LYMPHOMA

This study is testing an immunotherapy drug called odronextamab in people with a specific type of slow-growing blood cancer (follicular lymphoma) who have not yet received any treatment and have a low amount of cancer. The goal is to see if this drug, which helps the body's own i…

This study is testing the safety and effectiveness of a combination of five targeted drugs (called ViPOR) for adults whose B-cell lymphoma has come back or not improved after prior treatment. The goal is to see if this drug mix can control the cancer. Participants will receive th…

This study is testing whether giving radiation therapy and chemotherapy at the same time can help control early-stage nasal NK cell lymphoma, a rare type of cancer. Researchers want to see if this combined approach is safe and effective at keeping the cancer from progressing. The…

This study is testing a two-part treatment for people newly diagnosed with Mantle Cell Lymphoma, a type of blood cancer. First, participants receive an intensive 6-month combination of chemotherapy and targeted drugs. Then, they receive up to two years of lower-dose 'maintenance'…

This early-stage study is testing the safety and effectiveness of a three-drug combination for people in the US with an aggressive form of lymphoma that has come back or stopped responding to prior treatments. It will enroll about 50 participants who have already tried at least o…

This study is testing whether a drug called mosunetuzumab, given alone or with another drug called zanubrutinib, is an effective first treatment for people with follicular lymphoma, a type of blood cancer. It will involve about 152 adults who have been recently diagnosed and have…

This trial is testing if a drug called alectinib, already approved for a type of lung cancer, can help treat other rare cancers that share the same genetic change (ALK mutation). It will involve about 30 adults and children with various rare or hard-to-treat cancers. The goal is …

This study is testing whether a drug called mosunetuzumab, given alone or with other leukemia medications, can clear very low levels of lingering cancer cells in people with chronic lymphocytic leukemia (CLL). The goal is to see if this approach can help control the disease bette…

This study is testing the drug nivolumab to see if it can slow or stop the growth of certain cancers linked to the Epstein-Barr virus (EBV). It is for people aged 12 and older with EBV-positive lymphomas or lymphoproliferative disorders who have no standard therapy options or who…

This study is testing whether a new combination of three drugs is safe and effective for people with an aggressive type of lymphoma that has come back or stopped responding to previous treatments. Researchers are enrolling adults whose cancer has returned after at least two prior…

This study is testing whether a pill called duvelisib works better than standard chemotherapy for people with a specific type of T-cell lymphoma that has come back or hasn't responded to prior treatment. About 124 participants will be randomly assigned to receive either the new p…

This small, early study is testing if eating foods high in magnesium and applying a magnesium lotion can safely improve magnesium levels in the blood of people with a history of lymphoma who are in remission. Researchers want to see if this approach is practical and well-tolerate…

This early study is testing if a drug called Darzalex Faspro can safely lower harmful antibodies in patients with blood cancers. Lowering these antibodies may allow patients who are currently ineligible to receive a potentially life-saving stem cell transplant from a donor. The s…

This study is observing how well umbilical cord blood stem cells from unrelated donors work for patients with serious blood cancers and disorders. Researchers will track how quickly patients' blood counts recover, how often the transplant fails, and the rates of disease relapse a…

This small pilot study is testing if adding a specific prebiotic fiber to food can improve gut health for people with multiple myeloma or lymphoma undergoing a stem cell transplant. Researchers believe a healthier gut might lead to better recovery and survival. About 30 participa…

This study is testing whether using a simple early warning system can help patients with serious blood cancers like leukemia and lymphoma. The system uses regular checks of vital signs (like heart rate and breathing) to identify patients at high risk of dangerous complications. I…

This study is testing whether adding a new drug called capivasertib to standard chemotherapy works better for adults with acute leukemia or lymphoblastic lymphoma. Researchers will first find the safest dose, then test if the combination helps patients achieve remission with no d…

This study is testing a new drug called repotrectinib in children and young adults (up to age 25) with advanced or spreading cancers that have specific genetic changes (ALK, ROS1, or NTRK). The first part aims to find a safe dose. The second part will see if the drug can shrink t…

