Bone fracture

This study is testing a new hip implant called the OR3O Dual Mobility System in 177 people who need hip replacement surgery. The goal is to see if the implant is safe and lasts longer without needing another surgery. Researchers will follow participants for up to 10 years to chec…

This study tests a special titanium implant, called iFuse-3D, along with screws to treat pelvic fractures in people aged 60 and older. The goal is to see if this surgery helps patients get back to their usual walking ability by the time they leave the hospital. Fifty participants…

This trial tests a fracture liaison service (FLS) — a coordinated care program for people aged 50 and older who have had a hip or spine fracture. The program follows best-practice standards to ensure patients receive bone density tests and appropriate osteoporosis management. Res…

This study tests a new device called VCFix for treating a broken bone in the spine (vertebral compression fracture). Ten adults with a single recent fracture will receive the implant to see if the procedure is safe and works as intended. The goal is to gather early data to plan a…

This study tests a service designed to help people with osteoporosis take their medications as prescribed. Participants receive education, reminders, and regular follow-up calls. The goal is to see if this support improves medication adherence and reduces fracture risk over 18 mo…

When a tooth is removed, the bone and gum often shrink, making it harder to place a dental implant later. This study tests a new magnesium membrane that is placed over a bone graft in the socket. Unlike standard membranes, it is rigid enough to protect the graft but dissolves on …

This study tests if a newer surgical plate placed on the front of the arm is as safe and effective as the standard method using two plates on the back. It involves 68 adults with a specific type of broken arm bone. The goal is to see which approach leads to better arm function an…

This study tests whether a graft made from a person's own extracted tooth, with or without low-level laser therapy, helps regrow jawbone after a tooth is pulled. About 21 healthy adults who need at least two back teeth removed and later replaced with implants will take part. The …

This study tests whether custom-made positioning guides and titanium plates, designed from a patient's own CT scan, can improve the accuracy and stability of surgery for cheekbone (zygomatic) fractures. Eight adults needing surgery will receive the custom implants, and their resu…

This study looks at how well the Insignia Hip Stem works and how safe it is for people needing a total hip replacement. It includes 313 adults with conditions like hip arthritis or fractures. Researchers will check implant survival and hip function for up to 10 years after surger…

This study tests whether a Fracture Liaison Service (FLS) helps people aged 50 and older who have had a hip or spine fracture. Half of the 400 participants get the FLS, which includes bone health checks, medication guidance, diet and exercise advice, and regular phone follow-ups …

This phase 3 trial tests whether adding a local injection of the antibiotic tobramycin to standard IV antibiotics can lower infection rates after open fracture surgery. Open fractures have a high risk of infection because the wound may not get enough blood flow for IV antibiotics…

This study tests a device called AGN1 LOEP SV Kit for people with painful spinal fractures caused by osteoporosis. The device is injected into the broken vertebra to stabilize it. Researchers will track pain relief over 12 months in 100 participants aged 50 and older.

This study tests satralizumab, a drug that calms inflammation, in 30 children aged 8 to 17 with Duchenne muscular dystrophy. The goal is to see if it improves bone density and muscle function. Participants receive injections for several months while continuing standard steroid th…

This study tests whether a single 3D titanium miniplate can replace the standard two-plate method for fixing a broken jaw (mandibular angle fracture). Twenty male patients will be randomly assigned to receive either the 3D plate or the standard two plates. The main goal is to see…

This study compares a new device (AGN1 LOEP) to standard bone cement for treating painful spine fractures caused by osteoporosis. The new device is injected into the broken vertebra, where it hardens and then slowly gets replaced by new bone. The trial involves 408 adults aged 50…

This study is testing a bone graft implant called OsteoPearl in 25 adults aged 50 and older who have a spinal compression fracture. The implant is placed during a standard procedure to stabilize the fracture. Researchers will track pain and quality of life over 30 days to see if …

This study compares two types of artificial elbow joints used to replace a broken bone in the elbow that can't be fixed. About 90 patients will be randomly assigned to receive one of two implant designs. Researchers will track their elbow function, pain, and movement for two year…

This study follows 200 adults getting a shoulder replacement with the Zimmer Trabecular Metal Reverse Shoulder System. It aims to see how long the implant lasts and how well it relieves pain and improves movement in people with conditions like arthritis, fractures, or failed prio…

This pilot study tests whether metformin, a common diabetes drug, can help older adults recover muscle and function after a hip fracture. Sixty people aged 60 and older will take either metformin or a placebo daily for 4 months after surgery. The main goal is to see if the study …

