LUNG CANCER

This study tests whether using the Zalo chat app to send results and answer questions helps people complete follow-up tests after an AI finds something abnormal on their chest X-ray. About 2,692 adults aged 40-62 with lung cancer or TB risk factors will be split into two groups: …

This study tests a new device that uses freezing and radiofrequency heat to destroy small lung tumors during a bronchoscopy, just before planned surgery. About 20 adults with early-stage lung cancer will take part. The main goals are to see if the procedure works as intended and …

This study tests a combination of two drugs, Sac-TMT and bevacizumab, in people with advanced non-squamous lung cancer whose cancer worsened after initial chemotherapy and immunotherapy. The goal is to see if this combo can shrink tumors or slow disease progression. About 31 adul…

This early-phase study tests DCTY1102, a personalized cell therapy, in 18 adults with advanced colorectal, lung, or pancreatic cancers that have a specific KRAS/NRAS G12D mutation and HLA type. Participants receive a single infusion of their own genetically modified immune cells …

This study compares two ways of doing robotic lung surgery for early-stage non-small cell lung cancer. In one method, the surgeon works alone using robotic tools; in the other, a bedside surgeon helps with handheld staplers. The goal is to see which approach costs less and leads …

This study compares two types of targeted therapy pills (first-generation vs third-generation EGFR TKIs) for people with advanced lung cancer that has a specific rare mutation called EGFR exon 19 deletion-insertion. About 94 participants will be randomly assigned to one of the tw…

This early-phase study tests a new drug called HS-10504 combined with other treatments in 400 people with advanced non-small cell lung cancer that has worsened after prior therapy. The goal is to find safe and effective doses and see how well the combination shrinks tumors. Parti…

This study looks at whether adding an SGLT2 inhibitor (a diabetes drug) to standard cancer treatment can help people with both advanced lung cancer and type 2 diabetes live longer or keep their cancer from growing. About 200 adults will take either the SGLT2 inhibitor or other di…

This study tests a new approach for lung cancer patients at high risk of incomplete tumor freezing during cryoablation. Before the freezing procedure, doctors will block small lung arteries with a temporary, absorbable material to improve the freezing effect and reduce bleeding r…

This study tests a combination of two drugs (Sac-TMT and bevacizumab) in 50 adults with a specific type of lung cancer (EGFR-mutant nonsquamous NSCLC) that has spread to the brain and stopped responding to standard targeted therapy. The goal is to see if the combo can shrink brai…

This study tests a precise type of radiation therapy using proton beams for people with early-stage lung cancer who cannot or choose not to have surgery. About 65 participants will receive a few high-dose radiation sessions tailored to their tumor location. Researchers will track…

This study tests whether a special omega-3-enriched nutritional drink can help people with lung or colorectal cancer who are losing weight and at risk of malnutrition. About 118 participants will either get the drink plus dietary advice, or just dietary advice alone. The goal is …

This study will test a new blood test that looks at RNA in platelets (a type of blood cell) to see if it can accurately detect lung cancer. Researchers will collect blood samples from 240 adults who either have lung cancer or a suspicious lung nodule. The goal is to see if this t…

This study tests whether using a special laser microscope (confocal laser endomicroscopy) along with a freezing biopsy probe can help doctors more accurately diagnose lung lesions. Forty adults with suspicious lung spots will be split into two groups: one gets the standard ultras…

This study tests a new PET imaging tracer called 68Ga-MY that targets a protein (5T4) found on many cancer cells but rarely on healthy cells. About 20 people with lung or breast cancer will receive the tracer and undergo PET/CT scans. The goal is to see if this new method finds t…

This study tests whether community pharmacists can increase lung cancer screening rates. Eligible adults (aged 50-77 with a heavy smoking history) will be offered a blood test or a CT scan referral during a pharmacy visit. The goal is to catch lung cancer earlier and save lives.

This study looks at whether the shingles vaccine can prevent shingles and improve survival in 500 lung cancer patients. Researchers will track how many get shingles within a year and check survival rates over time. The goal is to see if the vaccine is safe and effective for this …

This study will check how well low-dose chest CT scans find lung cancer early in 20,000 current or former smokers aged 50-74 in France. Participants must have a heavy smoking history. The goal is to see if this screening method can catch cancer sooner, when it's easier to treat.

