LUNG CANCER

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at high risk of coming back after radiation alone. About 134 adults with brain tumors from cancers like melanoma, lung, breast, or …

This study looks at whether using a special breathing device (AEROBIKA) after chest surgery for lung cancer or other chest tumors can reduce the chance of lung collapse (atelectasis). About 72 adults having surgery will be randomly assigned to standard rehab or standard rehab plu…

This study offers ongoing treatment with ruxolitinib (alone or with other cancer therapy) to people with pancreatic, colorectal, breast, or lung cancer who were already benefiting from it in a previous Incyte study. It includes up to 10 participants and focuses on tracking side e…

This study tests an experimental drug called QBS72S in 21 adults with advanced breast or lung cancer that has spread to the brain. The goal is to see if the drug can shrink or control brain tumors. Participants receive the drug and are monitored for side effects and tumor respons…

This phase 3 study tests a targeted drug called almonertinib in people with a specific type of advanced lung cancer (EGFR-mutant, stage III) that cannot be removed by surgery. After initial treatment, doctors use a sensitive blood test (MRD) to decide if more treatment is needed.…

This study tests a new drug called QL1706 combined with chemotherapy for people with advanced non-small cell lung cancer that does not have a specific protein (PD-L1) or genetic mutations. About 606 adults will be randomly assigned to receive either QL1706 plus chemo or another d…

This study tests a combination of two immunotherapy drugs (nivolumab and ipilimumab) plus two rounds of chemotherapy as a first treatment for people with advanced lung cancer that has spread to the brain. The goal is to see if this approach can control the cancer in the brain for…

This study tests a new treatment for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells, called T cells, which are genetically modified in a lab to better recognize and attack cancer cells. The main goa…

This study tests a drug called JDQ443, alone or with other treatments, in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drug is safe and can shrink tumors. About 344 adults with lung, colorectal, or other cancers who have tri…

This early-stage study tests an experimental drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal is to find a safe dose and see how the body handles the drugs. Participants must …

This study tests whether adding the immunotherapy drug durvalumab to precise radiation therapy (SBRT) can better control early-stage non-small cell lung cancer compared to radiation alone. About 13 adults with stage I to IIIA lung cancer received the combination. The main goal is…

This early-phase study tests a new drug, amivantamab, combined with standard targeted therapies (TKIs) in 12 adults with advanced non-small cell lung cancer that has specific gene changes (ALK, ROS1, or RET). The goal is to see if the combination can overcome resistance that ofte…

This early-phase study tests whether combining two drugs—sarilumab (Kevzara) and cemiplimab—can safely control non-small cell lung cancer with specific gene changes (EGFR or LKB1/STK11 mutations). About 56 adults with advanced disease will receive the combination. The main goal i…

This study tests whether a shot under the skin (subcutaneous) of the immunotherapy drug pembrolizumab works as well as the standard IV infusion for people with advanced non-small cell lung cancer that has spread. About 67 participants will receive either the shot or the IV, and r…

This study tests a combination of two immune-boosting drugs (zimberelimab and domvanalimab) as a first treatment for people with advanced non-small cell lung cancer that has high levels of a protein called PD-L1. The goal is to see if the combo helps control the cancer longer tha…

This study tests a drug called ado-trastuzumab emtansine (T-DM1) in adults with advanced solid tumors that have a specific HER2 gene change. The goal is to see how well the drug shrinks or controls the cancer. About 131 people with lung, bladder, or other HER2-related cancers are…

This study tests whether a pulmonary rehabilitation program can improve lung function enough to make people with lung cancer eligible for surgery. Researchers will enroll 75 patients who were initially not healthy enough for surgery due to poor lung function or overall health. Th…

This study tests whether combining the drug durvalumab with radiation therapy can slow down lung cancer growth in people with stage II or III non-small cell lung cancer. Unlike standard treatment, this approach skips chemotherapy. The goal is to see if more patients stay cancer-f…

This early-phase trial tests a precise radiation technique for lung tumors located very close to the windpipe or food pipe. Up to 38 adults will receive daily MR-guided radiation that adapts to tumor movement. The main goal is to find the highest safe dose by monitoring side effe…

This early-stage trial tests a new treatment for people with advanced solid tumors (like head and neck, melanoma, or lung cancer) that haven't responded to standard therapies. Doctors take a patient's own immune cells from the tumor, pick out the ones best at fighting cancer, gro…

