LUNG CANCER

This early-stage study aims to find out if adding an experimental oral drug called AZD6244 to standard chemotherapy is safe and tolerable for people with advanced solid tumors. The trial will enroll 140 patients with cancers like breast, colon, lung, kidney, or melanoma that have…

This study is exploring if a simple blood test, called a liquid biopsy, can help doctors monitor how well the drug brigatinib is working for patients with a specific type of advanced non-small cell lung cancer. The drug is taken daily to control the cancer. The research aims to s…

This study is testing a drug called osimertinib as part of a treatment plan for adults with a specific type of advanced, inoperable lung cancer. Participants will take osimertinib for about 8 weeks, then receive standard chemoradiation, and then continue taking osimertinib long-t…

This early-stage study is testing a new oral medication called HBI-2438 in people with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find the highest safe dose and understand how the body processes the drug. It includes 44 adult…

This early-stage study is testing whether using an MRI machine to guide radiation treatment can allow doctors to safely deliver higher, more effective doses to lung tumors located dangerously close to major airways or the esophagus. The goal is to find the highest radiation dose …

This trial is testing a new treatment for advanced cancers that have spread to the lining of the lungs (pleura), including mesothelioma, lung cancer, and breast cancer. Doctors collect a patient's own immune cells (T cells), genetically modify them to recognize a cancer marker ca…

This study is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy after lung cancer surgery can better prevent the cancer from returning. It is for patients who have had surgery for certain stages of non-small cell lung cancer and still have traces…

This early-stage trial is testing the safety of a new two-part treatment for advanced non-small cell lung cancer. The treatment combines a modified virus designed to attack tumors with an existing immunotherapy drug. It is for patients whose cancer has continued to grow despite p…

This study is testing whether combining two existing cancer drugs, pembrolizumab and vorinostat, is safe and more effective at controlling advanced non-small cell lung cancer than using pembrolizumab alone. It involves about 120 adults whose cancer has progressed after at least o…

This study is testing whether a 3-4 week pulmonary rehabilitation program can improve lung function in people with lung cancer who are currently too weak for surgery. The goal is to help these patients become strong enough to have their tumors surgically removed. Researchers will…

This program offered an investigational cancer drug called NanoPac to patients with advanced pancreatic, prostate, or lung cancer who could not join the main clinical trials. It was a way for people who did not meet the strict trial requirements to potentially try the treatment. …

This study is testing whether adding a short, intense course of radiation (called a 'boost') to a standard immunotherapy drug (durvalumab) is safe and more effective for controlling stage III non-small cell lung cancer. The treatment is for patients who have already completed sta…

This study is testing whether an investigational drug called QBS72S can shrink tumors that have spread to the brain from breast or lung cancer. It involves 21 adults with advanced cancer that has spread to the central nervous system. Researchers will measure how well the drug wor…

This study is testing whether a drug called ado-trastuzumab emtansine can help control advanced solid tumors that have specific abnormalities in the HER2 gene. The trial is enrolling adults with cancers like lung, bladder, and urinary tract cancers that have these genetic feature…

This study is checking how safe it is to combine two standard treatments—radiation therapy and immunotherapy drugs—for people with advanced lung cancer that has spread. Researchers are watching 12 patients to see what side effects occur and how the treatment affects their quality…

This study tests whether using a patient's own blood as a patch can help seal air leaks that sometimes occur after lung cancer surgery. The trial involves 120 patients who still have an air leak three days after their operation. Researchers will compare outcomes between patients …

This study is testing whether adding an older drug called DFMO to the immunotherapy pembrolizumab can help control advanced lung cancer in people whose tumors have a specific genetic change (STK11 mutation). The first part finds the safest dose, and the second part checks if the …

This study is testing whether adding an immunotherapy drug called durvalumab to a precise form of radiation therapy (SBRT) works better than radiation alone for early-stage lung cancer. It is for patients with a higher risk of their cancer returning who are not candidates for sur…

This trial is testing if adding chest radiation therapy to a maintenance immunotherapy drug (durvalumab) can better control advanced small cell lung cancer. Patients first receive standard chemotherapy combined with durvalumab. If the cancer responds or stays stable, they then re…

