Mental disorder

This study tests different ways to bring mental health treatment into methadone clinics in Ukraine. 1,350 patients from 12 clinics are taking part. Some clinics get extra training and financial rewards to help screen and treat depression. The goal is to see if these strategies im…

Researchers are studying a once-weekly tablet form of brexpiprazole, an antipsychotic drug, in adults with schizophrenia. The trial follows about 247 participants for 52 weeks to see how well they tolerate the medicine and whether it remains safe over the long term. Everyone in t…

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

This study tested a special program to help people with both bipolar disorder and substance use problems stick to their treatment after leaving the hospital. 178 adults were split into two groups: one received extra counseling and support, while the other got enhanced safety moni…

This study follows adults in the United States who were prescribed zuranolone for postpartum depression (PPD) after giving birth. Researchers will track symptom changes using a standard questionnaire called the Edinburgh Postnatal Depression Scale (EPDS) at several time points, i…

This trial tests whether combining an online form of Acceptance and Commitment Therapy with a noninvasive brain stimulation technique can improve sleep quality in adolescents with depression and sleep problems. About 160 teens aged 11 to 19 are randomly assigned to receive the co…

This trial tests whether adding minocycline or celecoxib to a standard antidepressant helps people with treatment-resistant depression. Treatment-resistant depression means symptoms have not improved enough with previous antidepressant treatment. About 78 adults aged 18 to 65 wil…

This phase 2 trial tests whether a single dose of insulin given through the nose can change how the brain produces energy and improve thinking in people with psychotic disorders like schizophrenia, schizoaffective disorder, or bipolar disorder with psychosis. Researchers will com…

This trial tests whether children with autism improve balance and coordination more when they exercise in a group or on their own. Researchers will randomly assign 16 children aged 3 to 12 to either individual or group exercise sessions, held three times a week for six weeks. The…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This trial tests whether continuous smartphone monitoring can detect early warning signs of depression or mania in people with bipolar disorder. Participants use an app that tracks activity and location, and some receive personalized alerts from their doctor when the app detects …

This trial compares three painkillers, hydromorphone, fentanyl, and butorphanol, given intravenously to ICU patients who are not on mechanical ventilation. The goal is to find the best dose of hydromorphone that achieves effective pain control while monitoring side effects like l…

This trial tests a web-based program called ePACE, which gives teens with mild to moderate substance use and mental health issues personalized choices about content and engagement. It compares ePACE to a fixed, non-tailored program (eFACE) and to a waitlist group. Researchers wil…

This trial tests whether combining cognitive behavioral therapy with social skills training helps young people with early-onset psychosis improve their symptoms and daily functioning. Participants receive either this combined therapy or a control program of psychoeducation and he…

This trial tests whether psilocybin, the active ingredient in magic mushrooms, given alongside psychological therapy, can help adults with treatment-resistant depression. Participants receive either psilocybin or a placebo in a single dosing session, combined with therapy. The st…

This trial tests whether a peer-led support program, where trained patients guide group sessions, can reduce depressive symptoms in adults with major depression. Researchers in Mallorca will compare this approach to an online mental health app. About 70 participants from primary …

This trial tests two online programs designed to improve thinking skills in people with schizophrenia. One program focuses on cognitive remediation, helping participants build learning strategies and confidence. The other, metacognitive training, targets how people interpret info…

This trial tests whether a specialized two-year early intervention service, called OPUS YOUNG, can improve daily and social functioning in adolescents aged 12-17 who have experienced a first episode of psychosis. Participants are randomly assigned to either OPUS YOUNG or standard…

This trial explores whether it is possible to run a larger study of mirtazapine, an antidepressant, in people who have both major depression and inflammatory bowel disease (IBD). About 76 adults with IBD and depression will be randomly assigned to take either mirtazapine or a pla…

This study tests whether adding DIR/Floortime—a child-led, relationship-based therapy—to standard care helps children aged 4-12 with mild-to-moderate autism improve emotional, social, communication, and daily living skills. Half the children receive the 10-week Floortime program …

This study tests whether a single low dose of ketamine can quickly reduce obsessive-compulsive disorder (OCD) symptoms. Adults with OCD will receive either ketamine or a comparison drug, and researchers will measure symptom changes using a standard OCD scale. The trial also uses …

This trial tests an 8-week online coaching program that teaches parents of preschool autistic children how to use everyday interactions to boost their child's social communication. Families are randomly assigned to either the coaching program or a waitlist, and the study measures…

This trial tests a Family Mental Health Navigator (FMHN) program for publicly insured youth aged 6-17 who are already receiving services at a San Francisco hospital. The program pairs families with a navigator who uses mobile health tools to help them get referrals and start trea…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This study tests a program called Compassionate Mind Training for Teachers (CMT-T) to see if it can reduce depression, anxiety, and self-criticism in elementary school teachers. Forty teachers from public schools in Aracaju, Brazil, will take part in group sessions that include m…

This study compares two treatments for depression in children aged 7 to 13: a family-focused therapy that works with both the child and parents, versus individual therapy for the child alone. The family approach aims to improve parent-child interactions, communication, and coping…

This study tests a new virtual reality (VR) software that delivers behavioral activation therapy for people with depression. Behavioral activation helps people re-engage in positive activities to improve mood. Participants use hand-tracking to interact with the VR environment, co…

This study tests whether a behavior therapy program called Partnering to Achieve School Success (PASS) can improve outcomes for children aged 5-11 with ADHD from low-income families. Children are randomly assigned to receive PASS integrated into their primary care visits or to re…

This trial studies three approaches for adults with major depression that hasn't responded to standard antidepressants. Participants either add aripiprazole (Abilify) to their current medication, add repetitive transcranial magnetic stimulation (rTMS), or switch to venlafaxine XR…

This study tests whether a combination of a special omega-3 supplement (LIPINOVA®) and a home-based exercise and education program can improve quality of life for people with lingering post-COVID symptoms. About 146 adults aged 18–70 who have had symptoms for more than 12 weeks w…

This trial tests whether a structured family support program helps relatives of critically ill patients in intensive care units (ICUs). The program includes a specialist nurse who supports families from admission through discharge and follow-up, plus better communication between …

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a behavioral program called CAE-AYA to help teens and young adults with bipolar disorder take their medication more consistently. The program included up to five in-person sessions and a follow-up phone call over eight weeks. Researchers measured adherence using…

This trial investigates whether adding low-intensity transcranial magnetic stimulation (Li-TMS) to standard antidepressant medication can improve depressive symptoms and sleep disorders in people with major depression. The study involves 40 participants who receive either real Li…

This study tested a stepped care model for depression in 14 HIV clinics in Malawi. 487 adults with moderate to severe depression received group counseling and, if needed, antidepressant medication. The goal was to see if this approach could reduce depression symptoms and improve …

This study tested whether a once-monthly injection of aripiprazole can help people with schizophrenia avoid a relapse of symptoms. Over 900 adults took part, first switching to oral aripiprazole, then receiving either the long-acting shot or another treatment for up to 38 weeks. …

This study tested whether N-acetylcysteine (NAC), an antioxidant drug, can improve motor skills and learning in children with neurofibromatosis type 1 (NF1). Twenty-five children aged 8 to 16 took NAC or a placebo for 8 weeks. The goal was to see if NAC is safe and helps with mov…

This study tested a special team-based program called R-FACT for people with serious mental illness who are also involved with the criminal justice system. The program provides intensive, community-based support with close coordination between mental health and justice staff. Res…

This study tested three ways to help children aged 7-11 with ADHD: a computer-based cognitive training program using a virtual classroom, the medication methylphenidate, and supportive talk therapy. Fifty-one children took part to see which approach best improves attention and re…

This study tested magnetic seizure therapy (MST) in 239 adults with treatment-resistant depression to see if it works as well as electroconvulsive therapy (ECT) but with fewer memory side effects. MST uses magnetic pulses to trigger a controlled seizure, aiming to relieve depress…

This study tested a Norwegian intensive habilitation program for children aged 2-6 with severe cerebral palsy or similar brain damage. The program aimed to improve the child's daily living skills and empower parents. 93 children and their families took part in a randomized trial …

This study looked at whether adding lithium to personalized maintenance ECT can help prevent depression relapse in people who already got better with ECT. 96 adults with major depression took part. The goal was to see if the combination keeps depression away longer than ECT alone…

This study is testing whether a mobile app can help detect postpartum depression early in pregnant women. Researchers will follow 120 women for 6 months, using daily mood questions and monthly surveys through the app. The goal is to understand how symptoms change over time and to…

Researchers are checking whether a short 3-question depression survey can identify moderate-to-severe depressive symptoms in older adults having surgery as accurately as the standard 9-question version. The study analyzes existing records from more than 10,000 patients aged 65 an…

This study tested whether a blood test called exome sequencing can find genetic causes of autism better than standard care. Researchers studied 300 people with autism to see if the test could identify risk genes. The goal is to improve diagnosis and help families understand the b…

This study tested a virtual reality application to help diagnose Attention Deficit Hyperactivity Disorder (ADHD) in children aged 8 to 12. The goal was to see if a 3D immersive environment could better measure attention and behavior compared to standard tests. Thirty children wit…

This study involves 60 young people at high risk for psychosis. They receive a stepped series of psychological treatments, starting with the least intensive options like group support, and moving to more intensive therapy if needed. The goal is to prevent the development of psych…

Researchers at Yale University are testing whether adding cognitive behavioral therapy (CBT) after esketamine treatment helps prevent relapse in people with major depression and suicidal thoughts. All participants receive esketamine, then half are randomly assigned to also get co…

This trial tests whether a group prenatal care model that includes social services can improve maternal mental health and reduce preterm birth compared to standard individual care with added services. Pregnant women eligible for Medi-Cal in central California are randomly assigne…

Heavy drinkers who need a breathing machine in intensive care often become agitated, which can lead to pulling out tubes, falling, or harming themselves or staff. This Phase 3 trial tests whether baclofen, a drug that calms the nervous system, can prevent these dangerous events b…

