ALCOHOL USE DISORDER

This phase 3 trial investigates whether high-dose psilocybin, given alongside psychotherapy, can prevent relapse in people with severe alcohol use disorder who also have depressive symptoms. Participants receive either a high dose (25 mg) or a low dose (3 mg) of psilocybin in two…

This study tests whether adding alcohol use disorder treatments (acamprosate and counseling) to standard liver therapy improves outcomes for people with severe alcohol-associated hepatitis. It also compares a new drug, F-652, against prednisone for liver treatment. About 216 adul…

This study tests whether a 30-day alcohol abstinence challenge, supported by a mobile app, is feasible and helps reduce heavy drinking. Researchers will enroll 150 adults in Oklahoma who drink regularly. Participants will try to completely avoid alcohol for one month, and the stu…

This study investigates whether ketamine, given as four intravenous infusions over two weeks, can reduce depression and alcohol cravings in adults who have both conditions. Participants are already in inpatient addiction therapy and are randomly assigned to receive either ketamin…

This phase 3 study tests whether brenipatide can help adults with moderate-to-severe alcohol use disorder drink less and feel less urge to drink. About 1,100 motivated participants will receive either the drug or a placebo for 56 weeks. The main goal is to see changes in drinking…

This study tests whether a drug called donepezil, combined with cognitive training (brain exercises), can help people with alcohol use disorder drink less heavily. Researchers will compare this combo to a placebo in 160 adults aged 18-80. The goal is to see if the treatment reduc…

This study tests an experimental medicine called brenipatide to see if it helps adults with alcohol use disorder drink less and reduce cravings. About 1,100 participants will receive either the drug or a placebo by injection for nearly a year. The goal is to find a safe, effectiv…

This study tests a device that uses magnetic pulses to stimulate the brain (Deep TMS) to help people with moderate to severe alcohol use disorder drink less. About 186 adults aged 18-86 will get either real or fake (sham) treatment over several weeks. The goal is to see if the re…

This study looks at whether having regular motivational conversations after leaving the hospital for alcohol withdrawal can help people stay sober longer. About 104 adults who want to quit drinking completely will be split into two groups: one gets standard care, the other also g…

This study tests whether full-spectrum or broad-spectrum CBD can help people with alcohol use disorder drink less. 180 adults who want to reduce or quit drinking will receive either CBD or a placebo for 12 weeks. Researchers will track changes in drinking habits, cravings, and an…

This study tests whether tirzepatide, a drug approved for weight management, can help people with alcohol use disorder and related liver disease drink less and improve liver health. 120 adults will receive weekly injections of tirzepatide or a placebo for 12 weeks. Researchers wi…

This study tests whether the drug apremilast can help people with alcohol use disorder drink less. About 80 adults aged 21-65 will receive either apremilast or a placebo, and researchers will measure how much alcohol they consume during a lab drinking session. The goal is to see …

This study tests whether a combined computer- and counselor-delivered alcohol treatment program can help people who receive an early liver transplant for severe alcoholic hepatitis stay alcohol-free. Researchers will compare this program to standard care in 200 participants, trac…

This early-phase study tests whether suvorexant, a drug used for insomnia, can reduce people's motivation to drink alcohol. Thirty adults with moderate to severe Alcohol Use Disorder will receive suvorexant or a placebo, then choose between alcohol and money. Researchers will mea…

This study tests a computer-based training called Approach Avoidance Training (AAT) for veterans with alcohol use disorder. Participants use a joystick to push away alcohol-related images, aiming to retrain their automatic urges. The trial will enroll 176 veterans and measure cha…

This study tests whether MDMA-assisted therapy can help veterans with both PTSD and alcohol use disorder. Eighty veterans will receive either a full dose of MDMA or a low-dose placebo during three therapy sessions. Researchers will measure changes in PTSD symptoms and drinking ha…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with alcohol use disorder drink less. About 80 adults will receive either the drug or a placebo shot weekly for 5 months. Researchers will measure changes in drinking, brain activity, …

This early-phase study tests whether spironolactone, a drug currently used for high blood pressure and heart failure, can be safely used in people with alcohol use disorder. Twenty participants will each stay at a clinic four times, taking either the drug or a placebo for five da…

This study tests whether guanfacine extended release (Intuniv), a drug currently used for ADHD and high blood pressure, can help 200 adults with moderate to severe alcohol use disorder drink less. Participants take either guanfacine or a placebo daily for 12 weeks, and report the…