This study is testing whether combining two drugs, savolitinib and durvalumab, can help control advanced lung cancer in Chinese patients whose tumors have a specific genetic change called a MET alteration. The goal is to see if this combination can slow or stop the cancer's growt…

This early-stage study is testing whether adding a new drug called amivantamab to standard targeted therapies can help control advanced lung cancer that has started growing again. It will involve about 12 adults whose cancer has specific genetic changes and has become resistant t…

This study is testing a new medical device that uses microwave energy to destroy small lung tumors. Doctors guide a thin tube through the patient's airway to reach and heat up the tumor. The main goals are to see if this procedure is safe and if the device can reliably reach and …

This study is testing if a text-message chatbot named 'Penny' can help people with lung cancer remember to take their daily oral medications and manage side effects. Researchers are comparing the chatbot to usual care in 75 patients to see if it improves how consistently patients…

This large Phase 3 trial is comparing a new drug combination (QL1706 plus chemotherapy) against a standard treatment for patients with advanced non-small cell lung cancer that has spread and tests negative for a specific biomarker called PD-L1. The study aims to see if the new co…

This early-stage study is testing whether combining two existing cancer drugs—ceritinib and docetaxel—can help control advanced lung cancer that has stopped responding to standard chemotherapy. The trial aims to find the safest dose of this combination and see if it can shrink tu…

This study is testing whether combining two immunotherapy drugs (zimberelimab and domvanalimab) can help control advanced non-small cell lung cancer in people who haven't had prior treatment. The trial is for patients whose cancer has high levels of a specific marker called PD-L1…

This study is testing whether combining a drug called durvalumab (an immunotherapy) with radiation therapy can help control locally advanced non-small cell lung cancer. It is for patients who are not eligible for the standard treatment of chemotherapy followed by radiation, often…

This early-stage study is testing whether combining an existing arthritis drug (sarilumab) with an existing cancer immunotherapy (cemiplimab) can help control advanced non-small cell lung cancer. It is enrolling 56 adults whose cancer has specific genetic changes (EGFR or LKB1 mu…

This is a first-in-human study testing a new personalized cell therapy for people with advanced solid tumors that have not responded to standard treatments. Doctors take a patient's own tumor-fighting immune cells from a tumor sample, grow large numbers of the most potent ones in…

This study tested a new system in a lung cancer clinic to help patients quit smoking. Researchers wanted to see if staff asked patients about smoking and offered them proven help like medication or counseling. They measured success by checking if patients actually quit, using bre…

This study is testing a new drug called JDQ443, both alone and in combination with other treatments, for patients with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find safe doses and see if the treatments can shrink tumors. It…

This study is testing if a short, high-precision form of radiation (SBRT) can help restart the effectiveness of immunotherapy drugs in patients whose cancer has started to grow again. It involves adults with certain advanced cancers (like melanoma, lung, or bladder cancer) who ar…

This study is testing the safety of adding a new immunotherapy drug (MPDL3280A) to the standard treatment of chemotherapy and radiation for patients with non-small cell lung cancer that cannot be removed by surgery. The goal is to see if this three-part combination is safe and ca…

This study is testing two different techniques for delivering a precise type of radiation treatment (SBRT) to lung tumors while patients hold their breath. The goal is to see which method causes fewer lung side effects and is more reliable at hitting the tumor accurately. It will…

This study is testing a new, simpler way to give an existing lung cancer drug. It compares giving the drug as an under-the-skin injection versus the standard method of an IV infusion. The main goals are to see if the injection gets similar drug levels into the body and is as safe…

This study allows patients who were already taking the drug ruxolitinib in a previous cancer trial to continue receiving it, along with their other cancer treatments, if they are benefiting. It's for people with pancreatic, colorectal, breast, or lung cancer who are doing well on…

This early-stage study tests a personalized cell therapy for people with advanced solid tumors. Doctors collect a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, then infuse them back into the patient. The main goals are to chec…