Researchers are testing a school-based program that screens adolescents for anxiety, depression, and other mental health concerns, then offers stepped support. Students at eight schools in Spain complete regular mental health questionnaires. Based on their results, they receive d…

This study tests a 12-session program called Forging Hopeful Futures, designed to reduce violence among teens ages 13-19. The program uses group discussions and activities to help youth understand how racism, gender inequality, and economic injustice can lead to violence, and tea…

This study tests whether computer-based training that targets emotional memory or attention can prevent major depression in young people who have depressive symptoms or have recovered from a depressive episode. Participants are randomly assigned to one of three active training pr…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This study tests whether a computer program called pronia.ai can help doctors identify young people at high risk for psychosis and offer them early, tailored treatment. Participants aged 16 to 40 with early warning signs will either receive standard care or the AI-guided approach…

This study tested whether personalized, intensive nursing follow-up (by phone, home visits, or hospital consultations) after a suicide attempt could prevent another attempt or crisis in people with mood disorders. 380 participants were followed for one year. The goal was to see i…

This study follows up on 217 children who took part in a cognitive behavioral therapy program for anxiety and depression 5 years earlier. Researchers want to see if the program helped prevent these conditions from developing or worsening over time. The children, now teenagers, wi…

Researchers at the University of Tulsa are testing a five-session psychological treatment called Exposure, Relaxation, and Rescripting Therapy for adults who have bipolar disorder and chronic trauma nightmares. The therapy asks participants to revisit and rewrite their nightmares…

Researchers at Karolinska Institutet are testing a parent training program for parents of children aged 8 to 16 who show angry, defiant, or aggressive behavior. The program teaches cognitive behavioral therapy skills and adds virtual reality role-plays so parents can practice res…

This study tested an oral soft capsule of nalbuphine, a painkiller, for people recovering from hemorrhoid surgery. 106 adults took either the drug or a placebo for up to 2 days. Researchers measured pain levels and how much extra pain relief was needed. The goal was to see if the…

Researchers at Karolinska Institutet are testing a program called YourSkills for children aged 10 to 16 who have elevated anger or disruptive behaviors. The program combines cognitive behavioral therapy with virtual reality role-plays to practice social skills. Children attend te…

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

Researchers are testing whether giving children a popit toy or a stress ball during inhaled medication can reduce anxiety, fear, and distress. The trial includes children aged 4 to 6 who come to a pediatric emergency unit with a respiratory condition needing nebulizer or inhaler …

Researchers are testing whether the 4-7-8 breathing technique can reduce anxiety, ease symptom burden, and improve sleep quality in people receiving chemotherapy. The trial enrolls 64 adults undergoing their third treatment cycle, splitting them into a group that practices the br…

This trial examines whether pelvic floor muscle exercises can improve vaginal and sexual health in postmenopausal women. Twenty women who are sexually active and have gone through menopause join the study. One group receives training from a physiotherapist and does home exercises…

Researchers are testing a stepped mental health program for adolescents in Pakistani public schools. The program starts with teacher-led support for emotional distress. Students who do not improve move to a CBT-based guided self-help app. The study checks whether this approach is…

This study tests an experimental drug called GM-2505 in people with major depressive disorder. Participants receive two doses of the drug two weeks apart. The study has three parts: one for people not on antidepressants, one for those partially responding to current treatment, an…

Researchers at the University of Tulsa are studying Exposure, Relaxation, and Rescripting Therapy (ERRT), a brief treatment for frequent trauma-related nightmares. The trial enrolls about 90 adults who have experienced trauma and have roughly one nightmare per week. Participants …

Researchers are testing whether a horticultural therapy program can reduce anxiety and improve quality of life in older adults. The trial enrolls 56 volunteers who take part in gardening activities. Participants complete standard questionnaires about anxiety and well-being before…

Researchers are testing whether a 10-week mindful yoga program eases depression, anxiety, and stress in women who have recently given birth. The trial enrolls 198 postpartum women with depressive symptoms and assigns them to either weekly mindful yoga sessions or a psychoeducatio…

Researchers are testing an accelerated form of brain stimulation called iTBS for depression. A single participant with major depressive disorder receives 50 iTBS sessions over 5 days while researchers monitor blood flow in the brain using fNIRS. The study measures changes in oxyg…

Researchers are testing a home-based program called action observation and motor imagery (AOMI) training for adults with spinal cord injury. Participants watch exercise videos and imagine themselves doing the movements without actually moving. The trial aims to see if this traini…

This study looked at whether mandala art therapy (a structured coloring activity) can lower anxiety and increase comfort in people who received a kidney transplant. Eighty adult first-time kidney transplant recipients took part. The goal was to see if this simple, non-drug approa…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

Tonsillectomy causes significant pain in children. Researchers are testing whether injecting ropivacaine, a local anesthetic, around the tonsils during surgery reduces postoperative pain. The trial enrolls 60 children aged 3 to 6 who are having their tonsils removed. Doctors comp…

Electromyography (EMG) and nerve conduction studies (NCS) check how nerves and muscles work, and many patients find them painful or stressful. Researchers are testing whether letting adults choose and listen to their own music during these tests lowers anxiety and pain compared w…

Researchers are testing a four-week acceptance and commitment therapy program for parents of children with complex medical conditions. The trial enrolls 24 parents who attend two-hour weekly sessions covering stress, values, mindfulness, and goal-setting. The study measures chang…

Researchers at Oregon State University are testing whether a brief, Spanish-language group program can reduce anxiety in Latino/a adults. The program teaches neuroscience-informed cognitive behavioral therapy over three weekly 90-minute sessions and asks participants to track the…

Researchers are testing whether giving mothers with ADHD a stimulant medication along with behavioral parent training works better than parent training alone for reducing ADHD-related problems in their young children. The study enrolls mothers aged 21 and older who meet criteria …

This study tests whether combining progressive muscle relaxation and guided imagery can lower stress, anxiety, and depression in people with stable coronary artery disease. Forty adults will be split into two groups: one gets eight sessions of these mind-body techniques over four…

Many people who move to a new country face depression, anxiety, stress, and trouble adjusting. This pilot study tests whether EMDR, a psychotherapy that uses guided eye movements to process distressing memories, can help when adapted for migration-related experiences. First-gener…

Researchers are testing whether a home-based program led by community health workers can reduce depression in older adults living in a low-resource district of Lima, Peru. The program, called VIDACTIVA, combines problem-solving exercises and physical activation over eight home se…

Researchers are studying whether adding a Chinese herbal capsule called Shuganjieyu to the antidepressant fluoxetine helps ease depression symptoms more than fluoxetine alone. The trial enrolls 160 adults with depression, ages 18 to 65, who score at least 18 on a standard depress…

This study tested whether a 3-month home exercise program on an elliptical machine and 3 months of bright light therapy could improve movement, balance, and mood in adults with traumatic brain injury. Thirty-four participants (including healthy volunteers) were enrolled. The goal…

Intravitreal injections deliver medicine directly into the eye and are usually quick, but many patients feel anxious before and during the procedure. Researchers are testing whether playing classical music during the injection lowers anxiety and pain compared with no music. The t…

This study tests whether a type of brain stimulation called cTBS can improve thinking and memory in people with schizophrenia. Forty participants will receive targeted stimulation to a brain network linked to daydreaming and self-focus. The goal is to see if this changes brain ac…

This study will test whether watching a liquid-gel or sand hourglass during blood collection can reduce pain, fear, and anxiety in children aged 5 to 10. About 120 children will be randomly assigned to use one type of hourglass or no hourglass. The goal is to find a simple, non-d…

Researchers are studying whether TENS, a device that sends mild electrical pulses through the skin, can lower pain and reduce the need for painkillers after total hip replacement. The trial enrolls 60 adults who have had hip replacement surgery and do not have a pacemaker, heart …

This study tests whether using a virtual reality headset showing nature scenes with relaxing music can reduce pain and anxiety during dressing changes for pressure sores. Sixty-two adults with pressure sores will be randomly assigned to either receive VR during dressing or standa…

This pilot study tests whether a short, 5-session writing therapy called Written Exposure Therapy (WET) is practical and helpful for pregnant or postpartum adolescents and young adults (ages 15-24) with PTSD. The therapy involves writing about traumatic experiences with minimal t…

This study looked at whether structured play activities could reduce anxiety in children aged 4-10 receiving chemotherapy and their parents. 62 children and their parents took part in play sessions during chemo. Anxiety levels were measured before and after play. The goal is to s…

Researchers in Chile are testing whether pediatricians trained to detect and respond to social withdrawal can help late and moderately late preterm infants engage more with their parents. The study enrolls 110 preterm infants born between 32 and 36 weeks and their Spanish-speakin…

Researchers are testing whether the experimental drug LY2140023 (pomaglumetad methionil) reduces schizophrenia symptoms better than a placebo. The trial enrolls adults diagnosed with schizophrenia who stay in a hospital or clinic during the four-week study. Participants take the …

Researchers are testing whether an experimental drug, LY2140023, eases schizophrenia symptoms better than placebo in people who are acutely ill. The trial also compares it to risperidone, an approved antipsychotic. About 1,100 patients with schizophrenia join this phase 2 study. …

Researchers in Pakistan are comparing two psychological treatments, Eye Movement Desensitization and Reprocessing (EMDR) and Cognitive Behavioral Therapy (CBT), for people with post-traumatic stress disorder (PTSD) and major depression. The trial enrolls 100 adults aged 18 to 60 …

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

Researchers test whether an 8-session mindfulness-based stress reduction program can lower anxiety and work-related burnout and improve job satisfaction among midwives. Midwives at a Turkish hospital join either the program or a control group. The program runs online twice a week…

This trial compares three common anesthetic blocks used during knee replacement surgery to see which one controls pain best right after the operation. It also looks at how well patients can move their knee in the first few days, and whether pain and recovery differ by age or sex.…

Researchers are testing whether a structured Enhanced Recovery After Surgery (ERAS) program improves recovery for people having their first coronary artery bypass graft. The program bundles 31 care steps before, during, and after surgery, including patient education, nutrition su…

