LUNG CANCER

This early-phase study tested two drugs, palbociclib and binimetinib, in 34 people with advanced lung cancer that has a specific KRAS gene change. The main goal was to find the safest dose and see if the combination can shrink tumors or slow cancer growth. Participants had to hav…

This study looked at 133 people with a first-time head, neck, or lung cancer who were still smoking. It compared two groups: one that received a structured addiction treatment program as part of their cancer care, and another that only got advice to seek help. The goal was to see…

This study tested a cancer vaccine called ETBX-011 in 43 people with advanced colorectal, lung, breast, or prostate cancers that make a protein called CEA. The vaccine uses a modified virus to teach the immune system to find and attack CEA-making cancer cells. The main goals were…

This study tested a program to help people with lung cancer stop smoking. Researchers worked with 263 patients to provide support and medication. The goal was to see if the program could help more patients quit and improve how doctors track tobacco treatment.

This study looked at giving a precise, high-dose radiation treatment called CyberKnife after standard chemotherapy and radiation for people with stage III non-small cell lung cancer that could not be removed with surgery. The goal was to find the safest highest dose of CyberKnife…

This study tested a combination of three drugs (nivolumab, ipilimumab, and plinabulin) in 39 adults with recurrent small cell lung cancer that had worsened after initial chemotherapy. The goal was to find the safest dose and see if the combo could slow cancer growth. While not a …

This early-stage study tested a new drug called COM902, alone or with another drug (COM701), in 94 people with advanced cancers like ovarian, lung, or colon cancer. The main goals were to check safety, find the best dose, and see if the drugs help control the disease. Participant…

This study tested whether adding an experimental drug (AZD1775) to standard chemotherapy (carboplatin and paclitaxel) helps people with advanced squamous cell lung cancer. 42 participants received the combination. Researchers tracked how long the cancer stayed under control and o…

This early-stage study tested a new drug (BI 765049) alone or with another drug (ezabenlimab) in 21 Asian adults with advanced cancers like stomach, lung, or liver cancer that had stopped responding to treatment. The goal was to find a safe dose and see if the drugs could shrink …

This study tested a new way to give radiation therapy for small lung tumors, aiming to finish treatment in just one day instead of the usual two to three weeks. Ten people with early-stage lung cancer or limited spread took part. The approach used advanced imaging and planning to…

This study gave 22 cancer patients ongoing access to the drug bintrafusp alfa after they completed earlier trials. Researchers tracked side effects and survival for up to 5 years to understand the drug's long-term safety and effectiveness. The goal was to keep treating patients w…

This study tested a new two-drug combination (itacitinib plus osimertinib) in 59 adults with advanced non-small cell lung cancer that has a specific genetic mutation (EGFR). The goal was to see if the combination is safe and helps shrink tumors. Participants received the drugs by…

This study tested a new way to remove small lung nodules using a CT scanner during surgery. 25 patients with small, outer-edge lung tumors were treated. The goal was to see if the approach is safe and can successfully remove the nodules. The technique aims to make surgery more pr…

This early-phase study tested an experimental drug called VS-6766, given by mouth on different schedules, in 104 adults with advanced solid tumors or multiple myeloma. The goal was to find a safe and tolerable dose, both when used alone and when combined with another drug (everol…

This early-phase trial tested whether adding the drug pirfenidone to standard chemotherapy is safe and effective for people with advanced non-small cell lung cancer. 48 participants received the combination to find the best dose and see if tumors shrank. The goal was to control t…

This study compared two types of surgery for people with small (≤2 cm) early-stage lung cancer: removing the entire lobe (lobectomy) versus removing only the tumor and a small margin (sublobar resection). The goal was to see if the less invasive approach works just as well with f…

This study tested a tool called MyLungHealth, delivered through a patient portal, to improve lung cancer screening. Over 31,000 people aged 50-79 with a smoking history took part. The tool helped identify who should be screened and increased the number of low-dose CT scans ordere…

This study compared a new type of PET scan (68Ga-FAPI) with the standard FDG-PET scan to see which one is better at finding lung cancer and its spread. 58 adults with known or suspected lung cancer received both scans, and the results were checked against tissue samples or follow…

