LUNG CANCER

This study tests a new approach for people with stage II to III non-small cell lung cancer that can be surgically removed. Before surgery, participants receive low-dose radiation, a precise high-dose radiation treatment (SBRT), and a combination of immunotherapy (tislelizumab) an…

This clinical trial is testing whether new combinations of drugs work better than standard treatments for people with non-small-cell lung cancer. The study includes patients with advanced cancer that has spread, as well as those with earlier-stage tumors that can be removed by su…

This study tests a new drug called TNG260 combined with an immunotherapy (pembrolizumab) in people with advanced solid tumors that have a specific gene change (STK11 mutation). The goal is to find the safest dose and see if the combination can shrink tumors. About 126 adults with…

This study tests a new way to treat lung cancer that has come back. Doctors place tiny devices called Alpha DaRT seeds directly into the tumor to deliver a special type of radiation. The goal is to see if this is safe and possible for up to 10 adults with small, treatable tumors.…

This study tests whether the drug osimertinib can stop small, hazy spots (called GGNs) left in the lungs from growing after surgery for a type of lung cancer. It includes 43 adults with stage I lung cancer and a specific gene mutation. Participants take a daily pill for one year,…

This early-phase trial tests an experimental drug called RSC-1255, given alone or with hydroxychloroquine, in adults with advanced solid tumors (such as lung, colon, pancreatic, or brain cancer) that have not responded to or cannot tolerate standard treatments. The study has two …

This study tests a new drug called FH-006 combined with other cancer treatments for people with advanced non-small cell lung cancer. The goal is to find the safest dose and see if the combination shrinks tumors. About 200 adults aged 18-75 with measurable tumors and good organ fu…

This study tests a drug called atezolizumab in about 200 adults with advanced solid tumors (like breast, lung, or colon cancer) whose tumor DNA suggests the drug might help. Participants get the same dose every 3 weeks, and researchers check if their cancer shrinks or stops growi…

This early-phase trial tests a personalized, accelerated radiation schedule for people with locally advanced lung cancer. The goal is to see if giving higher daily doses over a shorter time is safe and can control the tumor. About 45 participants will receive this tailored radiat…

This early study tests whether dapagliflozin, a drug approved for diabetes and heart failure, is safe and tolerable when given before surgery to people with stage IA lung adenocarcinoma. About 48 participants will take the drug for a short time before their planned surgery. The g…

This study tests an experimental treatment called OBX-115 for people with advanced melanoma or non-small cell lung cancer that has spread or stopped responding to standard therapies. OBX-115 uses a patient's own tumor-fighting immune cells (TILs) that have been modified to produc…

This early-stage study tests a new treatment called CEA-targeted CAR-T cells for people with advanced solid tumors (such as lung, stomach, colon, rectal, esophageal, or pancreatic cancer) that have not responded to standard therapies. The treatment uses a patient's own immune cel…

This early-phase study tests a new drug called BL-M07D1 in adults with advanced HER2-positive solid tumors (including breast, lung, stomach, and ovarian cancers) that have not responded to at least two prior treatments. The main goals are to check the drug's safety, find the best…

This study is for people newly diagnosed with extensive-stage small cell lung cancer that has spread. Researchers want to see if adding focused radiation to the standard treatment of durvalumab and chemotherapy can help people live longer without their cancer getting worse. About…

This early-phase study tests a new drug, CLSP-1025, designed to direct immune cells to attack tumors that have a specific p53 R175H mutation. The trial enrolls adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have worsened after standard treatments.…

This study tests a new treatment for people with a specific type of advanced small cell lung cancer (SLFN-11 positive). It combines low-dose radiation, chemotherapy, and two drugs (sugemalimab and olaparib) to see if it is safe and effective. About 45 adults who have not had prio…

This study is for people with advanced lung or head & neck cancers. It tests a new way of giving chemotherapy and immunotherapy (pembrolizumab) by alternating cycles. The goal is to see if this schedule helps patients complete more treatment cycles and improves cancer control. Ab…

This study is testing whether doctors can deliver very focused, high-dose radiation to tumors in the abdomen or chest while limiting damage to nearby healthy organs. The approach uses a special MRI machine combined with a linear accelerator (MR-Linac) to guide the radiation in re…

This study tests a drug called osimertinib, which targets a specific genetic change in lung cancer cells. It is given before and after radiation therapy to people with stage III lung cancer who cannot have or refuse chemotherapy. The goal is to see if this approach helps control …

This study looks at whether adding Chinese herbal medicine to standard chemotherapy and immunotherapy can help prevent lung cancer from coming back after surgery. About 367 adults with a certain type of lung cancer (non-small cell, stage Ib to IIIb) will take part. The herbs are …

This study tests a new experimental drug combination (BMS-986507) in about 416 adults with advanced lung or breast cancer that has spread. The main goals are to find safe doses and see if the drugs can shrink tumors. Participants must have tried other treatments and be in relativ…

This early-stage study tests the safety of combining the drug talazoparib with low-dose chest radiation in people with extensive-stage small cell lung cancer. About 24 participants who have finished initial chemotherapy without their cancer getting worse will take talazoparib pil…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The goal is to see if the drug is safe and shrinks tumors. About 300 adults whose cancer has worsened after prior treatment will take the drug al…

This study tests a combination of three drugs (datopotamab deruxtecan, carboplatin, and pembrolizumab) in 46 adults with non-small cell lung cancer that has spread to the brain and has not been treated before. The goal is to see how well the drugs shrink brain tumors. Treatment c…