This early-stage study is testing whether adding pembrolizumab, an immunotherapy drug, to standard chemotherapy helps treat primary central nervous system lymphoma, a rare cancer that starts in the brain or spinal cord. The study will enroll about 15 adults with newly diagnosed d…

This early study is testing if a simple, at-home device that gently stimulates a nerve in the ear can help protect the heart in people receiving chemotherapy for breast cancer or lymphoma. The goal is to see if this stimulation improves heart function and reduces inflammation. Ab…

This study is testing whether combining two medications—mosunetuzumab and zanubrutinib—can help control a type of blood cancer called marginal zone lymphoma that has come back or hasn't responded to previous treatments. The trial will enroll 36 adults to see how well the combinat…

This study is testing whether a personalized immune cell therapy called liso-cel can effectively treat primary central nervous system lymphoma (a rare brain cancer) as the first treatment for patients who are not eligible for stem cell transplants. The trial will enroll 65 adults…

This study is testing whether the drug epcoritamab can help people with follicular lymphoma whose cancer did not completely disappear after their initial treatment. The drug works by activating the immune system to attack cancer cells. About 35 adults who had a partial response o…

This early-stage study aims to find a safe and effective dose of a targeted radiation drug for children and teenagers with specific cancers that have come back or stopped responding to standard treatments. The therapy delivers radiation directly to cancer cells. Researchers will …

This early-stage study is testing an experimental drug called MDX2003 for people with several types of B-cell lymphoma that have come back or stopped responding to at least two prior treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. It will…

This study is testing if the antiviral drug remdesivir can safely treat RSV (a common respiratory virus) in adults with weakened immune systems. Participants are people with cancer or autoimmune diseases who recently received treatments like stem cell transplants or specialized a…

This early-stage study is testing a new combination of six different targeted drugs for adults whose B-cell lymphoma has come back or hasn't responded to previous treatment. The main goal is to find the safest dose of this combination and see if it can help control the cancer. Re…

This study is testing the safety and effectiveness of the drug pembrolizumab in Japanese children with specific solid tumors or lymphomas, and in Japanese adults with advanced Merkel cell carcinoma, a rare and aggressive skin cancer. Researchers will measure how the body processe…

This study is testing a new two-drug combination (ZG005 and gecacitinib) for people with lymphoma that has returned or hasn't responded to previous treatments. The first part aims to find a safe and effective dose, while the second part will measure how well the combination works…

This study is testing if a combination of two drugs, rituximab and venetoclax, can effectively treat marginal zone lymphoma (MZL) in people who haven't had chemotherapy before. The goal is to control the cancer and keep it from coming back. About 33 participants will receive the …

This study is testing if a very low dose of radiation can control a slow-growing blood cancer called marginal zone lymphoma. It will enroll 50 adults with early-stage disease. Doctors will give a small initial dose and only add more radiation if the cancer doesn't respond well en…

This Florida-based study is testing a new AI-powered approach to find personalized treatments for cancer patients whose disease has returned or stopped responding to standard therapies. It aims to serve 210 patients, with a special focus on reaching children and underserved commu…

This study is testing whether a simple, non-invasive procedure called remote ischemic conditioning can protect the heart in lymphoma patients receiving a common but potentially heart-damaging chemotherapy. Over 600 patients at risk for heart problems will be randomly assigned to …

This study is testing a new way to treat certain lymphomas linked to the Epstein-Barr virus (EBV). Doctors take a patient's own white blood cells, train them in a lab to recognize and attack EBV-infected cancer cells, and then infuse them back into the patient. The main goals are…

This study is testing a new three-drug combination (valemetostat, rituximab, and lenalidomide) for adults with follicular lymphoma that has returned or stopped responding to prior treatment. The main goals are to find a safe and effective dose and to see how well the combination …

This study is testing whether a drug called loncastuximab tesirine can help control large B-cell lymphoma in patients whose cancer has come back or didn't fully respond to previous treatments. The research focuses on people who showed a partial response after receiving CAR T-cell…

This early-stage trial is testing a new drug called TLN-121 for people with non-Hodgkin lymphoma that has come back or hasn't responded to previous treatments. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined …

