Engineered immune cells take on brain cancer in pioneering trial

NCT ID NCT07015242

Recruiting now Disease control Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 30, 2026 · Updated 4 times

Summary

This study is testing a new type of immunotherapy called liso-cel (Breyanzi) as the first treatment for primary central nervous system lymphoma (PCNSL), a rare brain cancer. The trial is for 65 adults who cannot have a stem cell transplant. Liso-cel is made from the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The goal is to see if this approach can control the disease and improve survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lisocabtagene maraleucel (liso-cel, Breyanzi) - a CAR T-cell therapy
What this could lead to: If successful, this could offer a new first-line treatment option for people with primary CNS lymphoma who cannot undergo a stem cell transplant, potentially improving disease control without the need for long-term chemotherapy.
What could go wrong: This is a small, early-phase (Phase 2) trial with only 65 participants. CAR T-cell therapy can cause serious side effects like cytokine release syndrome and neurological problems. It is not yet known if it will work better than current treatments.

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Conditions

The condition(s) this trial relates to.

lymphoma primary central nervous system lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA

Contacts and locations

Locations

CHU Montpellier
RECRUITING

Montpellier, 34295, France
CHU de Dijon Bourgogne - Hopital Francois Mitterand
RECRUITING

Dijon, 21079, France
CHU de Rennes - Hopital de Pontchaillou
RECRUITING

Rennes, 35033, France
Centre Henri Becquerel
RECRUITING

Rouen, 79038, France
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
RECRUITING

Nantes, Loire-Atlantique, 44093 Cedex 1, France
Charité - Universitätsmedizin Berlin
RECRUITING

Berlin, 12203, Germany
Chru De Lille - Hopital Claude Huriez
RECRUITING

Lille, 59037, France
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Institut Universitaire du Cancer de Toulouse (IUCT) - Oncopole
RECRUITING

Toulouse, 31059, France
Klinikum Chemnitz gGmbH
RECRUITING

Chemnitz, Saxony, 09116, Germany
Klinikum Stuttgart - Katharinenhospital
RECRUITING

Stuttgart, 70174, Germany
Local Institution - 0102
NOT_YET_RECRUITING

Paris, 75013, France
Local Institution - 0103
NOT_YET_RECRUITING

Pierre-Bénite, Rhône, 69495, France
Local Institution - 0108
NOT_YET_RECRUITING

Pessac, 33600, France
Local Institution - 0110
NOT_YET_RECRUITING

Saint-Cloud, 92210, France
Local Institution - 0111
NOT_YET_RECRUITING

Nice, Alpes-Maritimes, 06202, France
Local Institution - 0112
NOT_YET_RECRUITING

Marseille, 13273, France
Local Institution - 0114
NOT_YET_RECRUITING

Paris, 75010, France
Local Institution - 0115
NOT_YET_RECRUITING

Strasbourg, 67098, France
Local Institution - 0116
NOT_YET_RECRUITING

Vandœuvre-lès-Nancy, 54500, France
Local Institution - 0202
NOT_YET_RECRUITING

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Local Institution - 0207
NOT_YET_RECRUITING

Göttingen, 37075, Germany
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10021, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612-9416, United States
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Sarah Cannon Research Institute Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43202-2224, United States
University Of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Universitätsklinikum Essen
RECRUITING

Essen, North Rhine-Westphalia, 45147, Germany
Universitätsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitätsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitätsklinikum Köln
RECRUITING

Cologne, North Rhine-Westphalia, 50937, Germany
Universitätsklinikum Ulm
RECRUITING

Ulm, Baden-Wurttemberg, 89070, Germany
Washington University School of Medicine in St. Louis
RECRUITING

St Louis, Missouri, 63110-1010, United States

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