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Fish oil and remote rehab: a new hope for long COVID sufferers?

NCT ID NCT06063031

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests whether a combination of a special omega-3 supplement (LIPINOVA®) and a home-based exercise and education program can improve quality of life for people with lingering post-COVID symptoms. About 146 adults aged 18–70 who have had symptoms for more than 12 weeks will take part. Half will receive the active supplement plus telerehabilitation, and the other half will receive a placebo supplement plus the same rehab program. The goal is to see if this approach can reduce inflammation and ease common long COVID problems like fatigue, shortness of breath, and mental fog.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Omega-3 fatty acids (EPA, DHA) and their natural anti-inflammatory metabolites (SPMs) as a dietary supplement (LIPINOVA®)
What this could lead to
If it works, this approach could offer a safe, non-drug way to reduce fatigue, brain fog, and other lingering post-COVID symptoms, improving daily life for millions.
What could go wrong
This is a relatively small, early-stage trial. The supplement may not reduce symptoms more than placebo, and individual results can vary. Dietary supplements are not strictly regulated like drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

146 people

The number who actually took part.

Started

Sep 2022

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * To have signed the informed consent form. * Age between 18 and 70 years with access to and knowledge of basic use of technological applications. * Patients with clinical criteria of having suffered from COVID-19 with diagnosis confirmed by diagnostic techniques and systems in health centers (PCR, rapid antigen test, and/or serology (positive anti-N antibodies). * Patients who remain symptomatic for more than 12 weeks after the onset of symptoms. * Patients who manifest symptoms compatible with CPCOVID since the end of the acute phase\*. * Patients with fatigue greater than or equal to an average of 4 points on the FSS. * Independent ambulation, even with the use of technical aids. Exclusion Criteria: * Patients with severe neurological diseases at the central and/or peripheral level that prevent them from following the program. * Patients with respiratory insufficiency: SaO2 \< 90% or respiratory rate ≧30. * Patients with rheumatic diseases or acute musculoskeletal injuries that do not allow exercise. * Patients who do not have access to the Internet or are unable to use the Internet on a daily basis. * Patients with clinical symptoms consistent with chronic fatigue syndrome (In the end, this criterion was not applied in the study) * Presence of symptoms consistent with CPCOVID prior to SARS Cov-2 infection. * Pregnant or lactating women or women of childbearing age who are trying to become pregnant. * Patients unable to follow oral and written instructions in Spanish. * Patients with an allergy to fish, shellfish, or any of the ingredients of the preparation. * Patients enrolled in another clinical trial for the treatment of symptomatology derived from COVID -19. * Patients who have completed another clinical trial in the 4 weeks prior to enrollment. * Patients who have received immunosuppressive medications and/or corticosteroids in the last 2 weeks prior to enrollment. Patients who have received nonsteroidal anti-inflammatory drugs (NSAIDs) continuously or on a fixed regimen in the 2 weeks prior to treatment initiation. Patients who have been taking NSAIDs may have a 7-day withdrawal period. * Women of childbearing age who are not willing to take NSAIDs should not be treated.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • IIS Aragón

    Zaragoza, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.