PERIODONTITIS

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This study compares two minimally invasive treatments for deep gum disease bone defects: a non-surgical approach (MINST) and a surgical one (MIST). Researchers want to see if the non-surgical method can achieve similar bone and gum attachment improvements as surgery, but with les…

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This study tested whether adding a light-based antibacterial treatment called photodynamic therapy (PDT) to standard deep cleaning improves gum health in people with moderate gum disease. Thirty adults received standard cleaning on one side of the mouth and standard cleaning plus…

This study looked at 40 adults aged 35–55 with a history of periodontitis (gum disease) who needed a dental implant. Each received one of two implant surface types: sandblasted acid-etched or plasma-sprayed. Researchers measured bone loss around the implant and gum health over on…

This study tested whether adding a light-activated therapy, called antimicrobial photodynamic therapy (aPDT), to standard deep-cleaning for gum disease could kill more bacteria and improve gum health. Fifty adults with severe periodontitis received standard cleaning alone or with…

This early-phase study tested whether an ozonated sunflower seed oil gel could improve gum disease treatment when used alongside standard deep cleaning. Sixty adults with stage II periodontitis were divided into groups receiving either cleaning alone or cleaning plus a regular or…

This study looked at whether adding ozone gas to standard deep cleaning helps treat severe gum disease (periodontitis). 39 adults received the usual cleaning plus ozone, and researchers measured bacteria levels and gum pocket depths. The goal was to see if ozone kills more bacter…

This study tested whether a melatonin gel applied to the gums can improve the results of standard deep-cleaning treatment for gum disease. Thirty adults with periodontitis received either the melatonin gel or a placebo gel alongside their regular dental cleaning. Researchers meas…

This study looked at 51 adults with advanced gum disease and loose front teeth. Researchers compared minimally invasive non-surgical therapy (MINST) alone versus MINST plus splinting (joining teeth together for support). The goal was to see if adding splints improves gum health a…

This study tested whether a special oral gel called PHTALOX® could make standard deep-cleaning treatments for gum disease more effective. Forty-five adults with moderate to severe periodontitis received standard scaling and root planing, plus either the PHTALOX® gel, a chlorhexid…

This study tested whether adding ozone gas to a standard deep cleaning (scaling and root planing) helps treat stubborn gum pockets in people with advanced gum disease. Twenty-six adults with stage III or IV periodontitis and pockets 5mm or deeper took part. Researchers measured g…

This study tested whether applying a probiotic (Lactobacillus reuteri) directly into gum pockets, alongside standard deep cleaning, improves gum health in people with type 2 diabetes. Fourteen adults with moderate to severe gum disease and controlled diabetes took part. Each pers…

This study tested a collagen-based gel called H42 in 38 adults with gum disease (periodontitis). The gel was placed into deep gum pockets after standard cleaning. Researchers measured how much pocket depth decreased over 12 weeks, along with other signs of gum health and patient …

This study tested whether adding ozone therapy to standard gum surgery improves outcomes for people with advanced gum disease (stage III periodontitis). Twenty-four adults received surgery on both sides of their mouth, with one side also getting ozone treatment. Researchers measu…

This study tested whether adding chlorhexidine and zinc to standard deep-cleaning (scaling and root planing) improves gum health in people with early-stage periodontitis. 44 participants were split into two groups: one received the standard cleaning with the antimicrobial solutio…

This study tested whether taking antibiotics along with standard deep-cleaning treatment (scaling and root planing) improves gum health in adults with periodontitis. 236 participants from dental practices across the U.S. were randomly assigned to receive either antibiotics (amoxi…

This study looked at whether adding platelet-rich fibrin (PRF) or injectable PRF, made from a patient's own blood, to standard deep cleaning can improve gum health in people with periodontitis. 56 participants received either standard treatment alone or with PRF/i-PRF added. Rese…

This completed trial tested a new bone substitute called ALBO-OS in 20 people with periodontitis (severe gum disease) or needing jawbone preservation after tooth extraction. The material was placed into deep gum pockets or empty tooth sockets to help new bone grow. Early results …

This study tested whether a hyaluronic acid gel or a chlorhexidine mouthwash works better as a follow-up home treatment after deep cleaning for gum disease. Forty adults with periodontitis used one of the two products for 15 days after their dental cleaning. Researchers measured …

This study looked at whether deep cleaning of the gums (non-surgical periodontal therapy) could reduce prostate-specific antigen (PSA) levels and urinary tract infections in men with both gum disease and chronic prostatitis or recurrent UTIs. Sixty men were split into three group…

This study tested two different lasers (Nd:YAG and diode) for treating stage II gum disease. Thirty-three adults with deep gum pockets received one of the laser treatments or standard care. Researchers measured bacteria levels and gum health to see which approach worked best.

