CBD oil shows promise for easing anxiety and depression in Parkinson's patients
NCT ID NCT07651930
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether full-spectrum CBD oil can help with anxiety and depression in people with Parkinson's disease. Twenty-seven participants took one of three daily doses (30, 60, or 300 mg) for two months. Researchers measured changes in anxiety and depression scores, along with sleep, fatigue, and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- full-spectrum cannabidiol (CBD) oil
- What this could lead to
- If it works, this could point toward a safe, natural supplement to ease anxiety and depression in people with Parkinson's disease.
- What could go wrong
- This is a small, early-phase trial with only 27 participants. The results may not apply to everyone, and CBD can cause side effects like drowsiness or stomach issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
27 people
The number who actually took part.
- Started
-
Dec 2023
- Finished
-
Nov 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
40 to 70 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosed Parkinson's Disease according to MDS Clinical Diagnostic Criteria (2015). * Disease duration ≥4 years before study inclusion. * Age between 40 and 70 years at enrollment. * Stable oral medication regimen (including Parkinson's disease medications, antidepressants, and anxiolytics) for at least 1 month prior to inclusion and maintained throughout the study (up to 2 months from inclusion). * Moderate or higher anxiety-depressive symptoms at baseline (BDI ≥11 points, BAI ≥16 points) Exclusion Criteria: * Dementia or cognitive impairment. * Advanced Parkinson's therapy (DBS, infusion pumps, ablation) or planned initiation within study duration (2 months). * No caregiver support. * Pregnancy, breastfeeding, or lack of contraception in women of childbearing potential. * Neurological or psychiatric disorders affecting evaluation (vascular CNS damage, previous CNS surgery). * Musculoskeletal conditions preventing motor assessments. * Active malignancy. * Cannabinoids use within the last 30 days. * Use of hepatotoxic drugs or drugs with potential toxic interaction with CBD (e.g., valproic acid, warfarin, haloperidol) within 90 days prior to inclusion. * Paracetamol intake exceeding 1 g/day during study participation
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw
Warsaw, Poland
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