Bone fracture

This study tests whether stem cells taken from a patient's own belly fat can improve bone healing after surgery for a broken jaw. Twenty adults with jaw fractures will either get standard surgery plus stem cells or standard surgery alone. Researchers will check bone density and c…

This study will follow 40 people who receive a shoulder replacement using the HUMELOCK II stem, either for a broken shoulder or to replace an old implant. Researchers will track how long the implant lasts, how well the shoulder moves, and any problems over 10 years. The goal is t…

This trial investigates whether applying vancomycin powder directly to open fracture wounds in the emergency department can reduce deep infections. Adults with open fractures are randomly assigned to receive either standard care or standard care plus a single dose of vancomycin p…

This study tests whether a new shelf-stable blood product (IFC) works faster than the standard cryoprecipitate to stop severe bleeding in trauma patients. About 320 adults with traumatic injuries and low fibrinogen levels will be enrolled. The goal is to see if IFC can be given m…

This study tests a less invasive surgical approach for severe thoracolumbar burst fractures, a type of spinal injury. The procedure combines vertebral augmentation (using a device to restore bone height) with percutaneous fixation (screws placed through small incisions). The goal…

This study compares two common surgeries for broken hand bones: placing a small screw inside the bone versus using pins and a cast. About 100 adults with hand fractures will be randomly assigned to one of these treatments. The goal is to see which method helps people regain movem…

This study compares robot-assisted surgery to conventional surgery for treating unstable pelvic fractures (Tile B and C types). About 88 adults with recent fractures will be randomly assigned to one of the two procedures. Researchers will measure pain, function, recovery speed, a…

This study will review medical records and call patients who received AGN1 LOEP, a device injected into the hip bone to treat osteoporosis. Researchers want to see how many patients later had hip fractures and whether any side effects occurred. The goal is to understand how well …

This study tests whether adding Platelet-Rich Fibrin (PRF) – a natural substance made from your own blood – to a bone graft helps the extraction site heal faster and grow more bone. Fourteen adults needing two tooth extractions will receive PRF plus bone graft in one socket and s…

This trial tests a new type of nail made from magnesium and titanium to fix broken leg or arm bones. The nail is designed to provide strong support while part of it gradually dissolves over time. Researchers will compare it to standard metal nails in 160 adults to see if it is ju…

This study compares two ways to treat a common elbow fracture in children (Gartland type II). Half the children will get a cast after the bone is set, and the other half will have surgery with pins. Researchers will measure how well the arm works, how much it can move, and pain l…

This study looks at whether applying a patient's own skin cells (called a basal cell suspension) to surgical wounds can help them heal faster and with less scarring. Researchers will compare 500 people who get this extra treatment with 500 who get standard surgery alone. The goal…

This study is testing whether adding a cold atmospheric plasma device to standard wound care helps different types of wounds heal better. The device uses low-temperature plasma to kill bacteria and promote healing. Researchers will compare 500 patients who get plasma therapy plus…

This study will follow 120 adults aged 60 and older who have a pelvic fracture and are scheduled to receive the iFuse TORQ TNT implant, a screw-like device that stabilizes the pelvis. Researchers will check if the device stays in place, doesn't break, and doesn't require addition…

This pilot study will compare two types of pedicle screws (monoaxial vs. polyaxial) used with cement and balloon kyphoplasty to treat spine fractures in people aged 60 and older. The goal is to see which screw type better corrects spine curvature and improves recovery. Forty-four…

This study looks at three ways to treat a specific type of shoulder fracture (greater tuberosity fracture) that also involves a rotator cuff injury. The three options are: non-surgical care, surgery right away, or surgery after a delay. The goal is to see which approach leads to …

This study looks at two different surgical methods for repairing a broken hip (hemiarthroplasty) in 100 adults. The goal is to see if one approach leads to better function and fewer complications after surgery. Participants will be randomly assigned to one of the two methods and …

This study tests whether custom-made 3D plates are better than standard titanium plates for fixing a specific type of jaw fracture (sub-condylar fracture). About 30 adults aged 18-60 with recent, displaced fractures will be randomly assigned to receive either a custom plate or a …

This study tests a special bone glue that dissolves over time, used alongside metal plates and screws to fix a broken wrist. About 20 adults with a specific type of wrist fracture will receive the glue during standard surgery. Researchers will check if the glue is safe and helps …

This study will test a new, personalized smart home care model for older adults (60+) recovering from a hip fracture. The goal is to predict and improve recovery, reduce falls, and support caregivers. About 218 people from northern Taiwan will take part.

