PERIODONTITIS

This study aims to see which biomaterial works best for repairing bone defects around teeth in people with gum disease (periodontitis). Thirty adults who still have deep gum pockets after non-surgical treatment will be randomly assigned to receive one of four treatments during gu…

This study tests whether using an electrolysed saline mouthwash (a special saltwater rinse) along with standard deep-cleaning can improve gum disease treatment. Sixty adults with advanced gum disease will be randomly assigned to use either the saline rinse, a common antiseptic mo…

This study looks at whether eating an anti-inflammatory diet can make standard gum disease treatment work better. One hundred adults with periodontitis will either get the usual deep-cleaning treatment alone or with extra nutrition education. Researchers will check gum health and…

This study tests a modified surgical technique for people with advanced gum disease and bone loss around their teeth. The procedure aims to reduce deep gum pockets and improve gum attachment without cutting into the gum papillae. Forty adults with periodontitis will be treated an…

This study tests whether adding a substance made from a patient's own blood (injectable platelet-rich fibrin) to a standard bone graft helps repair bone damage caused by gum disease. Sixteen adults with advanced gum disease and deep bone defects will receive either the combinatio…

This study compares two bone graft materials (bovine bone granules and a sponge-like collagen matrix) used alongside a special enamel protein to repair bone defects from gum disease. Forty adults with deep gum pockets and bone loss will receive one of the two grafts after microsu…

This study tests whether a para-probiotic toothpaste and mouthwash can improve gum health and blood sugar control in 40 adults with type 2 diabetes and gum disease. All participants receive standard gum treatment, then use either the probiotic products or a standard antiseptic ri…

This study tests if adding a special light therapy (antimicrobial photodynamic therapy) to standard deep cleaning improves gum health in people with both gum disease and obesity. Twenty-four adults with obesity and moderate to severe gum disease will receive either standard clean…

This study compares two ways to treat early gum disease (gingivitis and mild periodontitis). One group uses a smart electric toothbrush with an app, while the other adds professional dental cleaning. The goal is to see if the toothbrush alone works just as well. About 92 adults w…

This study tests a new toothpaste designed to help control periodontitis, a serious gum infection. 28 adults with regular dental cleanings will brush with the toothpaste for 3 months. Researchers will check if it improves gum health by supporting a balanced mouth microbiome.

This study is testing a step-by-step treatment plan called Bioperio® for people with gum disease (periodontitis). It involves professional cleaning, oral hygiene coaching, and for severe cases, a special gel applied to deep gum pockets. The goal is to see how well this approach c…

This study compares two ways to treat gum disease without surgery: using an ultrasonic device (Vector®) or special hand tools (mini-five curettes). About 36 adults with moderate to severe gum disease will be randomly assigned to one treatment. Researchers will measure gum pocket …

This study compares three surgical techniques to regenerate gum tissue in people with periodontitis, a serious gum infection. Researchers will test a newer method that avoids cutting the small triangles of gum between teeth against two standard approaches. The goal is to see whic…

This study tests a new gum cleaning method called guided biofilm therapy against the standard deep cleaning for people with gum disease (periodontitis). Researchers will measure gum pocket depth, bleeding, and certain proteins in the gum fluid to see which method works better. Th…

This study tests a new, less invasive cleaning method (MINST) against the standard non-surgical treatment for peri-implantitis, a gum infection around dental implants. About 106 adults with infected implants will receive one of the two treatments and be followed for 12 months. Th…

This study tests whether a manuka honey mouthwash can improve gum health in people with severe kidney disease who are on dialysis. Gum disease is very common in these patients and can lead to tooth loss. The trial will compare standard gum treatment plus honey rinse versus standa…

This study tests whether a gel made from polynucleotides and hyaluronic acid, combined with a bone graft, can help repair deep gum and bone damage caused by periodontitis. About 66 adults with advanced gum disease will receive standard surgery alone, surgery with bone graft, or s…

This study looks at whether adding a diode laser to standard deep-cleaning treatment can improve gum health in people who have had a kidney transplant and also have gum disease. Eighty participants will be split into two groups: one gets standard cleaning plus laser, the other ge…

This study tests whether a gel containing lovastatin (a cholesterol drug) placed under the gum can improve standard gum disease treatment. About 44 adults with periodontitis, both smokers and non-smokers, will receive the medicated gel on one tooth and a placebo gel on another af…

This study tests whether adding low-level laser therapy and hyaluronic acid to standard deep-cleaning treatment helps people with advanced gum disease. Researchers will measure changes in gum pocket depth and bleeding. The study enrolls 45 healthy, non-smoking adults with untreat…

This study looks at whether a special liquid made from a patient's own blood can improve healing after standard deep cleaning for gum disease (periodontitis stages II-IV). About 14 adults with at least 20 teeth and deep gum pockets will receive the blood-based rinse in half of th…

This study looks at whether taking a probiotic called Prodentis for a long time helps control gum disease (periodontitis) better than taking it for just three months after standard treatment. Twenty adults with advanced gum disease will be followed to see changes in gum pocket de…

This study tests whether digital tools (intraoral scanners and cone-beam CT) can detect dental problems as well as a standard in-person exam. About 350 adults will get both a regular checkup and digital imaging. The goal is to see if digital methods can make diagnosis faster and …

This study is testing whether simpler, less invasive methods like taking mouth photos, X-rays, and analyzing spit and plaque samples can accurately detect gum disease. Researchers will compare these methods to the standard full-mouth dental exam. The goal is to find a faster, eas…

This study tests whether a special gel, made with hyaluronic acid and octenidine, can improve early healing after non-surgical gum treatment for periodontitis. About 26 adults with advanced gum disease will receive either standard deep cleaning alone or deep cleaning plus the gel…

