PERIODONTITIS
Clinical trials for PERIODONTITIS explained in plain language.
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Shining a light on gum disease: laser therapy aims to zap harmful bacteria
Disease control CompletedThis study tested whether adding a special laser light treatment could improve results for people with severe gum disease. After a standard deep cleaning, researchers applied a light-activated gel to the gums and then used a laser to try to kill leftover harmful bacteria. The goa…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Universita di Verona • Aim: Disease control
Last updated Apr 02, 2026 00:42 UTC
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Ozone gas tested to supercharge gum disease treatment
Disease control CompletedThis study tested whether adding ozone gas therapy improves the standard non-surgical cleaning treatment for severe gum disease (periodontitis). Researchers worked with 39 adults who had severe gum disease to see if the ozone treatment killed more harmful bacteria and led to bett…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Universita di Verona • Aim: Disease control
Last updated Apr 02, 2026 00:41 UTC
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New mouthwash formula tested to fight gum disease
Disease control CompletedThis study compared two different mouthwash formulas to see which one works better at reducing gum inflammation and preventing gum disease from coming back. 72 people with gingivitis used either a standard 0.12% chlorhexidine mouthwash or a new formula with a lower dose of chlorh…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: University of Siena • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Scientists test Zinc-Infused bone graft to rebuild jawbone lost to gum disease
Disease control CompletedThis study tested whether a new bone graft material, enhanced with zinc and combined with a patient's own concentrated healing factors (platelet-rich fibrin), could help regrow bone lost to severe gum disease (periodontitis). Thirty adult patients with healthy gums but deep bone …
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Suez Canal University • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Deep cleaning transforms lives: gum therapy restores chewing and boosts happiness
Disease control CompletedThis study tested how treating severe gum disease affects a person's ability to chew and their overall quality of life. Forty adults—20 with severe gum disease and 20 with healthy gums—participated. The patients with gum disease received deep cleaning treatments and, when needed,…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Ankara Medipol University • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Could your own blood help fix your gums?
Disease control CompletedThis study tested if adding a special preparation made from a patient's own blood, called injectable platelet-rich fibrin (i-PRF), could improve results from standard gum surgery. Forty-two adults with moderate to severe gum disease had surgery. Half received the standard treatme…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Halil Ata BIÇAKÇIOGLU • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Own blood used to fight gum disease and regrow bone
Disease control CompletedThis study tested whether adding a material made from a patient's own blood, called Platelet-Rich Fibrin (PRF), could help regrow bone and gum tissue lost to severe gum disease. 60 adults with gum disease and bone loss were randomly assigned to receive either standard gum surgery…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Armed Forces Institute of Dentistry, Pakistan • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Study tests gels to fight diabetic gum disease
Disease control CompletedThis study tested whether adding antibiotic gels to a standard dental cleaning improves gum health for people with diabetes who have periodontitis (serious gum disease). 380 patients were divided into four groups to compare cleaning alone versus cleaning plus one or two different…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Riphah International University • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Laser light boosts gum healing in smokers, study finds
Disease control CompletedThis study tested whether adding a special laser treatment to standard deep cleaning improves gum health for smokers with severe gum disease. Thirty-three smokers received either the standard cleaning alone or the cleaning plus laser therapy. After three months, the group that re…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Selcuk University • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Fasting diet tested to calm gum disease Flare-Ups after treatment
Disease control CompletedThis study tested whether a special 5-day plant-based diet, designed to mimic the effects of fasting, could reduce harmful inflammation in the body and gums after deep cleaning treatment for advanced gum disease. Researchers compared 28 patients who either followed this diet for …
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Universitat Internacional de Catalunya • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Shining a light on gum disease: laser treatment study seeks better results
Disease control CompletedThis study tested whether adding a special light-activated treatment (Fotosan®630) to standard care helps people with severe, ongoing gum disease. It involved 36 adults with significant gum damage to see if this approach improved gum health over six months. The goal was to find o…
Matched conditions: PERIODONTITIS
Phase: PHASE4 • Sponsor: University Hospital, Strasbourg, France • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Shine a light on gum disease: home device aims to zap harmful bacteria
Disease control CompletedThis study tested a special light device for home use, designed to help control chronic gum disease. The device uses a mouth rinse that sticks to plaque, then a light activates it to kill bacteria, potentially reducing inflammation and bleeding gums. Researchers wanted to see if …
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Koite Health Oy • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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Surprising link: gum treatment may ease prostate and bladder woes
Disease control CompletedThis study tested whether treating gum disease could help men with chronic prostate inflammation or repeated urinary tract infections. Researchers divided 60 men with both gum disease and these urinary conditions into groups that received different levels of dental care. They mea…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: University of Salamanca • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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Night guard fights gum disease in snorers
Disease control CompletedThis study tested whether wearing a special oral appliance (mouthpiece) with a shield at night could help reduce symptoms of gum disease in adults who snore and breathe through their mouth. Over 12 weeks, 43 participants with mild to moderate gum disease used the device while als…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Texas A&M University • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Gentler gum cleaning tested to replace painful scraping
Disease control CompletedThis study tested if a gentler air-polishing device using a sugar alcohol powder works as well as traditional deep cleaning (scaling and root planing) for maintaining gum health. It involved 20 patients with treated gum disease, comparing how well each method reduced gum problems…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Cardenal Herrera University • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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Could a deep dental clean ease arthritis pain?