This study tests a flexible microwave probe that can be guided through the airways to destroy small lung cancer nodules (up to 3 cm) in people with stage I or II lung cancer. The goal is to see if the procedure works as planned and how much tumor tissue is killed. Ten participant…

This early-stage study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells and boost the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatments.…

This study tests a special radiation method called lattice radiation therapy (LRT) combined with immunotherapy for people with advanced solid tumors that have not responded to standard treatments. The goal is to see if this combination can shrink tumors and control the disease be…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another drug (pembrolizumab), in people with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The goal is to find a safe dose and see if it can shrink…

This study tests a new treatment for people with advanced lung cancer that has not responded to standard therapies. The treatment uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goal is to find a safe dose and…

This study tests whether adding a special gut bacteria treatment (RMT) to standard immunotherapy and chemotherapy can help control advanced lung cancer better than standard treatment alone. About 82 adults with untreated, advanced non-small cell lung cancer will receive either RM…

This early-stage study tests an experimental pill called CID-078 in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. About 220 adults with cancers like lung, breast…

This study tests a new device that uses microwaves to destroy lung cancer nodules. It is for people who cannot have surgery or choose not to. The goal is to see if the device safely and completely treats the tumor. Participants will be followed for one year with scans and check-u…

This study tests a new medical device that uses microwave energy to heat and destroy lung cancer tumors. The goal is to see if it is safe and works well. Up to 18 people who are already scheduled for lung surgery will receive this extra treatment first. If successful, this approa…

This early-phase study tests whether adding carotuximab to the standard drug osimertinib is safe and tolerable for people with advanced EGFR-mutated non-small cell lung cancer that has stopped responding to treatment. About 60 participants will receive the combination to find the…

This study tests a device that uses short electric pulses to destroy lung tumors before they are surgically removed. It involves 25 adults with suspected or confirmed lung cancer who are already scheduled for surgery. The goal is to see if the procedure is safe and feasible.

This study tests a new drug called 3H-10000 in people with advanced lung or stomach cancer that cannot be removed by surgery or has spread. The drug is designed to target and kill cancer cells while limiting harm to healthy cells. The trial aims to find the safest dose and see if…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have lost a specif…

This study is testing a freezing technique called cryoablation to treat small lung nodules that are early-stage lung cancer. It is for people who cannot have surgery due to age, health problems, or having multiple nodules. The goal is to see if this minimally invasive treatment c…

This study looks at whether a simple blood test that measures tumor DNA (ctDNA) can help doctors decide when to add chemotherapy to standard immunotherapy for people with advanced lung cancer. About 230 participants will receive pembrolizumab, and if their ctDNA levels don't drop…

This study tests a new drug called HRS-4508 combined with other cancer treatments for people with advanced non-small cell lung cancer that has not responded to standard therapy. About 100 adults aged 18-75 will participate to find the best dose and check safety. The goal is to se…

This study looks at people with a specific type of lung cancer that has spread to the brain but isn't causing major symptoms. Half get alectinib alone, the other half get alectinib plus targeted brain radiation. The goal is to see if delaying radiation keeps the brain healthy and…

This study looks at whether treating small numbers of cancer spread (1 to 10 spots) right away helps people live longer compared to waiting six months. It includes adults with lung, colorectal, or prostate cancer that has newly spread. The goal is to see if immediate treatment im…

This study tests a new oral drug, TNG456, in people with advanced solid tumors that lack a gene called MTAP. The drug aims to slow or stop cancer growth by blocking a protein these tumors rely on. The trial has two parts: first finding the safest dose, then testing how well it wo…

This study is testing a new type of radiation therapy called SMART, which uses MRI scans to guide treatment in real time. It includes up to 397 adults with various cancers like pancreas, lung, or prostate cancer. The goal is to see if this approach is safe and improves tumor cont…

This early-phase study tests a new drug, QXL138AM, for safety and tolerability in about 100 people with advanced solid tumors (like ovarian, pancreatic, or lung cancer) or multiple myeloma. Participants must have tried standard treatments without success. The study will also look…

This early-phase study tests a new treatment called GC203 TIL, which uses a patient's own immune cells that are modified in a lab to better attack cancer. The trial enrolls 18 adults with advanced solid tumors (including breast, lung, and gastrointestinal cancers) who have not re…

This early-phase study tests a new radioactive drug (lutetium [177Lu]-BL-ARC001) in 22 adults with advanced lung, breast, head/neck, or other solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug s…

This study tests if axelopran, a drug typically used for opioid-induced constipation, can help control tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran daily for…

This study tests a personalized cancer vaccine made from patients' own tumor cells. The goal is to train the immune system to fight metastatic cancers like melanoma, breast, lung, and colorectal cancer. Participants receive eight injections over 16 weeks. The study is for adults …

This study tests whether a new experimental drug (PF-08634404) combined with chemotherapy works better than the current standard treatment (pembrolizumab plus chemo) for adults with advanced non-small cell lung cancer that has spread. About 1,410 participants will be randomly ass…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer and other solid tumors that have spread or cannot be removed. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. About 470 adults will take part.

