LYMPHOMA

This study looks at whether a pneumonia vaccine (PCV20) works better as a single shot or a two-dose booster in people who have beaten B-cell lymphoma after treatment with anti-CD20 therapy. About 30 adults whose lymphoma has been in remission for at least a year will take part. T…

This study was designed to see if adding tazemetostat to standard CHOP chemotherapy could improve outcomes for people with untreated peripheral T cell lymphoma. It was withdrawn before any participants enrolled, so no results are available. The goal was to increase the number of …

This study tests a stem cell transplant using donors who are not a perfect match for people with blood cancers like leukemia or lymphoma. The goal is to see if adding certain drugs after the transplant can prevent complications and improve survival. About 300 adults and children …

This study tested a stem cell transplant using blood stem cells from a half-matched (haploidentical) donor for people with blood cancers like leukemia and lymphoma. The goal was to see how many patients survived and had successful engraftment by 100 days and one year after transp…

This study tests the drug CPI-613 in people with aggressive lymphomas (Burkitt lymphoma or high-grade B-cell lymphoma) that have returned or not responded to prior treatment. The goal is to see if the drug can shrink or control the cancer. The trial involves 24 participants aged …

This study is for people with aggressive B-cell lymphoma that has returned or not responded to treatment. It tests new combinations of drugs to see if they work better than the standard treatment. The goal is to shrink or control the cancer, not to cure it. About 129 adults will …

This early-phase study tests a combination of three drugs (rituximab, bendamustine, and melphalan) followed by a stem cell transplant using the patient's own cells. The goal is to see if this gentler regimen causes fewer severe side effects than standard treatments for older adul…

This study tests the safety of the drug neratinib in children and teens with solid tumors, brain tumors, lymphoma, or leukemia that have returned or not responded to standard treatments. The goal is to find the right dose and see what side effects occur. 14 participants are enrol…

This early-phase study tests a new treatment for people with relapsed lymphoma tied to the Epstein-Barr virus. The therapy uses the patient's own immune cells, modified to resist a substance tumors use to hide. The goal is to find a safe dose and see if these cells can shrink tum…

This study tests a drug called zanubrutinib in 25 people with cold agglutinin disease, a rare condition where the immune system destroys red blood cells, especially in cold weather. The drug targets the cells that make the harmful antibodies. The goal is to see if it can control …

This study tested the drug pembrolizumab in 18 people with aggressive lymphomas or rare immune cell cancers that had come back or not responded to other treatments. The goal was to see if the drug could shrink tumors. The trial was suspended, so results are limited.

This early-phase study tests a new treatment for people with Hodgkin lymphoma or cutaneous T-cell lymphoma that has not responded to standard therapy or has returned. The treatment uses a patient's own immune cells (T cells) that are genetically modified to recognize and attack c…

This study tests a new treatment for children and young adults up to age 30 whose leukemia or lymphoma has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells that carr…

This early-phase study tests a personalized cell therapy for children and young adults with a type of leukemia that has come back or not responded to standard treatments. The therapy uses the patient's own immune cells, modified to recognize two markers (CD19 and CD22) on leukemi…

This study tests whether combining lenalidomide and rituximab can help control chronic lymphocytic leukemia or small lymphocytic lymphoma. It includes 120 adults who either have not been treated before or whose cancer has returned. The goal is to see how well the drugs shrink or …

This study was designed to see if a new combination of three drugs—epcoritamab, lenalidomide, and tafasitamab—could safely and effectively treat people with a type of blood cancer called diffuse large B-cell lymphoma that had come back or stopped responding to treatment. It was p…

This study tests an experimental drug called ASTX660 in people with advanced solid tumors or lymphomas that have not responded to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow disease progression. About 253 adults will take…

This study tests a new treatment for people with certain blood cancers (lymphoma, multiple myeloma, or CLL) that have returned or not responded to standard therapy. Researchers take a patient's own immune cells (T cells) and modify them in the lab to better recognize and attack c…

This study tests a drug called brentuximab vedotin in 79 people with CD30-positive skin lymphomas (ALCL, mycosis fungoides, or lymphomatoid papulosis). The goal is to see if the drug can shrink or control the skin tumors. Participants receive the drug every 3 weeks, and researche…