Disease control CompletedThis study tested whether professional dental cleaning (nonsurgical periodontal therapy) could help people who have both rheumatoid arthritis and serious gum disease. Researchers wanted to see if reducing gum inflammation would also lower body-wide inflammation, potentially impro…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: University of Malaya • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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Could cleaning your teeth help you smell better?
Disease control CompletedThis study looked at the connection between gum disease, bad breath, and the sense of smell. Researchers followed 101 adults with gum disease and bad breath before and after they received a standard deep dental cleaning. They measured bad breath chemicals and tested smell ability…
Matched conditions: PERIODONTITIS
Sponsor: Batman University • Aim: Disease control
Last updated Mar 25, 2026 14:09 UTC
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Could your own blood help save your teeth? new gum disease gel tested
Disease control CompletedThis study tested if adding a special gel made from a patient's own blood could improve healing after a deep cleaning for gum disease. In 23 adults with moderate-to-severe gum disease, one side of the mouth received the standard cleaning plus the gel, while the other side receive…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Saglik Bilimleri Universitesi • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Fish oil pills & aspirin: a new hope for Smokers' failing gums?
Disease control CompletedThis study tested whether taking omega-3 fish oil supplements and low-dose aspirin, with or without an antibiotic, could improve the results of professional gum cleaning for smokers with severe gum disease. It involved 45 smoker participants to see if this combination reduced gum…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Alexandria University • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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Shining a light on gum disease: laser therapy tested as new treatment
Disease control CompletedThis study tested whether adding two types of laser light therapy to the standard deep cleaning treatment helps people with moderate-to-severe gum disease. Twenty participants received either the laser treatments or a placebo alongside their regular cleaning. Researchers measured…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Universidade Federal Fluminense • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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Laser battle for healthier gums
Disease control CompletedThis study compared two types of laser treatments for moderate gum disease (periodontitis) to see which was better at controlling the condition. Thirty-three participants with specific gum problems received either a diode laser treatment, an Nd:YAG laser treatment, or conventiona…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Nada Shaban • Aim: Disease control
Last updated Mar 23, 2026 15:14 UTC
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Gum surgery gel showdown: can new option match gold standard?
Disease control CompletedThis study tested whether a hyaluronic acid gel works as well as a standard protein gel when both are used with a bone graft material during gum surgery. The goal was to see which gel helps regrow more bone, reduce deep gum pockets, and improve attachment in adults with severe gu…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Medical University of Sofia • Aim: Disease control
Last updated Mar 20, 2026 14:48 UTC
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Ozone gas tested to boost gum disease treatment
Disease control CompletedThis study tested whether adding ozone gas treatment to standard deep cleaning helps people with gum disease (periodontitis). In 18 participants, researchers compared one side of the mouth that received cleaning plus ozone to the other side that received cleaning alone. They chec…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Biruni University • Aim: Disease control
Last updated Mar 16, 2026 15:25 UTC
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Can fixing gums stop teeth grinding?
Disease control CompletedThis study tested whether treating severe gum disease could reduce teeth grinding and clenching, both while awake and asleep. It involved 40 adults with and without gum disease, measuring their grinding activity before and three months after a standard gum cleaning treatment. The…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: University of Siena • Aim: Disease control
Last updated Mar 16, 2026 15:24 UTC
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Could cleaning your gums help you smell better?
Disease control CompletedThis study looked at whether treating gum disease (periodontitis) could improve a person's sense of smell and reduce tongue coating. Researchers treated 108 non-smoking adults with gum disease and measured their smell ability and tongue coating before and after treatment. The goa…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Batman University • Aim: Disease control
Last updated Mar 11, 2026 14:53 UTC
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Gentle spray vs. metal tools: which cleans gums better?