This study tests a program called Kisoboka for men living with HIV who drink heavily in fishing communities. The goal is to help them drink less, take their HIV medication as prescribed, and achieve undetectable viral loads. About 716 men will be randomly assigned to different co…

This small pilot study at Yale tests whether semaglutide (a drug used for diabetes and weight loss) can help people who have had bariatric surgery and now struggle with alcohol use disorder. Ten adults will take the drug for three months and be followed for three more months to s…

This study tests a new behavioral therapy called CM-PST, designed to help young adults (ages 18-24) with alcohol use disorder achieve and maintain abstinence. The therapy combines rewards for abstinence with skills to manage daily challenges. The trial first checks if the therapy…

This study tests whether capsules containing bacteria from healthy people can safely reduce alcohol cravings and drinking in adults with alcohol-related liver disease and cirrhosis. About 80 participants will receive either the bacteria capsules or a placebo, and researchers will…

This study tests whether a virtual reality experience can help people in early recovery from alcohol use disorder drink less and stay abstinent longer. About 500 participants who have been sober for at least two weeks but less than a year will use a VR program designed to strengt…

This study tests a smartphone app called Smart-T Alcohol that sends personalized messages to help homeless adults reduce their drinking. About 600 people from shelters in Dallas and Oklahoma City will either get the app plus usual care, or usual care alone. The goal is to see if …

This study is testing whether apremilast (Otezla), a drug currently used for psoriasis and arthritis, can reduce alcohol cravings in people with moderate to severe alcohol use disorder. Researchers will compare two different doses of the drug against a placebo in 100 adults who w…

This study is testing a medication called brexpiprazole to see if it can help people with alcohol use disorder drink less. Researchers want to know if a person's genes affect how well the drug works. The study involves 250 adults who are not currently seeking treatment for their …

This study tests an adaptive web-based program called Partners Connect for military couples. It aims to reduce drinking in concerned partners and encourage service members to seek help for alcohol use. About 744 couples will participate, comparing the online program to standard w…

This study tests whether a smartphone app called Connections can help people with alcohol-related liver disease stop drinking. About 298 participants from two medical centers will use the app along with their usual care, or just receive usual care alone. The goal is to see if the…

This early-stage trial tests a new drug called NTX-2001 in 50 adults with alcohol use disorder. Participants take the drug or a placebo daily for two weeks. Researchers will measure how much alcohol they drink and check for side effects. The goal is to see if this drug can safely…

This study is testing whether a type of brain stimulation called theta burst stimulation (TBS) can reduce heavy drinking and cravings in people with alcohol use disorder. Researchers will apply magnetic pulses to a brain region linked to drinking patterns, comparing real stimulat…

This study is testing whether cannabidiol (CBD) can help people who drink alcohol regularly cut down on their drinking. Researchers are giving 150 adults either full-spectrum CBD, broad-spectrum CBD, or a placebo daily for 12 weeks. They will measure how much participants drink i…

This study is testing a new drug called CMND-100 (MEAI) in healthy volunteers and people with alcohol use disorder. The goal is to find a safe dose and see if it can reduce drinking and cravings. The trial is currently recruiting 84 participants.

This study tests whether deep brain stimulation (DBS) can safely reduce drinking in people with severe alcohol use disorder who haven't improved with standard treatments. DBS uses implanted electrodes to send small electrical signals to brain areas linked to craving and self-cont…

This study tests whether cannabidiol (CBD) can reduce alcohol cravings and drinking in people with alcohol use disorder. Thirty-six participants will receive both CBD and a placebo at different times to compare effects. The goal is to see if CBD can help control alcohol use, but …

This study tests a computerized task where teens push or pull a joystick in response to images, aiming to change automatic habits around cannabis and alcohol. Fifty-two participants aged 13-17 who use both substances will be followed for three months. The goal is to see if this s…

This study tests a new behavioral program called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines 12-step facilitation with motivational and cognitive-behavioral therapy. Researchers will compare it to standard therapy to see if it leads to more day…

This Phase 2 trial tests whether guanfacine, a drug used for high blood pressure and ADHD, can help people with alcohol use disorder drink less. Researchers will compare guanfacine to a placebo in 160 men and women, measuring alcohol consumption in lab sessions and during a treat…

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid returning to heavy drinking. About 150 adults from a Johns Hopkins HIV clinic will take part. The goal is to see if the program helps them stay alcohol-free longer and drink le…