This study is testing whether adding an oral drug called Eliglustat makes existing CD30-targeted immunotherapies work better against CD30-positive lymphoma. It will enroll about 40 adults who have had at least one prior treatment. The main goals are to see if the combination is s…

This study is testing if a fecal microbiota transplant (FMT) can help treat gut-related side effects caused by antibiotics in lymphoma patients receiving a powerful cell therapy called CAR-T. Researchers will give FMT to some participants and compare their side effects and treatm…

This study aims to find the best drug combination to prevent graft-versus-host disease (GVHD), a serious complication where donor immune cells attack the patient's body after a stem cell transplant. Researchers are comparing two new drug combinations against the current standard …

This early-stage study is testing a new immunotherapy drug called OSE-279, both alone and in combination with another drug, for people with advanced solid tumors or lymphomas. The trial aims to find safe doses and see if these treatments can help control cancer growth. It's speci…

This study is testing whether adding two newer drugs, glofitamab and polatuzumab, to a standard chemotherapy regimen (R-CHP) works better for people with newly diagnosed, high-risk diffuse large B-cell lymphoma. About 40 participants will receive the drug combination for up to 8 …

This study is testing a new type of CAR T-cell therapy for children and young adults (up to age 21) whose blood cancers have come back or haven't responded to standard treatments. The main goal of this early-phase trial is to find a safe and effective dose. Doctors will first giv…

This study is testing a drug called ponatinib in children and teenagers (ages 1 to 18) whose cancers have come back or have not responded to standard treatments. The main goals are to find a safe dose and see if the drug can help control various advanced cancers, including leukem…

This early-stage study is testing a new oral drug called TLN-254 in adults with T-cell lymphoma that has come back or hasn't responded to standard treatments. The main goals are to see if the drug shrinks tumors, how safe it is, and how the body processes it. The study will enrol…

This study is comparing a new drug called glofitamab against standard treatment options for people with mantle cell lymphoma that has returned or stopped responding to previous therapies. Researchers want to see if glofitamab helps patients live longer without their cancer gettin…

This study is testing whether a combination of three drugs—epcoritamab, zanubrutinib, and rituximab—is safe and effective for people whose follicular or marginal zone lymphoma has come back or hasn't responded to prior treatments. About 45 participants will receive the treatment …

This study is developing and testing a video game designed to help young leukemia and lymphoma survivors after stem cell transplant. Researchers want to see if the game can encourage better health habits and improve recovery. They're gathering feedback from patients ages 15-39 to…

This study is testing whether the drug ruxolitinib can help control advanced T or NK cell lymphomas that have returned or stopped responding to other treatments. It will enroll about 83 adults whose cancer has progressed after at least one prior therapy. The drug works by blockin…

This study is testing if a special blood test can help doctors personalize treatment for a common type of lymphoma called DLBCL. The goal is to see if patients who show no signs of cancer in their blood halfway through standard chemotherapy can safely stop the chemo drugs early a…

This early-stage study is testing a new drug called NUC-7738 in adults with advanced cancers that have not responded to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors, either by itself or combined with another immunotherapy drug.…

This is a first-in-human, early-stage study to check the safety and find the right dose of an experimental drug called LB1410. The drug is designed to help the immune system fight cancer by blocking two different targets (PD-1 and TIM-3) at once. It will be given by IV to about 1…

This study is testing whether smartwatch technology and artificial intelligence can reliably monitor heart function in people who have survived lymphoma or sarcoma. Researchers want to see if these wearable devices can detect early signs of heart problems caused by cancer treatme…

This study aims to find the best imaging method for detecting tumors in children and young adults. Researchers will compare three types of scans—whole-body MRI, combined PET/MR, and PET/CT—to see which is most accurate at finding tumors. The goal is to improve diagnosis for young…

This study is testing a new, more detailed ultrasound technology to help doctors better tell if a swollen lymph node is cancerous or benign. It will involve 779 adults with suspicious lymph nodes who are already scheduled for a biopsy or surgery. The goal is to see if this advanc…

This study is testing a new blood test designed to detect many types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can accurately spot cancer signals and identify where in the body the cancer started. The t…