This study tests whether adding denosumab to standard care can strengthen bones and prevent fractures in 358 adults with type 2 diabetes who are at high risk for breaks. Participants will receive the drug or a placebo, and researchers will measure changes in bone density and frac…

This study will compare aspirin tablets to daily injections of low molecular weight heparin (LMWH) for preventing dangerous blood clots in people who break their hip. Over 21,000 patients aged 60 and older across 96 UK hospitals will take part. Hospitals will switch between the t…

This study looks at whether using both a nail and a plate together can better fix certain complex hip fractures. The approach is meant to prevent the bone from collapsing and help people heal faster. Seventeen adults with these fractures will be followed for six months to check b…

This study compares two ways to treat a Colles' fracture (a broken wrist). One group gets a plaster cast after the bone is set; the other gets a small metal pin (K-wire) plus a cast. Researchers will check wrist function in 60 adults aged 18–60 to see which method works better.

This study will compare two surgical techniques for fixing specific types of fractures in the roof of the mouth (palate). Forty patients will be randomly assigned to receive either a miniplate or a wire stabilization procedure. The main goals are to see which method better restor…

This pilot study tests whether a combination of two blood thinners (rivaroxaban and aspirin) can prevent heart attacks and blood clots in patients who had a hip fracture surgery and also suffered a heart injury. About 100 adults aged 45 and older will be randomly assigned to eith…

This study tests whether adding a patient's own fat tissue under a standard skin graft can improve healing and reduce scarring after severe burns or traumatic wounds. About 68 adults with deep skin loss will receive either the new fat-plus-skin graft or a traditional skin graft a…

This phase 4 trial will test whether tranexamic acid (TXA), a drug that reduces bleeding, can safely lower blood loss in 200 orthopedic trauma patients who are on anticoagulants (blood thinners). Participants will have surgery for broken leg or thigh bones. The study compares tho…

This study compares three common surgical techniques for fixing simple hand fractures: a screw, a plate, or pins. About 111 adults with fractures in the long fingers (excluding the thumb) will be randomly assigned to one method. The goal is to see which approach gives the best ha…

This study tests whether using a 3D-printed surgical guide and pre-bent metal plates can make jaw fracture surgery more accurate than the standard approach. Twenty adults with a specific type of jaw fracture will be randomly assigned to either the new precision method or the usua…

This study looks at whether adding an ultrasound to a CT scan can find more rib cartilage fractures than a CT scan alone. Researchers will follow 100 adults with chest injuries to see if finding these hidden fractures changes treatment, such as whether surgery is needed. Particip…

This study tests whether an AI software called RBfracture helps clinicians better identify fractures, dislocations, and joint fluid buildup on X-rays. Sixteen doctors will review X-rays from 415 adult patients with and without the AI's help. The goal is to see if the AI improves …

This study tests a safety bundle—staff training, checklists, and audits—to prevent surgical site infections after emergency C-sections and open leg fracture repairs in Ethiopia. About 1,000 patients at public hospitals will be followed for 2 years to measure infection rates and d…

This study tests whether a higher dose of the blood thinner enoxaparin can better prevent dangerous blood clots in the legs or lungs of severely injured patients. About 540 adults in intensive care after trauma will receive either the standard or a double dose. The goal is to see…

This trial tests whether adding a specific nerve block (Quadro-Iliac Plane Block or Suprainguinal Fascia Iliaca Block) to standard pain management reduces the need for opioids after hip fracture surgery. About 90 adults having hip fracture surgery under spinal anesthesia will be …

This study tests two ways to numb the arm for wrist fracture surgery in people at high risk for severe pain. One method uses a long-acting numbing drug (liposomal bupivacaine) plus regular bupivacaine, and the other uses a steroid (dexamethasone) plus regular bupivacaine. The goa…