This early-phase study tests whether adding N-acetylcysteine (N-AC) to standard CAR T-cell therapy (Yescarta) is safe for people with lymphoma. Researchers will try different doses of N-AC to find the highest dose with few or mild side effects. The study involves 9 adults who are…

This early-phase study tests whether giving two drugs (acalabrutinib and rituximab) followed by a special immune cell treatment (brexucabtagene autoleucel, a type of CAR T-cell therapy) can help control high-risk mantle cell lymphoma that hasn't been treated before. About 22 peop…

This study tests a new drug called BYON4228, alone or with another drug (rituximab), in people with a type of blood cancer (B-cell non-Hodgkin lymphoma) that has not responded to or has returned after at least two prior treatments. The main goal is to check safety and find the ri…

This study tested whether giving chemotherapy and radiation therapy at the same time can better control stage I or II nasal NK cell lymphoma. Twenty-six newly diagnosed patients received both treatments together. The goal was to see how long the cancer stayed away and to check th…

This study is for people with blood cancers like leukemia or lymphoma who have had a stem cell transplant or cell therapy. It tests a new COVID-19 vaccine (GEO-CM04S1) to see if it provides better protection against COVID-19 than the standard mRNA vaccines. The goal is to help th…

This study tests a stem cell transplant from unrelated or partially matched donors for people with blood cancers like leukemia, lymphoma, or myelodysplasia. The donated cells are specially treated to remove certain immune cells, which may help the transplant take hold and reduce …

This study tests an experimental drug called BGB-11417 in 100 adults whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has come back or stopped responding to other treatments. The goal is to see if the drug can shrink or eliminate cancer cells. Particip…

This study tests a new drug called glofitamab added to standard chemotherapy (R-CHOP) for people with a high-risk type of lymphoma (DLBCL) who have not been treated before. The goal is to see if the combination is safe and helps more patients achieve complete remission. About 46 …

This early-phase study tests a new type of CAR T-cell therapy for people with B-cell lymphoma that has come back or not responded to treatment. The T-cells are engineered to recognize and attack cancer cells, but also include a safety switch that can be activated to reduce severe…

This study tests whether giving two drugs—simvastatin (a cholesterol pill) and dexamethasone (a steroid injected into the spine)—can safely prevent or reduce brain-related side effects from a powerful lymphoma cell therapy called axi-cel. About 37 adults with certain types of B-c…

This early-phase study tests the safety and best dose of a drug called copanlisib combined with immunotherapy drugs (nivolumab, with or without ipilimumab) in adults with advanced solid tumors or lymphoma that has not responded to standard treatments. The goal is to find a dose t…

This study looks at two different chemotherapy treatments for people newly diagnosed with primary CNS B-cell lymphoma, a rare type of brain cancer. One group gets high-dose chemotherapy followed by a stem cell transplant, while the other gets standard chemotherapy alone. The goal…

This study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections while still preventing graft-versus-host disease (a condition where donor cells attack the patient's body). About 3…

This study is testing a new cell therapy for people with Hodgkin's or Non-Hodgkin's lymphoma that has come back or hasn't responded to other treatments. Doctors take a patient's own immune cells, modify them in a lab to better target cancer, and then infuse them back. The main go…

This early-phase study tests a new radioactive drug called F-Glutamine, which is used with PET scanners to see if it can find tumors in people with solid cancers or lymphoma. Researchers want to learn how long the drug stays in the blood and where it goes in the body. If successf…

This study tests whether a probiotic called Lactobacillus plantarum can prevent acute graft-versus-host disease (GvHD) in the gut of children receiving donor stem cell transplants. About 173 children with blood cancers or other conditions will take the probiotic or a placebo. The…

This study looks at whether cognitive behavioral therapy (CBT) can help people with acute myeloid leukemia or lymphoma who feel very tired from their cancer or treatment. About 48 patients will take part in up to 7 counseling sessions to learn new ways to cope with fatigue. The g…

This study tests if shorter courses of radiation are safe for people with lymphoma that has returned or not responded to treatment. About 30 participants will receive different shortened radiation schedules to find the safest dose. The goal is to reduce treatment time while contr…

