LYMPHOMA

This study is testing a new COVID-19 vaccine called GEO-CM04S1 against standard mRNA vaccines in people with blood cancers who have received a stem cell transplant or cellular therapy. The goal is to see if the new vaccine creates a stronger immune response in these vulnerable pa…

This study is testing a drug called neratinib in children and young adults whose solid tumors, brain tumors, lymphoma, or leukemia have returned or did not respond to standard treatments. The main goals are to find a safe dose and see what effects, both good and bad, the drug has…

This study is testing whether adding the drug tazemetostat to standard CHOP chemotherapy works better for people with newly diagnosed T cell lymphoma. About 24 participants will receive the combination treatment, and researchers will measure how well the cancer responds and how l…

This early-stage study is testing the safety of a new type of personalized cell therapy for adults with B-cell lymphoma that has come back or not responded to other treatments. Doctors take a patient's own immune cells (T cells), modify them in a lab to better target cancer, and …

This study is testing whether adding an over-the-counter antioxidant called N-Acetylcysteine (NAC) to a powerful cell therapy (CAR-T) is safe for people with lymphoma. Researchers want to find the highest dose of NAC that causes few or mild side effects when given alongside the C…

This trial is testing a stem cell transplant method for people with blood cancers who don't have a perfectly matched donor. It uses stem cells from a partially matched, unrelated donor along with specific medications to prevent complications. The main goal is to see if this appro…

This study is testing new combinations of cancer drugs to see if they work better than the current standard treatment for aggressive B-cell lymphoma that has come back or stopped responding to initial therapy. About 129 patients will be randomly assigned to receive either a new d…

This study is testing a drug called pembrolizumab for people with rare, aggressive cancers of the immune system (like certain lymphomas and histiocyte/dendritic cell sarcomas) that have come back or stopped responding to standard treatments. The drug aims to help the body's own i…

This early-stage study is testing a new type of personalized immune cell therapy for children and young adults with a specific type of leukemia that has come back or hasn't responded to other treatments. Doctors take a patient's own immune cells (T-cells), modify them in a lab to…

This study is testing if using a lower dose of a standard drug (cyclophosphamide) given after a stem cell transplant can reduce serious infections in the first 100 days. The trial aims to see if this lower dose is just as good at preventing graft-versus-host disease, a common and…

This study tested whether the drug brentuximab vedotin could help control three types of CD30-positive skin lymphomas in patients whose disease had come back or did not respond to prior treatments. The drug is designed to find and enter cancer cells with a specific marker (CD30) …

This study is testing whether combining two existing drugs, lenalidomide and rituximab, can help control chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It is for adults who are either newly diagnosed and not candidates for standard chemo, or who have had …

This study is testing a new cell therapy for people whose Hodgkin's or Non-Hodgkin's lymphoma has come back or hasn't responded to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to better target cancer cells, and then infuse them back into th…

This study is testing whether a combination of tools can help cancer survivors living in rural areas better manage their health after treatment ends. Participants create their own survivorship care plan and some receive a phone-based education session. The goal is to see if this …

This study is testing a new oral drug called ASTX660 in adults with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The main goals are to find the safest and most effective dose and to see if the drug can help control the cancer. The trial i…

This study is testing a new type of personalized cell therapy for adults whose CD30+ lymphomas have come back or not responded to standard treatments. Doctors take a patient's own immune cells (T cells), genetically modify them to better find and attack cancer cells, and then inf…

This study is testing whether adding an experimental drug called glofitamab to standard chemotherapy (R-CHOP) works better for people with high-risk, untreated diffuse large B-cell lymphoma. Researchers will enroll about 46 patients who have specific high-risk markers in their bl…

This early-stage study is testing a new combination of chemotherapy drugs (RBM) given before a patient's own stem cells are transplanted back into them. The goal is to see if this regimen is safer and has fewer severe side effects than the standard treatment for older adults (age…