Researchers are testing whether virtual reality glasses that show nature scenes with nature sounds can reduce pain and anxiety in women after a cesarean section. The trial enrolls 80 women who had spinal anesthesia and a healthy pregnancy, assigning half to use the VR glasses for…

Researchers at Atlas University are comparing three daily breathing practices, mindfulness breathing, box breathing, and Nadi Shodhana pranayama, in 48 healthy adults aged 18 to 40. Participants practice one technique at home for six weeks after learning it in person. The trial m…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tests whether pairing meditation with a brain stimulation technique called rTMS can better treat depression. rTMS is already FDA-approved but only works for about 15-30% of patients. The researchers hope that adding a focus on internal attention (like breathing) during…

Researchers are testing MDMA-assisted therapy in military veterans who have both alcohol use disorder and post-traumatic stress disorder. The treatment combines two monthly therapy sessions with the drug MDMA, along with preparation and follow-up counseling. The study measures ch…

Researchers are comparing two 9-week group classes for veterans who have a history of mild traumatic brain injury and post-traumatic stress disorder. One class teaches mindfulness, meditation, and yoga; the other teaches how the brain works and recovers after injury. The study me…

York University researchers are testing two ways to train teachers to help children with dyslexia who have not improved with standard classroom reading instruction. One program adds morphology, which teaches shared word meanings like sign, design, and signal. The other adds set-f…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This study will test whether watching a short educational video or having a standard talk with a doctor is better at reducing anxiety and stress in women scheduled for a planned cesarean delivery. 140 women will be randomly assigned to one of the two groups. Their anxiety levels …

This study tests whether a nerve block called the serratus posterior superior intercostal plane block can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard…

Researchers at the University of Guadalajara are testing whether a short acceptance and commitment therapy (ACT) program can reduce anxiety in medical students. The program runs four in-person group sessions that teach students to accept difficult thoughts and feelings, step back…

Researchers are testing an experimental drug called soticlestat in people with two rare genetic conditions: Dup15q syndrome and CDKL5 deficiency disorder. Both conditions cause frequent motor seizures that are hard to control. The trial enrolls about 20 participants who take one …

This study tests whether 80 sessions of a gentle brain stimulation technique called tDCS, given over 12 months, can improve attention, social skills, and language in 180 children aged 6 to 11 who have autism along with rare diseases, genetic problems, or PANDAS. The treatment is …

Researchers are testing a smartphone app called Pai.ACT that uses acceptance and commitment therapy to help parents of children with special needs manage stress and improve well-being. The study enrolls 60 Cantonese-speaking parents in Hong Kong who care for children aged 2 to 8 …

This trial tests whether acupressure, a traditional therapy that presses on specific body points, can reduce pain and anxiety in women who have just had a cesarean delivery. Sixty postpartum women will receive either acupressure or a sham version, along with standard medical care…

Researchers are testing a full-spectrum medicinal cannabis extract with very low THC to see if it can reduce the severity of autism spectrum disorder in young people aged 8 to 17. The study compares the extract to a control and then allows some participants to receive it openly. …

Researchers at Saveetha University studied a structured play-based program called the B.A.S.I.C.S. framework for children with autism spectrum disorder. The program combines balance, social, thinking, and self-reliance activities into 45-minute sessions three times a week for six…

People with type 2 diabetes often face higher rates of anxiety and depression than the general public. Researchers at Dasman Diabetes Institute are testing whether six weeks of guided breath awareness, practiced inside a pyramid-shaped structure, can reduce those symptoms. The pi…

Researchers test whether adding cognitive training to a 10-week exercise program helps children with developmental coordination disorder improve balance, motor skills, and fitness more than exercise alone. Twenty children aged 7 to 11 join the study and are randomly assigned to e…

This study tested whether a special type of heated yoga (hyperthermic yoga) could help adults with mild to moderate depression. 80 people were randomly assigned to either take yoga classes twice a week or join a waitlist. The main goals were to see if people would stick with the …

This study tests a group cognitive-behavioral therapy (CBT) program designed to help young adults who struggle with uncertainty. The program includes techniques like cognitive restructuring and exposure to uncertain situations, and it considers how a person's social environment a…

Researchers are testing transcranial direct current stimulation (tDCS), a non-invasive technique that applies a weak electrical current to the scalp, in adults with severe obsessive-compulsive disorder that has not improved with at least two antidepressants. The study compares ac…

Researchers at the University of Utah are testing a new non-invasive brain stimulation method for people with moderate-to-severe depression. The study uses a device called the Diadem prototype to deliver personalized low-intensity focused ultrasound to specific brain areas. Parti…

Researchers at MIT are testing whether a smartwatch that vibrates in time with your heartbeat can improve interoceptive awareness, the ability to sense what is happening inside your body. The study enrolls 29 people with high alexithymia scores, a trait linked to difficulty ident…

Researchers are testing a full-spectrum medicinal cannabis extract called NTI164 in girls and young women with Rett syndrome, a rare genetic disorder that affects movement, speech, and behavior. The study includes 14 participants aged 5 to 20 who take the extract daily for 16 wee…

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults (ages 18-24) who have faced early life hardships find the program helpful and easy to use. The study also checks if the program reduces sympto…

Researchers are testing an AI-integrated proactive thought control program for young adults with social anxiety disorder. The program uses two computer tasks: one where participants type the first word that comes to mind after seeing a social threat word, and another where they c…

Researchers are testing whether transcranial direct current stimulation (tDCS) can reduce symptoms in people with severe obsessive-compulsive disorder that has not improved with standard medications. The study enrolls 20 adults aged 18 to 70 who have chronic OCD and have tried at…

This study tests a smartphone app called CT-155 designed to help people with schizophrenia manage negative symptoms like low motivation and reduced pleasure. About 262 adults with schizophrenia will use the app for 16 weeks, with an optional extension. Researchers will track symp…

This study tests a nasal spray containing (R)-Ketamine, a fast-acting drug, in 98 adults with major depression who are currently having suicidal thoughts. Participants receive either the spray or a placebo twice a week for 4 weeks. The goal is to see if the spray can quickly redu…

Researchers are testing whether propranolol, a common blood pressure drug, can help people with fibromyalgia who also have post-traumatic stress disorder. Participants take propranolol and then read their own traumatic story about 75 minutes later, once a week for six weeks. The …

This trial tests a telephone-based coaching program called MOTIVATE for older veterans who live with chronic musculoskeletal pain and depression. Participants receive eight individual phone sessions with a health coach over up to five months, focusing on managing pain and mood. R…

This trial tests whether a daily oral oil made from a full-spectrum cannabis plant extract with very low THC (FEN164) can safely help children with autism. The study will include 18 children aged 8 to 17 with moderate to severe autism (Level 2 or 3). Over 20 weeks, researchers wi…

This trial tests whether teaching mothers how to perform aspiration care for their children in the intensive care unit can lower their anxiety and hopelessness. Researchers will compare two teaching methods: a video and a picture booklet. The study includes mothers whose children…

Researchers at the University of Reading are testing an online guided-writing program for people who care for a loved one with Parkinson's disease. The program asks caregivers to complete four writing exercises that encourage them to respond to their own struggles with the same k…

This trial tests whether a quilling exercise, a paper craft activity, can reduce fear and anxiety in children aged 9-12 who are about to undergo cardiac catheterization and angiography. Half an hour before the procedure, children in the intervention group will spend 15-20 minutes…

This trial tests whether letting children play video games or paint a mask during nebulizer treatment reduces their anxiety and improves how well they cooperate. The study includes children aged 7 to 12 who are receiving their first nebulizer treatment in the hospital. Researcher…

This study looks at whether mindfulness meditation can help first-generation college students feel less anxious or depressed and stay in school. About 53 students will be randomly assigned to either mindfulness meditation or a general mental health education group. Researchers wi…

Researchers are testing whether chewing mint-flavored sugar-free gum during childbirth can reduce pain and anxiety in first-time mothers. The trial includes 106 pregnant women at term with no complications, who will chew the gum for at least 20 minutes at different stages of labo…

Researchers are testing whether psilocybin, the active compound in magic mushrooms, can safely help people with Parkinson's disease who also struggle with depression or anxiety. In this pilot study, 12 participants receive two oral doses of psilocybin with psychological support. …

This study is testing whether two devices used together can help new mothers with both depression and urinary incontinence. One device uses magnetic pulses to stimulate brain areas linked to mood, while the other strengthens pelvic floor muscles with electromagnetic energy. Sixty…

This study tests whether a text-message based chatbot support program can reduce symptoms of postpartum depression in people of color who recently gave birth. About 156 participants will either get the chatbot or usual care. The goal is to see if the chatbot lowers depression sco…

This study tested a new cognitive behavioral skills program (CBI) delivered in the metaverse for people with depression and anxiety. 306 participants were split into three groups: one using virtual reality, one using a flat-screen device, and a waitlist group. The program taught …

This trial tests whether a digital cognitive behavioral therapy (CBT) app called Daylight can reduce anxiety and improve health behaviors in adults who have had a heart event, such as a heart attack or stroke, and also experience significant anxiety. Participants will either use …

This study tests whether adding a group therapy called Kiesler Circle Training (KCT) to standard cognitive behavioral therapy (CBT) helps people with depression or anxiety improve their interpersonal skills. About 156 participants will receive either CBT alone or CBT plus KCT. Th…

Researchers are testing whether a series of multisensory stimulation sessions can reduce depressive symptoms in adults with moderate-to-severe depression. Fifteen participants receive nine 20-minute sessions combining auditory, thermal, and pressure stimuli, calibrated to about 6…

This trial tests two ultrasound-guided nerve blocks for pain relief after thoracotomy, a surgery that opens the chest. One block targets the paravertebral space, while the other targets a point between the transverse process and the pleura. Researchers will compare how much morph…

This study tests whether giving a small amount of the sedative midazolam during anesthesia can lower the risk of delirium (sudden confusion) and anxiety in older adults after surgery. About 612 patients aged 65-85 having non-heart, non-brain surgery will be randomly assigned to r…