Disease control CompletedThis study compared two standard deep cleaning methods for treating gum disease (periodontitis). Researchers tested a gentle spray system (Airflow®) against traditional metal hand tools to see which causes less tissue damage and better reduces inflammation. They measured gum heal…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Universidad de Granada • Aim: Disease control
Last updated Mar 11, 2026 14:53 UTC
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Shining a light on bad breath: laser therapy tested
Disease control CompletedThis study tested whether adding a special laser treatment to standard gum cleaning and tongue scraping helps control chronic bad breath in people with serious gum disease. Researchers worked with 40 adults who had both conditions. They measured bad breath using a professional's …
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Federal University of Minas Gerais • Aim: Disease control
Last updated Mar 06, 2026 15:38 UTC
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Could cleaning your teeth ease your arthritis?
Disease control CompletedThis small study tested whether treating gum disease (periodontitis) could help reduce the severity of rheumatoid arthritis (RA) in people who have both conditions. Researchers enrolled 22 patients with both RA and gum disease to see if professional dental cleaning and treatment …
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: University Hospital, Toulouse • Aim: Disease control
Last updated Mar 02, 2026 15:25 UTC
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Could a painless laser make braces faster and more comfortable?
Symptom relief CompletedThis study tested if a gentle, painless laser treatment could help people wearing braces. Researchers wanted to see if the laser could reduce common problems like pain and gum inflammation, and possibly help teeth move faster. They compared two groups of 108 young adults getting …
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Aga Khan University • Aim: Symptom relief
Last updated Mar 23, 2026 15:19 UTC
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Spit test could reveal hidden health links
Knowledge-focused CompletedThis study aimed to better understand the links between gum disease, type 2 diabetes, and diabetic kidney disease by measuring specific inflammation markers. Researchers compared 126 people with either newly diagnosed diabetes or diabetes with kidney problems, grouping them by th…
Matched conditions: PERIODONTITIS
Sponsor: Pamukkale University • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Scientists probe Smoking's hidden role in worsening gum disease
Knowledge-focused CompletedThis study aimed to understand how smoking changes the body's immune response in gum disease (periodontitis). Researchers collected small gum tissue samples from 80 adult volunteers, including smokers and non-smokers with and without gum disease. They analyzed these samples to se…
Matched conditions: PERIODONTITIS
Sponsor: Suleyman Demirel University • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Dental x-rays could reveal hidden signs of gum disease
Knowledge-focused CompletedThis study looked at whether standard dental X-rays can show differences in jawbone quality between people with gum disease and healthy people. Researchers analyzed 120 existing X-rays using special computer measurements to compare bone patterns. The goal was to see if these X-ra…
Matched conditions: PERIODONTITIS
Sponsor: Istanbul University • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Scientists use 3D and heat imaging to watch gum surgery healing
Knowledge-focused CompletedThis study compared how patients heal after two different gum surgery procedures for periodontal disease. Researchers used 3D imaging to measure swelling and thermal imaging to track temperature changes in the healing area. The goal was to understand which surgical technique caus…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Queen Mary University of London • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Scientists search for gum disease clues in your Mouth's fluid
Knowledge-focused CompletedThis study aimed to understand gum disease better by measuring specific inflammation markers in the fluid around the gums. It involved 90 people with healthy gums, gingivitis, or periodontitis. Researchers collected fluid samples before and after a standard professional teeth cle…
Matched conditions: PERIODONTITIS
Phase: NA • Sponsor: Giresun University • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC
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Could your fitness level protect your gums?
Knowledge-focused CompletedThis study looked back at health records to see if there's a link between a person's physical fitness, body weight, and the health of their gums. Researchers analyzed data from 61 adults, checking their gum health, activity levels, and body measurements. The goal was to understan…
Matched conditions: PERIODONTITIS
Sponsor: Universidad Rey Juan Carlos • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:35 UTC
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Researchers ask: how do mouth problems affect daily life for IBD patients?