This study will test whether a low-dose CT scan can help find lung cancer early and save lives in high-risk smokers. Researchers will enroll 15,000 current or former heavy smokers aged 50-79 in Hong Kong. Half will get the scan, and half will not, and the team will track who dies…

This study tests whether an 8-week home exercise and breathing program before lung cancer surgery, followed by 4 weeks of rehab after, helps patients recover faster and feel better. About 84 adults with operable lung cancer will take part. The program uses a smartphone app to gui…

This study tests whether a 20-minute exercise session on a stationary bike, done right before each radiation treatment, is practical and safe for people with stage I-III non-small cell lung cancer. Thirty participants will be enrolled to see how many can stick with the program an…

This study tests a program to help long-term lung cancer survivors feel more supported and improve their quality of life. Thirty survivors will be randomly assigned to either the program or a control group. The program uses cognitive behavioral therapy (CBT) techniques to reduce …

This pilot study will test whether a personalized exercise program is practical for 20 adults with stage II or III non-small cell lung cancer who have not yet started treatment. Participants will follow the Precise Exercise Regimen for Cancer Care (PERCC) program before beginning…

This study tests if doing special breathing exercises (for inhaling and exhaling) before lung cancer surgery can lower the risk of lung problems after surgery and help patients leave the hospital sooner. About 70 adults with early-to-mid stage lung cancer will be randomly assigne…

This study tests if a home-based exercise program can help people with stomach, esophagus, pancreas, colon, rectal, or lung cancer better tolerate chemotherapy. About 120 adults will be randomly assigned to either an aerobic and resistance exercise program or a stretching program…

This study tests a special breathing tube with a tiny camera to help doctors place it correctly during repeat lung surgery. About 500 adults who have had lung surgery before will take part. The goal is to see if the video tube reduces problems and makes the procedure smoother.

This study tests whether a combination of two anti-nausea drugs (rolapitant and palonosetron) can prevent vomiting and severe nausea in lung cancer patients receiving both chemotherapy and radiation. About 238 adults with lung cancer will take part. The goal is to find a better w…

This study looks at whether mindfulness-based breathing exercises can reduce shortness of breath, control symptoms, and improve quality of life in people with lung cancer who are getting chemotherapy. About 60 patients will take part, with half learning the breathing exercises an…

This pilot study tests whether gentle osteopathic manipulations can stimulate the vagus nerve in 80 people with stage 4 lung cancer. The goal is to improve heart rate variability, which is linked to better outcomes and less anxiety during chemotherapy. Researchers will measure ch…

This study aims to see if using prediction models to identify Veterans who would benefit most from lung cancer screening can increase screening rates and reduce racial disparities. About 23,520 Veterans from VA sites will be included. The approach uses personalized risk informati…

This study looks at whether community health workers can help more people get lung cancer screening and quit smoking. Researchers will work with 80 adults who are at risk for lung cancer. The goal is to see if this approach is practical and acceptable before testing it in a large…

This study will observe about 477 current or former smokers in Brazil to see how well lung cancer screening works in a region where other lung diseases are common. The goal is to find out how often screening gives false alarms, which can lead to extra tests and worry. No new trea…

This study looks at how the body processes a lung cancer drug called anecatibin in people with different levels of liver function. It will compare 24 adults with and without liver impairment to measure drug levels and safety. The goal is to gather information, not to treat the di…

This study will see if using artificial intelligence (AI) to help read low-dose CT scans can find lung cancer more accurately than standard methods. About 1,120 adults at risk for lung cancer will take part, and their scans will be read either with or without AI assistance. The g…

This study looks at how breathing in wildfire smoke can harm your lungs and brain over time. Researchers will expose 24 healthy adults to different amounts of smoke in a safe setting to measure changes in breathing and thinking. The goal is to find out who is most at risk and how…

This study compares two ways to plan lung cancer surgery: a standard CT scan with contrast dye versus a 3D model made from a CT scan without dye. Researchers want to see if the 3D model is just as accurate for finding tumors and mapping blood vessels. About 50 adults with early-s…

This study will test a new way to detect lung cancer early by combining CT scans with a blood test that looks for DNA changes. Researchers will study 14,300 people aged 40-74 who have been diagnosed with cancer but haven't started treatment yet. The goal is to see if this combine…

This study will check if low-dose CT scans can help find lung cancer early in people at high risk, such as long-term smokers. About 1,716 participants in India will get a scan and, if needed, a quick referral to a team of specialists. The study also looks at how well cancer care …

This study will follow about 2,000 people in China who have a specific type of lung cancer (EGFR-mutated) and have had surgery. After surgery, they take a targeted pill (EGFR-TKI) to try to prevent the cancer from coming back. Researchers will track how long patients live and how…

This early-phase study compares an inhaled version of the cancer drug afatinib to the standard oral pill in 24 healthy adult smokers. Researchers want to see if the inhaled form delivers the drug more directly to the lungs with fewer side effects. Participants will receive both f…

This study will enroll over 3,200 adults in Delhi, India, to understand how air pollution, along with smoking and genetics, increases the risk of lung cancer. Researchers will track participants and analyze exposure to fine particulate matter (PM2.5) to identify who is most vulne…

This study looks at how a personalized strength training program affects people with different cancers (lung, colon, breast, lymphoma, and leukemia). 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers will…

This study looks at how cancer and its treatments change the way patients experience food, including taste, appetite, and enjoyment of eating. Researchers will survey 180 adults with breast, head and neck, gynecologic, gastrointestinal, or lung cancer to understand which factors …

This study tests whether a special type of CT scan (dual-energy CT) can be as good as MRI for outlining tumors and healthy organs before radiation therapy. About 80 adults with brain, bone, head/neck, or lung cancer will get both scans, and doctors will compare how accurately the…