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to activate the immune system, followed by an infusion…

This study tests whether giving a targeted drug (sotorasib) together with standard chemotherapy before surgery can shrink tumors more effectively in people with a specific genetic mutation (KRAS G12C) in non-squamous non-small cell lung cancer. About 27 adults with stage IIA to I…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to shrink or control advanced solid tumors like lung, pancreas, and colorectal cancer. About 54 adults whose cancers hav…

This study tests whether adding a vitamin A-like drug (ATRA) to a platelet-boosting medication (romiplostim N01) works better than the platelet drug alone for cancer survivors whose platelet counts stay low after chemotherapy. About 220 adults with gynecologic, breast, or lung ca…

This early-stage study tests a new treatment called CD70-targeted CAR-T cells in people with advanced solid tumors, including kidney, lung, and ovarian cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have a specific marke…

This study is testing whether a precise type of radiation called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. About 62 adults with up to 20 brain tumors will receive SRS, and researchers will track how many are alive af…

This study tests a new drug called TNG462, given with other cancer medicines, for people with pancreatic or lung cancer that has a specific genetic change (MTAP loss). The goal is to find safe doses and see if the combination shrinks tumors. About 183 adults with advanced cancer …

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The drug targets a protein called HER3 found on some cancer cells. About 740 adults with various cancers like lung, breast, or melanoma w…

This early-stage study tests an experimental drug called VSV-02 in 6 adults with advanced solid tumors (like melanoma, breast, or lung cancer) who have run out of standard treatments. The drug is given both into a vein and directly into the tumor to see if it can shrink or contro…

This study tests whether adding the investigational drug NKTR-255 to the standard drug durvalumab can help people with advanced non-small cell lung cancer live longer after chemoradiation. About 39 adults will receive the combination to see if it restores immune cells and improve…

This study tests whether adding valemetostat to the standard immunotherapy pembrolizumab helps people with advanced non-small cell lung cancer that has high PD-L1 levels. About 137 adults who have not had prior treatment for advanced disease will take part. The goal is to see if …

This study tests a new treatment called LK101, given together with standard immunotherapy drugs, for people with advanced lung cancer that has not responded to previous treatments. The goal is to see if the combination is safe and can shrink tumors. About 60 adults with non-small…

This study tests whether adding certolizumab (an anti-inflammatory drug) to standard chemotherapy before surgery can shrink stage II-III lung cancers more than chemo alone. About 60 adults with operable lung cancer will receive the combination, then have surgery to remove any rem…

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This early-phase study tests a new oral drug, DO-2, in adults with advanced solid tumors (like lung cancer) that have a specific MET gene change and no standard treatment options left. The main goal is to check the drug's safety and find the right dose. About 55 participants will…

This study tests whether adding trilaciclib to the standard drug lurbinectedin can lower the risk of dangerous low white blood cell counts (neutropenia) in people with advanced small cell lung cancer that has stopped responding to initial treatment. About 30 adults will receive t…

This study looks at whether using a nurse navigator and telehealth (phone or video visits) can help more people at high risk for lung cancer get screened with low-dose CT scans. Researchers will identify eligible participants (aged 50-80 with a heavy smoking history) through medi…

This study is testing whether a blood test (liquid biopsy) can help detect lung cancer by looking at genetic markers called miRNA and DNA methylation. Researchers will compare results from people with and without lung cancer. The goal is to find a less invasive way to screen for …

This study is testing a new type of PET scan that targets a protein called Trop2, found on many solid tumors. The goal is to see if this scan can find and stage cancers like bladder, lung, liver, and ovarian cancer better than current methods. About 400 adults with confirmed or s…

This study tests a new imaging system called LungVision to help doctors mark suspicious lung nodules before surgery. The goal is to make it easier to find and remove the entire nodule during surgery, while saving as much healthy lung tissue as possible. Five adults with partially…

This study aims to improve how doctors tell if a small lung nodule (≤20 mm) is cancerous. During a routine bronchoscopy, a fluid sample is taken and tested for DNA changes linked to cancer. The goal is to see if this test is more accurate than current methods, potentially reducin…

This study tests a special PET probe called [68Ga]CBP8 to see if it can detect tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation. The goal is to find early signs of r…

This study tests an AI tool that looks at routine chest X-rays and medical records to find people at high risk for lung cancer. The AI alerts their doctor to discuss screening CT scans. The goal is to see if this alert increases the number of high-risk patients who get screened. …

This study is testing a new breath test to see if it can find early signs of lung cancer as well as low-dose CT scans. Researchers will collect breath samples from 3,200 current or former smokers aged 55-74 who are at high risk. If successful, this cheap and easy test could be us…

This study looks at whether special markers in the body (biomarkers) can help find lung cancer early, before symptoms start. About 3,600 people who are at high or low risk for lung cancer will give samples and get yearly CT scans. The goal is to see if biomarkers can spot cancer …

This study aims to improve early lung cancer screening by combining breath analysis, blood tests, and CT scans. The goal is to reduce false alarms from CT scans and accurately identify who has cancer. Researchers will enroll 1,800 participants, including people with lung cancer, …

This early-phase study is testing a new radioactive tracer for PET scans that may better detect non-small cell lung cancer that has spread to the brain. About 20 adults with this type of lung cancer and brain metastases will receive the tracer and undergo imaging. The goal is to …

This study tests a special dye called abenacianine that makes cancer cells glow during lung surgery. About 132 adults having lung cancer surgery will receive the dye, and surgeons will use a special camera to see the glow. The goal is to help surgeons find cancer that is hard to …

This study is testing whether a blood test can be used as a first step to screen for lung cancer in people at high risk. If the blood test is negative, those individuals might not need a CT scan, reducing radiation exposure and healthcare costs. The study involves 140 participant…

This study is testing a new blood test that looks for signs of a specific type of lung cancer (EGFR-positive) in healthy Asian and Latinx adults who are at risk but cannot get standard lung cancer screening. The test measures DNA fragments in the blood. Researchers will enroll 1,…

This study is testing a lung cancer screening program in Singapore using low-dose CT scans and blood tests. It will include 1,000 people at high risk, both smokers and non-smokers, to see if this approach is practical and accurate. The goal is to find lung cancer earlier and impr…