This study tested a new anxiety program designed for autistic youth ages 7 to 17. The program was delivered in community care centers to make it more accessible. Researchers wanted to see if it was practical and helpful for reducing anxiety symptoms. The study involved 32 partici…

This study tested a wearable morning light device (Re-Timer) for women with postpartum depression. 95 women wore either bright or dim light glasses for 60 minutes each morning for 5 weeks. Researchers measured changes in depression symptoms, sleep, and body clock timing. The goal…

Many children with autism are picky eaters, often refusing fruits, vegetables, and proteins, which can lead to poor nutrition and obesity. This trial tests whether nutritional counseling focused on the Mediterranean diet can help these children become less selective and adopt hea…

This study tests whether using a virtual reality headset during labor can help reduce pain and anxiety and make the childbirth experience more satisfying. About 92 women in Taiwan will be randomly assigned to either use VR with calming nature scenes and music or receive standard …

Researchers at Brigham and Women's Hospital are testing whether automated motivational messages or coach support can improve engagement with SilverCloud, a digital mental health intervention for depression and anxiety. The trial enrolls adults with clinically significant symptoms…

This study looked at whether teaching patients about pain before a planned hysterectomy (removal of the uterus) could help lower their anxiety, stress, and pain after surgery. 62 adults took part and received either standard care or extra education about pain. The goal was to see…

This study tests whether chamomile or valerian extracts can reduce dental anxiety in healthy children aged 6 to 10 who need a tooth pulled. Kids are randomly given one of the herbal extracts or a placebo before the procedure. Researchers measure anxiety using child-friendly emoji…

This small study tests whether empagliflozin (Jardiance), a diabetes medication, can reduce symptoms of major depression. The drug helps the body produce ketones, which may provide an alternative energy source for the brain. Sixteen adults with moderate to severe depression will …

This trial tests whether aromatherapy with rose oil or a massage using that oil can reduce pain, anxiety, and discomfort in women after a cesarean delivery. About 90 first-time mothers will be randomly assigned to receive one of these treatments or a placebo. The goal is to see i…

This study tests whether a 6-week group class on nonviolent communication (NVC) can improve mental well-being in parents of primary-school children. About 172 parents with mild to severe anxiety or depression symptoms will be randomly assigned to take the class right away or wait…

This study tested whether a type of compassion meditation could help Veterans with chronic pain who also have depression or PTSD. 142 Veterans were randomly assigned to either compassion meditation training or a health education group. The goal was to see if meditation could redu…

This study tested a new drug called ropanicant in 41 adults with moderate to severe major depressive disorder. The main goal was to check safety and side effects, while also measuring how well it improved depression symptoms using a standard rating scale. The trial was open-label…

Researchers at UCLA are testing whether a savoring intervention, which teaches people to focus on and amplify positive experiences, can improve mood and reduce inflammation in young adults with low positive affect. The study involves 20 participants aged 18 to 25 who will complet…

This trial tests whether watching short family videos or virtual reality nature scenes can reduce anxiety, agitation, and pain in adults staying in intensive care. Researchers will randomly assign 72 participants to one of three groups: family videos, family videos plus VR nature…

This trial investigates whether a structured educational program led by nurses can reduce anxiety and improve outcomes for adults undergoing their first heart surgery. Participants are randomly assigned to receive either the nurse-led program or usual care. The program covers pre…

This study tested a new therapy called Processing of Positive Memories Technique (PPMT) for people with PTSD. Unlike standard treatments that focus on trauma, PPMT helps patients recall and describe positive memories. 70 adults with PTSD were randomly assigned to either PPMT or s…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This study tests whether a common probiotic (Lactobacillus rhamnosus GG) can reduce stomach issues like constipation and diarrhea in children with autism spectrum disorder. About 50 children aged 4 to 12 with both autism and ongoing stomach problems will receive the probiotic or …

This trial tests a web-based parent training program, called Parenting Wisely for Residential Treatment, for parents of adolescents aged 11 to 17 in psychiatric residential treatment. The program includes online modules and facilitated parent groups to prepare families for the te…

This trial tests a year-long caregiver training program called MISC-CBO. The program uses video feedback to help community-based organization caseworkers improve their interactions with orphaned and vulnerable children. Researchers will compare children whose caseworkers receive …

This trial tests whether virtual reality-based breathing yoga can reduce pain and anxiety in adults before chest tube removal after cardiac surgery. Participants are randomly assigned to either watch breathing yoga videos through VR glasses for 15-20 minutes before the procedure,…

This pilot study tests a 10-session group program called AgingUP, designed for adults aged 50 and older living with severe mental illness. The program uses cognitive-behavioral and self-compassion techniques to help participants challenge negative beliefs about aging and mental i…

This trial tests whether a six-week program of mandala coloring—two 20-30 minute sessions per week—can improve psychological resilience among midwives working in hospital delivery rooms. These professionals face high stress from heavy workloads, shift work, and traumatic events, …

Researchers are testing whether a virtual-reality program called RC2S+ can be used remotely to help people with schizophrenia improve social cognition, such as recognizing emotions and understanding others' thoughts. The study enrolls 15 adults with schizophrenia or related psych…

Researchers are testing whether daily sessions with a bright light lamp can ease depressive episodes in people with bipolar II disorder. The trial compares a bright 10,000 lux lamp against a dim placebo lamp, with each session lasting 30 minutes. Participants are adults whose dep…

This trial tests whether acupressure applied to the Yintang point—a spot on the forehead—can reduce pain, anxiety, and improve satisfaction during childbirth. About 104 first-time mothers in active labor will receive either Yintang acupressure or a light touch at a non-therapeuti…

This study tests whether using brain scans to guide transcranial magnetic stimulation (TMS) works better than standard head measurements for treating depression. Participants with major depressive disorder receive accelerated TMS, but they won't know if their treatment spot was c…

This trial tests whether a structured, adapted physical activity program can improve emotion regulation in adults with depressive disorders who have recently been discharged from psychiatric hospitalization. Participants are randomly assigned to either a standard exercise program…

This trial explores whether an internet-based cognitive behavioral therapy (CBT) program, combined with COPD education, can improve mental health, disease knowledge, and quality of life in adults with chronic obstructive pulmonary disease (COPD). Participants complete the 8-10 we…

This study tests whether playing movement-based digital games can improve motor skills in children aged 6-10 with mild or moderate autism. Half the participants will play these games twice a week for 10 weeks, while the other half continues their usual education and rehabilitatio…

This study tests whether making music in a group can help people with schizophrenia who hear voices. Participants will be randomly assigned to one of four activities: creating and performing their own song, singing karaoke, listening to popular music, or curating playlists. The g…

This trial tests whether a robotic pet or a video can reduce pain, fear, and anxiety in children aged 5-10 during a blood draw (venipuncture). Children are randomly assigned to interact with a robotic pet, watch an animal video, or receive routine care during the procedure. Resea…

This trial tests whether a group-based psychological treatment for insomnia, adapted for people with depression, anxiety, or PTSD, can improve sleep and reduce psychiatric symptoms. Participants receive either the adjusted CBT-i program or usual care. The study measures changes i…

This study tests a new device that uses mild electrical currents to stimulate the brain in people with major depression. The device adjusts the stimulation in real time based on brain activity. The goal is to see if the device works correctly and if it can help reduce depression …

This trial tests whether using real-world props, like a kayak paddle or sitting in an actual kayak, can lower anxiety during a virtual reality (VR) kayaking game in adolescents with mild to moderate intellectual disabilities. Participants will be randomly assigned to play the VR …

This trial tests a new psychoeducation program that teaches military veterans with PTSD how sensory processing affects their stress, emotions, and daily life. Participants learn strategies to better regulate overwhelming situations, improve sleep, and engage socially. The study a…

This trial tests whether adding virtual reality to cognitive behavioural therapy (CBT) can better reduce persecutory thoughts in people with schizophrenia spectrum disorders compared to traditional CBT alone. About 256 participants will receive either VR-assisted CBT or standard …

This trial is testing a program called TEAMSS, designed to help fifth graders with elevated anxiety transition more smoothly to middle school. The program includes reading materials, a school tour, group sessions, parent meetings, and teacher consultations. The goal is to see if …

This trial asks whether letting mothers use their personal cellphones during a planned C-section under spinal anesthesia can lower anxiety and stress and improve satisfaction. About 82 low-risk pregnant women will be randomly assigned to either use their phones freely during surg…

This pilot trial tests whether pediatric primary care providers can effectively deliver a brief intervention called the Anxiety Action Plan (AxAP) to help children aged 6-17 with elevated anxiety symptoms. Providers receive training and coaching to administer the intervention, wh…

This study tests a mobile program called Compass for Care, designed to help people caring for a loved one with Alzheimer's or related dementias. The program delivers 12 weekly modules and tailored messages focusing on five self-care behaviors, such as taking time to recharge and …

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce agitation in people with bipolar disorder. About 380 adults with bipolar I or II who were very agitated took part. The goal was to see if the film safely calms agitation better than a pla…

This Phase 3 trial tested a sublingual film containing dexmedetomidine (BXCL501) to quickly reduce agitation in 380 adults with schizophrenia or related disorders. Participants received either the drug or a placebo film, and researchers measured changes in agitation symptoms over…

This study tests a new type of brain training for children with ADHD. It uses a device that measures brain activity and gives feedback, sometimes with virtual reality goggles. The goal is to see if this training can improve attention and reduce hyperactivity. About 110 children a…

This study tests whether weekly live harp music sessions can reduce behavioral symptoms like agitation and anxiety in nursing home residents with moderate-to-severe dementia. Participants in memory care units will listen to a harp therapist play during the late afternoon, a time …

This trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood shortly after a single dose. Around 53 generally healthy adults will take either one of the supplements or a placebo, then complete a series of computer and paper…

