New hope for lymphoma patients: drug combo trial aims to shrink tumors

NCT ID NCT06624085

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 4 times

Summary

This early-phase study tests a new drug (glofitamab) combined with two chemotherapy drugs (gemcitabine and oxaliplatin) in about 50 U.S. adults whose diffuse large B-cell lymphoma has returned or stopped responding to prior treatment. The main goals are to check safety and see how many patients achieve complete remission. The study also includes people from racial and ethnic groups often underrepresented in research.

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Conditions

The condition(s) this trial relates to.

lymphoma relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA

Contacts and locations

Locations

AdventHealth Cancer Institute

Orlando, Florida, 32804, United States
Auxilio Mutuo Cancer Center

San Juan, 00917, Puerto Rico
Baylor College of Medicine

Houston, Texas, 77030, United States
Christus Health - Christus St. Vincent Regional Medical Center

Santa Fe, New Mexico, 87505, United States
East Carolina University

Greenville, North Carolina, 27834, United States
Georgetown University

Washington D.C., District of Columbia, 20007, United States
Hoag Memorial Hospital

Newport Beach, California, 92658, United States
Kansas City VA Medical Center

Kansas City, Kansas, 64128, United States
Renovatio Clinical

The Woodlands, Texas, 77380, United States
Renovatio Clinical - El Paso

El Paso, Texas, 79915, United States
Saddleback Memorial Medical Center

Laguna Hills, California, 92653, United States
Stony Brook Univ Cancer Ctr

Stony Brook, New York, 11794, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
University of California Los Angeles (UCLA) - Cancer Care - Santa Monica

Santa Monica, California, 90404-2023, United States
University of Illinois Cancer Center

Chicago, Illinois, 60612, United States
Winship Cancer Institute of Emory University

Atlanta, Georgia, 30329, United States

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