This early-phase study tests a radioactive imaging agent called [68Ga]CBP8 to see if it can safely detect collagen buildup (scarring) in the lungs of people with pulmonary fibrosis and lung cancer. Researchers will compare scans from healthy volunteers and patients to see if the …

This study is testing a new type of PET scan that uses a special tracer to find cancers like pancreatic, breast, lung, and others. The goal is to see if this scan can better detect and stage tumors compared to standard scans. About 26 adults with suspected or confirmed cancer, pl…

This study is for people aged 50-80 who have never smoked but have a family history of lung cancer. Researchers will use questionnaires, blood tests, and CT scans to build a model that better predicts lung cancer risk in non-smokers. The goal is to catch lung cancer early in this…

This study aims to see if a computer can create a synthetic PET image from a regular CT scan to help diagnose and treat lung cancer more accurately. Researchers will enroll 10,000 people with non-small cell lung cancer to compare the synthetic images with real PET scans. If succe…

This study compares a newer, less invasive technique called EBUS-TBNA with standard CT/PET scans to see which more accurately stages lymph nodes in patients with early-stage lung cancer who are scheduled for stereotactic body radiotherapy (SBRT). Accurate staging helps doctors de…

This study is testing whether a breath test, analyzed by artificial intelligence, can accurately tell the difference between harmless and cancerous lung nodules. Researchers will collect breath samples from 3,000 adults who have lung nodules and need surgery. The goal is to devel…

This study offers free mobile low-dose CT scans to people aged 40-54 who have smoked heavily (30 pack-years or more) and live in North or South Carolina. The goal is to see if screening at a younger age can catch lung cancer earlier, when it's easier to treat. About 1,160 partici…

This study looks at a new way to diagnose and treat ground-glass lung nodules, which can be early signs of lung cancer. About 200 people with small nodules (3 cm or less) will get microwave ablation to destroy the nodule, plus a biopsy during the same procedure to check if it's c…

This study aims to see if artificial intelligence (AI) can help detect lung cancer early in non-smokers who have a close family member with lung cancer. 3,000 participants aged 50-75 will receive a low-dose CT scan and blood test. The AI will analyze the scans for suspicious nodu…

This study is testing whether low-dose CT scans can detect lung cancer early in over 6,600 high-risk people in Taiwan. Participants include heavy smokers who have quit, people with a family history of lung cancer, and those exposed to air pollution or other risks at work or home.…

This study is testing a lung cancer screening program for current and former smokers aged 45 to 74. It uses low-dose CT scans and metabolomics to find suspicious lung nodules early. The goal is to see how well the program works in a public health setting and to help smokers quit.…

This study tests whether combining a referral to a lung cancer screening program with text message reminders can increase screening rates among emergency department patients. About 300 eligible smokers aged 50-80 will be randomly assigned to receive either a basic referral or a f…

This study is testing a new blood test that uses laser light and artificial intelligence to find signs of five different cancers (breast, colon, pancreatic, ovarian, and lung) at an early stage. Researchers will collect blood samples from 1,400 people aged 45 and older who are su…

This study compares standard bronchoscopy (a lung scope procedure) with and without a special laser imaging tool called nCLE. The goal is to see if nCLE helps doctors place the biopsy needle more accurately, leading to a clear diagnosis more often. About 208 adults with suspiciou…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This study looks at whether smokers are more likely to get a lung cancer screening CT scan when their family doctor recommends it. About 500 adults aged 50-74 who smoke or quit recently will take part. The goal is to see how many complete the scan and track changes in smoking hab…

This study tests a new way to help people in the Bronx get screened for lung cancer. A Central Screening Unit will handle tasks like checking who is eligible and scheduling scans, so busy doctors don't have to. The goal is to catch lung cancer earlier, especially in low-income an…

This study tests a short, intensive pulmonary rehab program for people who smoke and have a lung nodule suspicious for cancer. Participants will do exercise training and get help to quit smoking before their lung cancer treatment. The goal is to see if this program is practical a…

This study compares a long-acting numbing medicine (liposomal bupivacaine) to a standard one for pain after lung surgery. About 210 adults having keyhole lung surgery will be randomly assigned to receive one of the two drugs or no nerve block. The goal is to see if the long-actin…

This study tests a new care plan that uses technology to help doctors better manage the health of older adults (70+) who have cancer and other medical conditions. The goal is to see if this approach improves their quality of life over six months. About 720 people with breast, lun…

This study compares two types of nerve blocks (RIB and ESPB) to see which one controls pain better after lung cancer surgery. Sixty adults having a thoracotomy will receive one of the blocks, and researchers will measure how much morphine they need in the first 24 hours. The goal…

This study tests a telemedicine program called FOCUS for people with advanced cancer. The program uses counseling techniques to help manage common symptoms like trouble sleeping, worry, tiredness, and low mood. Researchers will enroll 120 adults with advanced lung, breast, prosta…

This early-phase study tests whether fecal microbiota transplantation (FMT) can safely reduce diarrhea and colon inflammation caused by immune-checkpoint inhibitors in people with genitourinary and other cancers. About 40 participants will receive FMT and be monitored for side ef…

This study tests a stress management program for people with lung cancer who feel anxious while waiting for routine scan results. About 60 participants will try coaching sessions and online modules to learn relaxation skills. The goal is to see if the program is helpful and easy …

This study tests whether adding intravenous vitamin C to standard chemotherapy can improve quality of life for people with advanced non-small cell lung cancer. About 90 adults with incurable lung cancer will receive either vitamin C or a placebo alongside their usual treatment. T…