This study tested a new way to biopsy small lung nodules (≤2 cm) using a robotic system called Ion and a special 3D imaging machine called Cios Spin. The goal was to see how well the system could guide the biopsy needle into the nodule and accurately diagnose lung cancer. The stu…

This study tested a new tool called the BioSpy System, which uses electrical signals to tell the difference between healthy lung tissue and tumors during a biopsy. Thirty adults with lung lesions took part. The goal was to see if the probe could successfully measure these signals…

This study collected blood samples from 109 adults, some with lung cancer and some without, to help create a blood test called OncoSweep. The goal is to find signals in the blood that can tell if a person has lung cancer. This test could help doctors diagnose lung cancer earlier …

This study looked at whether adding a special scope test (EBUS-TBNA) after a PET/CT scan can more accurately stage early-stage non-small cell lung cancer. 150 patients with stage I-IIA lung cancer who were being considered for precise radiation therapy took part. The goal was to …

This study tested a special dye called VGT-309 that makes lung cancer cells glow during surgery. About 89 people having lung cancer surgery received the dye to see if it helps surgeons find tumors that standard methods might miss. The goal is to improve how completely cancer is r…

This study checked if specially trained dogs can detect breast, lung, prostate, or colorectal cancer just by smelling a person's breath. Over 1,300 adults gave breath samples by breathing into a mask. The dogs then sniffed the masks and said whether they thought cancer was presen…

This study looked at whether low-dose CT scans can find lung cancer early in people with HIV who have a history of heavy smoking. About 450 participants aged 40 and older received a CT scan to check for lung cancer. The goal was to see how common lung cancer is in this group and …

This study tested whether a robotic bronchoscopy system, guided by real-time 3D CT scans, can more accurately biopsy lung nodules. 200 adults with suspicious lung nodules took part. The goal was to see how often the biopsy tool reached the exact nodule location before sampling, w…

This study tested a low-cost, portable exercise program to help people with non-small cell lung cancer manage severe tiredness after surgery. 235 adults took part. The program aimed to reduce fatigue and improve quality of life by teaching patients how to self-manage their energy…

This pilot study tested a 10-week virtual self-compassion program for adults with lung cancer who feel stigmatized. 79 participants were randomly assigned to the program or a waitlist. The goal was to see if the program could reduce stigma and improve well-being. Results will sho…

This study tested a program to help lung cancer patients stop smoking and avoid starting again. It included 21 participants and used phone calls and online videos for support. The main goal was to see if the program was easy to use and liked by patients.

This study looked at whether a structured program of chest physiotherapy, breathing exercises, and early movement after lung cancer surgery helps patients recover faster. Researchers compared two age groups (45-59 and 60-90) to see if age affects how well the program works. The m…

This study tested whether a special education session before lung cancer surgery helps patients recover faster. 100 adults were split into two groups: one received a nurse-led lesson with a booklet, the other got usual care. Results showed that those who learned about their surge…

This study tested whether augmented reality (AR) can replace the standard CT-guided hook-wire method for locating small lung nodules before surgery. 270 adults with lung nodules up to 2 cm were enrolled. AR overlays a virtual image of the nodule onto the patient during surgery, p…

This study looked at whether a home-based pulmonary rehabilitation program delivered via video calls could help people recover after lung cancer surgery. 36 patients aged 55-75 who had part or all of a lung removed took part. The program aimed to improve exercise ability, lung fu…

This study tested whether watching 360° virtual reality movies can help lower fear and anxiety in cancer patients before they start radiation treatment. 292 adults with breast, lung, prostate, head and neck cancer, or a brain tumor took part. Researchers measured their stress lev…

This study tested whether a simple walking program, using fitness trackers, helps cancer patients tolerate their daily chemotherapy and radiation treatments without missing doses. 166 adults with various cancers (brain, head/neck, lung, GI, or cervical) who were scheduled for cur…

This study looked at whether firefighters have different lung scan results compared to non-firefighters, and if a blood test can help predict lung cancer risk. Researchers enrolled 734 current and retired firefighters to compare their low-dose CT scans with those of matched contr…

