Could one antibiotic replace two for chemo fevers? major trial launches

NCT ID NCT07483736

Not yet recruiting Disease control Sponsor: Versailles Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a single antibiotic (amoxicillin-clavulanate) against the standard two-drug combination (amoxicillin-clavulanate plus ciprofloxacin) for treating fever caused by chemotherapy in adults with certain blood cancers. The goal is to see if the simpler treatment works just as well, while reducing side effects and antibiotic resistance. About 1,500 participants will be randomly assigned to one of the two treatments.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia Febrile Neutropenia lymphoma myelodysplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

C15.378

Contacts and locations

Locations

CH Jacques Coeur

Bourges, France
CH Poissy Saint-Germain-en-Laye

Poissy, France
CH de BRIVE LA GAILLARDE

Brive-la-Gaillarde, France
CH de Perigueux

Périgueux, France
CH de SAINT NAZAIRE

Saint-Nazaire, France
CH de SAUMUR

Saumur, France
CH de Valence

Valence, France
CH de Versailles

Le Chesnay, France
CHU Caen-Normandie

Caen, France
CHU d'ORLEANS

Orléans, France
CHU de SAINT-ETIENNE

Saint-Priest-en-Jarez, France
Groupe Hospitalier Haute Saône Vesoul

Vesoul, France
Hopital Necker Enfants Malade

Paris, France
Hopital Saint Louis

Paris, France
Hopital de La Pitie Salpetriere

Paris, France
Institut Curie

Saint-Cloud, France

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