This study tests a mobile app-based training designed to help people with social anxiety disorder interpret ambiguous social situations in a more positive, less threatening way. Adults aged 18-60 with moderate to severe social anxiety will use the app over several sessions, and r…

This trial tests whether transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, can reduce auditory hallucinations in people with schizophrenia who haven't found relief from antipsychotic medications. Participants receive either real tDCS or a…

This trial tests whether a smartphone app called MindBoba, which uses problem-solving therapy techniques, can help Chinese Americans reduce stress and anxiety. Participants will be randomly assigned to use MindBoba, a standard cognitive-behavioral therapy app, or receive no app. …

This trial tests whether daily omega-3 fish oil supplements can improve sleep, mood, and behavior in children who have sleep problems and symptoms of ADHD, autism, or both. The study takes a symptom-focused approach, aiming to identify which specific difficulties—like emotional u…

This study follows 140 people with obstructive defecation syndrome (ODS) — a condition that causes straining and difficulty passing stool — who are scheduled for surgery. Researchers will measure depression and anxiety using standard questionnaires before and after the procedure,…

This trial tests whether an augmented reality (AR) app-based cognitive behavioral therapy (CBT) program can help children aged 6 to 12 who are undergoing chemotherapy for cancer cope with treatment-related distress and improve their quality of life. Participants are randomly assi…

This 12-week trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood in healthy adults. Participants take one of the supplements or a placebo daily and complete four one-hour sessions of cognitive and mood tests. The goal i…

This study tested whether monthly 45-minute psychological interviews over 6 months could reduce post-traumatic stress symptoms in cancer patients affected by the COVID-19 pandemic. It included 29 adults with solid tumors who had moderate to high PTSD symptoms. The goal was to see…

This trial tests whether an internet-based self-help program called Couple HOPES can reduce PTSD symptoms and improve relationship satisfaction in couples where one partner is a military member, veteran, first responder, or healthcare worker with COVID-19-related PTSD. Participan…

This study explores whether virtual reality goggles and noise-cancelling headphones can make ketamine/esketamine treatment for depression more tolerable and effective. Participants receive a single treatment while immersed in a relaxing virtual environment. The goal is to see if …

This trial compares two simple educational tools—an animated video and a brochure—against routine care to see which best lowers anxiety and fear in children aged 7 to 10 who need an echocardiogram. All participants have a congenital heart condition and are scheduled for a follow-…

This trial tests whether an eight-session cognitive-behavioral psychoeducation program can reduce internalized stigma in adults with bipolar disorder who are in remission. Participants are randomly assigned to the program or usual care, and their stigma levels are measured before…

This trial tests whether a structured, therapist-led dance program can improve cognitive-motor skills, balance, self-esteem, and sensory processing in children aged 6 to 12 with ADHD. Over five weeks, participants attend ten dance sessions designed to combine rhythm and movement …

This trial tests whether choline alphoscerate, a dietary supplement, can improve depression, anxiety, and memory complaints in adults aged 60 and older with major depression. Participants take either the supplement or a placebo alongside their usual antidepressant medication. The…

This trial tests whether using an immersive virtual reality headset during the first postoperative orthopedic dressing change can reduce anxiety and pain in children and adolescents aged 6 to 18. Participants are randomly assigned to either wear the VR headset during the procedur…

This trial tests whether coloring pre-drawn mandala patterns for at least 30 minutes each day can lower anxiety and depression in adults awaiting open-heart surgery. About 69 first-time heart surgery patients will be randomly assigned to either the coloring activity or usual care…

This study tests whether giving family members of ICU patients a QR code that links to an educational video can improve their understanding of the ICU and reduce their anxiety. Participants are randomly assigned to receive either standard verbal information or the same informatio…

This trial tests whether a gentle electrical stimulation of the vagus nerve through the ear (tVNS) can help athletes recover more quickly after intense training. About 121 professional athletes in sports like swimming, athletics, and gymnastics will use the device daily for 60 mi…

This phase 2 trial tests whether a single local dose of HTX-011, a long-acting anesthetic, can reduce pain after bunionectomy better than a placebo. About 70 adults undergoing foot surgery receive either the drug or a saline injection, and their pain is tracked over 24 hours. The…

This study tests whether watching an animated educational video before laparoscopic tubal ligation reduces anxiety and pain more than standard verbal counseling. Eighty women are split into two groups: one receives routine verbal information, the other watches a video. Researcher…

This trial investigates whether wearing AI-powered active noise-cancelling headphones during rotational atherectomy — a heart procedure that generates loud drilling noise — can reduce patient anxiety and improve heart rate stability. One hundred adults with severe coronary artery…

This trial compares two ways to manage pain during hip replacement surgery: an ultrasound-guided nerve block (PENG block) versus injecting anesthetic directly into the joint. The study includes 60 adults scheduled for anterior hip replacement under general anesthesia. The main go…

This trial tests whether a newer nerve block called PENG block provides better pain relief than the standard intra-articular injection for people undergoing hip replacement surgery. Both methods use the anesthetic lidocaine. The study will measure how much morphine patients need …

This study tests whether using a stress ball or watching a short aquarium video with music can reduce fear, anxiety, and pain in children aged 6 to 12 who need an enema for constipation or bloating in the emergency department. Children are randomly assigned to one of the two dist…

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tests a specially adapted form of cognitive behavioral therapy for insomnia (CBT-i) in people with bipolar disorder who have sleep problems. The therapy includes sleep scheduling, light exposure, and relaxation techniques. Researchers want to see if it improves sleep q…

This study tests whether a very low dose of LSD (26 micrograms) can improve mood in people with depression compared to a placebo. Researchers measure mood changes, sleep quality, and brain activity using EEG. The trial involves 41 adults with depression and aims to see if this ap…

This pilot study tests whether a brief psychological program called Problem Management Plus (PM+) can help reduce anxiety and depression symptoms in people held in Dutch remand prisons. The program, developed by the World Health Organization, teaches problem-solving, stress manag…

This study tests whether a 10-week storytelling (narrative therapy) program can reduce anxiety and depression in middle school students living in refugee camps in northern Palestine. About 120 students aged 12-15 with moderate-to-severe symptoms took part. The program uses cultur…

This trial tests whether a device called Cognilum, which shines light on the head (transcranial photobiomodulation), can reduce autism symptoms in children aged 2 to 6 with moderate to severe autism. Children wear the device for up to 15 minutes twice a week for 8 weeks. Research…

This study tests whether a one-day Acceptance and Commitment Therapy (ACT) workshop can improve psychological flexibility and well-being in university students who have moderate to severe anxiety or depression. Participants are randomly assigned to either attend the workshop or j…

This study tests whether a 6-week online self-help program can help people with psychotic disorders who hear voices at least once a week. The program combines metacognitive training and mindfulness techniques to reduce the frequency and distress of auditory hallucinations. Partic…

This pilot study tested whether adding structured supportive psychotherapy to the antipsychotic risperidone could improve cognitive function and reduce inflammation in 44 hospitalized adults with schizophrenia. Participants received either risperidone plus 12 weekly talk therapy …

This trial tests whether rhythmic electrical pulses delivered to the wrist (median nerve stimulation) can reduce tics and the urge to tic in people with Tourette syndrome or chronic tic disorder. Participants wear a portable device for 15 minutes at a time over four weeks. The st…

This pilot study tests whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help reduce PTSD symptoms in adults who are in residential treatment for substance use disorders. Participants complete five guided writing sessions about their trauma. The st…

This study tests whether adding passive sensing technology (like smartphone data) to a standard counseling program helps community health workers better treat postpartum depression in low-resource settings. The trial compares the digital-enhanced approach to standard counseling a…

This trial tests whether a brief online group therapy called EMDR Flash can help adults who survived the 2023 Kahramanmaraş earthquakes in Türkiye. Participants receive two 60-90 minute group sessions via Zoom and are compared to a waitlist group. The study measures changes in PT…

This study tested a 5-month early time-restricted eating plan (eating only between 7 AM and 3 PM) in 100 highly trained young male judo athletes. Researchers measured changes in body composition, muscle damage markers, and psychological factors like anxiety and self-confidence. T…

This study tested whether a single infusion of stem cells from donated umbilical cord tissue could improve social communication in children with autism. 137 children aged 4 to 12 took part. The main goal was to see if their socialization and communication scores improved after si…

This study tested whether adding dog-assisted therapy to usual care helps teens aged 12-18 with mental health issues like anxiety, depression, and emotional dysregulation. 70 teens in a day hospital were randomly assigned to either get dog therapy plus usual care or usual care al…

This pilot study tested whether a non-invasive device that uses magnetic pulses to stimulate the brain (rTMS) could safely help cancer survivors with depression and anxiety. Twenty-four adults who had been treated for any type of cancer and still had major depression received eit…

This trial investigates whether a double-reading animated film, watched by both children and their parents before surgery, can reduce anxiety in children aged 3 to 7. The film uses avatars to walk the child through their hospital journey, from room to operating room. Researchers …

This study tested whether repeating positive affirmations during a routine pregnancy test (Non-Stress Test) can lower pain, anxiety, fear, and stress. 90 pregnant women participated, with some using affirmations and others receiving standard care. The goal is to see if this simpl…

This study tested whether daily gummies containing L-theanine and lion's mane mushroom extract could reduce stress, anxiety, and improve sleep in university students. 67 students aged 18-25 took either the gummies or no supplement for 8 weeks. The goal was to see if this natural …

This study looked at whether touch-massage can reduce anxiety in people with blood disorders (like leukemia or lymphoma) who are hospitalized in a sterile, isolated room. Sixty-two patients received three massage sessions, and researchers measured their anxiety levels before and …

This study tested whether Swedish massage with lavender or chamomile oils can help reduce pain, fear, and anxiety during labor. 90 pregnant women were split into three groups: one got massage with chamomile oil, one with lavender oil, and one with plain carrier oil. Researchers m…

This study tests two short behavioral therapies delivered over video calls for adults with chronic orofacial (jaw or face) muscle pain and insomnia. One therapy focuses on sleep habits and routines; the other uses jaw relaxation and breathing exercises. The goal is to see which a…

This study tested a swimming and water safety program designed for children with autism spectrum disorder. The program uses individualized teaching methods and sensory modifications to help kids learn to swim and stay safe around water. Over 350 children with autism took part, an…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study looked at whether teaching cancer patients about their portable chemotherapy pump (elastomeric pump) can make them feel more comfortable and less anxious. 70 adults receiving 5-FU treatment were split into two groups: one got extra education and a booklet, the other go…

This study looked at whether adding supervised Pilates exercises and structured prenatal education to standard care could reduce depressive symptoms, low back pain, and labor pain in first-time mothers. 85 pregnant women participated, with some attending the program and others re…

This study tested whether full-spectrum CBD oil can help with anxiety and depression in people with Parkinson's disease. Twenty-seven participants took one of three daily doses (30, 60, or 300 mg) for two months. Researchers measured changes in anxiety and depression scores, alon…

This study tested whether watching telenovela-style educational videos can help family caregivers of hospice patients feel more confident and less anxious. 59 caregivers participated over 8 weeks. The approach used weekly video lessons during regular hospice visits.