This study is checking how well a new hip replacement part (the HYPE stem) works and lasts over 10 years. About 180 people with hip disease from arthritis or injury will get the implant. Doctors will use X-rays and surveys to see if the implant stays firmly in place and helps red…

This study planned to test a new hip replacement device (the HYPE stem) in people with hip arthritis or other hip damage. The goal was to see how well the device works and if it is safe. However, the study was withdrawn before any participants were enrolled, so no results are ava…

This study reviews the safety and performance of Stryker's Facial iD Universal Plate Configurator, a device used to fix facial fractures or during reconstructive surgery. Researchers will look at medical records of 726 patients who received the implant to see if unplanned revisio…

This study follows 757 people who received the Persona Partial Knee system, a device used to replace only the damaged part of the knee. The goal is to see how long the implant lasts and how well patients function afterward. Participants have knee arthritis or related conditions a…

This study looks at how well a metal nail system (T2 Alpha Femur Antegrade GT/PF Nail) works for treating broken thigh bones (femur fractures). About 66 adults will receive the nail, and their leg function will be checked after 12 months. The goal is to see if this nail helps peo…

This study looks at whether taking cocoa extract or a daily multivitamin can reduce falls and improve physical performance in older adults. Over 21,000 men and women aged 60 and older are participating. Researchers are tracking falls that require medical care and repeated falls t…

This study compares two bone cements used to treat painful spinal fractures caused by osteoporosis. One cement includes a softener (V-Flex) to make it less rigid, while the other is standard cement (V-Steady). The goal is to see if the softer cement reduces the chance of new frac…

This study tests whether adding a blood flow restriction (BFR) cuff to standard physical therapy helps people recover better after wrist fracture surgery. The cuff is placed on the arm during low-intensity exercises to mimic the effects of high-intensity training. Researchers wil…

This study is following 110 people who received a Tornier HRS shoulder replacement to see how well it improves pain and function. Participants have conditions like arthritis, fractures, or rotator cuff tears. The goal is to collect long-term safety and performance data for regula…

This study was designed to see if giving calcium right away to trauma patients who need large blood transfusions could help their blood clot better, reduce the need for more transfusions, and improve survival. The trial was withdrawn before enrolling any participants, so no resul…

This study follows 52 people who already received a Vivacit-E hip liner during total hip replacement. Researchers will track how long the implant lasts and any problems over 10 years. The goal is to confirm the liner is safe and helps reduce pain and improve movement for conditio…

This study followed 413 people with hip arthritis who received a new type of hip replacement called the OXINIUM DH system. The goal was to see how well the implant worked and how safe it was over 10 years. Researchers checked pain, movement, and whether the implant stayed in plac…

This study is checking the long-term safety and performance of two hip implant devices (RingLoc Bipolar Acetabular Cup and Endo II Femoral Head) used in hip replacement surgery. Researchers will follow 116 patients who had their surgery at least eight years ago, tracking complica…

This study compares two types of antibiotic-loaded bone cement used during hip fracture surgery to see which better prevents joint infections. About 7000 patients aged 60 and older with displaced femoral neck fractures will be included. Hospitals are randomly assigned to use eith…

This study looks at two kinds of plastic used in total knee replacement surgery: one with vitamin E and one without. The goal is to see which one lasts longer, causes less wear, and helps patients move better. About 605 adults with knee arthritis or similar problems took part, an…

This study looks at the safety and performance of a cemented hip stem (TrendHip®) in 119 people who had hip replacement surgery. It tracks pain, function, and quality of life for up to 5 years after surgery. The goal is to confirm the device works well in everyday use.

This study looks at people with a single broken bone in the middle-to-lower back (thoracolumbar burst fracture) but no nerve damage. It compares two standard treatments: surgery and non-surgical care (like a brace). The goal is to see which approach leads to better daily function…

This study looks at a metal plate and screw system used to fix certain types of broken upper arm bones. About 135 adults who need surgery for a fresh fracture or one that didn't heal with a cast will be followed for one year. The main goal is to see how often a second surgery is …

This early-stage trial is testing a new stem cell treatment called HMM910 in 9 postmenopausal women with osteoporosis who are at high risk of breaking a bone. The stem cells are given through an IV drip. The main goal is to see if the treatment is safe and tolerable, not yet to p…

This study tests whether custom-made 3D titanium plates are better than standard two-plate systems for fixing a specific type of jaw fracture. Eighteen adults with a broken jaw angle (non-infected, within two weeks of injury) will receive one of the two treatments. The main goal …

This study follows 102 people who received the aneXys hip replacement cup to see how safe and effective it is over 2 years. Researchers measure if the cup moves and track pain and function using standard scores. The goal is to confirm the device works well in everyday use.