This study looked at whether a toothpaste made from black seed (Nigella sativa) can lower signs of gum inflammation in 100 Indonesian soldiers with gingivitis. Researchers measured certain proteins in saliva that are linked to gum disease. The goal was to see if this toothpaste c…

This study tested whether adding laser therapy to standard deep cleaning improves gum health in people with severe periodontitis. Twenty adults received either antimicrobial photodynamic therapy (using a blue dye and laser) or photobiomodulation (red or infrared laser) alongside …

This study tested whether a gel made from patients' own blood, called albumin platelet-rich fibrin (Alb-PRF), can improve gum healing after deep cleaning for advanced gum disease. Twenty-three adults with Stage 3 periodontitis received the gel in deep gum pockets on one side of t…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This study tested whether adding ozone gas to standard deep-cleaning treatment helps people with gum disease (periodontitis). 18 healthy, non-smoking adults received standard cleaning on one side of the mouth and cleaning plus ozone on the other side. Researchers measured pocket …

This study tested whether platelet-rich fibrin (PRF), made from a patient's own blood, can improve gum and bone regeneration after standard periodontal surgery. Sixty adults with chronic gum disease and bone defects were randomly assigned to surgery alone or surgery plus PRF. Res…

This study tested whether adding omega-3 fish oil and low-dose aspirin to standard deep-cleaning treatment helps smokers with severe gum disease. Forty-five smokers were split into three groups: one got omega-3 and aspirin, another got those plus the antibiotic doxycycline, and t…

This study tested a light-activated treatment called Fotosan®630 for severe gum disease (periodontitis). The goal was to see if it could reduce deep gum pockets and infection better than standard care. The trial involved 36 adults with severe chronic periodontitis and followed th…

This study tested if a special light device used at home can help manage chronic periodontitis, a serious gum infection. 202 adults with gum disease used the device regularly to see if it reduced bleeding and improved gum health. The goal was to offer an easy, non-invasive way to…

This study tested a new combination treatment for gum disease-related bone loss. Thirty adults with deep gum pockets received a graft made from zinc-substituted nano-hydroxyapatite (a bone-like material) mixed with advanced platelet-rich fibrin (a blood-derived healing scaffold).…

This study looked at whether treating gum disease (periodontitis) can improve blood sugar control in people with diabetes. 91 patients were randomly assigned to receive either gum treatment or no treatment (with treatment offered later). The main measure was change in hemoglobin …

This study looked at whether treating gum disease (periodontitis) can reduce the severity of rheumatoid arthritis (RA) in people who have both conditions. Researchers enrolled 22 adults with RA and gum disease, providing periodontal treatment and measuring changes in RA activity …

This study tested two mouthwashes—one with 0.12% chlorhexidine and another with a lower dose of chlorhexidine plus cetylpyridinium chloride—to see which better controls gum inflammation and bacteria in people with gum disease. 72 adults used one of the rinses for a month after a …

This study tested whether a hyaluronic acid gel (HyaDent BG) works as well as Emdogain, a standard treatment, for repairing bone defects caused by gum disease. Both were used with a bone graft material during surgery. Seventeen adults with advanced periodontitis took part. The go…

This study tested a gum surgery that combines a connective tissue graft with a special protein gel (enamel matrix derivative) to help regrow bone and gum tissue in people with advanced gum disease. Seventeen adults with deep gum pockets received the treatment, and researchers mea…

This study tested whether adding a diode laser to standard deep cleaning helps smokers with severe gum disease. 33 smokers were split into two groups: one got standard cleaning alone, the other got cleaning plus laser. After 3 months, the laser group had shallower gum pockets, le…

This study tested whether a gel made from patients' own blood (injectable platelet-rich fibrin, or i-PRF) could improve healing after standard gum surgery for periodontitis. 42 adults with deep gum pockets received surgery alone or surgery plus i-PRF and a root-cleaning gel. Rese…

