Can shorter antibiotic courses prevent infections in Kids' broken bones?
NCT ID NCT06055712
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at 800 children with mild open fractures to see how much antibiotic is needed to prevent infections. Some kids get one dose, some get 24 hours, and some get 24 hours plus five days of pills. The goal is to find the best balance between preventing infection and avoiding unnecessary antibiotics.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cefazolin and cephalexin (antibiotics)
What this could lead to
If successful, this could identify the shortest effective antibiotic course to prevent infections in children with mild open fractures, reducing unnecessary antibiotic use.
What could go wrong
This is a phase 4 study, so the drugs are already approved, but the optimal duration is unknown. The results may not apply to more severe fractures or older patients.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Saint Louis University
St Louis, Missouri, 63110, United States