This study is developing an artificial intelligence (AI) system to help doctors analyze MRI scans and identify different types of malignant brain tumors. It will use data from 3000 adults with confirmed brain tumors to train the AI. The goal is to create a tool that makes non-inv…

This study is testing if blood thinner pills (apixaban or rivaroxaban) are as safe and effective as standard daily shots (low-molecular-weight heparin) at preventing dangerous blood clots in people being treated for blood cancers like leukemia, lymphoma, or multiple myeloma. Abou…

This study is testing whether the drug mogamulizumab can prevent a serious type of blood cancer called adult T-cell leukemia/lymphoma (ATL) from developing. It is for people who carry the HTLV-1 virus and have specific changes in their immune cells that put them at high risk for …

This study is testing whether a 12-week home exercise program with remote guidance from a coach helps lymphoma survivors improve their fitness and quality of life better than standard center-based training. It will involve 80 people who have recently finished cancer treatment. Re…

This study is testing the safety and how the body processes a drug called eflapegrastim in children with solid tumors or lymphoma. The drug is given alongside standard chemotherapy and aims to help the body rebuild white blood cells, which are crucial for fighting infections. The…

This study is testing a home-based recovery program for people with lymphoma or myeloma who are undergoing CAR-T cell therapy. The program uses a tablet or smartphone to guide patients through personalized exercise, nutrition, and counseling plans from home. The main goal is to s…

This study is testing a digital health program called AYA STEPS that helps young adult cancer survivors manage symptoms like pain, fatigue, and emotional distress. The program teaches skills to improve communication with healthcare providers and engagement with recommended follow…

This study is testing whether a simple 12-week program of short activity breaks is helpful for people newly diagnosed with lymphoma who are receiving chemotherapy. Researchers want to see if interrupting long periods of sitting can improve heart health and reduce some side effect…

This study is testing a new therapy program called UPLYFT, designed to help people who have finished lymphoma treatment but are still worried about their cancer coming back. The program provides information and coping tools through weekly sessions. Researchers want to see if this…

This study is testing whether a special support program helps older adults feel better physically and mentally after finishing cancer treatment. It compares a comprehensive program of health education, exercise, and geriatric care advice to standard follow-up care. The goal is to…

This study is testing a new hospice care program that provides blood transfusions at home for patients with advanced blood cancers. The goal is to see if this program improves patients' quality of life and mood, and helps more people choose hospice care, compared to the usual sta…

This study is testing whether personalized diet counseling from a nutritionist can help lymphoma survivors who have persistent fatigue. Over 100 participants will receive either the special diet plan or general health advice over three months. Researchers will check if the diet i…

This study is testing an 8-week online rehabilitation program designed to help cancer survivors manage long-term side effects and improve their daily function. Researchers will compare the virtual program to usual care for 388 adults who have finished primary cancer treatment but…

This study aims to see if adding a non-addictive pain medication (toradol) to standard opioid painkillers can better manage pain and reduce overall opioid use after a specific leg surgery. It involves 60 adult patients with bone cancer who are having a rod placed in their thigh b…

This study aims to collect and link research data from cancer patients who participate in multiple treatment trials at the National Cancer Institute. By connecting information from blood tests, biopsies, and treatment responses across different studies, researchers hope to unders…

This study is testing a new tool that uses an AI chatbot to create a personalized list of questions for patients with lymphoma or multiple myeloma to ask during their doctor's appointments. Researchers want to see if this helps patients feel more confident talking to their doctor…

This study is testing whether an AI-powered chatbot can help patients with blood cancers like leukemia and lymphoma better understand clinical trials. Researchers want to see if this personalized, computer-based education increases patients' willingness to consider joining a tria…

This study aims to understand the inherited genetic factors that cause lymphoma, leukemia, and related cancers within families. Researchers are recruiting individuals and their family members who have a personal or family history of these diseases. The main goal is to collect DNA…

This early-phase study is testing a new type of PET scan to see if it can detect changes in the body's cancer-fighting immune cells after radiation therapy. It will enroll about 10 adults with metastatic solid tumors or lymphoma who are scheduled to receive a precise form of radi…