This study tested a new treatment for people with extensive-stage small cell lung cancer, a fast-growing cancer that has spread. The treatment combines low-dose radiation, an immunotherapy drug (durvalumab), and standard chemotherapy. The goal was to see if this combination helps…

This study tests whether adding a precise, high-dose radiation treatment (SBRT) can help restart the immune system's fight against cancer when immunotherapy drugs start to lose effect. About 69 adults with metastatic cancers (melanoma, lung, bladder, kidney, or head/neck) will re…

This study tests a drug called DFMO combined with the immunotherapy pembrolizumab in people with advanced non-small cell lung cancer that has a change in the STK11 gene. The goal is to find a safe dose and see if the combination shrinks tumors. About 45 adults will take part.

This study observes how patients with advanced non-small cell lung cancer and a specific gene mutation (EGFR-positive) respond to the drug dacomitinib in real-world settings in Taiwan. It includes 29 adults who took dacomitinib as their first treatment. Researchers track dosage c…

This study tests whether injecting a patient's own blood into the chest can stop air leaks after lung cancer surgery. About 60 adults who still have an air leak three days after surgery will receive the blood patch. The goal is to see if it shortens hospital stays and improves qu…

This study tests whether giving the targeted drug osimertinib before and after standard chemoradiation helps adults with a specific type of stage III lung cancer (EGFR mutation-positive) that cannot be removed by surgery. About 76 participants will receive osimertinib first, then…

This early-stage study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic) that have a specific genetic mutation called KRAS G12C. The main goals are to find a safe dose and understand how the drug moves through the body. About 44 adults …

This study tests a combination of two drugs, savolitinib and durvalumab, in Chinese adults with a certain type of advanced lung cancer (non-small cell lung cancer with MET gene changes) that has not responded to standard treatments. The goal is to see if the combination can shrin…

This program offered expanded access to NanoPac, a cancer treatment, for patients with advanced pancreatic, prostate, or lung cancer who could not join ongoing clinical trials. The goal was to provide treatment options for those with limited alternatives. The program is no longer…

This study tests whether adding a short, high-dose radiation boost to the main lung tumor, along with the immunotherapy drug durvalumab, is safe and effective for people with stage III non-small cell lung cancer after standard chemoradiation. About 6 participants will receive thi…

This study tests whether adding the drug zipalertinib to standard chemotherapy after lung cancer surgery helps prevent the cancer from returning. It includes 360 adults with early-stage lung cancer (stage IB-IIIA) that has certain uncommon EGFR gene mutations. Participants will r…

This study tests whether adding chest radiation to an immunotherapy drug (durvalumab) after initial chemotherapy can help people with advanced small cell lung cancer live longer without the disease getting worse. About 46 adults with extensive-stage small cell lung cancer will re…

This study looks at whether a blood test (liquid biopsy) can help doctors see how well the drug brigatinib is working in people with a specific type of advanced lung cancer (ALK-positive NSCLC). About 33 patients will take brigatinib pills and give blood samples over time. The go…

This study tests whether combining two drugs, pembrolizumab and vorinostat, can help people with advanced non-small cell lung cancer. About 120 adults with stage IV disease will receive either the combination or pembrolizumab alone. The goal is to see if the combo is safe and can…

This early-phase study tests a combination of two drugs, ceritinib and docetaxel, in people with advanced non-small cell lung cancer that does not have certain gene changes (ALK-negative, EGFR wild-type). The main goal is to find the safest dose and see if the combination can shr…

This study tests a new tool that uses microwave energy to destroy small lung tumors. The tool is inserted through a tube into the lungs, avoiding the need for open surgery. The study includes 35 adults with lung nodules that are either confirmed or suspected to be cancer. The mai…

This study aimed to compare three different immunotherapy approaches (atezolizumab, nivolumab, and pembrolizumab) given before and after surgery for people with early-stage non-small-cell lung cancer. The goal was to see which approach best prevented the cancer from coming back. …

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy after lung cancer surgery can clear tiny bits of tumor DNA from the blood. About 100 adults with early-stage non-small cell lung cancer who had surgery and still have detectable tumor DNA…

This early-stage trial tests a new treatment for people with advanced non-small cell lung cancer that no longer responds to standard immunotherapy. The treatment combines a specially designed virus (TILT-123) that targets cancer cells with pembrolizumab, an immunotherapy drug. Th…

