PERIODONTITIS

This study investigates how bacteria that cause tooth decay and gum disease spread among family members. Researchers will treat either the child alone, the child and parents, or all family members with professional dental cleaning. They will track bacterial transmission using DNA…

This study looks at whether a special gel, called Sterify Gel, can improve the results of standard non-surgical gum disease treatment. Researchers will review records from 20 adults with moderate to severe periodontitis who received deep cleaning plus the gel. The main goal is to…

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This study tests whether adding a light-activated dye (photodynamic therapy) to standard deep cleaning improves gum disease more than cleaning alone. Thirty adults with periodontitis will have one side of their mouth treated with cleaning plus the dye/laser, and the other side wi…

This study tests whether adding hyaluronic acid gel to standard deep-cleaning treatment improves gum healing in smokers with advanced periodontitis. Twenty-three smokers will receive the standard cleaning, then some gum pockets will also get the gel. Researchers will measure gum …

This study tests a new gel that slowly releases medicine to treat advanced gum disease (periodontitis). The gel is placed directly into deep gum pockets to fight infection, reduce swelling, and help bone grow back. Researchers will study 80 people with severe gum disease to see i…

This study tests an injectable gel containing a bone-growth protein (BMP-2) to help regrow bone damaged by severe gum disease. The gel is designed to fight bacteria, reduce inflammation, and promote bone repair. Researchers will enroll 80 people with advanced periodontitis and bo…

This study tests an experimental drug called LP-005, given as an injection into the gums, for people with moderate-to-severe gum disease (periodontitis). About 100 adults aged 18-70 will receive either the drug or a placebo to see if it reduces gum inflammation, bleeding, and bon…

This study tests a new gel made from peptides (protein fragments) to see if it can help regrow bone and tissue damaged by gum disease. Forty adults with advanced periodontitis will receive either the new peptide gel or a standard hyaluronic acid gel during surgery. Researchers wi…

This study tests whether stem cells taken from donated teeth can be safely injected into the gums to treat periodontitis, a serious gum infection that damages tissue and bone. The goal is to help regrow lost gum and bone without the need for traditional surgery. The trial will en…

This study tests whether using a laser along with ultrasonic cleaning works as well as the standard manual scraping plus ultrasonic cleaning for treating advanced gum disease. About 174 adults with severe periodontitis will receive one of the two treatments on different sides of …

This study looks at two different approaches to help pregnant people with gum disease get better dental care. Participants will receive free dental check-ups, cleanings, and supplies. The goal is to see which method reduces gum inflammation and improves oral health habits, and wh…

This trial tests whether adding a sodium hypochlorite/amino acid gel, with or without cross-linked hyaluronic acid, to standard non-surgical gum treatment helps adults with periodontitis. 78 participants will receive one of three treatments and be checked after three months. The …

This study tests whether a toothpaste and powder made from tinder fungus can improve gum health in people with advanced periodontitis. About 70 adults will use either the fungus product or a regular toothpaste alongside standard deep-cleaning treatment for 30 days. The main goal …

This study tests two different gum dressings—Ora-Aid and Coe-Pak—placed after a deep cleaning (scaling and root planing) in 25 adults with Stage 3 gum disease. Researchers will measure pocket depth, gum inflammation, plaque, and bacteria over 3 months to see which dressing helps …

This study tests whether a new mouthwash called Amphion can improve gum health when used after standard deep cleaning for periodontitis. Sixty adults with gum disease will receive either Amphion or a placebo mouthwash to use at home twice daily. The goal is to see if the mouthwas…

This study tests whether adding a special anti-inflammatory mouthwash to a deep-cleaning procedure helps heal advanced gum disease better than the cleaning alone. About 20 adults with severe gum disease will be randomly assigned to use either the active mouthwash or a placebo for…

This study compares three oral hygiene routines in 90 adults aged 60+ who have gum disease and mild cognitive impairment. One group uses a special light device (Lumoral) plus a manual toothbrush, another uses a powered toothbrush (Oral-B iO), and a control group uses a manual too…

This study tests whether sending SMS reminders and advice to people with type 2 diabetes and gum disease can improve their blood sugar control over two years. 516 adults who recently completed gum disease treatment will be split into two groups: one gets standard follow-up, the o…

This study aims to validate an Italian version of a widely used questionnaire for screening periodontitis (gum disease). Researchers will also develop an enhanced version with additional questions and test how accurately it identifies people with the condition. About 495 adults a…

This study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…

This study is developing a new, non-invasive saliva test that uses artificial intelligence to detect gum disease (periodontitis) early. Researchers will collect saliva from 200 adults—some with gum disease and some healthy—and analyze it with a special sensor. The goal is to see …

This study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and questionnaires can accurately detect gum disease compared to a standard clinical exam. Researchers will use artificial intelligence to analyze the images and combine data…

This study tests whether motivational interviewing, a patient-centered counseling approach, can improve outcomes of standard gum disease treatment (subgingival instrumentation) in 66 adults aged 30-50 with periodontitis. Participants will receive either motivational interviewing …

This study will measure how well people with gum disease can chew. One hundred adults with periodontitis will chew a special gum for 20 cycles to test their chewing performance. Researchers will also check the severity of their gum disease to see if there is a link. This is an ob…