This study is exploring whether fasting for 24 hours before and after chemotherapy is safe, practical, and acceptable for people with Hodgkin or Diffuse Large B-Cell Lymphoma. Researchers will compare 40 patients who fast to those who follow standard care, tracking side effects, …

This study is testing a new, personalized way to calculate the dose of melphalan chemotherapy given to lymphoma patients before a stem cell transplant. Instead of using a standard dose based on height and weight, researchers are using a mathematical model to calculate an optimal …

This is an early-stage safety study testing a new type of cell therapy for adults with certain recurring B-cell blood cancers (like lymphoma, myeloma, or CLL) that have not responded to standard treatments. Doctors take a patient's own immune cells (T cells), genetically modify t…

This study aims to determine which treatment approach works better for newly diagnosed primary brain lymphoma: a standard chemotherapy regimen or a more intensive approach that adds a stem cell transplant. It enrolled 113 adults to compare how long patients remain cancer-free and…

This study is testing whether a shorter course of radiation treatment is safe for adults whose Hodgkin or non-Hodgkin lymphoma has returned or not responded to standard treatments. Instead of the usual 5-6 weeks of radiation, researchers aim to find the highest safe dose that can…

This trial is testing a modified stem cell transplant for people with blood cancers like leukemia and lymphoma who don't have a perfectly matched donor. Doctors use a special process to remove certain immune cells from the donor's stem cells before the transplant. The goal is to …

This is the first study in people testing a new immune-boosting drug called BYON4228, both alone and combined with an existing lymphoma drug (rituximab). It aims to find safe doses and see if it helps patients whose B-cell non-Hodgkin's lymphoma has returned or hasn't responded t…

This study collects a person's own white blood cells to potentially make a future cancer treatment called CAR-T cell therapy. It is for children and adults (ages 3-65) with certain types of leukemia or lymphoma that have not been cured by standard treatments. The collected cells …

This study is testing a new cell therapy for children and young adults (up to age 30) whose leukemia or lymphoma has returned or not responded to other treatments. Doctors take a patient's own immune cells (T-cells), modify them in a lab to recognize a protein called CD22 on canc…

This study is testing a specific type of stem cell transplant for patients with various blood cancers. It uses stem cells from a partially matched family donor instead of bone marrow. The main goals are to see how well patients survive and recover, and to learn how the immune sys…

This early-stage study is testing whether giving two existing drugs—dexamethasone (into the spine) and simvastatin (a pill)—can safely prevent or reduce serious brain-related side effects in adults with lymphoma receiving a powerful treatment called CAR-T cell therapy. The main g…

This study is testing a new cell therapy for lymphoma that has come back after treatment and is linked to Epstein-Barr virus (EBV). Researchers are giving patients special immune cells (T cells) that have been genetically modified to resist a substance released by the tumor and t…

This large national trial is testing whether choosing cancer drugs based on the specific genetic changes found in a patient's tumor is more effective than standard approaches. It is for adults with advanced solid tumors, lymphoma, or multiple myeloma that have progressed after at…

This early-phase study is testing a three-step treatment for people newly diagnosed with a high-risk form of mantle cell lymphoma, a type of blood cancer. First, patients receive two drugs (acalabrutinib and rituximab), followed by an infusion of their own genetically modified im…

This early-phase study is testing the safety and best doses of combining the cancer drug copanlisib with immunotherapy drugs (nivolumab alone or with ipilimumab). It involves 64 adults with advanced solid tumors or lymphoma that have progressed after standard treatments. The goal…

This study is testing an experimental drug called BGB-11417 in adults whose chronic lymphocytic leukemia or small lymphocytic lymphoma has returned or stopped responding to standard treatments. The trial aims to see how well the drug controls the cancer and how safe it is for pat…