This study tests the safety of adding an experimental drug (MPDL3280A) to standard chemotherapy and radiation for people with a type of lung cancer that cannot be removed by surgery. About 52 participants will receive the combination therapy. The main goal is to see how safe the …

This study tests a treatment using a patient's own immune cells (T cells) that are modified in a lab to attack cancer cells with a protein called mesothelin. It is for people with malignant pleural disease, including mesothelioma and cancers that have spread to the chest lining. …

This pilot study tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to find cancers that produce a protein called CEA. The goal is to see if this scan can detect tumors that standard methods might miss. About 20 adults with breast, colon, lung, or other CEA-positi…

This study tests a new radioactive imaging agent called [18F]-C-SNAT4 to see how it spreads in the body and whether it can help spot lung cancer on PET scans. It includes 5 healthy volunteers and 15 people with lung cancer. The goal is to check safety, radiation exposure, and whe…

This study follows 45 uninsured current or former heavy smokers to find lung cancer earlier. Researchers use CT scans, lab tests, and medical records to spot warning signs. The goal is to improve early diagnosis in people who often lack access to regular screening.

This study tests a new technology called breathprinting (or e-nose) that analyzes breath to detect early-stage lung cancer. About 119 adults with a suspicious lung nodule will provide a breath sample, and the device's results will be compared to standard biopsy or surgery finding…

This study tests a robotic bronchoscopy system that uses real-time 3D imaging to help doctors reach and sample small lung nodules more accurately. About 132 adults with lung nodules between 6 mm and 3 cm will take part. The goal is to see how often the robot helps get a clear dia…

This study looks at whether an AI program called qXR can help doctors find lung cancer sooner by flagging suspicious chest X-rays for faster review. About 60,000 adults in Scotland are taking part. The goal is to see if AI can cut down the time it takes to decide whether a patien…

This study is developing a blood test to find early-stage lung cancer in people at high risk, like heavy smokers. Researchers will collect blood samples from 5,000 participants to see how accurate the test is. The goal is to create a simple, non-invasive screening tool that could…

This study looks at whether fluid washed from inside a lung tumor can find genetic changes in early-stage lung cancer. About 50 adults with suspected lung cancer will have a special bronchoscopy to collect this fluid. The goal is to see if this method is as accurate as standard t…

This study compares a new technique that combines cone-beam CT scans with a robot-assisted bronchoscope against standard methods for taking lung tissue samples. The goal is to see if the new approach improves the chance of getting a clear diagnosis for suspicious lung spots or ot…

This study compares a robotic-assisted bronchoscopy system (Ion) to standard electromagnetic navigation for diagnosing lung nodules. About 354 adults with suspicious lung nodules will undergo one of the two procedures. The main goal is to see which method more accurately identifi…

This study looks at whether heavy smokers at high risk for lung cancer can be screened every two years instead of every year with low-dose CT scans, without missing early-stage cancers. It also offers a smoking cessation program to help participants quit. The goal is to make lung…

This study is testing a new blood test called DELFI to see how well it can detect lung cancer in people at high risk (current or former smokers aged 50+). About 12,000 participants will give a blood sample and have a standard CT scan. The goal is to see if the blood test is accur…

This study is testing a new blood test (GuardantLUNAR-2) to see how well it can find lung cancer in people at high risk. About 12,000 adults aged 50-80 who smoke or recently quit will give a blood sample and also get a standard low-dose CT scan. The goal is to see if the blood te…

This study looks at whether a large-scale lung cancer screening program can be set up in Germany. It involves 12,100 current or former smokers aged 55-79. The goal is to see which method (NELSON or PLCO) works best for finding lung cancer early, so treatment can start sooner.

This study tests whether a program combining low-dose aspirin, help quitting smoking, diet changes, and more physical activity can reduce inflammation and prevent lung cancer in long-term smokers aged 55 to 75. About 2,000 participants will also get yearly low-dose CT scans for e…

This study tests a brief educational and support program for adults who have just finished lung cancer treatment with the goal of curing their cancer. The program is designed to help improve quality of life and reduce fear of the cancer coming back. About 100 participants will be…

This study tests whether a smartphone app called AmDTx is practical for helping lung cancer patients manage anxiety before and after surgery. Six participants will use the app, which adjusts to their needs based on doctor prescriptions. Researchers will track how many people stic…