This study looks at whether fasting for 24 hours before and after chemotherapy is safe and acceptable for people with lymphoma. About 40 patients will either fast or receive standard care. Researchers will track side effects, weight changes, and quality of life to see if a larger…

This study tests a new way to calculate the dose of the chemotherapy drug melphalan for lymphoma patients getting a stem cell transplant. Instead of a standard dose based on height and weight, researchers use a model that considers how previous patients processed the drug. The go…

This study looks at whether a special fencing program can help adults with leukemia or lymphoma avoid getting weak during intensive hospital treatment. About 80 patients will try adapted fencing exercises that can be done in bed, a chair, or standing up. The main goal is to see i…

This study looks at whether a 12-week program of online chair-based exercise and health education, combined with a full geriatric assessment, can help older adults (65+) with cancer and their support person. The goal is to see if the program is practical and acceptable, and if it…

This study tests a mind-body program (meditation and relaxation) to see if it improves quality of life in adolescents and young adults recently diagnosed with lymphoma. About 71 participants will be randomly assigned to the program or a control group. The goal is to lower distres…

This study tests a program that lets cancer patients receive care at home through remote monitoring during chemotherapy or radiation. The goal is to see if this approach reduces hospital visits and emergency department stays. About 300 adults with certain cancers (like pancreatic…

This study tests a program that helps cancer patients and their caregivers manage difficult emotions and communicate better about the illness. It includes a version tailored for Latinx participants. The goal is to reduce distress, improve quality of life, and help families discus…

This study tests whether analyzing the genes of a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to standard therapy are enrolled. The goal is to see if targe…

This study looks at whether a commercial genetic test (MF Portrait) can quickly provide useful information for treating lymphoma. About 111 adults with a type of lymphoma called diffuse large B-cell lymphoma are taking part. The main goal is to see if test results can be delivere…

This study was designed to look back at medical records to see how often people diagnosed with lymphoma also had another cancer within six months. Researchers planned to describe patient characteristics and explore possible causes. However, the study was withdrawn before any part…

This study follows 1,000 people with CD30-positive lymphoma who are already receiving or about to receive the drug brentuximab vedotin as part of their normal care. The main goal is to track any serious side effects that occur in real-world settings, not in a controlled trial. Re…

This study was designed to track how the immune system recovers after CAR-T cell therapy and whether a pneumonia vaccine (PCV-21) given six months later can work. It planned to enroll 50 adults with blood cancers or solid tumors. However, the study was withdrawn before any partic…

This study tracks over 1,400 breast cancer and lymphoma patients to see how chemotherapy affects memory, attention, and thinking skills. Participants are tested before treatment, after treatment, and during follow-ups. The goal is to better understand who is most at risk for cogn…

This study compares a new, faster total-body PET/CT scanner (uEXPLORER) to standard PET/CT scanners in 180 adults with lung cancer, lymphoma, or melanoma. The goal is to find the shortest scan time that still produces clear, high-quality images for cancer staging. Participants wi…

This study collects white blood cells from people aged 3 to 65 with leukemia or lymphoma that hasn't been cured by standard treatments. The cells are used to create a personalized therapy called CAR T-cells, which may be given later. The procedure, called leukapheresis, takes 4-6…

This study looks at whether a daily mindfulness app can help adult survivors of childhood leukemia or lymphoma manage stress. About 50 participants will use the app for 30 days and wear a wrist device to track stress signs like heart rate and skin temperature. The goal is to see …

This study follows about 150 people who have already received Caribou cell therapy for blood cancers like lymphoma or leukemia. The goal is to track any long-term side effects for up to 15 years after treatment. No new treatments are given—just regular check-ups to monitor safety…

This study collects tissue samples from people receiving bone marrow transplants and their donors. Researchers will analyze these samples to identify genes and proteins that may play a role in cancer development and progression. The goal is to better understand transplant outcome…

This study looks at whether a special website can help women with cancer make better decisions about preserving their ability to have children after treatment. About 130 women with certain cancers (like breast or lymphoma) will use the website or get usual care. The goal is to se…

This long-term study aims to understand why farmers and their families may have higher risks for certain cancers, like prostate cancer and lymphoma. Researchers are following about 90,000 pesticide applicators and their spouses in Iowa and North Carolina, collecting information o…