This study looks at whether using a high-flow nasal cannula (a special oxygen device) during a lung cancer biopsy procedure called EBUS bronchoscopy can prevent breathing problems and procedure pauses. About 198 adults having this procedure will be randomly assigned to receive ei…

This study is for 250 vulnerable lung cancer patients who may struggle with treatment due to health or social barriers. It tests whether a nurse-led program—including symptom tracking, exercise, and help navigating the healthcare system—can improve survival and quality of life co…

This study tests a new way to plan radiation therapy for people with stage 3 lung cancer. The method uses CT ventilation imaging to identify and avoid the healthiest parts of the lungs. Researchers want to see if this approach helps patients maintain a better quality of life and …

This study tests whether adding personalized integrative care—like naturopathic support, a Mediterranean diet, and physical activity—before and after surgery can improve quality of life and reduce complications for people with lung, stomach, or esophageal cancer. About 20 adults …

This study looks at whether a non-invasive electrical stimulation on acupoints can help reduce coughing in people who have had lung cancer surgery. Researchers will track cough severity and quality of life in 84 participants over time. The goal is to find a simple, drug-free way …

This study tests whether injecting a patient's own blood into the lung lining after tumor ablation can prevent air leaks. About 106 adults having lung ablation will be randomly assigned to receive the blood patch or standard care. The goal is to see if the patch reduces the need …

This study tests a new way to plan radiation therapy for advanced lung cancer. Doctors will use a special scan (SPECT/CT) to see which parts of the lung work best, then aim radiation away from those areas to reduce side effects like coughing and shortness of breath. About 90 peop…

This study tests which nerve block method works better for pain after lung cancer surgery. About 60 adults having lung surgery will receive one of two types of pain blocks. The goal is to see which approach lowers pain scores more during rest and coughing.

This study compares two types of nerve blocks to control pain after lung cancer surgery. About 70 adults having a thoracotomy will receive either a costotransverse foramen block or a thoracic paravertebral block. The goal is to see which method reduces the need for morphine and p…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study tests whether a supervised exercise and breathing program (pulmonary rehabilitation) can improve shortness of breath and quality of life in people with advanced non-small cell lung cancer. Half of the 85 participants will receive 8 weeks of rehab, while the other half …

This study tests a special program designed to help lung cancer survivors living in rural areas feel better and manage their health. About 300 survivors will either join the program or receive standard information. The goal is to see if the program improves quality of life and he…

This study tests whether adding acupuncture to standard anti-nausea medicine works better than medicine alone for people with nausea caused by chemotherapy. About 90 adults with breast, prostate, lung, gynecologic, colorectal, or metastatic pancreatic cancer will be split into tw…

This study tests whether spiritual care sessions can improve spiritual well-being and reduce anxiety and depression in people with stage IV lung or gastrointestinal cancer. About 36 adults will be randomly assigned to receive either spiritual care or informational support. The go…

This study tests a short supportive program called Pathways for people with advanced lung cancer. It helps them set and work toward personal goals while managing treatment. Researchers want to see if it improves mood, hope, and quality of life compared to usual care. About 234 ad…

This study tests a home-based telerehabilitation program for 40 veteran lung cancer survivors who have completed curative treatment. The program aims to reduce shortness of breath, fatigue, and fear of cancer recurrence, and improve physical function and quality of life. Particip…

This study tests whether using an incentive spirometer—a device that encourages deep breathing—can lower the risk of lung inflammation (pneumonitis) in people with advanced lung cancer receiving chemotherapy and radiation. About 100 participants will use the device 10 times every…

This study is testing a special nutrition supplement in 52 people with head and neck, lung, or rectal cancer who are receiving standard cancer treatments like chemotherapy or radiation. The goal is to see if the supplement can reduce serious side effects and help patients stay on…

This study looks at whether special breathing exercises can help people who have had lung cancer surgery breathe easier, move better, and feel steadier on their feet. About 40 adults aged 18-80 who are cancer-free and recovering from surgery will take part. The goal is to see if …

This study tests whether two medicines—N-acetyl cysteine (a supplement) and dexamethasone (a steroid)—can reduce shortness of breath after radiation therapy for lung cancer in people who also have interstitial lung disease. About 98 participants will receive one or both drugs or …

This study tests whether a couple-based meditation program can improve physical, emotional, and spiritual well-being for people with metastatic lung cancer and their romantic partners. Researchers will enroll 300 couples to see if the program is practical and helpful. The goal is…

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This study looks at whether having a conversation about care goals in the emergency department can improve quality of life for people with advanced lung or gastrointestinal cancer. It involves 200 adults who are at least 18, have advanced cancer, and have certain severe symptoms.…

This study looks at whether a 12-week exercise program at different intensity levels is possible and helpful for people with advanced lung cancer who are already receiving immunotherapy. Researchers will track how many participants complete the exercise sessions and measure immun…

This study compares two types of minimally invasive surgery—robotic-assisted and video-assisted—for people with early-stage non-small cell lung cancer. The goal is to see which approach leads to better quality of life and recovery. About 512 adults across Europe will take part, a…

This study looks at whether adding endurance training (like cycling) to standard physical therapy helps people recover better after minimally invasive lung cancer surgery. About 184 adults having lung surgery will be randomly assigned to standard rehab or standard rehab plus extr…

This study is testing whether a blood test that looks for tiny bits of tumor DNA (ctDNA) can find cancer early after treatment. Researchers will follow about 100 people with different solid tumors, plus healthy volunteers, to see if the test helps predict when cancer comes back. …

This study is gathering health information from 12,000 adults with lung or other chest cancers. Researchers want to see how factors like genes, lifestyle, and treatments affect outcomes in everyday medical practice. No new treatments are tested—just data collected to help doctors…