This study looks at whether a 12-week program of online chair-based exercise and health education, along with a full geriatric assessment, can help older adults (65+) with cancer and their support person. The goal is to see if this approach is practical and helps improve physical…

This study tests whether a chatbot combined with continuous activity monitoring via a smartphone can help detect and manage symptoms early in people undergoing chemotherapy and radiation for lung, gastrointestinal, or head and neck cancers. The goal is to reduce unplanned hospita…

This study tests whether a text-message helper called 'Penny' can help lung cancer patients stick to their daily oral targeted therapy and manage side effects. About 75 adults with non-small cell lung cancer will either use Penny or get usual care. The goal is to see if real-time…

This study tests whether live exercise coaching plus a personalized digital app can improve quality of life for cancer survivors. About 146 adults with breast, lung, prostate, colorectal, or other cancers who had treatment in the last year will use the program for 18 months. Rese…

This study looks at whether a special payment model helps doctors coordinate care better for cancer patients in Hawaii. It involves 7 participants with breast, colon, or lung cancer who are getting chemotherapy. The goal is to see if this approach improves health outcomes and low…

This research study aims to learn more about how chest cancers like lung cancer, thymus cancer, and mesothelioma develop and spread. Researchers will collect blood, tumor tissue, and other fluids from 1,000 adult participants to look for biological markers. The goal is to find cl…

This study looks at conversations between lung cancer patients and their healthcare team. Researchers want to learn how these talks affect patient well-being and if training doctors in empathy can improve communication. About 294 patients and their clinicians are taking part.

This study looks at survival rates for people with cancers like melanoma, breast, colon, and lung cancer using data from Russian cancer registries. Researchers will analyze records from 100,000 patients to see how long they live after diagnosis. The goal is to better understand c…

This study looks at lung health in over 2,000 people who worked at the World Trade Center site after 9/11. Researchers will review chest CT scans and breathing tests to find links between their exposures and lung diseases like asthma, COPD, and scarring. The goal is to better und…

This study tests whether a new method called the Engaged Approach to Lung Cancer Screening (EA-LCS) is practical and acceptable in different screening programs across Colorado and the US. About 40 staff members from up to 8 screening sites will try the approach and share their fe…

This study tests a new imaging method that helps surgeons find and remove the very first lymph node that drains from a lung tumor. By targeting this node, doctors hope to better detect and remove cancer cells that may have spread. The study involves 57 adults with early-stage lun…

This study looks at how well the Ion Endoluminal System works in everyday medical practice for taking tissue samples from lung spots or nodules. About 1,300 adults who need a lung biopsy or lesion localization will be observed. The goal is to see how often the system correctly di…

This study tests a new imaging tool called HyperSight that takes clearer, faster 3D scans during radiation therapy. The goal is to see if these scans are good enough to help doctors adjust treatment more accurately for cancers of the head/neck, breast, lung, stomach, or pelvis. A…

This study tests a new computer program that reduces blurring in cone-beam CT scans to help doctors better locate lung tumors during radiation therapy. It involves 17 adults with lung cancer who are already scheduled for radiation. The program also tracks small markers placed in …

This study looks at whether combining artificial intelligence with blood tests and CT scans can better predict lung cancer risk in heavy smokers. Researchers will analyze data from 650 current or former heavy smokers to see if these tools can tell which lung nodules are likely to…

This study tests whether a new imaging method can track lung tumors during radiation treatment without needing to implant markers. Five adults with early-stage lung cancer or limited lung metastases will have their radiation sessions recorded and analyzed offline. The goal is to …

This study observes 12 people with stage IV non-small cell lung cancer who are already receiving immunotherapy (nivolumab or pembrolizumab) and also get palliative radiation to the chest. The goal is to track side effects from the combination and how it affects quality of life. P…

This study is looking at whether having low muscle mass (sarcopenia) before lung cancer surgery affects how well patients recover. Researchers are following 400 older adults to see if muscle loss is linked to survival and cancer return. The goal is to find out if checking muscle …

This study gathers information from 100 adults with breast, lung, gastrointestinal cancer, or multiple myeloma. Participants complete weekly online surveys about their symptoms and treatment experience for at least 12 weeks. The goal is to understand how symptoms change over time…

This study works with the Choctaw Nation to find better ways to get lung cancer screening to people who need it. Researchers will talk with patients and doctors to understand barriers, then test a program that helps eligible people get screened and quit smoking. The goal is to ca…

This study explores whether a special type of radiation therapy can protect the ovaries of young women (ages 18-50) undergoing pelvic radiation for cancers like uterine, rectal, or cervical cancer. The goal is to see if doctors can consistently see the ovaries on daily scans and …

This study looks at whether patient education and reminders can help more people get their yearly lung cancer screening. About 1,837 adults aged 50-78 who had a negative scan will take part. The goal is to see if these simple tools improve repeat screening and early detection.