This study tested a community support program to help people attend lung cancer screening appointments. Researchers compared attendance rates among West Philadelphia residents who opted into the program, those who did not, and residents from another area. The goal was to see if t…

This study tested a new type of CT scanner that takes pictures while a patient lies on the treatment couch during radiation therapy. 41 adults with head and neck, lung, breast, abdominal, or pelvic cancer participated. The goal was to see if the scanner produces clear images that…

This study looks at how well the drug T-DXd works compared to usual treatments for people with advanced HER2-positive solid tumors (like lung, colon, and ovarian cancers). Researchers will use data from past clinical trials and real-world patient records to compare survival rates…

This project offered free transportation and scheduling help to people in Philadelphia who needed lung cancer screening. The goal was to see if these services helped more people attend their appointments. The study included 252 participants and compared attendance among those who…

This study looked at whether giving doctors access to a simple blood test called FirstLook™ would encourage more people at high risk for lung cancer to get screened. The study involved 28 medical practices and their patients who were eligible for lung cancer screening but had not…

This study followed 385 adults with a first-time lung or head and neck cancer to see how many continued smoking or drinking alcohol over the first year. Researchers also looked at how these habits affected cancer progression and survival. The goal was to understand risk factors f…

This study looked at whether having cancer patients report their own symptoms during radiation treatment helps doctors better understand and manage side effects. 104 adults with lung, esophageal, or other gastrointestinal cancers took part. Doctors reviewed patient-reported sympt…

This study looked back at the medical records of 60 people with advanced lung cancer to see if taking a common heart medication (beta-blockers) alongside immunotherapy affected their treatment results. Researchers compared how long the cancer was controlled and survival rates bet…

This study tested whether free, open-source 3D lung reconstructions could help surgeons perform lung cancer surgery. 13 patients with suspected or confirmed lung cancer took part. The goal was to see if these 3D models were easy to use and accurate compared to standard CT scans.

This study tested whether Facebook ads and a tailored online tool called LungTalk could increase awareness and knowledge about lung cancer screening among high-risk individuals. Over 500 current or former heavy smokers participated. The goal was to see if social media can effecti…

This study looked at whether the body's natural 24-hour cycle (circadian rhythm) affects how lung cancer cells spread through the blood. Researchers took blood samples from 27 people with advanced lung cancer before they started treatment. The goal was to see if the number of cir…

This study analyzed blood, urine, and tissue samples from 273 adults with lung or brain cancer who were receiving radiation therapy. The goal was to find biomarkers that could predict which patients are more likely to develop serious side effects from radiation, such as lung infl…

This study tested a program to help more people at high risk for lung cancer get a low-dose CT scan, which can catch the disease early and save lives. The program included notifying doctors, educating patients, offering financial help, and reminding patients to talk about screeni…

This study tested a smartphone reminder app designed to help lung cancer patients stay active during radiation therapy. Since patients often feel tired, the app sends alerts to encourage walking. Before testing it with patients, 30 healthy volunteers used the app and rated how ea…

This study looked at whether a care plan led by a geriatrician and a trained nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study tested a telehealth program to help people remember and complete their annual lung cancer screening. 22 adults who were due for a follow-up screening took part. The program used video calls to guide them through the process. Researchers measured how many people finishe…

This study tested a new automated method to grow cancer cells from patients inside chicken eggs. Researchers used samples from 101 people with metastatic cancers like prostate, breast, and lung cancer. The goal was to see if the automated system could successfully grow tumors at …

This study tested a program that uses text messages to help people at community health centers get screened for lung cancer. The program helped with risk assessment, shared decision-making, and scheduling. 65 current or former smokers aged 50-80 took part. The goal was to see if …

This study looked at nearly 2000 lung cancer patients to understand how their bodies build immunity after catching COVID-19 or getting vaccinated. Researchers collected medical records and tested blood for antibodies. The goal was to describe patient characteristics and immune re…