This study looks at how well the ExploR Radial Head implant works over time for people who had elbow replacement surgery after an injury. Researchers will track about 93 patients to see how long the implant lasts and if any problems arise. The goal is to confirm the device is saf…

This study tests whether adding a daily supplement (vitamins D, K, C, magnesium, zinc, copper) to pulsed electromagnetic field therapy helps women aged 45-55 heal faster from a wrist fracture. Sixty women will either use the device alone or the device plus supplement for 30 days.…

This study tests a new surgical method that uses a tiny camera (endoscope) to repair broken facial bones through small, hidden cuts instead of large incisions. The goal is to see if this approach works as well as standard surgery while reducing scarring and nerve damage. Thirty a…

This study tests a new heating device called Therm'Up to manage hypothermia in trauma patients. Hypothermia, when body temperature drops below 35°C, can worsen injuries and increase death risk. The trial will enroll 100 adults at risk of hypothermia due to trauma, cold exposure, …

This study follows 200 adults who receive the Shoulder iD™ implant to treat severe rotator cuff tears or shoulder arthritis. Researchers measure how well the shoulder works and how often the implant needs to be fixed or replaced over 10 years. Participants attend regular check-up…

This study looks at two ways to treat serious shoulder fractures in people aged 65 to 85: a reverse total shoulder replacement (surgery) or non-surgical care like a sling and physical therapy. The goal is to see which approach leads to better arm and shoulder function and quality…

This study was designed to test a new metal implant called the Artemis Proximal Femoral Nail for fixing a common type of hip fracture. The plan was to compare results from patients who received this implant to similar patients from the past who received other implants. However, t…

This study tracks 100 adults who need a hip replacement to see how well the Avenir cemented hip stem works and holds up over time. Participants have conditions like arthritis, hip fractures, or hip damage from past surgeries. The main goal is to measure how long the implant lasts…

This study tests a special nail made from a fiber-reinforced material that integrates with bone over time, instead of staying in the body like metal. Ten people with knee fractures will get the implant and be followed for up to two years. The goal is to see if it reduces pain and…

This study looks at how well two specific shoulder replacement parts work over time. It includes 146 adults who already had or will have shoulder replacement surgery. Researchers will check for problems and ask patients about their shoulder function for up to 10 years after surge…

This study looks at how well Biomet Cannulated Bone Screws work for fixing broken bones, fusing joints, or correcting bone cuts. It includes 51 adults who already had or will have surgery with these screws. Researchers track complications, revisions, and patient feedback to confi…

This study looks at how well a special shoulder implant works for people who need a joint replacement due to arthritis, injury, or bone loss. Researchers will track 22 participants to see how long the implant lasts and if there are any problems. The goal is to make sure the impla…

This study is following 202 people who received a special hip liner during hip replacement surgery. The goal is to see how long the liner lasts and whether it causes any problems over time. Participants are adults aged 18 to 80 with conditions like arthritis or hip fractures. The…

This study looks at 800 children with mild open fractures to see how much antibiotic is needed to prevent infections. Some kids get one dose, some get 24 hours, and some get 24 hours plus five days of pills. The goal is to find the best balance between preventing infection and av…

This study follows 200 adults who received the Medacta Shoulder System to treat shoulder problems like arthritis, fractures, or to replace a previous implant. Researchers are checking how long the implant lasts, how well the shoulder works, and any side effects. The goal is to co…

This study follows 100 people who need a hip replacement to see how long the MiniMAX hip stem lasts and how well it works. Participants receive the stem during surgery and are checked for implant survival and hip function using the Harris Hip Score. The goal is to confirm the ste…

This trial tests a new Z-shaped bone plate for fixing broken jaws. 18 patients with certain types of jaw fractures are split into two groups: one gets the Z-shaped plate, the other gets standard plates. Researchers will compare healing, pain, and stability over several months to …

This study tests a surgical technique called retrograde elastic nailing with a pollar K-wire for children aged 3-15 with hard-to-heal wrist fractures. The goal is to see if this method improves bone alignment and reduces complications. Twenty children who failed closed reduction …

This study tests a new ultrasound device that measures bone properties in the lower leg to predict fracture risk in adults over 55. It aims to see if it works as well as or better than standard DXA scans, without using radiation. Researchers will follow 1,600 participants for thr…