This study aims to create a short assessment and behavioral program to help older adults with lung cancer address aging-specific issues like symptom management. In the first phase, patients, caregivers, and providers give feedback on the program materials. In the second phase, 16…

This study looks at whether DNA from blood, sputum, lung fluid, and breath can help find genetic changes in non-small cell lung cancer. About 210 people having surgery to remove their lung cancer will provide samples before and after surgery. Researchers will check if these sampl…

This study watches 2,400 lung cancer patients who are getting immunotherapy (immune checkpoint inhibitors) to see how often they develop dangerous blood clots. Researchers will compare patients who get clots with those who don't, looking for clues in their health records and lab …

This study is observing how well the Ion endoluminal system works for taking samples from lung nodules in everyday medical practice. About 1,200 adults across Europe who are scheduled for a lung biopsy or localization procedure using the Ion system will take part. The main goal i…

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer. Researchers will use these samples to develop and improve tests that detect cancer DNA in the blood, which may help monitor for cancer return or how well treatment is working. …

This study tests whether training oncology care providers (doctors, nurse practitioners, and physician assistants) in empathic communication skills can reduce the stigma lung cancer patients often feel during medical visits. About 1,232 providers across the U.S. will be trained a…

This study collects blood, urine, sputum, and lung tissue samples from 4,000 adults who are at high risk for lung cancer. Researchers will analyze these samples to find DNA changes and other molecular markers that could help predict cancer development. The goal is to better under…

This study tests whether a special CT scan that shows how different parts of the lung work can better predict lung function after lung cancer surgery compared to the usual method. Fifteen adults scheduled for lung cancer surgery will get both the standard and new scans before the…

This study aims to find the genetic and immune system changes that cause lung cancer to start and grow. Researchers will collect tissue samples from 6,000 people with lung cancer or suspicious lung growths. The goal is to identify markers that predict cancer risk, not to test a n…

This study looks at whether low-dose CT scans are a good way to screen for lung cancer in Black individuals aged 50-80 who have smoked. Researchers want to see if this group will take part in screening and how well the scans find cancer. The goal is to improve early detection in …

This study enrolls 2,000 Hispanic current or former smokers aged 50-80 who are not already getting lung cancer screening. Participants watch an educational video about screening and complete short surveys. The goal is to find out what stops people from getting screened and whethe…

This study aims to develop a non-invasive test using cough samples to detect lung diseases like cancer, asthma, and COPD early. Researchers will collect cough, mouthwash, and lung fluid from 2000 adults to analyze DNA and protein markers. The goal is to create a simple, breath-ba…

This study collects sputum and tissue samples from 700 people with precancerous lung changes or certain cancers (lung, head and neck, esophageal). Researchers look for genetic markers that might help detect cancer earlier. The goal is to build a tissue bank for future research, n…

This study tests a new, standardized way for pathologists to examine lung tissue removed during surgery for lung cancer. The goal is to find more lymph nodes that might contain cancer cells, which could lead to better staging and help more patients get the right follow-up treatme…

This study tests a new X-ray technology that aims to track lung tumors during radiation treatment without needing to implant markers in the lung. About 30 people with early-stage lung cancer or limited lung metastases will participate. The goal is to see if the markerless trackin…

This study compares two ways of taking tissue samples from lung tumors: the standard needle method (EBUS-TBNA) and a newer freezing technique (cryobiopsy). The goal is to see which method provides better samples for genetic testing, which helps doctors choose the right treatment.…

This study looks at how a person's muscle and fat levels affect the side effects of chemotherapy for advanced lung cancer. Researchers want to see if adjusting the chemo dose based on body composition can reduce toxicity. About 132 patients will be followed to track side effects …

This study tests a new type of CT scan (real-time gated 4DCT) to see if it can produce clearer images for planning lung cancer radiation therapy. About 30 adults with lung cancer will receive one extra scan before or after their standard planning scan. The goal is to reduce image…

This study looks at the best times to send messages encouraging physical activity to older cancer survivors (age 65+) who have chronic pain. Researchers will track activity levels and pain ratings to see how messages affect movement and pain episodes. The goal is to learn how to …

This study observes how hospitals currently process and diagnose tissue samples from people with suspected lung or breast cancer. Researchers will also test artificial intelligence (AI) programs to see if they can help pathologists read slides faster and more accurately. About 60…

This study looks at whether combining PET scan images with genetic information can better predict how well lung cancer treatments will work and how long patients might survive. Researchers will study 120 adults with non-small cell lung cancer. The goal is to create a more accurat…

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial resources. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it helps them feel more …

This study follows 110 adults with head/neck, lung, or rectal cancer to track changes in their nutrition and body composition during standard treatment. Researchers measure daily food intake, muscle mass, and strength over time. The goal is to gather data that will help design a …

This study is developing and testing two new kits that aim to predict if early-stage lung cancer will come back after surgery. Researchers will use protein markers from tumor samples and blood tests to identify high-risk patients. The goal is to help doctors decide who needs more…

This study aims to find out if tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. About 120 adults with certain cancers will give blood samples and answer questionnaires before, during, and after treatment. The goal is to …

This study is creating a large database of 10,000 lung cancer patients who received radiotherapy. Researchers will collect information on tumor control, side effects, and quality of life to build models that predict treatment outcomes. The goal is to improve future treatment plan…

This study is collecting information from 180 lung cancer patients to learn more about why they become malnourished and how their metabolism changes. Researchers will look at factors like genetics and gut bacteria to build a model that can suggest personalized diets. The goal is …

This study is testing a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner and finish it on time. About 320 adults with solid tumors like lung, breast, or colon cancer…

