PERIODONTITIS

This study compares two mouthwashes used alongside standard gum disease treatment. One contains a higher dose of chlorhexidine (0.2%), while the other combines a lower dose of chlorhexidine (0.12%) with cetylpyridinium chloride. The goal is to see if the lower-dose combination wo…

This study is testing whether teaching people with periodontitis (gum disease) to follow an anti-inflammatory diet can improve the results of standard non-surgical gum treatment. One hundred adults with a pro-inflammatory diet will be split into groups; some will get diet educati…

This study tests whether a substance made from a patient's own blood (injectable platelet-rich fibrin, or i-PRF) can improve bone regrowth when used with a gentle, non-surgical deep cleaning for gum disease. About 40 adults with advanced periodontitis and deep bone pockets will b…

This study is testing whether a special laser device (FX-405) can improve the treatment of gum disease when used along with standard deep cleaning (scaling and root planing). About 70 adults with moderate to severe gum disease will receive eight 10-minute laser sessions over five…

This study tests whether an electrolysed saline mouth rinse can improve standard gum disease treatment. Sixty adults with advanced periodontitis will use either the saline rinse, a standard antiseptic rinse, or a placebo for one month. The goal is to see if the rinse reduces deep…

This study tests whether adding a special light treatment (antimicrobial photodynamic therapy) to standard deep cleaning helps people with obesity and gum disease. 24 participants will receive either standard cleaning alone or cleaning plus the light therapy. Researchers will che…

This study is testing a new treatment plan called Bioperio® for people with gum disease (periodontitis). The plan includes professional teeth cleaning, oral hygiene training, and for severe cases, a special gel to help gums reattach. The goal is to close deep gum pockets and impr…

This study tests whether using a smart electric toothbrush with an app and flossing can control gum inflammation as well as getting a professional dental cleaning. 92 adults with mild gum disease will be split into two groups: one uses the smart toothbrush alone, the other gets a…

This study tests two different bone graft materials—one from cow bone and one synthetic—combined with a special enamel protein to repair deep gum and bone defects caused by periodontitis. Forty adults with at least one deep gum pocket (6 mm or more) and a bone defect will receive…

This study tests whether a gel made from polynucleotide and hyaluronic acid, combined with a bone graft, can help repair bone defects caused by advanced gum disease. 66 adults with severe periodontitis will receive either standard surgery, surgery with bone graft alone, or surger…

This study looks at whether taking a probiotic supplement called Prodentis for a long time after standard gum treatment can improve gum health and immune response. Twenty adults with advanced gum disease who have already had one round of treatment will be followed. Researchers wi…

This study tests whether adding a diode laser to standard deep cleaning (scaling and root planing) improves gum health in kidney transplant patients with gum disease. Eighty participants will be randomly assigned to receive either standard cleaning alone or standard cleaning plus…

This study tests whether adding different biomaterials (like artificial bone, enamel proteins, or a blood concentrate) to standard gum surgery helps repair bone defects around teeth. Thirty adults with deep gum pockets after initial treatment will receive one of four biomaterial …

This study tests a new, less invasive non-surgical treatment (MINST) against standard non-surgical care for people with gum disease around dental implants (peri-implantitis). About 106 adults will receive one of the two treatments and be followed for 12 months to see which better…

This study compares two ways to treat gum disease without surgery: using an ultrasonic device or special hand tools. About 36 adults with moderate to severe periodontitis will be randomly assigned to one method. Researchers will check gum pocket depth and bone levels over a year …

This study tests a new gum cleaning method called guided biofilm therapy (GBT) against standard deep cleaning for people with gum disease (periodontitis). 18 adults will receive either GBT or standard treatment, and researchers will measure gum pocket depth, bleeding, and biomark…

This study tests whether a gel containing lovastatin, a cholesterol drug, can improve standard gum disease treatment. Researchers will compare the medicated gel to a placebo gel in 44 adults with periodontitis, including both smokers and non-smokers. The goal is to see if the gel…

This study tests whether a special toothpaste and mouthwash containing natural 'para-probiotics' can improve gum health and help control blood sugar in people with type 2 diabetes. Forty adults with gum disease and diabetes will use either the para-probiotic products or a standar…

This study tests a new surgical method for treating advanced gum disease. Instead of removing all inflamed tissue, the surgeon preserves the granulation tissue (the body's natural healing tissue) to see if it leads to better gum attachment and less bleeding. The trial involves 50…

This study tests a new surgical technique called NIPSA, combined with a gum graft and special proteins, to treat severe gum disease. Forty adults with periodontitis and deep gum pockets will receive the procedure. The goal is to see if this approach can reduce pocket depth and im…

This study compares three different surgical methods to treat gum disease (periodontitis). The goal is to see which technique best reduces deep gum pockets and helps gums reattach to teeth. About 60 adults with gum disease will be randomly assigned to one of the three procedures.…

This pilot study tests a new toothpaste designed to protect the natural balance of bacteria in the mouth. 28 adults with periodontitis will brush twice daily for 3 months while continuing their usual gum disease care. Researchers will check if the toothpaste improves oral health …