This study looks at whether a new DNA sequencing technology (Nanopore) can better identify infections in broken bones compared to standard lab cultures. Researchers will collect bone samples from 100 adults with fracture-related infections and compare the results from both method…

This study tests a handheld device called the Osteoprobe that measures bone strength by pressing on the shinbone. Researchers want to see if it can identify women at risk for hip and wrist fractures better than standard bone density scans. About 190 women with recent fractures an…

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This study tests whether injecting bone cement into the spine can prevent fractures after high-dose radiation treatment for cancer that has spread to the backbone. About 87 patients with solid tumors and spinal metastases will receive either standard radiation alone or radiation …

This study looks at whether a fall prevention discharge class can reduce repeat fall-related ER visits in adults aged 60 and older. Researchers will compare those who attended the class to those who did not. The goal is to see if this simple education step can help prevent future…

This study compares three care models to prevent falls and fractures in older adults recovering from a broken bone in a skilled nursing facility. About 3,780 participants across 42 facilities will receive either medication reduction, bone health management, or both. The goal is t…

This study tests whether a saphenous nerve block can safely reduce pain after surgery for a tibial plateau fracture. Typically, nerve blocks are avoided in these fractures because numbness might mask compartment syndrome, a serious complication. The saphenous nerve block targets …

This study looks at two ways to lower anxiety in children aged 3 to 10 who need surgical pins removed from an elbow fracture. One approach removes the pins right after the cast comes off, before an X-ray, instead of after. The other uses a virtual reality headset during the pin r…

This study compares two types of nerve blocks (PENG and FICB) to see which provides better pain relief for people with hip fractures in the emergency department. About 50 adults with a broken hip will receive one of the two blocks, and researchers will measure their pain scores a…

This study tests whether using virtual reality and action observation therapy during the time a wrist or hand is in a cast can improve recovery. Participants watch first-person videos of hand movements through a VR headset and then practice those movements. The goal is to prevent…

This study compares two ways to manage pain before spinal anesthesia for hip fracture surgery: a fascia iliaca block (a numbing injection near the hip) versus intravenous nalbuphine (a painkiller given through a vein). Researchers will measure pain scores and how well patients ca…

This study tests whether a nerve block called erector spinae plane block can reduce the amount of morphine needed for pain after spinal fracture surgery. About 86 adults having minimally invasive spine surgery will be randomly assigned to receive either the nerve block or a place…

This study tests a communication tool called Best Case/Worst Case-ICU for older adults (50+) with serious injuries in the ICU. The tool helps doctors, patients, and families discuss possible outcomes and treatment options using simple graphics. Researchers will measure if it impr…

This pilot study tests whether robot-assisted gait training can improve walking in people with lower limb burns and fractures. Five participants will receive 30 minutes of robot training plus 30 minutes of conventional therapy daily for 8 weeks. The goal is to see if this combina…

This trial tests whether a Pain and Coordination Plan (PAC-plan) can reduce opioid use and improve quality of life in adults who have had surgery after an accidental injury. Participants receive the plan at hospital discharge, which includes an opioid management plan, a follow-up…

This study aimed to compare two ways to manage pain from broken ribs: a continuous IV drip of lidocaine versus a nerve block called an erector spinae plane (ESP) block. The goal was to see which method reduces pain and improves breathing better. However, the study was withdrawn b…

This study tests a new method of spinal anesthesia for elderly patients (65+) having hip fracture surgery. The goal is to see if using a mix of two types of anesthetic given in small doses can reduce dangerous drops in blood pressure compared to standard methods. The study involv…

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and aims to reduce PTSD symptoms and the number of emergency room visits over time. About 424 participants are involved, and t…

This study looks at whether a special pain injection given around the knee during surgery can lower pain for people with a tibial plateau fracture (a break in the top of the shinbone). About 150 adults with this type of fracture will receive the injection, and their pain scores w…

This study tests whether remote monitoring through a secure app can safely replace in-person follow-up visits after wrist fracture surgery. Researchers will compare recovery, satisfaction, and complication rates between 160 adults who use virtual check-ins and those who attend st…

This study compares two ways to numb the wrist during a broken bone repair: a hematoma block (injecting numbing medicine into the fracture site) and a Bier block (using a tourniquet and IV numbing medicine). 500 adults with a broken wrist will be enrolled to see which method prov…