This study is testing a new radioactive imaging agent to see if it can help find cancers that produce a specific protein called CEA. Twenty patients with various CEA-positive cancers will receive the agent and undergo PET scans to see if it highlights their tumors. The goal is to…

This study is testing whether an artificial intelligence (AI) software program can help doctors find lung cancer faster. The software analyzes chest X-rays and flags the ones that look most suspicious, so radiologists can review those urgent cases first. Researchers will measure …

This study is testing whether a new blood test can accurately detect lung cancer in people at high risk. The test looks for DNA fragments and other markers in the blood that might signal cancer. Researchers are comparing the blood test results to standard CT scans in over 11,000 …

This study is testing a new method to help surgeons see and remove the lymph nodes most likely to contain lung cancer cells during surgery. Doctors inject a tiny, safe amount of a special dye near the tumor and use a special near-infrared light to make it glow, highlighting the k…

This study is testing whether a new, less invasive method can accurately find genetic changes in early-stage lung cancer. Researchers will collect fluid from inside lung tumors during a thin-tube procedure and analyze it with advanced genetic testing. The goal is to see if this f…

This study is testing whether a new blood test called GuardantLUNAR-2 can accurately detect lung cancer in people at high risk. It will enroll 12,000 current or former heavy smokers who are already scheduled for a standard CT scan. Researchers will compare the blood test results …

This study is testing a new blood test called Lung EpiCheck to see if it can accurately detect early-stage lung cancer. It involves 5,000 current or former heavy smokers who are either getting a routine CT scan for screening or have a suspected or confirmed lung cancer diagnosis.…

This study is testing a new robotic system designed to help doctors more accurately biopsy suspicious lung nodules. It involves 132 patients with lung nodules at moderate to high risk for cancer. The goal is to see if this robotic system, combined with 3D imaging, can improve the…

This study is testing a new imaging technology called HyperSight to see if it can take clearer pictures during radiation therapy. The goal is to help doctors more accurately target cancer cells while better protecting healthy tissue. About 40 adults with head and neck, breast, lu…

This study aims to find the best way to collect tissue samples during a lung cancer biopsy to ensure there is enough material for advanced genetic testing. It will compare taking two needle passes versus three passes from suspicious lymph nodes. The study will also test if a simp…

This early-stage study is testing a new radioactive tracer called [18F]-C-SNAT4 for PET scans. The goal is to see if this tracer can safely and effectively help doctors better see and monitor lung cancer. The study will involve 20 people, including healthy volunteers and patients…

This study is testing how to best set up a national lung cancer screening program in Germany. It will enroll over 12,000 current and former smokers aged 55-79 to compare different methods of identifying high-risk people and using CT scans to find cancer early. The goal is to crea…

This study is testing simple reminder systems to help more people get their recommended annual lung cancer screenings. Researchers are sending text messages to patients and alerts to their doctors when a screening is due. The goal is to remove common barriers and make it easier f…

This study is testing a comprehensive prevention program for long-term smokers aged 55-75. The program combines low-dose aspirin, a quit-smoking medication, a Mediterranean-style diet, and increased physical activity, along with annual lung scans. The goal is to see if this multi…

This study is testing a new program to help more people at risk for lung cancer get screened. It uses text messages, videos, and telehealth calls to guide patients through the screening process and help them overcome common barriers like confusion or scheduling. The goal is to se…

This study is testing different reminder messages to help people who smoke or used to smoke get screened for lung cancer. Researchers want to find the most effective way to remind eligible adults aged 40-80 to get this important preventive screening. The goal is to increase scree…

This study tests a program designed to help more Hispanic patients get screened for lung cancer. It works by reminding doctors, educating patients, helping with costs, and prompting discussions during doctor visits. The goal is to see if this approach gets more eligible patients …

This study is testing two new programs to help more people get their yearly lung cancer screening scans on time. It involves nearly 1,800 Kaiser Permanente members who are at high risk for lung cancer. The programs focus on patient education and sending reminders to see if they i…

This study is testing whether a simple chatbot on a patient's phone, combined with a Fitbit-like activity tracker, can help spot and manage symptoms from cancer treatment earlier. The goal is to see if this early warning system can help patients feel better and reduce unplanned t…