This study tested a structured online program for parents of children with autism or ADHD. 90 families took part to see if the program could lower parental stress, improve coping skills, and boost social support. Researchers compared parents who received the program to those who …

This study looked at whether giving a special therapy called EMDR to people in the emergency room right after a traumatic event could help prevent post-traumatic stress disorder (PTSD). About 110 adults who were at high risk for PTSD took part. The therapy uses eye movements to h…

This study tested whether a gentle ear stimulation technique could reduce stress and anxiety in healthcare workers during the COVID-19 pandemic. 62 workers were randomly assigned to receive the stimulation or be placed on a waiting list. The goal was to see if this simple, non-dr…

This study tested a virtual reality app called StoryTelling Medicine (STM) to see if it could reduce anxiety in children aged 8–13 before elective surgery. The app guides kids through hospital settings in a fun, interactive way. Researchers measured anxiety, heart rate, and stres…

This study tested whether using magnetic pulses (rTMS) on the brain while people recall their traumatic memories can reduce PTSD symptoms. 39 adults with PTSD for at least 3 months received either 10Hz or 1Hz rTMS over 2 weeks. Researchers measured changes in PTSD severity using …

This study looked at whether music therapy can lower anxiety in women with early-stage breast cancer during chemotherapy. Twenty-seven patients took part, with some receiving music therapy sessions while others did not. Researchers measured anxiety levels before and after each ch…

This study tested whether a natural supplement called ultramicronized palmitoylethanolamide (umPEA) can improve smell, taste, and other sensory issues in children with autism. Eighty children took either umPEA or a standard treatment (probiotics plus omega-3) for six months. Rese…

This study looked at whether using a virtual reality hypnosis headset during a frozen embryo transfer is practical and can help lower anxiety. Fifty women undergoing IVF used the headset during the procedure. The main goal was to see if the headset could be used without technical…

This study tested a program to reduce anticholinergic medications (like benztropine) in 53 adults with schizophrenia, bipolar disorder, or other serious mental illnesses who had been taking these drugs for at least 6 months. The goal was to safely taper or stop these medications …

This study tested an online guided self-help program called EMPOWER for medical professionals with mild depression or anxiety. The program teaches problem-solving and acceptance skills through videos and stories. 161 participants were randomly assigned to the program or a control…

This study tested whether listening to music during a daily cleaning procedure can reduce pain in children aged 6 months to 15 years in a pediatric intensive care unit. Each child experienced the cleaning twice—once with music and once without—and pain was measured using a standa…

This study tested whether wearing virtual reality goggles during the needle stick for dialysis can lower pain and anxiety. Fifty adults on hemodialysis were randomly assigned to either watch VR content during the procedure or receive usual care. The results will show if a simple,…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested a 6-week mindful self-compassion program for homeless women with PTSD and substance use. The program includes meditation, group discussions, and home practices. Researchers compared the program to usual care in 202 women living in a residential drug treatment fa…

This study tested whether internet-delivered cognitive behavior therapy (ICBT) can help teens aged 13-17 with mild to moderate depression. 219 participants were randomly assigned to guided ICBT (with therapist support), self-guided ICBT (without support), or usual care. The goal …

This study tested an 8-week program called STAIRS for people recovering from depression. The program combines group meetings with homework exercises to help improve personal recovery and daily functioning. 36 adults in the final phase of depression treatment took part. The goal w…

This study tested whether squeezing a stress ball during an ultrasound-guided biopsy can reduce pain and anxiety. 79 adults were randomly assigned to either use a stress ball or receive standard care alone. Researchers measured pain, anxiety levels, and vital signs before and aft…

This study looked at whether adding cognitive behavioral therapy (CBT) to standard medication (risperidone) could improve cognitive function in 42 adults with stable schizophrenia. Participants either received risperidone alone or risperidone plus 10 weekly CBT sessions. Research…

This small study tested whether adding whole-body hyperthermia (like a sauna session) to cognitive behavioral therapy (CBT) is feasible for adults with major depression. Sixteen participants received up to 8 weekly or 4 bi-weekly sauna sessions along with 8 weekly CBT sessions. T…

This study tested whether a short digital task could help NHS staff who kept having unwanted, intrusive memories of traumatic events from working during the COVID-19 pandemic. About 122 healthcare workers took part, using either a memory-competing computer game, a music-listening…

This study tested whether taking buprenorphine (a low-dose opioid) after a ketamine infusion can reduce suicidal thoughts more quickly and effectively than ketamine alone in people with major depression. Fifty adults participated, and researchers measured changes in suicidal idea…

This study tested whether aromatherapy with essential oils can reduce anxiety in adults before elective upper limb surgery. 289 participants were randomly assigned to either receive aromatherapy or not. The goal was to see if the scent helped people feel calmer in the operating r…

This study tested a 6-week program called BUILT for families with children aged 6 to 12 who have ADHD. The program teaches healthy habits around sleep, nutrition, and exercise to help improve focus and behavior. Researchers measured changes in physical activity, sleep, diet, and …

This study tested whether giving clonidine, a blood pressure medication, before electroconvulsive therapy (ECT) could reduce the confusion and agitation that often follows the procedure. ECT is effective for severe depression and bipolar disorder, but up to 65% of patients experi…

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This study tested whether a smartphone app could help people with PTSD quit smoking and avoid starting again. Participants received counseling, stop-smoking medications, and rewards for not smoking, plus the app. The goal was to see if the app made it easier to stay smoke-free co…

This study tested whether adding a virtual reality (VR) module that helps children imagine future events could improve standard brain-training exercises for kids with ADHD. Eighty children aged 5 to 12 took part, with half doing only the standard training and half also using VR h…

This study tested a new system called FamilyNet that uses a smart speaker and a mobile app to help parents of children aged 10-17 with challenging behaviors like oppositional defiant disorder or conduct disorder. The system helps parents create a positive behavior plan and sends …

This study tested a new drug, centanafadine, in 337 adults with major depression who hadn't responded well to at least one prior treatment. Some participants took the drug alone, others added it to their current antidepressant. The main goal was to see if it reduced depression sy…

This study tested a 3-week program that helps cancer patients identify their personal strengths (like hobbies, social support, or personal qualities) and use them to cope better. 32 adults with different cancers took part in card-sorting sessions, phone calls, and home exercises.…

This study tested whether a short, trauma-focused therapy called Narrative Exposure Therapy (NET) can help low-income urban teens aged 16–25 who have PTSD from violence and are at risk for substance use. Researchers measured changes in PTSD symptoms and alcohol use. The goal was …

This study tested whether a 6-session educational program could help people receiving electroconvulsive therapy (ECT) feel less stigma and anxiety about their mental health treatment. Sixty adult inpatients with conditions like depression or bipolar disorder took part. Those who …

This study tested whether Acceptance and Commitment Therapy (ACT) can improve the well-being of parents caring for children with autism. Thirty parents in Saudi Arabia took part in online ACT sessions over five weeks. Researchers measured changes in stigma, mindfulness, and stres…

This study tested a group therapy program called HUGS for mothers with postpartum depression. The goal was to see if it improves the mother-baby relationship compared to a playtime group. 104 mothers participated, and researchers measured bonding through video analysis. The thera…

This study tested whether wearing virtual reality goggles showing relaxing nature scenes and music during IUD insertion could reduce pain and anxiety. 70 women were randomly assigned to either VR or standard care. Researchers measured pain, anxiety, comfort, and vital signs. The …

This study tested whether wearing a virtual reality mask during blood draws and allergy skin tests helps children aged 7 to 13 feel less pain and anxiety. About 300 kids from two hospitals took part. The goal was to see if distracting them with VR makes these procedures easier to…

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study tested whether virtual peer support groups, co-led by a mental health clinician and a trained peer specialist, could help veterans with serious mental illness (like schizophrenia or bipolar with psychosis) feel more socially connected and less distressed. Twenty-eight …

This study tested an online program called ORCHID that helps people with HIV feel more positive emotions. The goal was to see if it could reduce depression and improve HIV care. 29 adults from Chicago clinics took part. The program was designed to be used on a phone or computer.

