ALCOHOL USE DISORDER

This study tests whether daridorexant, a medication that blocks certain brain signals related to wakefulness, can help people with alcohol use disorder who also have trouble sleeping. About 150 adults will receive either the drug or a placebo, and researchers will measure changes…

This study tests whether eating fiber-rich snacks (with inulin and pectin) for 28 days, alongside standard care, can improve gut health and reduce cravings in people with alcohol use disorder. About 138 adults hospitalized for alcohol withdrawal will be randomly assigned to eithe…

This study tests a coordinated care program for men with alcohol problems in primary care clinics in Goa, India. About 1,022 men will receive either the program or standard care. The program uses mobile messages, counseling, or home detox and therapy based on drinking severity, d…

This small pilot study will test whether nimodipine, a drug used for blood pressure, can help reduce alcohol consumption in heavy drinkers. Five adults with Alcohol Use Disorder will stay overnight at a hospital, take nimodipine, and then participate in a lab session where they c…

This study tests whether giving people with alcohol-related liver disease financial rewards for clean blood tests can help them stop or reduce drinking. The blood test detects alcohol use over the past month. 90 participants will be randomly assigned to either a rewards group tha…

This study looks at whether adding a medication called cytisine to intensive counseling helps people with HIV in Kenya quit smoking and stop heavy drinking. About 300 participants will be followed to see if they can stay smoke-free and avoid heavy alcohol use. The goal is to impr…

This study tests a non-invasive brain stimulation method called tTIS to see if it can reduce alcohol cravings and prevent relapse in people with alcohol use disorder. Sixty adults aged 18-60 who meet the criteria for alcohol use disorder will receive the stimulation targeting the…

This study tests whether MDMA-assisted therapy can help veterans who have both PTSD and alcohol use disorder. About 80 veterans will receive either MDMA or a low-dose placebo during three therapy sessions, plus non-drug counseling. The goal is to see if this treatment reduces PTS…

This study tests if semaglutide, a drug used for diabetes, can help veterans with alcohol use disorder drink less. About 622 veterans will get either the drug or a placebo injection for 28 weeks. The goal is to see if it safely reduces risky drinking levels.

This study tests whether the drug apremilast can help people with alcohol use disorder drink less. About 80 adults who drink heavily will receive either apremilast or a placebo, and researchers will measure how much alcohol they consume during a lab drinking session. The goal is …

This study tests whether semaglutide (a GLP-1 drug used for diabetes and weight loss) can help people with obesity and fatty liver disease stop drinking alcohol. About 64 participants will receive either semaglutide or a placebo, plus counseling, for 16 weeks. The main goal is to…

This study looks at whether having a peer support specialist can help people who received a liver transplant due to alcohol-related disease stay sober and keep up with their medical care. About 95 participants who have been alcohol-free for 1 to 3 years will be assigned to work w…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help adults with severe alcohol use disorder reduce heavy drinking. Thirty-six participants who recently completed detox will receive either a full dose (30-40mg) or a lo…

This early-stage study tests whether combining semaglutide (a diabetes drug) with naltrexone (a craving-reducing medication) can safely help people with alcohol use disorder drink less. About 45 adults in a residential treatment program will take the combo for 4 weeks. Researcher…

This study tests whether a non-invasive brain stimulation technique called TMS can help people with opioid or alcohol use disorder reduce cravings, withdrawal symptoms, and improve engagement in therapy. Sixty adults enrolled in an intensive outpatient rehab program will receive …

This study tests whether adding a cognitive training program to standard addiction treatment can improve overall self-confidence in people with alcohol use disorder. Researchers will enroll 130 adults who are recently abstinent and have mild cognitive difficulties. Participants w…

This study tests whether personalized, machine-learning-generated messages can help people with alcohol use disorder reduce heavy drinking and stay on track. About 416 adults who recently stopped drinking will use a recovery app and complete surveys over 4 months. The goal is to …

This pilot study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction better manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also at…

This study tests whether a nutritional ketone supplement can change how the brain uses energy and affect alcohol consumption in people with alcohol use disorder. Sixty adults who drink heavily but are not seeking treatment will receive either the supplement or a placebo, then und…

This study will test if a smart chatbot can help young adults aged 18-29 who drink heavily to reduce their alcohol use. The chatbot will have personalized conversations to encourage healthier drinking habits. The main goal is to see if young people find the chatbot easy and helpf…

This study examines how the liver processes fat in people with alcohol use disorder who are going through detox. Researchers will take two small liver samples—one early in detox and one after four weeks—to compare gene activity changes as fatty liver resolves. The goal is to bett…

This study looks at how severe alcohol use disorder changes the brain and makes it harder to understand others' emotions and intentions. Researchers will use brain scans and daily smartphone surveys to track social interactions in 60 adults. The goal is to find better ways to sup…

This study looks at how acceptable alcohol counseling is to both staff and patients, and what social or economic factors affect whether people stick with treatment. Researchers will review data from 2,000 patients and interview staff who provided these services. The goal is to im…

This study looks at whether a single dose of methylphenidate (Ritalin) changes how the brain responds to pictures of alcohol in young adults aged 18-25 with alcohol use disorder. Participants will have brain scans and complete tasks to measure attention and cravings. The goal is …

This study aims to adapt a proven suicide prevention program for people with alcohol use disorder in Tanzania, where mental health resources are scarce. Researchers will enroll 30 adults who drink heavily and have had recent suicidal thoughts, then test whether the telehealth int…

This study looks at whether recent federal policy changes made it easier for veterans with opioid or alcohol use disorder to get and stay on medication-assisted treatment. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using da…

This study tests a digital pill system that tracks when medication is taken and provides personalized support based on cognitive behavioral therapy. The goal is to help 50 adults with alcohol use disorder and alcohol-related liver disease stick to their acamprosate regimen. Resea…

This study looks at how personal traits like anxiety, self-esteem, and perfectionism influence the way people with alcohol use disorder adapt to change. About 30 adults receiving care at Paul Brousse Hospital will complete a computer task and questionnaires in one 45-minute sessi…

This study looks at how inflammation in the body might influence mood and alcohol cravings. Researchers will give a low dose of endotoxin (a substance that causes mild, temporary inflammation) or a placebo to 64 adults—half with alcohol use disorder and half without. They will me…

This pilot study will test whether it is practical to run a larger trial comparing two ways to help people with alcohol use disorder. Sixty participants will either be invited to meet a therapist at the hospital for up to 10 sessions, or be given guidance on finding community tre…