This study tests whether taking ibuprofen after a deep dental cleaning can lower inflammation and pain in adults with gum disease. Researchers will measure blood markers of inflammation and pain levels in 30 participants. The goal is to see if a common painkiller can make recover…

This study tests whether adding antimicrobial photodynamic therapy (aPDT) to standard gum cleaning and tongue scraping can better reduce bad breath in people with type 2 diabetes and advanced gum disease. About 32 adults will receive either standard care or standard care plus aPD…

This study looks at whether adding tongue scraping to standard gum disease treatment can improve bad breath. Researchers will enroll 39 adults with gum disease and bad breath. Participants will receive standard gum cleaning and be taught to scrape their tongue daily. The main goa…

This study will check 120 adults for two types of tiny parasites in their saliva and gum pockets. Researchers want to see if these parasites are more common in people with gum disease (gingivitis or periodontitis) compared to healthy gums. Participants will give a saliva sample a…

This study aims to find out if a bacteria called Treponema parvum is more common in people with gum disease (periodontitis) compared to healthy people. Researchers will collect plaque samples from the gums of 112 participants and use a DNA test to measure the bacteria. The result…

This study is creating and testing a Hindi version of a questionnaire that measures how chronic gum disease (periodontitis) affects a person's quality of life. Researchers will enroll 180 adults with gum disease to check if the translated questionnaire is accurate and reliable. T…

This study looks at two proteins, Gas6 and sMerTK, in the fluid from gums of people with healthy gums, gingivitis, or periodontitis. Researchers will compare protein levels among 90 participants to see if these markers relate to gum disease severity. No treatments or drugs are gi…

This study looks at how gum disease and hepatitis B and D infection affect each other, and whether the drug bulevirtide changes that relationship. Researchers will measure signs of inflammation in saliva and gum fluid from 25 adults, including people with hepatitis B+D (some on b…

This study looks at the connection between sleep quality and gum disease (periodontitis) in 48 healthy adults. Researchers will measure participants' sleep patterns, fatigue levels, and certain substances in saliva to see if poor sleep is linked to worse gum health. No treatments…

This study looks at how a standard deep-cleaning treatment for gum disease changes certain proteins in the saliva of smokers and non-smokers. Researchers will measure these proteins and gum health before and six weeks after treatment in 44 adults with moderate to advanced gum dis…

This study watches how gum pocket depth changes after standard non-surgical treatment in 50 adults with advanced periodontitis. Researchers only use routine dental records—no extra pokes or procedures. The goal is to see how well current treatments work in real-world care.

This study aims to understand if a specific cell signaling pathway (JAK1/2) is overactive in people with gum disease (periodontitis) compared to those with healthy gums. Researchers will collect gum tissue from 30 adults to measure pathway activity. The goal is to learn more abou…

This study aims to discover biological markers that can predict which people with mild gum inflammation will develop serious gum disease. Researchers will analyze saliva, tissue, and bacteria samples from 228 adults aged 18-40 with gingivitis or early-stage periodontitis. The goa…

This study looks at how the tiny bacteria living in your gums change after three types of dental surgery: gum reshaping, gum rebuilding, or implant infection treatment. Researchers will collect bacteria samples before and after surgery from 84 adults with gum disease or implant i…

This study compares five different non-surgical gum disease treatments to see how each affects bacteria entering the bloodstream and body-wide inflammation. Researchers will measure blood markers before and after treatment in 75 adults with severe periodontitis. The goal is to fi…

This study uses ultra-high frequency ultrasound (70 MHz) to look at gum tissue in 40 adults—some with healthy gums and some with gingivitis. The goal is to see if ultrasound can detect differences in tissue thickness, texture, and blood flow caused by inflammation. Participants w…

This study looks at whether gum disease increases the chance of having a heart attack. Researchers will compare the gum health of 320 people—some who recently had a heart attack and some who haven't—while accounting for other risk factors like smoking and diabetes. The goal is to…

This study checks how well a Hindi questionnaire (OHIP-P-HIN) captures changes in quality of life for people with gum disease (periodontitis). About 106 adults will fill out the form to help researchers find the smallest meaningful difference in scores. The goal is to improve how…

This observational study looks at whether bacteria in the mouth can influence the stability of plaques in the carotid arteries, which supply blood to the brain. Researchers will collect samples from 200 adults scheduled for carotid surgery to compare the bacteria found in their m…

This study observes 160 adults to understand how their oral hygiene habits and gum health (like gingivitis or periodontitis) relate to their quality of life. Participants will have their gums examined and fill out a questionnaire about how their mouth affects daily living. No tre…

This study aims to find out how often the fungus Candida albicans appears in Syrian adults with gum disease (periodontitis) and how it affects their condition. Researchers will collect samples from 100 patients to detect the fungus and measure gum health. The goal is to better un…

This observational study looks at two types of gum tissue from people with severe periodontitis to understand their role in healing after treatment. Researchers will collect tissue samples during surgery and compare them between smokers and non-smokers. The goal is to learn how t…

This study aims to understand why some people with gum disease (periodontitis) or infections around dental implants (peri-implantitis) lose bone around their teeth. Researchers will collect samples like saliva and gum fluid from 219 adults with severe gum disease and compare them…

This study looks at whether certain markers in blood and saliva can help predict how well people with gum disease will heal after non-surgical treatment. Researchers will measure these markers in 180 adults (healthy, with gingivitis, or with advanced periodontitis) before and aft…

This study looks at how gum disease and smoking change certain proteins (inflammasomes) in your saliva. Researchers will compare these proteins in people with healthy gums, those with gum disease, and smokers. The goal is to find a simple saliva test that could help diagnose gum …