This study enrolls 50 adults with lung cancer (NSCLC or SCLC) whose disease has progressed while on immunotherapy. Researchers will take a new tumor sample (rebiopsy) to study why the cancer stopped responding. The goal is to learn more about resistance mechanisms, not to provide…

This study looks at how common severe fear of cancer recurrence is among people treated for breast or lung cancer. Researchers will survey 200 patients and interview 40 of them to understand their experiences and what kind of support they need. The goal is to improve how hospital…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. Researchers will measure changes in food security, di…

This study collects fluid from around the lungs (pleural fluid) from patients with lung cancer, breast cancer, or lung infections. The goal is to build a registry of samples and health information for future research. No new treatments are tested—this is purely for understanding …

This study is creating a large collection of blood and other biological samples from 3,000 people with lung nodules or lung cancer. Researchers will use these samples to identify new biomarkers that could improve how lung cancer is diagnosed, predicted, and treated. The goal is t…

This study follows up with people who previously took part in cancer vaccine studies using gene therapy. It does not give any new treatment. Instead, researchers check participants' health each year for 15 years to watch for any long-term side effects. The goal is to make sure th…

This study looks at different types of immune cells called neutrophils in the blood of people with lung cancer. Researchers want to see if certain neutrophil subtypes are linked to tumor growth and resistance to treatment. They will compare blood samples from 100 lung cancer pati…

This study looks at whether an online program and reminder messages can help more people test their homes for radon, a gas that can cause lung cancer. About 172 adults from New Hampshire and Vermont who have never tested their homes will take surveys and view either a standard in…

This study is collecting information from 500 people who need a second round of high-dose radiation for lung or other chest cancers. The goal is to learn how to give this treatment more safely by tracking side effects and survival. Researchers hope the findings will help doctors …

This study is for adults aged 70 and older with non-small cell lung cancer who are starting their first treatment. Researchers will observe how well standard treatments work in everyday practice, including their effects on cancer progression, side effects, and quality of life. Th…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used in future research to better understand how cancers grow and respond to treatment. No new treatments are being tested; the goal…

This study collects blood, tumor, and other tissue samples from up to 1,250 people with head and neck, lung, or gastrointestinal cancers. The goal is to learn how the immune system changes during cancer treatments that affect immunity. Participants donate samples and fill out que…

This study is collecting blood, tissue, urine, and saliva from 7,000 people with many types of cancer to look for tiny bits of cancer DNA left after treatment. The goal is to find out if this DNA test can spot remaining cancer early and help doctors decide on next treatments. Par…

This study is testing whether an artificial intelligence (AI) system can accurately identify different types of lung cancer by analyzing PET/CT scans and patient information like age, smoking history, and blood markers. Researchers will enroll 5,500 adults with newly diagnosed lu…

This study collects samples from the airways, stool, and blood of 48 adults with advanced lung cancer who are starting immunotherapy. Researchers want to see if the types of bacteria in the lungs and gut can predict how well the treatment works. The goal is to better understand w…

This study looks at how 400 adults (ages 50–80) who smoke or used to smoke feel about an artificial intelligence tool that estimates their risk of getting lung cancer in the next 3 years. Researchers will survey participants before and after they receive their risk results to mea…

This study is testing whether a special MRI scan using an inhaled gas (hyperpolarized xenon-129) can help doctors see and predict lung damage caused by radiation therapy for lung cancer. About 70 people will take part, including healthy volunteers and lung cancer patients receivi…

This study is collecting information from 600 people with early-stage lung cancer who are having a type of surgery called pulmonary segmentectomy. Participants fill out questionnaires before surgery, a few weeks after, and 6 months later. The goal is to learn how many people rema…

This study looks at CT scans from 2,000 people with early-stage lung cancer to see if computer models can better predict biopsy results and treatment outcomes. Researchers will review medical records and use data from a national screening trial. The goal is to improve how doctors…

This study tests whether a large language model (a type of AI) can help junior doctors write more accurate and efficient cancer treatment reports. 40 junior doctors will be split into two groups: one uses AI assistance, the other uses traditional methods. Their reports will be sc…

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after chemotherapy. Researchers will also analyze genes in the samples and link them to patient health details. The study does not provide any treatment, but pa…

This study compares different outreach methods to see which works best for getting people at high risk for lung cancer to complete a screening CT scan. It includes 27,000 participants, focusing on racial/ethnic minorities and rural residents. The goal is to find the most effectiv…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study aims to improve how doctors find and diagnose lung cancer early. Researchers will collect blood samples from 5,000 people who have suspicious spots on their lungs. They will use artificial intelligence to analyze the blood and CT scans, hoping to create a tool that cat…

This study is testing a new imaging method called full-field optical coherence tomography (FFOCT) on small lung biopsy samples. The goal is to see if FFOCT can give the same information as the standard lab analysis, but faster. About 20 adults with lung cancer or sarcoidosis who …

This study will collect genetic information and health records from 25,000 people who have cancer or are at risk for it. The goal is to learn more about what drives cancer and how to better tailor treatments. Participants will not receive a new therapy, but their data may help fu…

This study creates a registry of 1500 lung cancer patients treated at one hospital. Researchers will collect data from 2019 to 2035 to learn about survival, how the disease changes over time, and how well different treatments work in real life. The goal is to improve future care …

This study looks at whether certain DNA markers in blood can help predict how well immunotherapy works before surgery for non-small cell lung cancer. Researchers will collect blood samples from 100 people with stage II-IIIB lung cancer who are scheduled to receive immunotherapy f…