This study tested whether a special oral appliance called myTAP, combined with a mouth shield and deep dental cleaning, can reduce gum disease in people who snore and breathe through their mouth. 43 adults with mild to moderate gum disease completed the 12-week trial. The device …

This study tested two antibiotic gels (metronidazole and minocycline) in 380 adults with both diabetes and gum disease. Participants received deep cleaning alone or with one or both gels. Researchers checked gum pocket depth and gum color/texture at 7 and 15 days to see which tre…

This study tested two deep-cleaning methods for gum disease (periodontitis) in 36 adults: a water-and-powder spray (Airflow®) and traditional hand scraping. Researchers measured gum bleeding, pocket depth, and signs of inflammation in mouth fluid to see which method causes less t…

This study tested a new mouth rinse made with coconut oil and xylitol to see if it could improve gum health in people with periodontitis. 120 adults used the rinse or a placebo three times a day for three weeks. Researchers measured gum appearance and bleeding before and after us…

This completed study tested a surgical technique called Entire Papilla Preservation (EPPT) alone or with added enamel matrix derivative and bone graft for repairing bone defects from gum disease. Fifty-eight adults with moderate to severe periodontitis took part. The goal was to …

This study looked at whether certain proteins and metals in saliva can signal the start of gum disease before teeth are damaged. Researchers measured these markers in 106 adults with healthy gums or various stages of gum disease. The goal was to find a way to predict gum disease …

This study looked at whether a deep dental cleaning (called subgingival instrumentation) can reduce jaw symptoms like pain, stiffness, and tension in people who grind their teeth (bruxers) and also have gum disease (periodontitis). Sixty adults aged 30-40 received the cleaning, a…

This study tested whether a special ultrasonic handpiece that sprays hydroxyapatite (a natural enamel mineral) can reduce tooth sensitivity during dental cleanings for people with gum disease. Forty adults with moderate to severe periodontitis had half their mouth cleaned with th…

This study looked at how comprehensive gum treatment affects chewing ability and quality of life in people with severe gum disease (Stage III periodontitis). Twenty patients with gum disease and twenty healthy people took part. Patients received deep cleaning and, if needed, gum …

This study tested whether using an air-polishing device with erythritol powder is as effective as standard scaling and root planing for maintaining gum health after initial treatment. Twenty adults with periodontitis were randomly assigned to one of the two cleaning methods. The …

This study tested whether non-surgical gum treatment can improve smell and reduce tongue coating in adults with periodontitis. 108 non-smoking participants had their smell tested before and three days after treatment. The goal was to see if treating gum disease leads to short-ter…

This study tested whether adding a special laser treatment (photodynamic therapy) to standard gum cleaning could reduce bad breath. Forty adults with gum disease and self-reported bad breath received full-mouth scaling plus a laser-activated gel on their tongue and deep gum pocke…

This study looked at ways to reduce tooth sensitivity after deep cleaning for gum disease. 48 adults with sensitive teeth received either a desensitizing gel (Gluma), a special laser, or both. Their pain was measured over 6 months. The goal was to see if combining treatments work…

This study tested whether low level laser therapy (LLLT) can reduce pain, speed up tooth movement, and improve gum health in people getting braces. 108 Pakistani patients aged 18-30 received either standard braces or braces plus laser treatment on their front teeth every three we…

This study tested whether a special 5-day fasting-mimicking diet (plant-based soups, bars, and drinks) could reduce inflammation after deep cleaning for advanced gum disease. Twenty-eight adults with stage III-IV periodontitis were randomly assigned to either follow the diet or e…

This study looked at how vaping and traditional smoking affect gum healing after a deep dental cleaning in people with stage II gum disease. Researchers measured gum pocket depth, bleeding, and inflammation markers in 117 participants. The goal was to see if vaping is less harmfu…

This study looked at whether certain amino acids in saliva differ between people with healthy gums, gingivitis, and periodontitis. Researchers also tracked how these amino acids changed after standard non-surgical gum treatment in 32 periodontitis patients. The goal is to see if …

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This completed study looked at 160 healthy adults to see if a blood test marker called Pan-Immune-Inflammation Value (PIV) is linked to the severity of gum disease. Researchers measured gum inflammation and compared it to PIV from routine blood work. The goal was to explore if th…

This study followed 130 adults with advanced gum disease (periodontitis) to see if those who used probiotics on their own during standard non-surgical treatment had better outcomes. Researchers measured plaque, bleeding, pocket depth, and quality of life at 1 and 3 months. The go…