This study tests whether a new type of screw (Bone Bolt) reduces pain better than standard screws after surgery for a specific pelvic fracture (LC-1). About 100 adults aged 18-80 will take part. The main goal is to see if the Bone Bolt leads to lower pain scores in the days after…

This study tests whether using a lower-pressure tourniquet during orthopedic surgeries can reduce pain and the need for opioid painkillers afterward. Standard tourniquets use high pressure, which can cause muscle weakness and pain. The experimental device sets pressure based on t…

This study looks at whether wearing a splint and going to formal physical therapy are necessary after surgery for a broken wrist. About 230 adults with a specific type of wrist fracture will be followed to see if early movement (no splint) leads to better outcomes and lower costs…

This study compares two sedative drugs (midazolam and dexmedetomidine) given as nasal sprays to 32 people having surgery for a broken lower jaw. The goal is to see which drug provides better sedation and how they affect heart rate and blood pressure. Participants are healthy adul…

This study compares two surgical techniques for repairing a broken hip (femoral neck fracture) in adults over 50. One is the standard direct lateral approach, and the other is a newer muscle-sparing method called SPAIRE. Researchers want to see which approach leads to better hip …

This study is testing two methods of giving pain medicine through a small tube placed near a nerve after surgery. One method gives a steady, low-dose drip, while the other gives larger doses at set times. The goal is to see which method provides better pain control and lasts long…

This early-phase trial compares two drugs—dexamethasone and dexmedetomidine—added to standard spinal anesthesia for pelvic fracture surgery. Sixty adults will be split into two groups to see which combination provides longer pain relief and better recovery. The goal is to find a …

This study planned to test whether giving ear acupuncture during wrist fracture surgery could lower the amount of opioid painkillers patients need afterward. It was designed for adults aged 18–64 having a specific type of wrist repair. However, the trial was withdrawn before enro…

This study planned to test whether adding ear acupuncture to standard pain management could reduce opioid use after surgery for lower leg fractures. It was designed for adults aged 18–64 undergoing ankle or foot fracture repair. However, the trial was withdrawn before enrolling a…

This study compares two recovery approaches after wrist fracture surgery: moving the wrist right away versus wearing a cast for two weeks. Researchers want to see which method helps patients return to work sooner and improves wrist function. About 240 adults aged 18-65 with a bro…

This study tests a surgical procedure called partial wrist denervation, done at the same time as standard fracture repair, to see if it reduces the chance of long-term wrist pain. Researchers are enrolling 56 adults with severe, shattered wrist fractures. The main goal is to meas…

This study tests whether ketamine or lidocaine infusions can better manage pain from multiple broken ribs, reducing the need for opioids. About 74 adults with at least three broken ribs will receive one of the two medications for 72 hours. The goal is to improve breathing, reduce…

This pilot study tests whether adding blood flow restriction therapy to standard physical therapy helps elderly patients (65 and older) recover muscle strength and size after hip fracture surgery. Twenty participants will have their thigh and leg measurements, muscle strength, pa…

This study tests whether a wearable robot suit can help people aged 65 and older recover leg function after hip fracture surgery. Participants will either do standard rehab or use the robot suit during therapy. The goal is to see if the robot improves walking, balance, and pain b…

This study looks at two different nerve block techniques used alongside low-dose spinal anesthesia for hip fracture surgery in elderly patients. The goal is to see which method better prevents severe drops in blood pressure during surgery and improves pain control afterward. Abou…

This study looks at two different nerve-block methods to control pain after hip surgery. One group gets a standard block that numbs the hip joint, while the other gets an extra block for the thigh skin. The goal is to see which method reduces pain, lowers the need for pain medici…

This study tests a chatbot called 'Wrist Health' that helps elderly patients (ages 60-90) recover from wrist fractures at home. The chatbot provides exercise instructions, education, and reminders, and tracks how often patients use it. Researchers want to see if using the chatbot…

This study tests two additional therapies for people recovering from a broken wrist (distal radius fracture) treated with surgery. One therapy uses gentle manual movements (Mulligan mobilisation), and the other uses mental imagery exercises (graded motor imagery) to retrain the b…

This study compares three types of local anesthesia for people with a broken wrist who need a fracture reduction in the emergency room. It aims to find which method—a nerve block, a hematoma block, or both—provides the best pain relief. About 105 adults will take part, and their …

This study tests whether adding suzetrigine to standard pain treatments helps adults with multiple broken ribs feel less pain and use fewer opioids. About 80 people will be randomly assigned to get either suzetrigine or a placebo alongside usual care. The goal is to improve breat…