This study looks at whether a campaign originally designed for breast cancer can also encourage women to get screened for lung cancer. About 5,500 women aged 50–80 who get mammograms at Christian Hospital will be invited to learn about lung cancer screening. Researchers will trac…

This study collects blood or cheek swab samples from people with cancer who are being treated at the National Cancer Institute. Researchers want to learn how genetic differences may affect how the body processes cancer treatments and whether certain genes are linked to side effec…

This study looks at whether a computer-based virtual agent or a real person is better at teaching lung cancer patients how to use devices at home to check their weight, blood pressure, heart rate, temperature, and oxygen levels. About 36 adults with solid tumors will be randomly …

This study looks at how minimally invasive lung cancer surgery affects the heart's electrical activity. Researchers will monitor 100 adult patients before, during, and after surgery to see if temporary changes occur. The goal is to better understand heart stress from this procedu…

This study is for people with advanced cancers who are taking targeted treatments for months or years. Researchers will interview 75 participants to understand their experiences and needs. The goal is to find better ways to support patients living with chronic cancer treatments.

This study aims to develop a new 4D-MRI imaging technique that creates 3D movies of the lungs and liver during breathing. The goal is to help doctors better target tumors in cancer patients receiving radiation therapy, especially when tumors move with breathing. The study will te…

This study is collecting information from 200 people with advanced lung cancer to build computer models that can predict how well a treatment will work. Researchers will gather medical, imaging, and lifestyle data to understand why some patients respond to therapy while others do…

This study is collecting health information and biological samples from 730 adults newly diagnosed with lung cancer. Researchers aim to track how patients respond to treatments in real-world settings, including those often excluded from clinical trials. The goal is to better unde…

This study screens up to 7,000 adults with cancers like melanoma, lung, or colorectal cancer to see if they qualify for experimental treatments developed by the National Cancer Institute's Surgery Branch. These treatments involve taking a patient's own immune cells, growing them …

This study is creating a new questionnaire to measure how well people with lung cancer follow their breathing rehabilitation program. About 281 Mexican patients will fill out the 56-question scale. The goal is to make sure the tool is accurate and reliable, so doctors can better …

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study aims to gather information from cancer patients (breast, lung, ovarian, multiple myeloma, or AML) who use a remote symptom monitoring system during their routine treatment. Participants will complete weekly surveys about their symptoms for at least 12 weeks. The goal i…

This study is testing a decision aid to help people decide whether to get screened for lung cancer. The tool is designed for patients in a safety-net healthcare system. Researchers will enroll 360 current or former smokers aged 50-80 who have no history of lung cancer. The goal i…

This study looks at two ways to remove small lung nodules in people with lung cancer. One method uses special imaging during surgery (iVATS), while the other is the standard VATS technique. Researchers will measure how long each surgery takes, how long patients stay in the hospit…

This study looks at whether a campaign called Pink & Pearl can encourage more women who are at risk for lung cancer to get screened. Researchers will track how many women complete lung cancer screening after seeing the campaign during their mammogram visit. The goal is to find be…

This study tests a new way to predict how well your lungs will work after lung cancer surgery. Doctors use a 3D CT scan to create a virtual model of your lungs and simulate the surgery beforehand. The goal is to improve safety and help plan recovery. About 60 adults with non-smal…

This study looks at whether tissue samples taken during a routine lung biopsy (called EBUS-TBNA) can be used to analyze gene changes in lung cancer. The goal is to see if these gene changes can help predict which treatments—like surgery, chemo, or radiation—will work best for eac…

This study looks at 400 people with non-small cell lung cancer who had pre-treatment (like chemo or immunotherapy) and then needed a specific type of lung surgery called sleeve lobectomy. Researchers want to see if a less invasive surgery (using small cuts and a camera) works as …

This study will screen 1,000 people in Mexico aged 50 or older who are at high risk for lung cancer—including heavy smokers, former smokers, and those exposed to wood smoke—using low-dose CT scans each year for 3 years. The goal is to find lung cancer at an early stage when it's …

This study is creating a large database of blood samples, tumor tissue, and medical images from 4,000 people with lung cancer. Researchers will follow participants for up to 10 years to collect information that can be used for future studies. The goal is to better understand lung…

This study looks at whether a special care program helps younger adults (under 50) with lung cancer feel more satisfied with their care. Researchers will also ask about the needs of patients and their families, and see if joining peer support groups makes a difference. About 75 p…

This study tests whether a patient navigation program helps more Black adults who are at high risk for lung cancer complete their lung cancer screening. Researchers will enroll 675 people and track how many get a low-dose CT scan. The goal is to see if having a guide through the …

This study aims to understand how lung tumors burn sugar for fuel using a special MRI scan and a natural sugar solution. About 200 adults with suspected lung cancer who need surgery will take part. The goal is to develop a method to see tumor metabolism, not to treat the disease.

This research study collects and analyzes lung tumor samples from 4,000 people with early-stage non-small cell lung cancer who are having surgery. The goal is to find unique patterns in RNA and proteins (molecular fingerprints) that may help predict cancer recurrence and survival…

This study collects tissue samples from 7,000 adults with lung cancer, COPD, lung transplants, or other chest diseases. The samples are stored in a repository to help researchers better understand how these diseases start, how to diagnose them early, and how to improve treatment.…

This study tests whether the emergency department can be used to identify people at high risk for lung cancer and help them get screened. Researchers will screen patients for social needs and offer a tailored program to encourage lung cancer screening. The goal is to see if this …

This study is creating a detailed atlas of pre-cancerous spots in the lungs to understand how they turn into cancer. Researchers will collect tissue samples from 240 adults with these spots using a scope down the airway. The goal is to find clues that could help prevent lung canc…