This study translated a questionnaire that measures how chronic gum disease affects quality of life into Hindi. Researchers tested it on 196 patients with periodontitis to ensure it is accurate and reliable. The goal is to give Hindi-speaking patients a way to report their oral h…

This study looks at proteins that help parts of cells communicate—specifically mitochondria and the endoplasmic reticulum—in people with healthy gums, gingivitis, or advanced gum disease. Researchers measure these proteins in saliva and gum fluid to see if they relate to inflamma…

This study looked at whether a natural antioxidant marker in gum tissue can help tell how severe gum disease (periodontitis) is. Researchers measured levels of thioredoxin reductase 1 and other markers in gum samples from 60 healthy people and patients with different stages of gu…

This completed study looked at how a specific inflammation trigger (NLRP3) relates to different stages of gum disease and aging-related inflammation. Researchers measured NLRP3 levels in fluid from the gums of 80 participants with various stages of periodontitis and healthy indiv…

This study looked at levels of a hormone called prolactin in the gum fluid of 26 people with obesity and gum disease (stage II or III). Researchers measured prolactin before and after non-surgical gum treatment to see if it changed. The goal was to better understand the link betw…

This study measured how often adults with gum disease have atypical swallowing (abnormal tongue movements). Researchers checked 125 adults for tongue posture and other mouth signs. The goal was to see if this swallowing pattern is linked to worse gum problems.

This study examined fluid from deep gum pockets in 30 people with severe periodontitis, both smokers and non-smokers. Researchers measured 40 inflammatory markers before and after non-surgical deep cleaning. The goal was to see which markers change with treatment and whether smok…

This completed study looked at 61 adults to see if physical fitness, body composition, and diet are linked to gum disease severity. Researchers reviewed dental records and lifestyle questionnaires from a previous study. No new treatments were tested; the goal was simply to unders…

This study measured levels of a protein called IL-36α in saliva and gum fluid from 80 people with gum disease, gingivitis, or healthy gums. The goal was to see if this protein is linked to gum inflammation and damage. No treatment was given; it was purely an observational study t…

This study examined how standard non-surgical gum disease treatment changes the jaw bone structure in 69 people with gingivitis or periodontitis. Researchers used fractal analysis of dental X-rays taken before and 6 months after treatment to detect subtle bone changes. The goal i…

This study measured certain inflammatory markers in the saliva and blood of 126 people with type 2 diabetes, some of whom also had kidney disease (diabetic nephropathy). The goal was to see if these markers differ based on gum health. Researchers hope to better understand the lin…

This study tested a French version of the Oral Health Impact Profile (OHIP) questionnaire, which measures how oral health affects daily life. Researchers enrolled 200 French-speaking adults, including people with gum disease and healthy controls. Participants filled out the quest…

This study aimed to create a computer model that can predict which gum disease treatment will work best for each person. Researchers looked at dental records from 86 patients, including gum measurements, X-rays, and personal details. The goal is to help dentists choose the most e…

This study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers examined 350 smokers with gingivitis or periodontitis, measuring their nicotine dependence with a standard test and asking about their gum health. The goal …

This study looked at whether gum inflammation affects the genes that control the body's daily (circadian) clock. Researchers collected gum tissue from 60 healthy adults with similar sleep habits, comparing those with healthy gums, gingivitis, or advanced gum disease. They measure…

This completed observational study looked at 61 people with peripheral artery disease to see if their gum health was linked to levels of a substance called TMAO in their blood and saliva. Researchers compared TMAO levels among those with healthy gums, gum disease, or no teeth. Th…

This study looked back at 126 patients who had gum regeneration surgery for severe gum disease. Researchers checked dental records and did a follow-up exam to see if the surgery helped close deep gum pockets and improve gum health. The goal was to understand how well these proced…

This study looked at 101 adults with gum disease and bad breath to see if treating the gums could also improve their sense of smell. Participants received standard deep-cleaning dental treatment. Researchers measured bad breath gases and smell function before and one week after t…

This study tested whether special cameras (2D and 3D) can measure swelling and temperature changes after gum surgery. 60 adults with gum disease had routine surgery, and the cameras tracked healing patterns. The goal was to see if this non-invasive method could help doctors monit…

This study examined 95 adults with diabetes and gum disease to see if blood sugar control and gum disease severity are linked to changes in gum cells. Researchers looked at cell samples under a microscope for signs of damage. The goal was to better understand how these conditions…