This study looks at whether starting weight bearing and active knee exercises soon after surgery for a tibial plateau fracture (a type of knee break) helps reduce pain, improve knee movement, and support bone healing. About 28 adults aged 18 to 50 who had a specific type of fract…

This early-phase trial aimed to see if a nose spray sedative (dexmedetomidine) could safely and effectively sedate children aged 2–18 with a broken forearm, compared to the standard IV ketamine. The study was withdrawn before any participants were enrolled, so no data was collect…

This study looks at whether wearing a cast for 4 weeks instead of 6 weeks helps adults with a broken wrist recover just as well. About 80 adults aged 18 to 50 with a specific type of wrist fracture will be randomly assigned to either 4 or 6 weeks of casting. The main goal is to s…

This study compares two types of nerve blocks—pericapsular nerve block and anterior quadratus lumborum block—for reducing pain during spinal anesthesia positioning and after surgery in people with hip fractures. Researchers will enroll 64 adults aged 30-85 scheduled for hip fract…

This study aimed to see if adding blood flow restriction (BFR) therapy to standard physical therapy improves recovery after surgery for a tibial plateau fracture. It planned to enroll adults who had that surgery and measure knee function, muscle size, and movement over one year. …

This study tests a one-time nerve-freezing procedure called cryoneurolysis to treat pain from broken ribs. The treatment uses a small probe to freeze the nerves around the fractured ribs, providing pain relief for up to 2-3 months without the side effects or addiction risk of opi…

This study looks at whether applying heat and giving abdominal massage soon after hip fracture surgery can improve bowel function and mental well-being. About 75 adults who had hip surgery and haven't had a bowel movement yet will receive these treatments twice a day for three da…

This study compares two types of nerve blocks (PENG and FIC) to see which provides better pain relief for adults with hip fractures in the emergency department. About 80 participants will receive one of the blocks and report their pain levels. The goal is to find a safer, opioid-…

This study aimed to see if giving a nerve block before and after hip fracture surgery could reduce pain, confusion, and hospital stays in patients 65 and older. The trial was withdrawn before any participants were enrolled, so no conclusions can be drawn.

This study looks at whether adding acupuncture to usual care (painkillers and physical therapy) can improve pain and mobility in people recovering from hip fracture surgery. About 90 adults aged 40–99 will be randomly assigned to receive either standard care alone or standard car…

This pilot study compares three pain relief methods for people with three or more broken ribs on one side. Participants will receive either a nerve block with a numbing medicine, a lidocaine infusion, or standard pain care. The goal is to see which approach reduces opioid use and…

This study compares two types of nerve blocks—SFIB and PENG—to see which one controls pain better after hip replacement surgery. Sixty patients will be randomly assigned to receive one of the blocks. The main goal is to measure how much morphine they need in the first 24 hours af…

This study follows 50 adults who had surgery for a broken shinbone to see if changes in the kneecap tendon's stiffness relate to knee pain. Researchers use a special ultrasound before and up to 6 months after surgery. The goal is to better understand why some people develop front…

This study was designed to compare two procedures—vertebroplasty and kyphoplasty—for treating spinal fractures caused by trauma. Researchers planned to measure how much bone cement was injected and how well the spine's shape and function were restored. However, the study was with…

This study looks at 200 older adults (65+) who had hip fracture surgery. Researchers compared two common rating systems—the ASA score and the Clinical Frailty Scale—to see which better predicts whether a patient will need intensive care after surgery. The goal is to help doctors …

This study looks back at medical records of 233 older adults (65+) who had hip fracture surgery. Researchers want to see if certain blood test results, taken before and after surgery, can help predict who is at higher risk of dying within 30 days or needing a longer stay in the i…

This registry will follow about 300 adults with orbital blow-out fractures to see how different treatments affect double vision and eye position over 6 months. Patients may receive surgery or non-surgical care as part of routine practice. The goal is to collect real-world data to…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study checks how well a commercially available nail system works for fixing broken upper arm bones. 100 adults who need surgery for a humerus fracture will be followed for 12 months to see if the bone heals enough for normal activities. The goal is to confirm the device is s…

This study aimed to see if using real-time ultrasound during a thoracic epidural block makes the procedure more reliable. It was designed for adults with chest or abdominal pain or rib fractures. The study was withdrawn before enrolling any participants, so no results are availab…

This study looks at over 110,000 people who had hip replacement surgery to see if a longer or shorter hip stem works better. It compares death rates, how often the hip implant needs to be replaced, and patient-reported pain and function. The goal is to find out which stem length …