Knowledge-focused CompletedThis study aimed to understand how oral health issues like gum disease, cavities, and tooth loss affect the daily life and well-being of people with Crohn's disease or ulcerative colitis. Researchers compared survey responses from 138 adults with IBD to people without IBD. The go…
Matched conditions: PERIODONTITIS
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:33 UTC
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Could your gum health be tied to Alzheimer's? new study investigates blood clues
Knowledge-focused CompletedThis study aimed to investigate a possible link between gum disease (periodontitis) and Alzheimer's disease by analyzing blood test results. Researchers compared 100 people who had both conditions to people who had gum disease alone. They looked for patterns in standard blood cel…
Matched conditions: PERIODONTITIS
Sponsor: Uskudar University • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:33 UTC
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Smokers' addiction may blind them to gum disease warning signs
Knowledge-focused CompletedThis study looked at whether a person's level of nicotine addiction affects how aware they are of their gum disease. Researchers surveyed and examined 350 adult smokers who had gingivitis or periodontitis. The goal was to understand if stronger addiction makes people less likely …
Matched conditions: PERIODONTITIS
Sponsor: Erzincan University • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:32 UTC
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Scientists look inside gum cells to unlock Diabetes-Oral health link
Knowledge-focused CompletedThis study aimed to understand the connection between diabetes, gum disease, and changes in gum cells. Researchers examined gum cells from 95 adults with diabetes and different levels of gum disease to see if poor blood sugar control was linked to visible cell damage. The goal wa…
Matched conditions: PERIODONTITIS
Sponsor: Çankırı Karatekin University • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:30 UTC
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Decade-Long study tracks why young people lose teeth to gum disease
Knowledge-focused CompletedThis study followed 471 young adults with gum disease for over 10 years to understand how the disease gets worse over time. Researchers wanted to find out what factors cause the disease to progress and why some young patients stop their treatment. They also looked for biological …
Matched conditions: PERIODONTITIS
Sponsor: Folktandvården Stockholms län AB • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:29 UTC
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Blood Sugar's hidden toll on your smile
Knowledge-focused CompletedThis study aimed to better understand the connection between diabetes and dental health. Researchers examined 120 adults with type 2 diabetes and gum disease to see if their level of blood sugar control was linked to the severity of their gum problems and tooth decay. The study d…
Matched conditions: PERIODONTITIS
Sponsor: Afyonkarahisar Health Sciences University • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:28 UTC
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Spit test for gum disease? researchers hunt for clues in saliva
Knowledge-focused CompletedThis study aimed to find out if certain inflammation markers in saliva can be used to diagnose gum disease. Researchers collected saliva from 60 people with healthy gums, gingivitis, or periodontitis. They measured three specific proteins to see if their levels differed between t…
Matched conditions: PERIODONTITIS
Sponsor: Izmir Katip Celebi University • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:03 UTC
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Decade-Long dental implant study reveals what makes patients happy
Knowledge-focused CompletedThis study followed 163 patients for 8-14 years after receiving dental implants to understand long-term satisfaction and complications. Researchers examined patients' mouths and asked about their experiences to identify what factors lead to successful implants versus problems lik…
Matched conditions: PERIODONTITIS
Sponsor: Folktandvården Stockholms län AB • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:20 UTC
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Scientists search for gum disease clues in spit
Knowledge-focused CompletedThis study aimed to understand gum disease better by comparing levels of specific proteins in saliva and gum fluid between people with periodontitis and healthy individuals. Researchers enrolled 44 participants—half with gum disease and half without—and measured these protein lev…
Matched conditions: PERIODONTITIS
Sponsor: Melis Yilmaz • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:19 UTC
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Looking back: does gum surgery hold up years later?
Knowledge-focused CompletedThis study looked back at the results of surgeries performed to treat severe gum disease (periodontitis). Researchers reviewed the dental records of 126 patients who had a specific type of gum surgery at a London hospital between 2017 and 2019. They then invited some patients bac…
Matched conditions: PERIODONTITIS
Sponsor: Queen Mary University of London • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:17 UTC
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Scientists probe if gum disease throws off your Body's clock
Knowledge-focused CompletedThis study aimed to understand if gum inflammation is linked to changes in the body's internal clock within the gums themselves. Researchers compared 60 adults with similar sleep patterns, who had either healthy gums, gingivitis, or more serious periodontitis. They analyzed small…
Matched conditions: PERIODONTITIS
Sponsor: Inonu University • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:16 UTC
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Scientists probe hidden chemical links in gum disease
Knowledge-focused CompletedThis study aimed to understand the connection between low oxygen levels, a specific inflammation-related chemical pathway, and the severity of gum disease (periodontitis). Researchers compared 23 people with gum disease to 22 people with healthy gums by analyzing their saliva and…
Matched conditions: PERIODONTITIS
Sponsor: Istanbul Medipol University Hospital • Aim: Knowledge-focused
Last updated Mar 16, 2026 15:25 UTC
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Better dental knowledge linked to healthier gums, study finds
Knowledge-focused CompletedThis completed study looked at whether people's understanding of oral health affects their gum health. Researchers examined 108 adults in Turkey, measuring their dental knowledge and checking their gums. The goal was to see if lower health knowledge is connected to worse gum dise…
Matched conditions: PERIODONTITIS
Sponsor: Biruni University • Aim: Knowledge-focused
Last updated Mar 03, 2026 14:06 UTC
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Scientists probe link between failing gums and nighttime jaw clenching
Knowledge-focused CompletedThis study aimed to understand if people with severe gum disease (periodontitis) have different patterns of nighttime teeth grinding (sleep bruxism) compared to people with healthy gums. Researchers monitored the jaw muscle activity of 40 adults, half with gum disease and half wi…
Matched conditions: PERIODONTITIS
Sponsor: University of Siena • Aim: Knowledge-focused
Last updated Mar 02, 2026 15:23 UTC