This study tests whether giving iron supplements to older adults (75+) after hip fracture surgery can reduce fatigue and improve recovery. 528 participants will receive either intravenous iron, oral iron pills, or a placebo. The goal is to see if iron helps with energy, mobility,…

This study compares two surgical methods for fixing a broken shinbone (tibia). One technique enters above the kneecap, the other from the side of the kneecap. Researchers will measure knee function, pain, and recovery in 40 adults aged 18-60. The goal is to find which approach le…

This study tests whether a single injection of a slow-release painkiller (liposomal bupivacaine) into a nerve block can control pain for up to 72 hours after hip fracture surgery in older adults. The standard drug only lasts about 12 hours, often leading to more pain and opioid u…

This study compares ketamine to morphine for treating acute pain in children visiting the emergency department. Over 1,000 children with abdominal pain or broken bones will receive either drug. The goal is to see if ketamine works as well as morphine but with fewer side effects.

This study tests a new combination of nerve blocks for elderly patients (65 and older) having surgery for a broken shoulder. The goal is to see if the new approach provides better pain relief during surgery and lowers the risk of temporary diaphragm paralysis, which can cause bre…

This study tests if using a floor pedal bike at home helps people recover from leg fractures and ankle injuries. Twenty adults with these injuries will get a bike at their first post-surgery visit and be asked to use it regularly. Researchers will track their physical activity an…

This study will compare two types of nerve blocks (SPSIP and ESP) to see which one works better for pain after rib fracture surgery. About 60 adults will take part, and researchers will measure pain levels, opioid use, and side effects. The goal is to find a safer, more effective…

This study tests whether a device called TENS, which sends mild electrical pulses through the skin, can reduce pain and the need for painkillers in older adults with hip fractures. Thirty-two participants will receive either active TENS or a sham (fake) version for 45 minutes. Re…

This study tests whether giving lidocaine through an IV during surgery can lower the amount of opioids needed for pain in children aged 3-18 having arm fracture repair. Half the children will get lidocaine, half a placebo, and researchers will compare opioid use and pain scores. …

This study tests whether special dissolving nails can heal children's broken forearm bones as well as standard titanium nails. The dissolving nails go away on their own, so many kids might not need a second operation to remove them. About 60 children who need surgery for a displa…

This study looks at whether adding a nerve block to the back of the hip to two standard front-hip blocks can improve pain relief after hip surgery. About 50 adults having hip surgery will be split into two groups to compare pain scores and the need for extra pain medicine in the …

This study looks at whether a nerve block called a serratus plane block can help people with multiple broken ribs breathe better and feel less pain. 72 adults with at least two broken ribs on one side will be split into three groups: standard painkillers alone, standard painkille…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study tests whether an AI-based smartphone app can improve recovery for 106 adults after hip or knee replacement or hip fracture surgery. Participants use the app for 12 weeks at home to get real-time feedback on their exercises, while a comparison group follows the same exe…

This early study tests whether applying nitroglycerin ointment (a medicine that widens blood vessels) to surgical wounds during high-risk leg surgeries can improve blood flow and reduce complications like infection or wound separation. Fifteen adults undergoing specific ankle, he…

This study looks at whether abdominal massage and drinking warm water can prevent constipation and improve recovery in people who have had hip fracture surgery. About 81 adults will be randomly assigned to receive massage, warm water, or standard care. The goal is to see if these…

This study tests whether listening to music with binaural beats (a type of sound that may influence brain activity) can help professional athletes who are afraid of getting hurt again after a musculoskeletal injury. Sixty-six athletes will listen to either binaural beat music, a …

This study tests a procedure that freezes the nerves around broken ribs to see if it reduces pain and helps people breathe better. About 30 adults with at least two broken ribs and severe pain will either get the freezing treatment or standard pain medicine. Researchers will trac…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study compares two spinal anesthesia methods for hip fracture surgery in people over 50. One method uses a single injection, the other uses a tiny tube to give the medicine in smaller doses. The goal is to see if the tube method causes fewer drops in blood pressure and relat…