This study tests whether a new gel containing hyaluronic acid and octenidine can improve gum healing after standard deep cleaning for periodontitis. About 26 adults with advanced gum disease will receive either cleaning alone or cleaning plus the gel. Researchers will measure hea…

This study tests whether a manuka honey mouthwash can improve gum health in people with kidney failure who are on dialysis and also have gum disease. About 150 adults will rinse with a diluted honey solution three times daily. Researchers will measure gum attachment, bleeding, pl…

This study tests whether a gel made from a patient's own blood can improve gum healing after standard deep cleaning for moderate to severe gum disease. About 14 adults with gum pockets of 5mm or deeper will receive the blood gel on one side of the mouth and a saltwater rinse on t…

This study tests whether a special dental gel (Livfresh) can improve gum health when used alongside standard deep cleaning. About 76 adults with moderate gum disease will brush with the gel twice daily for 6 months. Researchers will measure changes in gum pocket depth and bleedin…

This study tests whether a hydrogen peroxide mouth rinse (OROXID®) can improve gum health when used alongside standard dental cleaning. About 90 adults with moderate-to-severe gum disease will use either a 1.5% or 3% rinse or a control rinse for 12 weeks. The goal is to see if it…

This study tests two materials used to fill bone defects caused by gum disease: a collagen matrix and a bovine bone mineral. 80 adults with advanced periodontitis will receive one of the two during surgery. Researchers will measure changes in gum attachment and other healing sign…

This study tests whether adding low-level laser therapy or hyaluronic acid gel to standard deep-cleaning (scaling and root planing) improves gum healing in people with periodontitis. Forty-five non-smoking adults with untreated gum disease will be randomly assigned to one of thre…

This study tests whether adding injectable platelet-rich fibrin (i-PRF) to a standard bone graft helps fill in bone defects caused by advanced gum disease. Sixteen adults with stage III periodontitis will receive either the combo treatment or the graft alone during surgery. Resea…

This study tests three different methods to rebuild the small triangle of gum tissue between teeth, known as the papilla. The methods are: injecting hyaluronic acid filler, injecting a special blood-based protein (ALB-PRF), or a minor surgical procedure. The trial will enroll 24 …

This study tests whether computer analysis of 3D dental scans can accurately detect gum disease, gingivitis, and cavities, compared to traditional manual exams. About 30 adults with at least one gum recession will participate. If successful, this approach could make dental diagno…

This study is testing whether a simple online questionnaire can accurately assess a person's risk for gum disease (periodontitis or gingivitis). About 393 adults in Saudi Arabia will fill out the questionnaire and then have a dental exam to compare results. The goal is to see if …

This study is testing whether simpler methods like mouth photos, dental X-rays, saliva tests, and questionnaires can accurately detect gum disease (gingivitis and periodontitis) compared to a standard full-mouth exam. About 2,000 adults from five centers will participate. The goa…

This study looks at whether digital tools like intraoral scanners and cone-beam CT can help dentists spot cavities, plaque, and gum disease more accurately than a standard exam. About 350 adults will get both a regular check-up and digital imaging, and researchers will compare th…

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

This study tests whether using a lactoferrin-based toothpaste and mouthwash twice daily, along with regular professional cleanings, can prevent gum disease in pregnant women. Forty pregnant women in their second trimester will be split into two groups: one using both the toothpas…

This study tests whether adding antimicrobial photodynamic therapy (aPDT) – a light-based treatment – to standard gum cleaning can reduce bad breath (halitosis) in people with type 2 diabetes and advanced gum disease. Thirty-two participants will receive either standard care or s…

This study tests whether taking ibuprofen before a deep gum cleaning reduces pain and inflammation afterward. Thirty adults with gum disease will either get ibuprofen or a placebo. Researchers will measure inflammatory markers in the blood and pain levels using a simple scale.

This study looks at whether adding tongue scraping to standard gum disease treatment can improve bad breath. About 39 adults with gum disease and bad breath will either get standard care or standard care plus twice-daily tongue scraping. Researchers will measure breath odor and s…

This study looks at how the types of bacteria in the mouth change in people with severe gum disease as they go from having some teeth left to having no teeth, and then after getting dental implants. Researchers will collect microbial samples and analyze DNA to see if different im…

This study looks at gum disease in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare 100 participants to those with chronic kidney disease and healthy controls. They aim to understand how comm…

This study looks at whether high uric acid levels (hyperuricemia) are linked to more severe gum disease and bone loss. Researchers will measure inflammation and oxidative stress markers in gum fluid and blood from 80 adults. Participants are grouped by gum health and uric acid st…

This study looks at whether certain proteins in saliva can signal the start of gum disease. Researchers will collect saliva from 240 adults with healthy gums, gingivitis, or periodontitis and measure specific biomarkers linked to bone loss. The goal is to find a simple, non-invas…

This study aims to fine-tune a Hindi questionnaire that measures how gum disease (periodontitis) affects a person's quality of life. Researchers will enroll 106 adults with gum disease to see how well the questionnaire detects meaningful changes over time. The goal is to make sur…