This study aims to understand how whole brain radiation therapy affects memory, thinking, and quality of life in patients with blood cancers like lymphoma and leukemia. Researchers will follow 100 adult patients for up to 5 years, using standard memory tests, questionnaires, and …

This study aims to understand how stem cell transplants affect how patients process medications. Researchers will collect DNA samples from adults with blood cancers before and after transplant to determine the best source for genetic testing. The goal is to improve medication dos…

This study aims to create a library of blood samples from cancer patients and people at high risk for cancer. Researchers will collect these 'liquid biopsies' to help future studies develop better ways to detect cancer early and monitor treatment. The study involves 2,500 partici…

This study is testing a new tool called PRIME that helps older adults with blood cancers and their doctors discuss treatment priorities. It compares whether using this tool helps patients feel their final treatment decision better matches their personal values compared to standar…

This study aims to understand the genetic makeup of advanced cancers to help match patients with the most suitable early-stage drug trials. It involves analyzing tumor tissue and blood samples from about 40 adults with advanced solid tumors or lymphoma. The goal is to learn if de…

This study aims to understand how a cancer drug called venetoclax works in the body when it's given as a liquid made from crushed tablets. It will enroll up to 30 children and young adults with blood cancers who are already receiving this liquid form because they cannot swallow p…

This study aims to understand how well vaccines work in adults with certain blood cancers like chronic lymphocytic leukemia and non-Hodgkin lymphoma. Researchers will measure immune responses to vaccines for illnesses like COVID-19, hepatitis B, and shingles. They will also test …

This study aims to understand how the services from the nonprofit Blood Cancer United affect people with blood cancers. Researchers will follow 400 patients for six months to see if the organization's help improves their access to medical care, quality of life, and financial stre…

This study aims to understand and improve survival for lymphoma patients who develop a severe, life-threatening immune system complication called HLH. Researchers will look back at the medical records of up to 2,000 patients to see which treatments and other factors were linked t…

This study is testing a new, detailed tool called the INTeRCePT assay to see if it can predict which patients with a type of blood cancer (lymphoma) will respond well to a treatment called CAR-T cell therapy. The study will enroll 50 adults with lymphoma who are already scheduled…

This study aims to understand why people react differently to cancer drugs. Researchers will collect blood or cheek swab samples from about 1,100 cancer patients already enrolled in treatment trials at the National Cancer Institute. By analyzing genes, they hope to learn which ge…

This study is collecting and storing blood and tissue samples from patients with blood cancers like leukemia and lymphoma. The goal is to build a library of samples for researchers to study, which may help them better understand these diseases and develop new treatments in the fu…

This study aims to understand how cancer treatments affect women's sexual function and ability to have children. Researchers will follow 475 women with breast cancer or lymphoma, collecting questionnaires and optional blood tests over time. The goal is to learn about these side e…

This study is testing a new training program called Hematolo-GIST, designed to help lymphoma doctors communicate more effectively with their patients. It involves 48 doctors and their patients with a specific type of aggressive lymphoma. The main goal is to see if the training is…

This study is collecting information about how patients with blood cancers and disorders respond to stem cell transplants in the high-altitude Tibetan region. Researchers are enrolling 1000 patients and their donors to track treatment patterns, recovery times, survival rates, and…

This study aims to gather detailed information on many different blood diseases in China, including cancers like leukemia and lymphoma, and conditions like hemophilia. It will follow 2,300 patients to learn how common these diseases are, what treatments patients receive, how well…

This study is testing a blood test to see if it can help doctors monitor lymphoma patients. The test looks for tiny pieces of cancer DNA in the blood before and after treatment. Researchers want to see if this test can predict how well treatment is working and if any cancer cells…

This study aims to understand if CAR T-cell therapy, a powerful treatment for aggressive blood cancers, affects how children and young adults think, learn, and remember. Researchers will follow 60 participants aged 5-35 for up to 3 years, giving them regular thinking and memory t…

This study aims to create the first detailed, long-term record of lymphoma patients in Malawi. Researchers will enroll 800 people with suspected lymphoma, perform standard biopsies for accurate diagnosis, and follow their health for up to five years. The goal is to gather reliabl…