This study tests whether tirzepatide, a drug used for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. Researchers will give weekly injections of tirzepatide or a placebo to 108 participants for 16 weeks, tracking heavy drinking d…

This study tests whether a single dose of a ketone ester drink can reduce alcohol cravings and consumption in people with alcohol use disorder. Twenty non-treatment-seeking participants will receive either the ketone drink or a placebo on two separate days, then undergo brain sca…

This study tests a new telehealth program called B-FIT, which adds a family member or friend to standard therapy for veterans with alcohol use disorder. The goal is to see if involving a loved one helps veterans drink less and improve family relationships. About 400 veterans and …

This study is testing a treatment called IR-TMS, which uses magnetic pulses to target specific brain areas, to see if it can help people with Alcohol Use Disorder drink less. About 150 adults who drink heavily will receive several sessions of this treatment, along with brain scan…

This Phase 2 trial tests whether the hormone pregnenolone can help people with alcohol use disorder drink less heavily. 150 adults aged 18-70 will take either 300 mg of pregnenolone or a placebo daily for 12 weeks. The main goal is to see if more people in the pregnenolone group …

This study tests whether a monthly injection of naltrexone (a medication that blocks alcohol's rewarding effects) helps people who drink for pleasure reduce heavy drinking more than a placebo. About 60 adults with alcohol use disorder who drink heavily will receive either the sho…

This study tests a computer-based training program designed to change the automatic urge to approach alcohol in people being treated for alcohol use disorder. 112 participants will be randomly assigned to one of three versions of the training, including a sham version. The goal i…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with therapy can change brain activity and reduce drinking in people with alcohol use disorder. Two hundred participants will receive either psilocybin or a placebo, plus supp…

This study is testing whether a computer-delivered cognitive behavioral therapy (CBT) program can help people who have both an anxiety disorder and alcohol use disorder. The program teaches skills like breathing control and problem solving to break the cycle of negative feelings …

This study tests whether suvorexant, a sleep medication, can help people with alcohol use disorder drink less and handle stress better. About 250 adults who want to cut back on alcohol will take either the drug or a placebo nightly for 8 weeks. Researchers will track drinking hab…

This study tests whether prazosin, a blood pressure medicine, can help people with alcohol use disorder who also have withdrawal symptoms drink less heavily. About 150 adults will receive either prazosin or a placebo for 12 weeks, along with weekly counseling. The main goal is to…

This study tests whether a single dose of psilocybin or ketamine, combined with talk therapy, can help people with moderate to severe alcohol use disorder drink less. Eighty adults who have at least four heavy drinking days per month will be randomly assigned to receive either ps…

This study tests whether offering specialized alcohol use disorder treatment right in the liver clinic helps people newly diagnosed with alcohol-related liver disease stop drinking. About 221 participants will either get this offer plus standard care, or standard care alone. The …

This study tests whether mindfulness-based relapse prevention, combined with wearable heart rate sensors, can help people with alcohol use disorder improve self-regulation and reduce drinking. About 120 adults will attend weekly group sessions for 8 weeks, answer mood and drinkin…

This study tests whether taking a probiotic called Lactobacillus rhamnosus GG (LGG) for 6 months can help people with alcohol use disorder reduce heavy drinking and improve liver health. Researchers will compare the probiotic to a placebo in 60 adults who drink heavily. The goal …

This study tests whether a weekly injection of tirzepatide, a drug used for diabetes and weight loss, can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking. About 42 participants will receive either the drug or a placebo for 8 weeks. The main g…

This study combines a mild brain stimulation technique called tDCS with computer-based cognitive training to see if it helps people with alcohol use disorder stay abstinent. Forty people who are already in a treatment program will receive 10 sessions over several weeks. Researche…

This study tests whether combining fMRI neurofeedback (brain activity training) and TMS (magnetic brain stimulation) can help people with alcohol use disorder drink less and feel fewer cravings. About 90 adults aged 19-65 who are already in treatment will attend weekly sessions f…

This study tests whether a modified ketogenic diet (very low in carbs) can help people with alcohol use disorder reduce their drinking. Fifty adults with the condition will follow the diet and receive nutritional counseling. Researchers will measure how well participants stick to…

This study is testing whether a mobile app called Pink Cloud can help people recovering from drug or alcohol problems stay sober. Over 1,400 adults who have completed treatment will use the app for a year, which includes a meeting finder, sobriety tracker, and planning tools. Res…