This study tests a device called the Verus frame, which supports the leg during surgery to fix a broken shinbone. The goal is to see if it helps surgeons align the bone more accurately. Twenty-five adults with tibial fractures will be enrolled, and their results will be compared …

This study tests whether listening to music for 20 minutes before a wrist fracture reduction can lower pain and stress. 192 adults will be randomly assigned to hear their favorite music, a therapist-chosen song, or no music. Researchers will measure pain scores, heart rate, and b…

This study tests whether applying platelet-rich fibrin (PRF) — a concentrate made from a patient's own blood — to the mental nerve during jaw fracture surgery can improve recovery of sensation in the chin and lower lip. 40 people with a broken jaw and numbness will be randomly as…

This study looks at whether giving trauma patients personalized information and a voluntary digital follow-up visit (instead of only standard care) helps them have less disability, return to work more often, and feel better overall. About 256 adults admitted to a Norwegian trauma…

This study tests a new, non-invasive chest stabilizer for people with multiple rib fractures from blunt chest trauma. The device is worn for 10 days and aims to reduce pain, improve breathing, and prevent lung complications like pneumonia. Researchers will compare it to standard …

This pilot study tests whether a mobile health app with step-by-step exercise videos can help people recover better after a proximal humerus (shoulder) fracture. Sixty adults with this injury will be split into two groups: one gets standard care, the other gets standard care plus…

This study tests whether using a small vibration tool after wrist fracture surgery can reduce pain and the need for opioid painkillers. One hundred adults who have had surgery for a broken wrist will be randomly assigned to use the vibration tool or not. Researchers will measure …

This study will compare one-on-one physical therapy sessions with group-based therapy for people recovering from a femoral neck fracture (a type of hip fracture). Forty adults aged 50 and older in Gaza will be randomly assigned to either individual or group therapy for 6 weeks. R…

This observational study will follow 150 people with thoracolumbar spine fractures to see how the injury and its treatment (surgery or non-surgical care) affect joint and disc degeneration over time. Researchers will compare CT scans and pain scores between treated patients and a…

This study looks at whether a small pressure sensor placed in the leg during surgery can help doctors spot a rare but serious problem called acute compartment syndrome. Teens aged 10 to 21 with a broken shinbone will have the sensor monitor pressure for at least 18 hours after th…

This study looks at how fear of moving the wrist (kinesiophobia) changes over time in adults with a common wrist fracture treated with a cast. Researchers will follow 100 people for 3 months after the cast comes off, measuring pain, grip strength, and wrist function. The goal is …

This study will compare two surgical methods for fixing a specific type of broken thigh bone near the knee in people aged 55 and older. Half the participants will get a single implant (a plate or a rod), while the other half will get two implants (a plate plus either a rod or a s…

This observational study will check vitamin C levels in 40 people with osteoporosis, comparing those who have had a spine fracture to those who haven't. The goal is to see if lower vitamin C is more common in the fracture group. No treatment is given; the study simply measures an…

This trial tests a software device called AI-TRiPS that uses real-time data from ambulances to predict the risk of death, bleeding, kidney injury, and need for blood transfusion in trauma patients. The tool displays these predictions to hospital trauma teams before the patient ar…

This study tests whether a structured, supervised exercise program can help adults recover from serious leg fractures. About 40 people who had surgery for a broken thigh or shin bone will either do the exercise program or get usual care. The main goal is to see if the program is …

This study checks if a French version of the New Mobility Score (NMS) works well for older adults hospitalized after a hip fracture. The NMS is a simple test that measures how well a person can move indoors, outdoors, and while shopping. Researchers will test it with 100 patients…

This study will train over 1,800 lay first responders—like taxi drivers and shopkeepers—in Cameroon to provide basic first aid and safe transport for injured people. Researchers will compare survival rates before and after the training program. The goal is to see if a data-driven…

This pilot study will use a very small camera, called a nano-arthroscope, to look inside the ankle joint of 25 people who have a severe type of ankle fracture (pilon fracture). The goal is to find out how often hidden cartilage injuries occur and whether seeing them changes the s…

