LYMPHOMA

This study tests a combination of three drugs (polatuzumab vedotin, glofitamab, and tafasitamab) as a first treatment for people with aggressive B-cell lymphomas, aiming to avoid standard chemotherapy. About 30 adults with newly diagnosed diffuse large B-cell lymphoma or high-gra…

This early-phase study tests a combination of four drugs (venetoclax, dexamethasone, bortezomib, and daratumumab) in teens and young adults aged 12 to 30 whose T-cell acute lymphoblastic leukemia or lymphoma has come back or stopped responding to treatment. The main goal is to ch…

This study tests a stem cell transplant tailored to each person with blood cancer caused by a RUNX1 gene mutation. About 98 participants aged 4 to 70 will receive chemotherapy and transplant, with medication doses adjusted individually. The goal is to see if this personalized app…

This early-phase study tests a new type of cell therapy for people with certain cancers (lymphoma, myeloma, and solid tumors like kidney cancer and sarcoma) that have returned or not responded to standard treatments. The therapy uses the patient's own T cells, which are modified …

This early-phase study tests a new drug called CS08399 in people with advanced solid tumors or lymphoma that have a specific genetic deletion (MTAP). The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. About 186 adults who have run out of …

This study tests a new drug called BT02 in people with blood cancers (leukemia, lymphoma, or multiple myeloma) that have returned or not improved with standard treatments. About 116 adults aged 18 to 70 will receive the drug by IV every 2-3 weeks for up to 2 years. The main goals…

This early study tests whether specially engineered immune cells from a donor (called CAR-T cells) are safe for people with B-cell blood cancers that have not responded to standard treatment or have returned. The trial will enroll 12 adults and aims to find the right dose while w…

This early-stage study tests a new type of CAR-T cell therapy that is made inside the body, avoiding the expensive and complex lab process normally needed. It targets two proteins (CD19 and BAFF-R) on cancer cells in people with relapsed or hard-to-treat B-cell acute leukemia or …

This study looks at how PET-CT scans can help doctors better understand lymphoma in people aged 60 and older. Researchers will examine scan images to find patterns that may improve diagnosis and predict outcomes. The goal is to make care more accurate for this age group.

This study tests whether a drug called sotagliflozin can prevent heart, muscle, and fat damage caused by a common type of chemotherapy (anthracycline) in people with newly diagnosed lymphoma. About 60 adults will receive either the drug or a placebo during their first round of ch…

This study tests whether a mind-body resilience group program can help lymphoma survivors better cope with challenges after finishing treatment. About 254 adults who completed lymphoma treatment within the past two years will participate. The program focuses on relaxation, recogn…

This study tests whether a resilience-building program can improve quality of life for lymphoma survivors who finished treatment within the last two years. About 254 adults will take part, comparing the resilience program to a health education program. The goal is to see if learn…

This study will gather information from 1,000 people newly diagnosed with lymphoma. Researchers will track their health over time to see which treatments work best in everyday medical practice. No new drugs are tested; the goal is to learn from real patient experiences to improve…

This study will follow 400 children and teens who have survived blood cancers like leukemia and lymphoma. Researchers want to understand the long-term health problems these survivors face and create a structured follow-up plan using an electronic platform. The goal is to improve …

This study looks at how a personalized strength training program affects people with different cancers (lung, colon, breast, lymphoma, and leukemia). 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers will…

This study tests a small patch called TempTraq that continuously monitors body temperature in cancer patients receiving immunotherapy. The goal is to see if catching fevers early can prevent severe cytokine release syndrome (CRS), a serious side effect. About 136 adults staying a…

This study will follow 5,000 adults with immune system issues to see how often they also have clonal hematopoiesis (a type of blood cell change) or related blood diseases like VEXAS syndrome. Researchers will track new cases over time to better understand these conditions. No tre…