This study compares an electronic brief intervention delivered via an app to a traditional face-to-face brief intervention for people with unhealthy alcohol use. Researchers will enroll 1,200 adults in Mexico and South Africa who score 8 or higher on an alcohol screening test. Pa…

This early-stage trial tests whether a single dose of insulin given as a nasal spray can reduce alcohol cravings and consumption in people with alcohol use disorder. Forty non-treatment-seeking volunteers will receive either insulin or a placebo and then be exposed to alcohol-rel…

This study tests a mobile health program called WINGS+PrEP for women who have experienced heavy drinking, partner violence, and involvement with the criminal legal system. The program provides information about PrEP (a daily pill that prevents HIV) and offers support sessions. Re…

This study tests whether a brief, two-session alcohol counseling program can help Veterans reduce their drinking and prevent intimate partner violence. Researchers will compare this program to alcohol education or standard check-in calls. 300 Veterans who are already in a partner…

This pilot study tests whether engaging in enjoyable activities and virtual reality can reduce alcohol cravings and drinking in people with alcohol use disorder. About 44 adults will attend up to 10 visits, comparing active sessions (games, VR, crafts) with passive sessions (watc…

This study is testing a smartphone-based system called STAR that uses machine learning to predict when someone with alcohol use disorder might relapse. Participants will complete surveys and use the system to receive personalized recovery support messages. The goal is to see if t…

This early-stage study tests whether mavoglurant, a drug taken as a pill, can reduce alcohol cravings and drinking in people who drink heavily. Researchers will give the drug or a placebo to 63 adults with Alcohol Use Disorder and measure how much they drink and crave alcohol. Th…

This study tests a wearable earpiece that gently stimulates nerves to help people going through alcohol withdrawal. Twenty adults with alcohol use disorder will wear the device or a sham version for 5 days during detox. Researchers will measure withdrawal severity, cravings, and …

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery in people with opioid and alcohol use disorders. Sixty adults enrolled in an intensive outpatient program will receive daily TMS sessions for four weeks, alongside their usual ther…

This study tests whether adding cognitive processing therapy (CPT) to standard relapse prevention (RP) helps people with both PTSD and alcohol use disorder more than RP alone. About 200 adults with moderate to severe alcohol use disorder and current PTSD will receive either CPT+R…

This study tests a brief, virtual cognitive remediation therapy (Action-Based Cognitive Remediation) for young people aged 16-30 with early psychosis who also misuse alcohol or cannabis. The therapy aims to improve thinking skills and reduce substance use. Researchers will enroll…

This pilot study will test whether short, immersive virtual reality nature sessions can reduce depression, anxiety, and stress in adults with alcohol use disorder who are in an intensive outpatient program. Fifty participants will either receive standard care or add up to 12 VR n…

This study tests whether a non-invasive device that gently stimulates the vagus nerve can reduce withdrawal symptoms, anxiety, and cravings in 80 veterans with moderate-to-severe alcohol use disorder. Participants will receive the stimulation and complete questionnaires and a bra…

This study is testing whether 12 weeks of group cognitive behavioral therapy (CBT) can help people reduce their alcohol or cannabis use. Researchers will enroll 400 adults with alcohol use disorder or cannabis use disorder. Participants will attend weekly CBT sessions, and the st…

This study tests whether a short, four-session therapy program that helps people rethink their identity and memories related to drinking can reduce alcohol use and cravings. Sixty adults with alcohol use disorder will be randomly assigned to either receive this therapy plus usual…

This study explores whether adding Acceptance and Commitment Therapy (ACT) to ketamine treatment is practical for 30 adults who have both alcohol use disorder and treatment-resistant depression. Participants will receive weekly ketamine infusions and ACT sessions for 8 weeks. The…

This study looks at how the drug acamprosate affects brain function in people with moderate to severe alcohol use disorder. Researchers will use EEG to measure brain waves in 48 adults who stay in the clinic for about 3 weeks. Half get acamprosate, half get a placebo, and brain a…

This pilot study tests a therapy called Deaf-MET, which is a version of motivational enhancement therapy designed specifically for Deaf adults who use American Sign Language. The goal is to see if the therapy is practical, acceptable, and helps participants become more ready to c…

This study tests whether a supervised exercise program can improve sleep in people with alcohol use disorder. Forty adults with sleep problems will take part in activities like walking, cycling, and yoga. Researchers will track sleep quality, melatonin levels, and how well partic…