This study compares two surgical techniques (posterior SPAIRE and anterior approach) for treating broken hips in people aged 70–90. Researchers will measure recovery, muscle damage, and bone density changes in 210 participants. The goal is to see if one approach leads to better o…

This study follows 70 adults aged 65 and older admitted to the hospital with an orthopedic injury. Researchers measure muscle strength, mobility, and thinking skills shortly after admission, again at day 7 or discharge, and 4-6 weeks after leaving the hospital. They also intervie…

This study is observing 60 people who received a special hip replacement cup (Plasmafit Revision Structan) during routine surgery. Researchers are checking how well the cup works and how long it lasts by tracking hip function and any need for repeat surgery. No new treatment is b…

This study aimed to compare three medicines (propofol, etomidate, and ketamine) given to adult trauma patients to help them breathe with a breathing tube. The goal was to see which drug leads to the best outcomes, like survival and fewer side effects. However, the study was withd…

This study looks at the medical records of over 550,000 athletes to understand how sports medicine services are used and how effective they are. The goal is to find ways to improve care and outcomes for people with sports injuries. No new treatments are being tested; instead, res…

This study looks at whether a computer model can predict heart injury after major orthopedic surgery in patients 65 and older. Researchers will combine blood tests, frailty scores, and other health data to build a machine learning tool. The goal is to help doctors spot high-risk …

This study tests whether sending information letters to doctors and patients after a fracture can improve osteoporosis care. Over 4,200 older adults in Manitoba who had a hip, spine, arm, or wrist fracture are included. The goal is to see if these notifications increase bone dens…

This study compares two recovery plans for people who had surgery for a specific type of knee fracture (unicondylar tibial plateau fracture). One group will start putting weight on their leg after 6 weeks, while the other follows the standard 10-week wait. Researchers will measur…

This study looks at how the body's inflammatory response after a specific type of knee fracture might be linked to developing arthritis later. Researchers will measure inflammatory markers in the joint fluid and blood of 60 adults with a tibial plateau fracture. They will also us…

This study compares genetic differences and muscle gene activity in people who develop acute compartment syndrome after a leg fracture versus those who do not. Researchers will measure a protein called myostatin in muscle tissue. The goal is to better understand why some people g…

This study looks at how vitamin D and vitamin K interact to affect bone density and fracture risk in older adults. Researchers are analyzing data from over 25,000 participants who took vitamin D and omega-3 supplements or placebos. The goal is to see if people with low vitamin K …

This study tests whether giving patients with hand problems like carpal tunnel syndrome or trigger finger a decision aid—a booklet with clear information about their condition and treatment options—helps them feel more satisfied and less conflicted about their choices. About 126 …

This study looks back at 300 patients who had a hip replacement after a cancer-weakened bone broke. Researchers want to see how well patients walk, their pain levels, and how long they live compared to patients from decades ago. The goal is to find what helps people walk again af…

This study follows 118 adults who received a shoulder replacement using the Tornier Perform® Humeral System after a fracture or related joint damage. Researchers will collect data on pain, function, and safety over 10 years. The goal is to monitor real-world performance, not to t…

This pilot study at Johns Hopkins will enroll 24 older adults having hip fracture surgery with bone cement. It compares general anesthesia to epidural (neuraxial) anesthesia to see which one lowers the risk of bone cement implantation syndrome—a serious complication that can caus…

This study looks at three ways surgeons place screws in the spine during surgery: using a robot, using a navigation system, or doing it by hand. The goal is to see which method leads to fewer screws needing to be fixed in a second surgery within the first year. About 932 adults w…

This study follows 248 adults receiving a CoreHip hip replacement to see how their hip function, pain, and leg length change over time. Participants are treated as part of routine care, and no extra tests or treatments are given. The goal is to collect real-world data on the impl…

This study looks at how the body's natural response to severe injury or major surgery can sometimes go wrong, leading to complications. Researchers will collect blood samples from 320 trauma patients and elective surgery patients to measure markers of inflammation and blood clott…

This pilot study tests whether stitches or staples are better for closing surgical wounds after fixing broken leg bones. About 50 adults with certain leg fractures will be randomly assigned to one closure method. The main goal is to see if such a study is practical, not to prove …

This observational registry will follow 5,000 adults with various wounds—like diabetic foot ulcers, burns, or surgical wounds—to see how different treatments (e.g., hydrocolloid, foam, silver dressings) perform in everyday medical settings. Researchers will measure wound healing,…