This study collects DNA from over 21,000 New York cancer patients to look for inherited gene changes linked to several cancer types. It is an exploratory project that does not offer treatment but aims to find clues for future research. Participants include people with breast, col…

This study tests whether simple reminders for patients and their doctors can help more people get their yearly lung cancer screening or follow-up tests. About 825 patients and their primary care doctors are taking part. The goal is to find out what works best to improve screening…

This study tests whether reminder messages can encourage adults aged 40 to 80 who smoke or used to smoke to get screened for lung cancer. About 133 participants will receive different reminders and then answer questions about how acceptable they found them. The goal is to see if …

This study looks at 120 people with suspected or confirmed non-small cell lung cancer who need a tissue sample for genetic testing. Researchers want to see if taking 2 samples from a lymph node works as well as 3 samples for getting enough material for testing. They also check if…

This study tests a very small camera, called a composite optical fiberscope, to see if it can reach and view lung tumors in the outer parts of the lung. Researchers will use lung tissue removed from 50 patients during surgery. The goal is to see if the camera can help doctors see…

This study involves 44 adults having lung surgery who will receive one-lung ventilation (only one lung breathing during the operation). Researchers will measure how air moves through the lungs before surgery and then track the lowest oxygen level during the procedure. The goal is…

This study collects leftover tissue and blood samples from people with known or suspected cancer who are already scheduled for surgery or biopsy. Researchers will compare cancerous and normal tissues to find differences that could lead to new treatments. No extra procedures are d…

This study tracks 126 adults aged 50 to 74 who are at high risk for lung cancer due to heavy smoking. Researchers want to see how many actually get their first low-dose CT scan and continue with follow-up scans over time. The goal is to understand real-world adherence to screenin…

This study explores whether a special PET scan using a tracer called FAZA can detect low oxygen levels (hypoxia) in lung cancer tumors. Low oxygen can affect how cancer grows and responds to treatments like radiation. The study involves 36 adults with stage II or III lung cancer …

This study looks at the genetic makeup of lung cancers that were found through low-dose CT scans. Researchers want to understand why some of these cancers grow quickly while others grow slowly. About 526 people who had surgery to remove their lung cancer are taking part. The goal…

This study tests a new way to confirm that a biopsy needle is correctly placed in a lung nodule during a procedure called navigation bronchoscopy. Researchers will compare two imaging methods: a special microscope at the needle tip and a 3D X-ray scan. The goal is to see if the m…

This study planned to give low-dose CT scans to firefighters aged 35 and older to check for lung cancer and other lung diseases caused by job-related smoke and chemical exposure. It aimed to see if screening based on occupation, not just smoking history, could catch cancers earli…

This study involves 30 lung cancer patients taking oral targeted therapy. They will use a smartphone app, a Fitbit, and a smart pill cap to track symptoms and medication use for up to 24 weeks. The goal is to see if this remote monitoring system is practical and can help improve …

This study looks at microplastic particles in the lungs of 119 patients, both with and without lung cancer. Researchers will collect fluid from the lungs during a routine procedure to measure how much plastic is there and what types. The goal is to understand if microplastic poll…

This study looks at two methods to help people with lung cancer hold their breath during a special type of radiation called SBRT. One method uses a camera system (SGRT) alone, and the other adds small markers placed in the lung. The goal is to see which method is safer and more r…

This study looks at whether certain inherited gene changes (EGFR mutations) increase the risk of lung cancer, especially in people who never smoked. Researchers collect saliva from cancer patients with a specific tumor mutation (T790M) to see if they carry an inherited mutation. …

This study looks at what helps increase lung cancer screening in people aged 50-80 who smoke or used to smoke. Researchers will test two different ways to encourage screening and compare them to usual care. About 2,869 participants from UC Davis clinics will take part. The goal i…

This study looks at whether a newer biopsy method called transbronchial cryobiopsy (using a freezing tool) is safer than the standard method for taking lung tissue samples. About 100 adults with known or suspected cancer will take part. The goal is to see if this technique causes…