This study will test a new program designed to help people who have been hospitalized for a physical injury. The program connects survivors with resources to meet their medical and social needs. Researchers will interview 25 participants and track which resources they use to see …

This study looks back at medical records of 60 adults who had surgery for severe pelvic fractures. It compares the standard open surgery (large cut) with a newer minimally invasive method (small cuts) to see which leads to better healing, fewer complications, and faster return to…

This study will review medical records of 8,000 adults with osteoporosis who have had a fragility fracture. Researchers want to measure how long it takes for patients to start medication that prevents future fractures. They also want to see if longer delays lead to more fractures…

This study will watch 50 children under 15 with a specific elbow fracture to see how often blood vessel injuries happen and what factors make them more likely. Researchers will also look at how different treatments work. The goal is to better understand and manage these complicat…

This observational study will use a non-invasive brain-computer interface and artificial intelligence to detect and record brain activity in terminally ill patients immediately after clinical death. Researchers aim to capture organized neurocognitive signals, such as gamma waves,…

This study at Montpellier University Hospital will look at whether low muscle mass and strength before hip replacement surgery affects how well people aged 75 and older regain their independence. About 20 volunteers will have blood tests, scans, and a tiny muscle sample taken dur…

This study watches real conversations between healthcare staff and people with dementia after hip fracture surgery. The goal is to find which words and phrases work best to encourage patients to stand or walk early. Researchers will record up to 50 care sessions on hospital wards…

This study looks at 400 severely injured patients treated by emergency medical teams in the Paris region. It aims to see if the time spent on scene before going to the hospital affects whether patients survive the first 24 hours. The goal is to find ways to improve emergency care…

This study looks at whether a special hospital program for older adults (65+) who need surgery can improve their outcomes. Researchers will compare patients treated before and after the program started, tracking deaths and complications within 28 days. About 150 participants will…

This study will analyze data from a pediatric trauma registry to understand injury patterns, outcomes, and what factors predict how severe an injury is. Researchers will look at records of 40 children under 18 who came to the hospital with a traumatic injury. The goal is to learn…

This study tests whether giving metoclopramide alone or with dexamethasone can speed up stomach emptying in trauma patients needing emergency surgery. Using bedside ultrasound, researchers will measure stomach contents to see which drug works better. The goal is to reduce the ris…

This study aims to find the smallest meaningful change in the push-off test for people recovering from a broken wrist (distal radius fracture). Researchers will measure wrist movement, grip strength, and pain in 109 adults aged 18 to 65. The goal is to help doctors better underst…

This study looks at 100 elderly patients with hip fractures to see if quick, easy tests like muscle ultrasound, handgrip strength, and routine blood work can predict frailty. Frailty affects recovery after surgery, so finding a fast way to measure it could help doctors provide sa…

This study aims to create an early warning system for osteoporotic vertebral compression fractures (OVCF) by combining Traditional Chinese Medicine (TCM) patterns with standard risk factors like bone density. Researchers will follow 200 adults aged 50-79 with new fractures or low…

This observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…

This study compares two types of numbing medicine for upper limb surgery: a standard one and a longer-acting version. Researchers want to see how quickly the diaphragm (the main breathing muscle) recovers after the nerve block. 120 adults having arm or hand surgery will be split …

This study compares two methods—mixed reality goggles and ultrasound—to help surgeons mark exactly where ribs are broken before surgery. About 30 adults with three or more broken ribs will take part. The goal is to see which method is more accurate and faster.

This observational study from the University of Nottingham aims to find out which factors predict chronic pain after a serious limb injury. Researchers will follow 450 major trauma patients with at least one broken limb for 6 months, asking them about their pain at 3 and 6 months…

This study will follow 100 adults aged 65 and older who have a broken shoulder (proximal humerus fracture). Some will receive surgery (plates, screws, or a shoulder replacement) and others will be treated without surgery. Researchers will measure shoulder movement, pain, and dail…

This study will look back at the medical records of about 2000 older adults (60+) who had surgery for a broken bone in Shanghai between 2010 and 2019. Researchers want to see how factors like age, nutrition, and which bone broke affect the risk of dying within 1, 3, or 5 years af…