating in other studies at the National Cancer Institute. Researchers will collect and link medical records and research samples from all of a participant's past, current, and future studies. The goal is to better under…

This study tests a new PET scan that tracks immune cells called CD8+ T cells, which help fight cancer. Ten adults with lymphoma or metastatic solid tumors will get the scan before and after radiation therapy. The goal is to see if radiation brings more immune cells to tumors, not…