This study tests a digital program called RITch®CBT that uses an avatar to guide men through cognitive behavioral therapy for addiction. The goal is to reduce cravings and substance use while also addressing relationship conflict. Forty men entering addiction treatment will use t…

This study tests whether showing people in early recovery from alcohol use disorder personalized, high-intensity images of future events can help them prefer delayed rewards and increase their interest in treatment. Twenty-one participants will be split into two groups: one recei…

This study looks at whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study involves …

This study tests whether a ketone supplement drink can reduce alcohol withdrawal symptoms in 30 adults with moderate to severe alcohol use disorder. Participants will receive either the ketone drink or a placebo for 4 days during inpatient detox. The main goal is to see if the ke…

This study tests whether low-intensity focused ultrasound (LIFU) can safely calm overactive brain areas linked to alcohol cravings. Twenty-five adults with alcohol use disorder will receive LIFU while researchers monitor side effects and measure brain activity changes with fMRI. …

This study looks at how the liver processes fat in people with alcohol use disorder who are quitting drinking. Researchers will take two small liver samples—one early in detox and one after four weeks—to compare gene activity. The goal is to understand how the liver clears fat wh…

This study is creating and testing simple computer tasks that can be done inside an MRI scanner to measure brain activity related to behavior. Researchers want to better understand how alcohol use disorder affects the brain. The study involves up to 400 healthy volunteers and peo…

This study follows up to 7,500 adults with or without alcohol use disorder to learn more about the condition. Researchers will collect health information, blood samples, and brain scans to better understand the biology and genetics behind alcohol problems. The goal is to improve …

This study looks at a brain protein called PDE4B in people with alcohol use disorder. Researchers want to see if levels of this protein change during alcohol withdrawal and after a few weeks of not drinking. The study involves 30 adults who will have two PET brain scans and possi…

This study investigates how acetate, a substance produced when the body breaks down alcohol, is used by the brain in heavy drinkers. Researchers will use a special imaging technique to track acetate metabolism and measure stress hormone levels. The goal is to understand the link …

This study looks at how alcohol changes a brain protein called PDE4B, which may be linked to alcohol use disorder. Healthy social drinkers aged 21 to 70 will have brain scans before and after receiving alcohol. The goal is to understand how alcohol affects this protein, which cou…

This study looks at how alcohol use disorder (AUD) changes a person's sense of taste and smell. Researchers will compare people with and without AUD using taste tests, smell tests, and brain activity measurements. The goal is to better understand these sensory changes, not to tes…

This study is testing whether a short, tailored alcohol intervention is practical and well-liked by people who are taking buprenorphine for opioid use and also drink alcohol. About 60 adults will take part. The goal is to see if this approach could work in a larger future study.

This study looks at whether a prebiotic supplement can help repair the gut barrier and reduce inflammation in people with HIV who also have alcohol use disorder. Forty participants will take either a prebiotic or a placebo for four weeks, then switch. Researchers will measure gut…

This study screens up to 10,000 adults aged 18-99 who have current, past, or no substance or alcohol use disorders. Participants undergo one visit with tests like physical exams, blood work, memory tests, and mental health evaluations. The goal is to find eligible volunteers for …

This study uses brain scans to see how stress-related proteins change in heavy drinkers compared to healthy people. Researchers give a stress hormone (hydrocortisone) and then scan the brain to measure these proteins. The goal is to understand if these proteins play a role in rel…

This study tests a program to help doctors in psychiatric clinics prescribe medications for alcohol use disorder to patients who also have serious mental illness. The program uses an external facilitator to work with clinic staff and overcome barriers to prescribing. The goal is …

This study looks at whether federal policy changes made during the COVID-19 pandemic helped more veterans get and stay on medication for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data …

This study looks at how severe alcohol use disorder changes the brain's ability to understand emotions and social cues. Researchers will use brain scans and tests to compare 60 people with the disorder to healthy volunteers. The goal is to learn how these brain changes affect dai…

This study tests whether a 4-week ketogenic diet changes how the brain responds to alcohol. Twenty adults will follow the diet and undergo alcohol tolerance tests and brain scans before, during, and after the diet. The goal is to understand how ketosis affects alcohol metabolism …