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study looks at whether a parent coaching and family navigation program (Project AFECT) can help families right after a child is diagnosed with autism. About 200 parents of children aged 1 to 5, who are Hispanic/Latino, Black/African-American, or have Medi-Cal insurance, will…

This study explores whether artificial intelligence can simplify the language used in informed consent forms for clinical trials. Researchers will test AI tools like ChatGPT and NotebookLM to rewrite these forms and see if people understand them better. The study involves 230 par…

Researchers at Hacettepe University are studying people who had surgery for a massive rotator cuff tear. They want to see how the brain's signals to shoulder muscles, shoulder function, and psychological resilience relate to each other. Participants complete shoulder and mood que…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This study looked at whether people with alcohol dependence or a history of early life stress have more trouble learning to feel calm after a scary event. Researchers used brain scans, mild electric shocks, and genetic tests to understand these differences. The goal was to learn …

This study looked at how hormone changes during perimenopause (the time around menopause) might affect mood and behavior. Over 1,100 women participated, including those with depression symptoms and healthy volunteers. No treatments were given; instead, researchers used surveys an…

This study explores the connection between anxiety and frailty in people aged 65 and older who are about to have hip replacement surgery. Researchers will measure anxiety and frailty using standard questionnaires before the operation. The goal is to understand how these factors r…

This completed study looked at how the brains of people with schizophrenia work when they are not taking antipsychotic medication. The goal was to tell apart the effects of the illness itself from the effects of the drugs. 648 participants stayed in a hospital and underwent brain…

This study tests a training program called DECIDE for MOM, designed to help healthcare providers better support pregnant and postpartum individuals with mental health concerns. The training teaches skills like shared decision-making and understanding patients' perspectives. Resea…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

Researchers at the University of California, San Francisco are studying how the brain processes rewards in people with early-onset schizophrenia, major depressive disorder, post-traumatic stress disorder, or gambling disorder, compared with healthy volunteers. Participants comple…

Researchers are studying whether immune and inflammatory markers in the blood relate to mood, fatigue, and thinking symptoms in people with major depression. The trial follows 30 adults starting SSRI antidepressants and compares them with 20 healthy volunteers. Participants give …

This study tests whether a training program for parents of children who have had a febrile convulsion (a seizure caused by fever) can lower parental anxiety and increase their knowledge about the condition. About 66 parents of children aged 6 months to 5 years will be randomly as…

This study follows people treated for anal cancer with radiotherapy to see how their sexual quality of life changes over time. Participants complete questionnaires during treatment, three months later, and two years after diagnosis. The goal is to understand the long-term impact …

This study is a small survey of 10 adults exploring how nutrition, mental health, and faith-based practices relate to recovery from trauma or PTSD. Researchers want to understand what helps people overcome life challenges after stressful events. The results will be used to design…

Researchers at Jacobs University Bremen are running a three-phase study to understand how environmentally friendly behaviors relate to eco-anxiety, well-being, and loneliness. About 1,684 adults complete surveys about their food choices, consumption habits, and feelings of social…

This study surveys Indonesian sports science undergraduates to understand how self-esteem, anxiety, sleep habits, and social media use relate to feelings of being a fraud (impostor phenomenon). Researchers aim to identify which psychological, behavioral, and structural factors mo…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers are collecting DNA and health information from 4,185 adults to understand the genetic causes of the condition. The goal is to improve diagnosis and treatment in the future, but th…

This study looked at 128 physiotherapy students to see if taking an academic literacy class helped with their reading, writing, and thinking skills. Researchers compared students who took the class to those who did not using surveys. The goal was to understand if such education b…

This study tested whether a 6-session psychoeducation program could improve autism knowledge, sibling relationships, well-being, and resilience in 88 adult siblings of people with autism. Participants were all neurotypical adults living in Greece. The program was designed to prov…

This study looks at whether certain immune system markers (IL-33, sST2, and CRP) are different in people with panic disorder compared to healthy individuals. Researchers will measure these markers in blood samples from 80 participants who have never taken medication for panic dis…

This study will measure levels of two proteins, LRFN5 and OLFM4, in the blood of 120 people—some with schizoaffective disorder and some healthy. Researchers want to see if these proteins are linked to symptoms, overall function, and inflammation. The goal is to better understand …

This study measures two blood proteins, LRFN5 and OLFM4, in people with methamphetamine use disorder, those with methamphetamine-induced psychosis, and healthy volunteers. Researchers want to see if these markers are linked to inflammation and symptom severity. The study involves…

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study aims to help people from underserved communities talk about their wishes for end-of-life care and complete advance directives. Researchers will use trusted community networks to host events where two conversation tools are tested. About 1500 adults will participate to …

This study looks at whether children diagnosed with a specific learning disorder that affects written expression have different fingertip touch, hand grip strength, and pain sensitivity compared to healthy children. Researchers will measure these sensations using simple tools lik…

This study tested a set of questions to better identify suicide risk in young people aged 8–17 with autism or other neurodevelopmental disorders. Researchers asked 278 participants and their parents about thoughts of self-harm and understanding of death. The goal was to create a …

This trial tests whether two mental training methods, computer-based multiple object tracking and mental imagery, can improve tennis performance, thinking skills, anxiety, and body responses in university students taking a tennis course. Participants either practiced tracking mov…

Researchers want to know whether people with depression spend more time looking at their own reflection after recalling a personal failure. The study uses an eye tracker to measure where participants look on a reflective black screen before and after a directed autobiographical r…

This trial tests whether a single session of transcranial magnetic stimulation (TMS) can alter brain activity related to reward processing in people with major depressive disorder. Researchers will compare active TMS to a sham (inactive) version, measuring brain signals during a …

This observational study examines how the brain processes rewards in people with major depressive disorder compared to those without. Using MRI and EEG, researchers measure brain responses during reward anticipation and feedback. The goal is to identify distinct neural patterns, …

This completed study at Massachusetts General Hospital tested whether a gentle brain stimulation technique called tDCS could help 86 adults with obsessive-compulsive disorder (OCD) unlearn fear responses. Participants received either real or fake (sham) stimulation while undergoi…

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This study looked at whether asking children with developmental language disorder to repeatedly recall new words helps them learn better than just hearing the words. Twenty-seven 4- and 5-year-olds learned made-up words during storybook reading. The goal was to see if retrieval p…

This study looks at how autistic people who also have anorexia nervosa differ in brain structure and behavior from autistic people without anorexia. Researchers want to understand if 'masking' (acting non-autistic to fit in) is linked to eating disorder symptoms and brain changes…

This study tests whether a structured communication protocol called StOP? helps surgical teams talk more clearly during operations. Researchers will compare death rates and other outcomes in 400 patients whose surgeons use the tool versus those who don't. The goal is to see if be…

This study follows children born moderately or late preterm (32-36 weeks) to age 9, measuring their thinking, movement, language, behavior, and growth. Researchers compare these kids to full-term peers to understand long-term effects. The goal is to learn how early development pr…

Researchers are testing whether a non-invasive brain stimulation technique called high-definition transcranial alternating current stimulation (HD-tACS) can change brain wave activity in people with schizophrenia who hear voices. The study compares patients with auditory hallucin…

This study tests whether a simple team debriefing tool, called an After-Action Review, can help child welfare teams better connect children and families to mental health services. Researchers will work with 320 participants, including caseworkers and family members, to see if the…

This pilot study is testing a program called Tiwahe Tewichaglapi, which adapts the Family Acceptance Project for Lakota 2SLGBTQ+ youth and their caregivers. The goal is to see if the program is acceptable, safe, and feasible, and to check if it helps reduce depression, anxiety, a…

This pilot study tested whether a nurse-led community-based rehabilitation program is feasible and acceptable for people with psychosis in Blantyre, Malawi. Sixty adults with psychosis were randomly assigned to either usual care or the home-based program. The study focused on rec…

This completed study at the NIH enrolled 96 children with known or suspected genetic disorders, including autism and Fragile X syndrome. The main goal was to give clinic staff hands-on experience and explore new research ideas. Participants received medical exams, lab tests, and …

This study tests whether brain scans and decision-making tasks can predict how well people with anxiety and depression respond to different types of talk therapy. Participants will be randomly assigned to one of three therapies: behavioral activation, exposure-based therapy, or s…

This study looks at women who have had bariatric (weight-loss) surgery and later given birth. It aims to understand if these women face higher rates of depression or anxiety after childbirth, and how their weight and nutrition change during this time. By tracking these factors, r…

This study investigates how emotional stress impacts sleep and learning in children aged 7 to 12 with autism spectrum disorder (ASD) or attention deficit hyperactivity disorder (ADHD). Researchers will use a social stress task to trigger emotional responses, then monitor sleep pa…

This study follows children with specific reading disorders (like dyslexia) who previously took part in a training program using the Poppins Clinical app, which combines musical, cognitive, and written language exercises. The goal is to see if the benefits of that training on rea…

This study asks whether a single 30-minute session of moderate exercise can raise natural brain chemicals called endocannabinoids and improve thinking, stress, and mood in children and teens aged 9 to 17. Participants are randomly assigned to brisk walking or jogging on a treadmi…

This study uses brain scans to compare how a single dose of two ADHD medications—guanfacine (a non-stimulant) and lisdexamfetamine (a stimulant)—affect brain function in children and teens with ADHD, relative to a placebo. Participants perform tasks of attention, working memory, …

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study investigates whether women who experience heavy bleeding (postpartum hemorrhage) after childbirth are more likely to develop depression, anxiety, or stress in the following year. Researchers will follow over 1,200 women who had a hemorrhage and compare them to those wh…

This study tests whether a French version of the Pain Sensitivity Questionnaire (PSQ) accurately measures a person's natural sensitivity to pain. The PSQ uses 17 questions about everyday situations that might cause pain. Researchers will compare answers from healthy volunteers an…

This study aims to adapt and validate a French version of the PAPA questionnaire, a tool designed to screen for psychological distress in fathers during the perinatal period. Researchers will test the questionnaire with 343 couples to see if it accurately captures symptoms like a…

This pilot trial tests whether adding social contact — personal stories and interactions with people who have mental illness — to standard mental health training can reduce stigma among primary care workers in Nepal. About 88 healthcare providers and their patients will take part…

This observational study looks at whether the types of bacteria living in the gut, along with diet and lifestyle, are linked to a person's risk of catching SARS-CoV-2. It follows over 900 children, their family members, and teachers in Spain for 17 months. Researchers collect sto…

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study looks at how a very low dose of LSD (13 micrograms) affects mood and behavior in 48 healthy adults. Some participants will be told exactly what they are getting (LSD or placebo), while others will not know. The goal is to understand whether people's expectations—not ju…

This study tests whether a script-guided conversation before surgery helps patients and their families better understand general anesthesia, the anesthesiologist's role, and the risks they are consenting to. Adults having elective surgery under general anesthesia will receive the…