This study looks at a protein called Surfactant Protein D (SP-D) in the gum fluid of people with gum disease (periodontitis). Researchers will measure SP-D levels before and 6 months after a gentle, non-surgical cleaning treatment. The goal is to see if SP-D levels change with tr…

This study looks at whether gum disease is more common in people who have had a heart attack. Researchers will compare the gum health of 320 adults—some who recently had a heart attack and some who haven't—to see if there's a link. The goal is to gather information that could lea…

This study is checking how often the fungus Candida albicans shows up in the gums of 100 Syrian adults with periodontitis (serious gum disease). Researchers will collect plaque samples and measure gum health to see if the fungus is linked to more severe disease. The goal is to be…

This study checks how often two tiny parasites (Entamoeba gingivalis and Trichomonas tenax) are found in the mouths of people with and without gum disease. Researchers will collect spit and plaque samples from 120 adults and look at them under a microscope. The goal is to learn i…

This study looks at how the community of bacteria in the mouth changes after three types of gum or implant surgery. Researchers will collect plaque samples before and after surgery from 84 adults with gum disease or implant infection. The goal is to learn which surgeries help res…

This study looks at how oral hygiene habits and gum health affect quality of life in 160 adults. Participants will have a dental exam and fill out a questionnaire about how their mouth feels day-to-day. No treatment is given—the goal is simply to understand the connection between…

This study looks at whether bacteria in your mouth can influence the buildup of fatty plaques in the neck arteries that supply blood to the brain. Researchers will collect samples from 200 adults having surgery to remove these plaques and compare the bacteria found in the mouth, …

This study is testing whether a standard deep-cleaning procedure for gum disease (scaling and root planing) changes the levels of three specific proteins in saliva. The researchers will compare these changes between smokers and non-smokers with moderate to advanced gum disease. A…

This study aims to find biological markers in saliva, gum fluid, and tissue that can predict which people with mild gum inflammation will develop serious periodontitis. Researchers will use advanced techniques to analyze samples from 228 adults aged 18-40 with gingivitis or early…

This observational study at the University of Chile is examining whether a specific immune pathway (JAK1/2) is overactive in people with periodontitis, a common gum disease. Researchers will compare gum tissue from 30 healthy adults and those with inflamed gums to measure pathway…

This study looks at two proteins, Gas6 and sMerTK, in the fluid around teeth to see if they differ between healthy gums, gingivitis, and periodontitis. Researchers will collect samples from 90 adults and measure these proteins. The goal is to better understand the biology of gum …

This study uses a special high-frequency ultrasound to take detailed images of gum tissue. Researchers will compare healthy gums to gums with gingivitis (early gum disease) to see if the ultrasound can detect inflammation. About 40 adults will participate, and the goal is to find…

This study looks at how standard gum disease treatments—deep cleaning with or without a special mouthwash—change proteins in your saliva and affect blood vessel health. Researchers will study 30 adults with gum disease to see if these treatments help or harm the good bacteria tha…

This study looks at the link between gum (periodontal) disease and hepatitis B+D infection, and whether the drug bulevirtide changes that relationship. Researchers will measure inflammation markers in saliva and gum fluid from 25 adults: those with hepatitis B+D on bulevirtide, t…

This study aims to find out if a specific bacteria called Treponema parvum is more common in people with gum disease (periodontitis) compared to healthy people. Researchers will collect plaque samples from the gums of 112 participants and use a DNA test to measure the amount of t…

This study looks at whether sleep quality is linked to gum disease (periodontitis). Researchers will measure sleep quality, fatigue, and certain substances in saliva from 48 healthy adults with or without gum disease. The goal is to better understand how oral health and sleep are…

This study looks at how gum disease and smoking change certain proteins in saliva. Researchers will collect saliva and check gum health in 116 people with and without periodontitis. The goal is to see if these proteins can help diagnose gum disease and understand smoking's role.

This study aims to better understand periodontitis and peri-implantitis by analyzing biological samples like plaque, saliva, and gum fluid from 219 participants. Researchers will compare samples from people with severe gum disease to those with healthy gums. The goal is to identi…

This study observes 50 adults with advanced gum disease (periodontitis) to see how much their deep gum pockets shrink after standard non-surgical treatment. Researchers measure pocket depth before treatment and again at 1, 3, and 6 months afterward. The goal is to understand how …

This study is looking at whether certain markers in blood and saliva can predict how well people with gum disease heal after non-surgical treatment. Researchers will measure these markers in 180 adults with healthy gums, gingivitis, or advanced periodontitis before and after trea…

This study looks at a protein called Mitofusin-1 in saliva to see if it can help measure how severe gum disease is and how well treatment works. Researchers will compare healthy people, those with mild to severe gum disease, and smokers with severe gum disease. Participants give …

This observational study in 46 people with severe gum disease aims to understand how two types of gum tissue (infra-osseous and supra-osseous granulation tissue) differ in their healing potential and infection-fighting properties. Researchers will collect tissue samples during pe…

This study compares five different non-surgical treatments for advanced gum disease (periodontitis) to see how they affect inflammation throughout the body and the risk of bacteria entering the bloodstream. Researchers will measure blood markers like C-reactive protein and interl…