This study looks at why alcohol use disorder is increasing faster in women than men. Researchers will measure brain activity, hormone levels, and drinking behavior in 100 adults to find sex-specific risk factors. The goal is to create better prevention and treatment strategies ta…

This study looks at how impulsivity and the way people feel when drinking alcohol are connected in young adults aged 21-25. Researchers will give alcohol or a placebo intravenously and track participants' responses in the lab and in daily life using a phone app. The goal is to fi…

This study aims to create a lab-based test to help screen medications for Alcohol Use Disorder (AUD). Researchers will observe how 90 adults with AUD resist drinking in a controlled setting. The goal is to develop a reliable method to test new treatments, not to provide direct th…

This study looks at how men and women react differently to two weeks of not drinking alcohol. Researchers will measure alcohol intake, brain responses, and personal feelings after the break. The goal is to use this information to create better ways to prevent and treat alcohol us…

This study looks at how the cerebellum, a part of the brain, influences alcohol cravings and reward in people with alcohol use disorder (AUD). Researchers will compare brain activity in people with AUD and healthy volunteers using MRI scans and a mild electrical stimulation techn…

This study tests a new program designed to help liver doctors provide treatment for alcohol use disorder. The program includes education for doctors and patients, decision support tools, and feedback on performance. Researchers want to see if this approach is practical and accept…

This study tests whether combining neurofeedback with integrative body-mind training can change brain function and reduce cravings and substance use in adults who regularly use alcohol, cannabis, and cigarettes. Researchers will use brain scans to measure changes in connectivity …

This study is testing whether a smartphone app can help people in Michigan on Medicaid who are recovering from both opioid and alcohol use disorders. The app uses rewards to encourage healthy behaviors. Researchers want to see if people find the app useful and easy to use, and if…

This study aims to understand the different reasons people with alcohol use disorder are motivated to drink. Researchers will give participants IV alcohol and ask them to press a button for more doses, while measuring mood, cravings, and thinking skills. The goal is to link these…

This study looks at 350 hospitalized patients with alcohol use disorder to find out what makes someone more likely to relapse after detox. Researchers will group patients by shared traits and test a feedback system that shows test results to patients and doctors. The goal is to l…

This study explores how transcranial magnetic stimulation (TMS) changes brain activity in people with and without heavy alcohol use. Researchers will use magnetoencephalography (MEG) to measure brain signals before and after TMS. The goal is to gather early data to support future…

This study looks at how drinking problems and posttraumatic stress disorder (PTSD) together may lead to violence between partners. Researchers will observe 70 couples in a lab and track their daily experiences for 28 days. The goal is to better understand these connections, not t…

This study is testing whether a new blood test can help tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will take blood samples and do mental health check-ins with 500 adults over several visits. The goal is…

This study looks at how sleep patterns and stressful events influence alcohol use in young adults aged 18-24 who are heavy drinkers. Researchers will track sleep, brain activity, and stress responses to understand why some people drink more. The goal is to use this knowledge to c…

This study looks at how stress and oral health habits relate to inflammation in people with alcohol use disorder (AUD). Researchers will test a new questionnaire about oral care and collect saliva, blood, and dental X-rays from 72 participants (AUD patients and healthy volunteers…

This study looks at how anxiety affects the brain in people with alcohol use disorder during early and long-term abstinence. Researchers will use fMRI scans and the medication disulfiram (Antabuse) to help participants stay sober. They aim to understand the brain circuits linked …

This study looks at why young adults with bipolar disorder are much more likely to develop alcohol use disorders. Researchers will give participants alcohol or a placebo and use brain scans to track changes over two years. The goal is to find early warning signs that could lead t…

This study looks at whether a blood marker called phosphatidylethanol (PEth), which reflects alcohol use over the past few weeks, can predict complications after surgery. Researchers will test PEth levels in 170 adults having elective surgery at University Hospitals Cleveland Med…

This study looks at medical records of 20 adults who had bariatric surgery and later received treatment for alcohol use disorder. Researchers want to understand if and how the surgery was considered during addiction follow-up. The goal is to improve care for patients with both co…

This early-phase study at Yale University is investigating how the drug mavoglurant affects brain activity in people with a family history of alcoholism. Researchers will give 80 participants a single dose of mavoglurant or a placebo and use MRI scans to measure brain responses t…

This study looks at whether having a specially trained peer recovery specialist in the emergency department helps people with substance use disorders connect to treatment and support services. Researchers will follow 400 adults who visit the ER for substance-related issues, compa…