This study looks at how fear of pain affects movement in 26 healthy adults. Researchers used verbal suggestions and inactive electrodes to create a sense of threat during walking and arm-pointing tasks. The goal is to understand how fear of movement changes walking speed, stride,…

This study looked at how adults with autism spectrum disorder (ASD) form emotional attachments to others. Researchers used questionnaires to measure social responsiveness and attachment styles in 32 adults with ASD. The goal was to better understand the link between autism and at…

This study tested whether three weekly sessions of basic disaster awareness education could improve disaster literacy and reduce earthquake anxiety in adolescents aged 10-14. A total of 128 students from two middle schools in Erzincan took part, with half receiving the education …

This completed study looked at how well a collaborative care model works for common mental health issues like anxiety and depression in four French health clinics. The model involves a care manager who coordinates between family doctors and mental health specialists. Researchers …

This study tested a 10-week emotional intelligence program for first-year college students aged 18-25. The program aimed to improve how students identify, understand, use, and manage emotions. Researchers measured changes in emotional attention, clarity, and regulation, as well a…

This study tests a tool called the Cultural Formulation Interview-Engagement Aid (CFI-EA), designed to help clinicians and patients from different cultural backgrounds communicate better. The goal is to see if using this tool improves patient satisfaction and keeps people in trea…

This study looked at how different ways of communicating (like talking in person vs. texting) change brain activity. Researchers used fMRI scans on 30 healthy young adults while they watched videos of different communication styles. The goal was to see if each style uses a differ…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This study looked at 30 adults aged 40-70 with treatment-resistant depression to see if changes in thinking skills (like memory and attention) could predict when depression improves. Researchers measured mood, daily function, and cognitive abilities before and after starting a ne…

This study tested a digital app called CICADAS, designed to improve thinking skills in teenagers with autism. Sixty-eight teens aged 11-18 used the app for up to 40 hours, doing exercises that adapt to their ability. The goal was to see if the app is acceptable and easy to use, n…

This study looked at how adults with autism spectrum disorder (ASD) and bipolar disorder (BD) experience and show emotions. Researchers measured things like heart rate, pupil size, and facial expressions in a lab, and also tracked emotions in daily life for a week. The goal was t…

This study used brain scans (fMRI) to look at how people process emotions and make decisions, comparing those who have attempted suicide, those with past suicidal thoughts, depressed patients without suicidal history, and healthy controls. The goal was to find brain activity patt…

This study tested whether using augmented reality (AR) or a 3D hip model helps first-year nursing students learn how to give intramuscular injections better than traditional methods. 146 students were randomly assigned to practice with AR, a 3D model, or a standard model. Researc…

This study looked at 40 people having both wisdom teeth removed, two weeks apart. Researchers measured two natural chemicals in the blood—serotonin and kynurenic acid—before and after surgery to see if they relate to pain and anxiety. The goal was to better understand how these c…

This study tested whether a computer program could predict which older patients (over 75) would have unnecessary days in the hospital. Researchers analyzed electronic health records from 102 patients in an acute geriatric unit. The goal was to create an algorithm that flags when …

This completed study looked at how adults with autism spectrum disorder (ASD) process emotions in moral situations, compared to people without autism. Researchers used stories about harm and accidents, then asked participants to quickly identify faces or judge if facial expressio…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This study looked at how people with schizophrenia process sounds and remember where information comes from. Researchers tested 50 participants (patients and healthy controls) using computer tasks. The goal was to understand if trouble telling sounds apart relates to difficulty d…

This pilot study tested a new type of brain training called neurofeedback for people with depression. Participants learned to control their own brain activity using real-time feedback from both EEG and fMRI scans. The goal was to see if combining these two methods could help impr…

This study follows couples who gave birth in either a midwifery-led birth unit or a standard obstetric unit in France. Researchers want to see if the type of care affects parents' mental health, especially post-traumatic stress, and the child's development up to two years later. …

This study looked at whether listening to upbeat music can change how people with depression perceive emotions in faces and voices. Researchers compared the effects of positive and neutral music in 39 adults with and without depression. The goal was to see if positive music could…

This study looked at how Doose syndrome, a rare form of epilepsy, affects children's ability to learn and develop. Researchers followed 9 children and asked their parents about the disease's impact on school and daily life. The goal was to better understand the link between seizu…

This pilot study tested a community-based intervention for people with psychosis in Malawi, Nigeria, Sierra Leone, and Zimbabwe. The program includes peer support from someone who has experienced psychosis, case management, and help with daily activities like finding work or soci…

This study tested whether a 6-session online class called HEARTS helps autistic adults feel more satisfied with their friendships and dating relationships, compared to a 6-week online discussion group. Ninety-two autistic adults took part over three months, completing surveys abo…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study tested a coaching program for doctors to improve communication with Black and Latinx families during hospital rounds. The program taught doctors to be more respectful, collaborative, and trauma-aware. Researchers measured whether families felt more trust and satisfacti…

This study looked at 103 adults with narcolepsy or obstructive sleep apnea to see if anxiety, social, or work factors affect their ability to stay awake during a standard test. Participants filled out an anxiety questionnaire before the test. The goal is to better understand why …

This study gave 100 healthy adults either 50 mg of CBG or a placebo to see how it affects anxiety, stress, mood, memory, and physical signs like heart rate and blood pressure. Researchers also tracked side effects like sleepiness or dry mouth. The goal is to better understand bot…

This study tested whether daily mood check-ins via a mobile app could help predict and prevent depression in people who recently had a stroke. Over 400 participants used the app for three months while researchers tracked their emotional symptoms. The goal was to see if this kind …

This study tested a program called Multi-Family Healing Spaces for families affected by the Rwandan genocide. 319 family members aged 12 and older from five districts took part. The program aimed to improve family communication, resilience, and mental health. Results will show if…

This study looked at whether a therapy called FAST (Forensic Outpatient Systemic Therapy) helps teens aged 12-21 with conduct disorder or aggressive behavior. The therapy involves weekly sessions with the teen and their caregivers for several months. Researchers measured changes …

This study tested a web application called PRATICAdr 2.0, designed to help healthcare workers on sick leave due to common mental disorders like depression or anxiety return to work. The app helps coordinators track progress and improve communication. Researchers compared workers …

This study looked at how low doses of LSD change the way healthy adults make decisions based on what they see. Thirty participants completed computer tasks that tested their ability to predict and respond to visual patterns. The goal was to understand how LSD influences brain sig…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tested a 4-session education program for people with early schizophrenia. The goal was to see if it helps patients feel more connected to their therapist, which is important for ongoing care. 21 hospitalized patients took part, and researchers measured changes in the p…

This study tested a new way to improve mental health services for people with psychosis in Uganda. Instead of just doctors making decisions, people who have experienced psychosis were trained to help at home, in the community, and at clinics. The goal was to see if this approach …

This study tested an 8-week parenting program called Circle of Security-Parenting for mothers with depression and infants showing signs of social withdrawal. Researchers compared it to standard care to see if it improves how mothers interact with their babies and helps the child'…

This study examines how often patients and their relatives develop post-traumatic stress disorder (PTSD) after a sudden cardiac arrest. Researchers interviewed 45 people (20 survivors and 20 relatives) within a week of the event and again at 3 months using standard questionnaires…

This study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques, which are linked to Alzheimer's disease. Researchers used a special PET scan to measure plaque levels after 8 weeks of antidepressant treatment. The goal was to unde…

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This study compared virtual reality (VR) training to standard classroom teaching for nursing students learning how to triage in a mass casualty incident. 100 nursing students took part. The goal was to see if VR helps them triage more accurately and quickly.

This study looked at brain activity in the frontal cortex of 14 people with Tourette syndrome using a 24-hour portable EEG. Participants pressed a button each time they had a tic, so researchers could compare brain signals with and without tics. The goal was to identify which bra…

This study looked at how often older adults feel anxious or depressed after breaking a bone from a fall and having surgery. Researchers used a simple questionnaire to check symptoms in 40 patients aged 65 and older, both those who had surgery and those who did not. The goal was t…

This study looked at 56 adults with fully remitted depression who wanted to stop their antidepressant. Researchers wanted to see how much of the withdrawal symptoms are caused by the drug itself versus the person's expectations. Participants were randomly assigned to either stop …

This study tested a 10-item questionnaire called DEPITAC, designed for nurses to screen road traffic accident patients for post-traumatic stress disorder (PTSD) while they are still in the surgical unit. Researchers enrolled 274 hospitalized accident victims to see if the simple …

This study aimed to find simple ways to predict how much pain people will feel after oral surgery, like having a tooth pulled. Researchers measured things like pain sensitivity before the procedure in 148 adults. The goal was to create a model that helps doctors plan better pain …

This study looked at how people with PTSD pay attention to their surroundings. Researchers used a change blindness test to see if patients are quicker to notice changes, especially emotional ones. 80 adults with PTSD and healthy controls participated. The goal was to understand t…

This study looked at 38 people who had a first stroke in the cerebellum, a brain area involved in mood. Researchers used interviews and smartphone tracking to measure depression, anxiety, and apathy in daily life. The goal was to better understand how these mood problems develop …

This completed study looked at sleep problems in over 1,100 children and adults with specific learning disabilities (like dyslexia or dyspraxia), with or without ADHD. Participants filled out online questionnaires about their sleep habits. The goal was to find out how common diff…

This study looked at brain activity in adults with ADHD while they performed tasks that required stopping an action. Researchers used EEG to measure electrical signals in the brain. The goal was to understand the brain processes behind impulse control problems in ADHD. No treatme…

This study interviewed 12 mothers who had participated in HUGS mother-baby therapy groups for postpartum depression. The goal was to understand how the program affected their bond with their baby and their daily lives, 6 to 12 months later. Researchers used in-depth interviews to…

This study looks at 128 children who were part of an early intervention program in infancy and are now teenagers. Researchers measure brain activity, stress responses, and behaviors like risk-taking and mood to see if early help made a difference. No new treatment is given; this …