This study followed 163 people who got dental implants between 1999 and 2005 to see how well the implants held up over time. Researchers checked patient satisfaction, implant survival, bone loss, and signs of inflammation. They also looked for risk factors that might lead to prob…

This completed study looked at 108 Turkish adults to see if understanding dental health information is linked to gum health. Participants took a reading test about dentistry and had a dental exam. The goal was to find out if people with lower health literacy have worse gum diseas…

This study looked at 100 people with gum disease, some also with obesity, to see how non-surgical gum cleaning affects the body's immune system. Researchers measured changes in inflammation and immune cells before and after treatment, comparing men and women. The goal was to find…

This study examined how smoking influences immune cells (macrophages) in gum disease. Researchers compared gum tissue from 80 smokers and non-smokers with and without periodontitis. They measured specific markers to see how smoking shifts the balance of immune responses, which ma…

This study looked at levels of two immune-related substances, fractalkine and CX3CR1, in the gum fluid of people with gingivitis or periodontitis. Researchers measured these before and after standard non-surgical gum treatment, like deep cleaning and oral hygiene advice. The goal…

This study looked at how inflammatory bowel disease (IBD) affects oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to understand which factors, like medic…

This study looked at whether gum disease (periodontitis) and Parkinson's disease are connected through inflammation. Researchers collected saliva and blood samples from 60 people—some with both conditions, some with only gum disease, and some healthy. They found that certain subs…

This study looked at three substances in saliva—Adseverin, 1-alpha defensin, and sRANKL—to see if they differ between people with healthy gums, gingivitis, or periodontitis. Researchers collected saliva from 60 non-smoking, systemically healthy adults and measured these biomarker…

This study tested whether a deep cleaning of the gums (nonsurgical periodontal therapy) could lower inflammation and improve quality of life in 20 people who have both rheumatoid arthritis and gum disease. Researchers measured changes in immune markers, bacteria in the mouth, and…

This study examined how gum disease (periodontitis) and type 2 diabetes affect each other. Researchers measured immune markers, bacteria, and other health signs in 226 adults aged 30-70. The goal was to better understand the connection between these two conditions, not to test a …

This study tested whether treating severe gum disease (periodontitis) with a deep cleaning procedure could also reduce teeth grinding (bruxism) during the day and night. Forty adults with advanced gum disease or healthy gums took part. Researchers measured grinding events before …

This study looked at three proteins in saliva—IL-6, IL-8, and LIGHT—to see if they can tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers measured these proteins in 60 non-smoking, healthy adults (20 …

This completed study analyzed blood test results from 100 people over age 50 to see if there is a connection between gum inflammation and Alzheimer's disease. Researchers measured gum health and looked at various blood cell counts. The goal was to find blood markers that might li…

This completed study looked at jawbone X-rays from 120 people—half with gum disease and half healthy. Researchers used special computer analysis to measure bone structure differences. The goal was to see if routine dental X-rays could help detect early bone changes caused by peri…

This study looked at certain proteins in the saliva and gum fluid of people with and without gum disease. The goal was to see if these proteins could help explain how gum disease develops. 44 healthy adults took part, and no treatments were given.

This completed study followed 471 young adults (under 36) with periodontitis for 10 years to see how their gum disease progressed. Researchers looked at factors like disease stage, treatment adherence, and biological markers to understand why some patients got worse or stopped tr…

This study looked at 120 adults with type 2 diabetes and gum disease to see how well their blood sugar was controlled and how it related to the severity of gum problems and cavities. Researchers measured gum health, tooth decay, and HbA1c levels (a measure of blood sugar control)…

This study looked at the free amino acids in saliva from 120 people with healthy gums, gingivitis, periodontitis, healthy implants, implant mucositis, or implantitis. Researchers wanted to see if different amino acid patterns could help tell these conditions apart. The goal is to…

This completed study looked at how low oxygen levels and a metabolic pathway called the kynurenine pathway are involved in gum inflammation (periodontitis). Researchers collected blood and saliva from 45 healthy adults with either periodontitis or healthy gums. They measured mark…

This completed study looked at whether people with advanced gum disease (periodontitis) also grind or clench their teeth more during sleep. Researchers used a small portable device to measure muscle activity in the jaw over 24 hours in 40 adults, half with severe gum disease and …