This study looks at whether treating gum disease (periodontitis) can improve how well people chew and their overall oral quality of life. Researchers will ask 44 adults with gum disease to fill out questionnaires, do a chewing test with colored gum, and provide saliva samples. Th…

This study looks at how mental health, especially stress, affects gum disease in people who grind their teeth. About 110 adults aged 30-50 with both teeth grinding and gum disease will answer mental health questions and get a dental check-up. The goal is to see if poor mental hea…

This study looks at how stress levels, sleep quality, and teeth grinding (bruxism) together affect gum disease in adults aged 30-45. Researchers will compare two groups of people with gum disease: those who grind their teeth and those who do not. The goal is to understand how the…

This study looks at whether psychological resilience — the ability to bounce back from stress — can reduce the harmful effects of stress on gums in people who grind their teeth (bruxers). Researchers will measure stress and resilience using questionnaires and check gum health in …

This study looks at how people with gum disease (periodontitis) value their dental health and how their oral health beliefs relate to the severity of their condition. Researchers will ask 112 adults aged 30-50 to complete questionnaires and a clinical exam in one visit. The goal …

This study looks at how obesity changes the way genes work in people with gum disease. Researchers will compare obese and non-obese adults before and after a deep cleaning treatment. They aim to understand why obese individuals may have worse gum inflammation and how it might be …

This study looks at whether people with oral lichen planus (a chronic mouth condition) have more gum disease than those without it. Researchers will compare 88 patients with oral lichen planus to 88 healthy people, all getting standard dental exams. The goal is to understand shar…

This study will check if people with Lynch syndrome, a genetic condition that raises cancer risk, have more gum disease than the general population. Researchers will look at dental records from 25 adults with Lynch syndrome. The goal is to see if gum disease is a hidden health is…

This study looks at whether a deep dental cleaning (called non-surgical periodontal therapy) can change levels of a substance called asprosin in the blood of people who have both stable angina and gum disease. Asprosin is a protein that may play a role in heart health and inflamm…

This study follows 400 obese adults in Norway to see how weight loss from lifestyle changes, medication, or surgery affects their oral health. Researchers will measure gum disease, cavities, and tooth erosion before and after weight loss. The goal is to understand the link betwee…

This study looks at how gum surgery changes inflammation markers in the blood. Researchers will take blood samples from 30 adults before, during, and after dental procedures. The goal is to see if surgical stress causes a different inflammatory response compared to non-surgical c…

This study aims to see if the amount of plaque on teeth can predict how well non-surgical gum treatment works. Researchers will follow 100 adults with gum disease for 12 months after treatment, measuring pocket depth and other gum health signs. The goal is to understand if a simp…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This observational study looks at how gum disease (periodontitis) and chronic kidney disease may be related. Researchers will examine mouth and gut bacteria in 80 adults aged 18 to 75 to see if these microbes play a role in the link between the two conditions. The goal is to bett…

This observational study looks at whether eating a diet that causes inflammation can make gum disease worse in people with metabolic syndrome. About 100 adults with metabolic syndrome will have their gum health checked and their diet analyzed using a special inflammation score. T…

This observational study looks at whether a diet that promotes inflammation can make gum disease worse in people with chronic kidney disease. Researchers will assess the diets and gum health of 100 adults with kidney disease. The goal is to understand if eating more inflammatory …

This study will check the gum health of 100 people—half with multiple sclerosis (MS) and half without—by measuring gum pockets, plaque, and inflammation. Researchers will also test saliva for certain bacteria and viruses to see if they are linked to MS. The goal is to better unde…

This study will test several over-the-counter mouthwashes to see how they affect the balance of bacteria in the mouth and whether they influence heart health. Researchers will recruit 200 adults with or without gum disease from dental clinics and a university campus. The goal is …

This study looks at whether standard gum treatment can improve heart health in people with stable angina. Researchers will measure certain blood markers before and after a routine dental cleaning. The study involves 60 adults, some with heart disease and some without. It aims to …

This study looks at whether certain substances in spit and fluid around dental implants can help detect a gum disease called peri-implantitis early. Researchers will compare 80 people with healthy gums, regular gum disease, or implant-related gum disease. The goal is to find bett…

This study looks at how metabolic syndrome (a cluster of conditions like high blood pressure and blood sugar) might make gum disease worse. Researchers will measure gum inflammation in 100 adults and compare it to their metabolic health. The goal is to see if a simple gum measure…

This study aims to find out if tiny plastic particles, called microplastics, are present in the deep gum pockets of people with severe gum disease (periodontitis). Researchers will collect plaque from 25 adults with advanced gum disease who have not yet started treatment. The goa…

This study looks at whether teeth that bear more chewing force are more likely to have severe gum disease. Researchers will measure bite patterns in 50 adults with natural teeth or fixed dental work. The goal is to understand the link between chewing loads and gum health, which c…

This pilot study will test whether a weekly injection of a GLP-1 receptor agonist (a type 2 diabetes drug) can improve gum health in 30 adults who have both periodontitis and diabetes. Researchers will measure changes in gum pocket depth, bleeding, and tooth mobility. The goal is…