This study is testing a new type of full-body PET/CT scanner called uEXPLORER. Researchers want to see if this new scanner can produce images as clear as standard scanners, but in a shorter amount of time. The study involves patients with lung cancer, lymphoma, or melanoma who ar…

This study is testing whether a specific probiotic (Lactobacillus plantarum) can prevent a serious complication called acute graft-versus-host disease (GvHD) in children, teens, and young adults getting a stem cell transplant from a donor for cancers like leukemia or lymphoma. Ab…

This study is testing whether giving two doses of a pneumonia vaccine works better than one dose for people who have survived B-cell lymphoma. The goal is to see which approach gives stronger, longer-lasting protection against serious lung infections. The study involves 30 adults…

This study aimed to see if regular clinic visits and a pneumonia vaccine could help prevent infections in cancer patients after they received CAR-T cell therapy. The plan was to enroll 50 adults with blood cancers or solid tumors who were getting this specialized treatment. Resea…

This study is testing whether a specially adapted fencing exercise program is practical and helpful for adults with leukemia or lymphoma who are receiving intensive treatment in the hospital. Researchers want to see if this unique form of physical activity can help patients maint…

This study is testing whether a meditation-based program can help young adults (ages 18-39) who were recently diagnosed with lymphoma feel better mentally and improve their overall quality of life. Participants are randomly assigned to either a 5-week meditation group or a 5-week…

This study is testing whether a daily mindfulness meditation app is a practical and helpful way for adult survivors of childhood leukemia or lymphoma to manage stress. Fifty participants will use the Headspace app for 30 days, wear a wrist device to measure stress signals, and an…

This study is testing a phone-based program designed to help patients with advanced cancer and their caregivers. The program focuses on improving communication, managing difficult emotions, and reducing caregiver stress. It offers a culturally tailored version for Latino/a partic…

This study is testing whether a type of talk therapy, delivered over the phone, can help patients with acute myeloid leukemia (AML) or lymphoma manage severe, long-lasting cancer-related fatigue. The therapy focuses on teaching patients skills to change unhelpful thoughts and beh…

This study aims to understand how chemotherapy affects memory, focus, and thinking skills in people with breast cancer or lymphoma. Researchers will follow over 1,400 patients and healthy volunteers, testing their cognitive function before, right after, and for years following tr…

This is a long-term observational study designed to understand if exposures common in farming—like pesticides, fuels, and dust—increase the risk of developing cancer and other diseases. It follows nearly 90,000 licensed pesticide applicators and their families in Iowa and North C…

This is the first time researchers are testing a new experimental imaging tracer called F-Glutamine in people. The study aims to see how long the tracer stays in the blood and where it goes in the body after injection. If successful, future studies will test if scans using this t…

This study is testing whether a special exercise program is safe and practical for older adults with blood cancers before they receive CAR-T cell therapy. Researchers want to see if patients can stick with the program and if it helps improve their strength and fitness. The goal i…

This study is testing a special website designed to help young women recently diagnosed with cancer make decisions about preserving their fertility. Cancer treatments can sometimes affect a woman's ability to have children later, and this tool provides information to help them un…

This study aims to collect real-world information on the safety and effectiveness of the drug brentuximab vedotin for patients with CD30-positive lymphoma. It will follow about 1000 patients in China who are already receiving this treatment as part of their standard care. The goa…

This study aimed to look back at past medical records to see if people diagnosed with lymphoma were more likely to also be diagnosed with another type of cancer at the same time. Researchers planned to analyze data from 2007 to 2012 to understand how often this happens and descri…

This study aims to collect tissue and blood samples from people who have received or donated bone marrow transplants for blood cancers like leukemia and lymphoma. Researchers will analyze these samples to better understand why complications happen and how to improve transplant su…

This study is testing whether advanced molecular analysis of a patient's lymphoma can help guide treatment decisions. Researchers will enroll 111 adults with diffuse large B-cell lymphoma to see how quickly test results can be returned and whether they reveal treatment options. T…