This study is testing whether it's practical to offer a smartphone app with mindfulness exercises to lung cancer patients before and after their surgery. The goal is to see if using the app helps reduce anxiety and distress related to their cancer diagnosis and treatment. The sma…

This study is testing whether a personalized mobile app with live coaching can improve quality of life for people who have had cancer. The 18-month program focuses on exercise, meditation, and diet advice. Researchers will compare the app's coaching to standard lifestyle resource…

This study collects tumor tissue and blood samples from people with cancer to help researchers find new targets for future treatments. Participants are adults who are already having surgery or biopsy for their cancer care. No experimental treatments are given—researchers only col…

This study is testing a new payment model for cancer care in Hawaii. It aims to see if better coordination between doctors improves patient health and lowers costs. The study involves doctors from a specific oncology group and focuses on patients with breast, colon, or lung cance…

This study aims to understand and overcome barriers to lung cancer screening in American Indian and Alaska Native communities. Researchers are working with the Choctaw Nation to develop and test a new support program that helps eligible patients navigate the screening process and…

This study is testing a remote monitoring system to better track symptoms and side effects in lung cancer patients taking oral targeted therapy pills. Participants use a smartphone app, a Fitbit watch, and a smart pill bottle cap for up to 24 weeks. The goal is to see if this sys…

This study aims to understand if having low muscle mass (sarcopenia) before lung cancer surgery affects how well patients recover afterward. Researchers will follow 400 elderly patients undergoing surgery to see if muscle measurements can help predict their survival, complication…

This study is testing a new technology designed to track lung tumors during radiation therapy without needing to implant physical markers near the tumor. The goal is to see if this 'markerless' tracking is accurate enough to guide radiation beams in real time. Five patients with …

This study aims to better understand the conversations between lung cancer patients and their doctors. Researchers are observing these consultations and asking patients about their experience to see how communication quality affects patient satisfaction and well-being. The study …

This research study aims to learn about the biological features of how chest cancers like lung cancer, thymus tumors, and mesothelioma develop and spread. Researchers will analyze blood, tumor tissue, and other fluids from about 1000 patients to look for genetic markers. The goal…

This study aims to understand if tiny plastic particles in the air we breathe end up in our lungs and if they are connected to lung cancer. Researchers are analyzing lung fluid samples from 119 patients who are already scheduled for a standard lung washing procedure. The goal is …

This study aims to understand if a patient's natural breathing pattern before surgery can help predict who might experience low oxygen levels during a specific type of lung cancer operation. Researchers will measure breathing patterns before surgery and monitor oxygen levels duri…

This study is testing a new support framework for clinics that run lung cancer screening programs. Researchers are asking staff at up to 8 clinics across the US to try this new approach and give their feedback. The goal is to see if the framework is practical, acceptable, and som…

This study aims to find better ways to detect lung cancer early in people at high risk. Researchers are following 45 current or former heavy smokers who are uninsured, collecting samples and performing regular chest scans over five years. The goal is to learn what signs might pre…

This study aims to better understand the real-world symptoms and treatment experiences of adults with certain cancers. About 100 participants with breast, lung, gastrointestinal cancer, or multiple myeloma will complete weekly digital surveys about their symptoms for at least 12 …

This study is testing a new type of MRI scan that uses a special inhaled gas to see if it can predict which lung cancer patients will develop serious lung inflammation from radiation therapy. Researchers will scan patients before, during, and after their radiation treatment to lo…

This study aims to understand if an inherited change in a gene called EGFR increases a person's risk of developing lung cancer, particularly in people who have never smoked. Researchers are recruiting people with a specific cancer mutation (T790M) and their family members to prov…

This study is testing a special type of PET scan to find areas of low oxygen inside lung cancer tumors. Low oxygen can make tumors harder to treat with radiation or chemotherapy. Researchers want to see if this scan can reliably provide this information to help guide future treat…

This study aims to gather information to design a better, more manageable care plan for people who have both cancer and COPD (a chronic lung disease). Researchers will interview 100 patients and healthcare providers to understand the challenges of managing both conditions. The go…