This study looks back at medical records of 146 adults with stable spine fractures caused by falls or accidents. It compares three treatments: wearing a brace, a minimally invasive bone cement procedure, or spinal fusion surgery. The goal is to see which option leads to the best …

This study follows about 1500 adults with hip, shin, ankle, upper arm, or wrist fractures for up to one year. Researchers collect information on healing, patient-reported symptoms, and activity patterns using questionnaires and wearable sensors. The goal is to understand recovery…

This study looks at two common surgeries for a certain type of hip fracture in people aged 60 and older: hip replacement or using screws/pins to hold the bone together. The main goal is to see if a larger study is possible by checking how many people join, how well the treatments…

This study is tracking over 600 people who received the GORE VIABAHN stent-graft as part of their normal medical care for conditions like peripheral artery disease or aneurysms. Researchers are monitoring how often serious device-related problems occur. The goal is to see how saf…

This study asks over 2,300 people with various joint conditions (like arthritis, fractures, and hip problems) to fill out surveys about their treatment preferences. Researchers want to learn how factors like pain, recovery time, cost, and surgery versus non-surgery affect patient…

This study looks at whether patients with surgically treated leg, pelvis, or hip socket fractures can safely start walking right away instead of waiting 6-12 weeks. About 100 adults will be randomly assigned to immediate weightbearing or delayed weightbearing. The goal is to see …

This study is testing whether RNA molecules in the blood can predict if a broken bone will heal normally, slowly, or not at all. Researchers will collect blood samples from 110 people with fractures at several time points after injury and compare the RNA test results to actual he…

This study looks at how well and how safe Global D implants work for people who need surgery on their jaw or face after an injury. About 102 patients aged 11 and older will take part. The main goal is to see how well the jaw works 6 months after surgery using a simple questionnai…

This study looks at whether people can go home the same day after surgery for a broken wrist, instead of staying in the hospital overnight. Researchers will compare recovery, function, and patient satisfaction between the two groups. The goal is to see if same-day discharge is a …

This study aimed to see if custom carbon fiber braces could reduce forces on the ankle joint after a fracture, potentially lowering the risk of arthritis. It planned to enroll adults with healed ankle fractures and test different brace designs. However, the study was withdrawn be…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study looks at two methods for setting the pressure of a tourniquet (a tight band that stops blood flow) during surgery for a broken wrist. The goal is to see which method gives surgeons a clearer view, causes less pain, and leads to fewer complications. About 140 adults hav…

This study compares two surgical methods for fixing a broken hip (femoral neck fracture) using a dynamic hip screw. In one method, the surgeon makes a larger cut to see the bone directly (open reduction); in the other, the bone is aligned without a large cut (closed reduction). T…

This study follows 150 adults undergoing back-of-the-neck and upper spine surgery with metal screws and rods (posterior fixation) for injuries, tumors, or worn-out discs. Researchers track complications, X-ray results, and patient-reported pain over time. The goal is to better un…

This study will track 100 people with traumatic hand and wrist injuries at Sohag University Hospital in Egypt from October 2025 to April 2026. Researchers want to learn how these injuries happen and what the outcomes are. It is an observational study, meaning no new treatment is …

This study aimed to see if a web-based fracture liaison service (e-FLS) could help more older adults start osteoporosis treatment after a fracture compared to standard in-person services. It planned to include men and women over 60 in France who had a low-trauma fracture. However…

This study checks how well 10 existing prediction models can estimate the chance of dying within 30 days after a hip fracture. Researchers will look at data from 3500 patients in the Netherlands, using about 35 health factors. The goal is to find models that are accurate and usef…

This study gathers information from 160 people who received a shoulder implant to see how long the implant lasts and how safe it is. Participants have conditions like arthritis or fractures. The goal is to use this data to make better implants and help doctors and patients make i…

This study follows 200 adults who received the Medacta Shoulder System to treat various shoulder issues like arthritis, fractures, or rotator cuff problems. The main goal is to see how long the implant lasts and how well the shoulder works after surgery. It is a post-market check…

This study was designed to see if a pre-surgery meeting with an occupational therapist helps people with hand injuries or thumb arthritis recover faster and attend their therapy appointments. It planned to include adults needing surgery for a broken wrist, a cut tendon, or thumb …

This registry follows 1,000 children with long bone fractures to see how different treatments (casts, surgery, or splints) affect healing. Doctors collect data on recovery, movement, and complications over two years. The goal is to learn which treatments work best for different f…