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New hope for tough lymphomas: experimental drug TLN-121 enters human testing

NCT ID NCT07082803

Recruiting now Disease control Sponsor: Treeline Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 4 times

Summary

This early-stage trial is testing a new drug called TLN-121, alone or with other medicines, in about 180 people whose Non-Hodgkin Lymphoma has returned or stopped responding to prior treatments. The main goals are to check the drug's safety and how the body processes it, while also looking for signs that it shrinks tumors. Participants must have certain types of lymphoma and have tried at least two prior therapies.

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Conditions

The condition(s) this trial relates to.

angioimmunoblastic T-cell lymphoma diffuse large B-cell lymphoma follicular lymphoma high grade B-cell lymphoma lymphoma lymphoma, non-Hodgkin, familial Nodal T-follicular helper cell lymphoma, follicular type non-Hodgkin lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA LYMPHOMA, NON-HODGKIN

Contacts and locations

Locations

  • BC Cancer - Vancouver

    RECRUITING

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Cabrini Health

    RECRUITING

    Malvern, Victoria, 3144, Australia

    Contact Email: •••••@•••••

  • Hospital of the University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Linear Clinical Research

    RECRUITING

    Perth, Western Australia, 6009, Australia

  • Macquarie University Hospital

    RECRUITING

    Macquarie Park, New South Wales, 2113, Australia

    Contact Email: •••••@•••••

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • Peter MacCallum Cancer Centre

    RECRUITING

    Melbourne, Victoria, Australia

  • Princess Alexandra Hospital

    RECRUITING

    Woolloongabba, Queensland, 4102, Australia

  • SCRI Oncology Partners

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Stanford Medicine Cancer Center

    RECRUITING

    Palo Alto, California, 94304, United States

  • The START Center for Cancer Care - Midwest

    RECRUITING

    Grand Rapids, Michigan, 49546, United States

  • The University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63108, United States

  • Weill Cornell Medicine - New York Presbyterian Hospital

    RECRUITING

    New York, New York, 10065, United States

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