PERIODONTITIS

This study tests whether a toothpaste and powder made from tinder fungus can improve gum health in people with advanced gum disease (periodontitis). Participants will use the fungus-based products or a regular toothpaste alongside standard deep cleaning. The main goal is to see i…

This study tests whether adding a sodium hypochlorite/amino acid gel, with or without cross-linked hyaluronic acid, to standard non-surgical gum treatment helps adults with periodontitis. About 78 participants will receive one of three treatments and be checked after three months…

This study compares two types of gum dressings (Ora-Aid and Coe-Pak) placed after a deep cleaning procedure for people with moderate gum disease. Twenty-five adults with Stage 3 periodontitis will receive both dressings on different sides of their mouth to see which one reduces p…

This study tests whether a new mouthwash called Amphion can improve standard gum disease treatment. About 60 adults with periodontitis will use the mouthwash along with deep cleaning. The goal is to reduce plaque and gum bleeding without relying on antibiotics.

This study tests whether injecting stem cells from donated teeth can help regrow gum and bone damaged by severe gum disease (periodontitis). Thirty adults with deep gum pockets and bone loss will receive the injection. The goal is to offer a less invasive alternative to tradition…

This study tests whether using a laser with ultrasonic cleaning works as well as the standard manual scraping plus ultrasonic cleaning for treating advanced gum disease. About 174 adults with severe periodontitis will receive one of the two treatments. The goal is to see if the l…

This study aims to validate an Italian version of a widely used gum disease screening questionnaire and develop an improved version with extra questions. Researchers will enroll 495 adults across 10 Italian centers to see how accurately the questionnaire identifies people with pe…

This study will check if simple methods like mouth photos, dental X-rays, and health questionnaires can accurately find gum disease compared to a full dentist exam. About 2,000 adults will take part, and the results will help create AI tools for faster, easier screening. The goal…

This study aims to see if a self-reported questionnaire can accurately identify gum disease (periodontitis or gingivitis) in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then receive a standard dental exam on the same visit. Researchers will …

This study aims to develop and validate an online self-assessment tool for periodontal (gum) disease risk. About 393 adults in Saudi Arabia will complete a questionnaire and then receive a clinical dental exam to see how well the tool matches professional diagnosis. The goal is t…

This study will test if chewing gum containing xylitol (a natural sweetener) during pregnancy can reduce the risk of preterm birth and low birthweight. About 6,000 pregnant women in Malawi will be randomly assigned to chew one of two doses of xylitol gum or a placebo gum daily. T…

This study looks at whether using a special anti-inflammatory mouthwash after a deep dental cleaning can improve healing for people with advanced gum disease. About 20 adults with deep gum pockets will either get the active mouthwash or a placebo, and their gum health will be tra…

This study will check if a gum disease measure called PISA can help show how metabolic syndrome (a cluster of conditions like high blood pressure and blood sugar) affects gum health. Researchers will look at 100 adults with metabolic syndrome to see if PISA is linked to diabetes …

This study will observe 100 adults with chronic kidney disease to see if a diet that causes inflammation is linked to worse gum disease. Participants will have their gum health checked and their food intake recorded. The goal is to understand if changing diet could help improve b…

This study looks at whether a full-mouth plaque score can predict how well non-surgical gum treatment works. One hundred adults with gum disease will have their plaque levels measured before treatment and then be followed for a year. The goal is to see if people with less plaque …

This study looks at how common and severe gum disease is in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare them to people with chronic kidney disease and healthy volunteers. Participants ge…

This observational study looks at 100 adults with metabolic syndrome to see if eating a pro-inflammatory diet is linked to more severe gum disease (periodontitis). Participants will have their gum health checked and fill out a food questionnaire. The goal is to understand how die…

This study looks at whether people with multiple sclerosis (MS) have different gum health compared to those without MS. Researchers will measure gum disease signs and check saliva for bacteria and other markers. The goal is to better understand how these two chronic inflammatory …

This observational study looks at how gum disease (periodontitis) and chronic kidney disease (CKD) may be connected through the 'oral-renal axis.' Researchers will study mouth and gut bacteria in 80 adults aged 18 to 75 to see if these microbes play a role. The goal is to better …

This pilot study looks at whether a common diabetes medication (GLP-1 receptor agonists) can improve gum health in people with both type 2 diabetes and periodontitis (severe gum disease). Researchers will measure changes in gum pocket depth, bleeding, and tooth mobility over time…

This study looks at how obesity is linked to oral health problems like gum disease, cavities, and tooth erosion. Researchers will follow 400 adults who are getting weight-loss treatment (either lifestyle changes or surgery) at a hospital in Norway. They will check participants' m…

This study aims to find out if tiny plastic particles, called microplastics, are present in the deep gum pockets of people with severe gum disease (periodontitis). Researchers will collect plaque samples from 25 adults who have not yet started treatment. The goal is to see if the…

This study looks at whether treating gum disease can improve heart health. Researchers will measure certain blood markers linked to heart disease before and after a standard, non-surgical gum cleaning. Adults with stable angina (a type of chest pain from heart disease) and those …

This study looks at whether teeth that bear more chewing force are more likely to have gum disease. Researchers will measure bite patterns in 50 adults and compare them to gum health. The goal is to understand if uneven chewing loads contribute to gum problems.