This study tested a virtual navigation system that helps doctors guide a bronchoscope to lung nodules for biopsy. Researchers compared results from 110 patients using the system to historical data from standard procedures. The goal was to see if the system improves diagnostic yie…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study tested whether AI-assisted software can help doctors outline organs at risk during radiation therapy planning for lung, breast, and esophageal cancers. 500 adults scheduled for chest radiation had their CT scans contoured manually, by AI alone, and by AI with manual tw…

This study followed 535 people in France with advanced non-small cell lung cancer who were already prescribed nivolumab after at least one round of chemotherapy. Researchers observed how long treatment worked, side effects, and patients' quality of life. The goal was to learn mor…

This study collected and stored biological samples like sputum, blood, and urine from over 9,700 tin miners in China who are at high risk for lung cancer due to workplace exposures. The goal was to create a resource for researchers to find early markers of the disease and study g…

This study looked at whether proteins and metabolites in blood and urine can help doctors monitor how well immunotherapy is working in people with advanced non-small cell lung cancer. Researchers tested samples from 150 patients before, during, and after treatment. The goal was t…

This study looked at sexual problems in 553 adults with lung cancer to find out how common and severe they are. The goal is to help doctors better manage and support patients' sexual health during and after cancer treatment. No new treatments were tested—only information was coll…

This study looked at chemical differences in blood, lung tissue, and breath between people with non-small cell lung cancer and those with harmless lung nodules. Researchers analyzed samples from 74 participants to find unique markers that could one day help detect lung cancer ear…

This study looked at 77 never-smokers newly diagnosed with lung cancer to see how many also have sleep apnea and whether sleep apnea affects their cancer outlook. Participants had a sleep test before starting cancer treatment. The goal is to understand if sleep apnea is linked to…

This study looked at whether using a CPAP breathing device during radiation therapy can reduce the amount of radiation reaching the lungs. Eight people with left-sided breast cancer or lung cancer took part. Researchers compared lung radiation doses when patients breathed normall…

This study tested a computer system called RUS Lung that creates a 3D model of the lungs to help surgeons locate and remove small lung cancer tumors during minimally invasive surgery. 34 adults with lung tumors 3 cm or smaller took part. The goal was to see if the system works re…

This study tested a special breathing-synchronized PET scan method to get clearer images of small lung nodules. 103 adults with lung nodules (from cancer or COPD) had a standard PET scan plus an extra 10-minute gated scan. The goal was to see if the new method reduces motion blur…

This study tested a brief virtual mindfulness program designed to reduce stigma in people with lung cancer, especially those from underserved groups. Researchers worked with a community advisory board of lung cancer patients to build the program. 108 adults with a history of toba…

This study looked at whether helping people with social needs like housing, food, or transportation could increase lung cancer screening rates. 101 adults aged 50-80 who smoke or recently quit were given either a standard educational tool or one that also screened for social need…

This study tested a new type of CT scanner that takes pictures during radiation therapy for lung, liver, breast, and other cancers. The goal was to see if the new scanner produces clearer images with fewer distortions. 31 people participated, and the results will help doctors bet…

This study tested a program to help Hispanic/Latinx patients get screened for lung cancer. 60 eligible adults received either extra support (education, reminders, and financial help) or usual care. The goal was to see if the program increased the number of people who got a low-do…

This study tested a program called KanSurvive-ECHO to help rural primary care clinics provide better follow-up care for cancer survivors. Researchers worked with 15 clinics to improve tasks like scheduling cancer screenings, checking for distress, and tracking weight and tobacco …

This study followed 150 people with lung cancer to see how their treatment (surgery, chemo, or radiation) affected their physical abilities, symptoms, and quality of life. Researchers measured things like walking distance, strength, and daily activity levels. The goal was to unde…

This study gathered information from 101 patients and healthcare providers to design a care pathway for COPD in people with lung or head and neck cancer. The goal was to reduce treatment burden and overcome common barriers to COPD care in community oncology clinics. Researchers u…

This study tested a new way to help surgeons find small lung nodules during a type of keyhole surgery called VATS. Doctors used a special CT scanner in the operating room to place tiny metal markers (microcoils) near the nodules before removing them. The goal was to see how much …