LYMPHOMA

This study tested a combination of five drugs as a first treatment for people with advanced follicular lymphoma, a type of blood cancer. The goal was to see how well the drug mix worked to control the cancer and to carefully track its side effects, especially nerve damage. It inv…

This early-stage study tested a new oral medication called CUDC-907 in children and young adults whose cancers had returned or stopped responding to standard treatments. The main goals were to check for side effects and find the safest dose for children, since this drug had only …

This study tested whether adding a specialized geriatric care team to standard cancer treatment could help older patients. It involved 792 patients aged 70 and older with various advanced cancers. The goal was to see if this coordinated care approach improved survival and quality…

This early-stage trial tested a new drug called ALRN-6924, alone or with another cancer drug, in 142 adults with advanced solid tumors or lymphomas that had stopped responding to standard treatments. The main goals were to find a safe dose and see if the drug could shrink tumors …

This study tested a new three-drug combination (PTCy, sirolimus, and VIC-1911) to prevent two major problems after a stem cell transplant: graft-versus-host disease (GVHD) and cancer relapse. It involved 16 adults with blood cancers like leukemia and lymphoma who received a high-…

This large, completed study aimed to find the better add-on treatment for newly diagnosed follicular lymphoma, a type of blood cancer. It compared standard chemotherapy (CHOP) combined with one of two different antibody drugs: rituximab or a radioactive antibody called tositumoma…

This study tested a two-step stem cell transplant method for patients with high-risk blood cancers like leukemia and lymphoma. It used a drug called cyclophosphamide before the transplant to help prevent a dangerous complication called graft-versus-host disease. The goal was to i…

This early-stage study tested the safety and dosing of a new drug called ulevostinag, which is injected directly into tumors. It was tested alone and combined with the immunotherapy drug pembrolizumab in 156 people with advanced or spreading solid tumors or lymphomas. The main go…

This study tested the safety and effectiveness of the drug vorinostat in people whose follicular lymphoma or similar slow-growing B-cell lymphomas had returned or stopped responding to previous treatments. It involved 56 participants who had tried up to four prior chemotherapy re…

This was the first human study of an experimental cancer drug called LY3039478. Researchers tested it in 247 patients with advanced or metastatic cancer to find the highest dose that could be given safely. The study also looked for early signs that the drug might help shrink tumo…

This study tested whether the drug brentuximab vedotin could shrink tumors in adults with anaplastic large cell lymphoma that had returned or didn't respond to previous chemotherapy. Fifty participants received the drug through an IV every three weeks. Researchers measured how ma…

This early-stage study tested the safety and effectiveness of a new three-drug combination (VVIP) for adults with aggressive non-Hodgkin lymphomas that had returned or not responded to prior treatments. The goal was to find the highest safe dose and see if the treatment could mak…

This study tested whether using phone and video calls (telemedicine) to monitor patients during chemotherapy for aggressive lymphoma helps them better tolerate their full treatment doses. It involved 350 patients across 10 hospitals, comparing those receiving standard in-person c…

This study tested a new oral medication called XNW5004 in patients with advanced lymphoma that had come back or stopped responding to standard treatments. The main goals were to find a safe dose and see how the body processes the drug. Researchers also looked for early signs that…

This study tested whether the drug dasatinib could help control chronic lymphocytic leukemia (CLL), a type of blood cancer. Seventeen patients who had previously received other treatments took dasatinib pills twice daily. Researchers monitored how well the cancer responded and ch…

This early-stage study tested a new two-step stem cell transplant method for children and young adults whose cancers had returned or didn't respond to standard treatments. The goal was to see if this approach, which uses specially processed cells from a partially matched family d…

This study tested a two-step treatment for older adults (65-80) newly diagnosed with a type of aggressive lymphoma. First, patients received a standard chemotherapy regimen. If they responded, they then received a second, targeted radiation treatment designed to seek out and kill…

This pilot study tested a new support program designed to help rural-dwelling and Hispanic cancer survivors manage their chronic pain. The program connected 51 participants with a care team by phone or video to create personalized pain management plans. Researchers aimed to refin…

This study tested if paying for blood transfusions would help people with advanced blood cancers choose hospice care earlier. Patients often delay hospice because they need transfusions, which hospice usually doesn't cover. The research provided free transfusions to see if this h…

This study tested a web-based support program designed to help children with cancer return to school. Researchers first interviewed kids and parents to understand their challenges, then created and tested the program with 20 children aged 8-17. The goal was to see if the program …

This study tested a mobile app program designed to help young adult cancer survivors manage their health after treatment. It aimed to reduce cancer-related distress and improve how well survivors follow recommended health check-ups. Researchers compared the app to standard online…

This study aimed to better understand the risk of heart damage in patients receiving a common chemotherapy regimen (R-CHOP) for a type of blood cancer called diffuse large B-cell lymphoma. Researchers observed 127 adult patients to identify early signs of heart problems linked to…

This study aimed to understand how CAR-T cell therapy, a powerful cancer treatment, affects the heart. Researchers followed 44 adults with leukemia or lymphoma, checking their heart function with scans and blood tests before and after treatment. The goal was to learn how often he…

This study aimed to understand how a common type of chemotherapy (anthracycline-based) affects the body's ability to control blood pressure and the health of blood vessels. Researchers measured these factors in 60 people with breast cancer or lymphoma, both during treatment and 1…

This study tested a new type of PET scan to see if it could measure changes in blood vessel growth inside lymphoma tumors. Researchers scanned 21 patients with a large tumor mass before and after two rounds of chemotherapy. The goal was to see if this scan could help understand h…

This completed study analyzed leftover tissue samples from lymphoma patients to understand how proteins in cancer cells are organized and modified. Researchers examined up to 300 samples using laboratory tests to identify patterns that might help explain how lymphomas develop and…

This study aimed to identify what helps older adults recover well after a bone marrow transplant for blood cancers like leukemia and lymphoma. Researchers measured physical ability, mental health, stress hormones, and other factors in 126 patients aged 60 and older before and aft…

This study is an open-label, controlled, multicenter, international, Phase III, randomized study of transplantation of NiCord® versus transplantation of one or two unmanipulated, unrelated cord blood units in patients with acute lymphoblastic leukemia or acute myeloid leukemia, m…