ALCOHOL USE DISORDER

This study tests whether peer support specialists—people who have been through liver transplant for alcohol-related disease themselves—can help others in the same situation stay sober and attend medical appointments. About 95 participants will meet regularly with a peer supporter…

This trial tests a culturally adapted program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) for trauma patients who drink alcohol. Emergency department staff in Cameroon will screen patients for risky drinking, offer a short motivational counseling sessi…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe alcohol use disorder reduce heavy drinking. Thirty-six adults who recently completed detox will receive either a high or low dose of psilocybin du…

This study tests whether giving hospitalized heavy drinkers a liver stiffness scan and personalized alcohol counseling can reduce future emergency hospital visits. 500 adults at risk of alcohol-related liver disease will be randomly assigned to get this extra support or usual car…

This Phase 2 trial at Johns Hopkins will test whether combining semaglutide (a GLP-1 drug used for diabetes) with naltrexone (a medication for alcohol dependence) is safe and helps reduce alcohol use. About 45 adults with alcohol use disorder will take the combination or a placeb…

This study tests a digital pill system that tracks when people with alcohol-related liver disease take their medication (acamprosate) and provides personalized support to help them stay on track. The system includes a sensor in the pill, a wearable patch, and a smartphone app wit…

This trial tests a coordinated care program called CCAP for men with alcohol problems in primary care centers in Goa, India. The program includes mobile messages for mild cases, counseling for moderate cases, and home detoxification for severe cases. Over 1,000 participants will …

This study tests whether daridorexant, a drug used for insomnia, can reduce alcohol cravings and drinking while improving sleep in people with alcohol use disorder and sleep problems. About 150 adults will receive either daridorexant or a placebo for several weeks. The goal is to…

This study tests if semaglutide, a drug used for diabetes, can help veterans with alcohol use disorder drink less. About 622 veterans will get either the drug or a placebo shot for 28 weeks. The goal is to see if it safely reduces heavy drinking and improves health.

This study tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) aimed at the amygdala, a brain region linked to cravings. Researchers will enroll 60 adults with alcohol use disorder to see if tTIS can reduce alcohol craving…

This study tests whether giving financial rewards based on a blood test can help people with alcohol-related liver disease stop or reduce drinking. The blood test detects alcohol use over the past month. 90 adults will be randomly assigned to either a rewards group that gets esca…

This study tests whether semaglutide (a GLP-1 drug used for diabetes and weight loss) can help people with obesity and fatty liver disease reduce or stop drinking alcohol. 64 participants will receive either semaglutide injections plus lifestyle counseling, or counseling alone. T…

This study tests whether eating fiber-rich snacks (with inulin and pectin) for 28 days, alongside standard care, can improve alcohol withdrawal in adults aged 19-65 with alcohol use disorder. The goal is to reduce gut permeability and support recovery. Participants will provide b…

This study in Nairobi, Kenya, will test whether a drug called cytisine, combined with counseling, can help 300 people with HIV quit smoking and reduce heavy drinking. Participants will receive either cytisine or a placebo, plus either intensive counseling or standard advice. The …

This study looks at whether a nutritional ketone supplement can alter how the brain uses energy and reduce alcohol consumption in people with alcohol use disorder. Sixty adults who drink heavily but are not seeking treatment will receive either the supplement or a placebo, then u…

This study tests a smartphone app called Senyo Health for people with bipolar disorder who also struggle with alcohol or drug use. The app offers therapy, rewards for healthy behaviors, and weekly check-ins with a care manager. The goal is to see if the app is easy to use and hel…

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This early study will test whether nimodipine, a drug usually used for blood pressure, can reduce alcohol drinking and cravings in heavy drinkers. Five adults with Alcohol Use Disorder will stay overnight at a hospital, take nimodipine, and then have the option to drink alcohol o…

This study is testing a short behavioral treatment for women veterans who drink too much. The treatment involves 4 to 6 sessions with a behavioral health provider in a primary care clinic. Researchers want to see if it is practical, acceptable, and helps reduce alcohol use and im…

This study tests a 10-week cognitive remediation program for people with alcohol use disorder who are recently sober. The program includes group and individual brain exercises to improve thinking skills and self-confidence. Researchers will measure changes in general self-efficac…

This study investigates how pomegranate dietary supplements influence gut bacteria and inflammation in people with alcohol use disorder and alcohol-related liver disease. Researchers will measure levels of beneficial gut metabolites called urolithins and inflammatory markers in b…

This study looks at whether adding alcohol-related smells to virtual reality scenes makes people with alcohol use disorder feel stronger cravings. Sixty participants will experience different combinations of visual scenes (neutral or alcohol-related) and smells (none or alcohol).…

This study will interview clinical staff and review patient data from an NHS alcohol care service in North West England. Researchers want to understand how acceptable the psychosocial interventions are to staff and what social or economic factors affect whether patients engage wi…

This study aims to understand how inflammation in the body influences mood and alcohol cravings in people with alcohol use disorder (AUD). Researchers will give 64 participants (32 with AUD and 32 without) a single low dose of a substance that causes temporary inflammation or a p…

This pilot study will test whether it is possible to run a larger trial comparing two ways to help people with alcohol use disorder. Sixty participants will either be invited to meet a therapist at the hospital for up to 10 sessions over 6 months, or receive guidance on finding a…

This study aims to adapt a proven suicide prevention program for people with alcohol use disorder in Tanzania, where mental health resources are scarce. Researchers will enroll 30 adults who drink heavily and have had recent suicidal thoughts, then test whether the telehealth int…

This study looks at how personal traits like anxiety, self-esteem, and perfectionism influence the ability to adapt in people with alcohol use disorder. Thirty participants will complete a computer task and questionnaires in one 45-minute session. No medication or treatment is in…

This study looks at whether a single dose of methylphenidate (Ritalin) changes how the brain responds to alcohol-related images in young adults aged 18-25 with alcohol use disorder. Participants will have brain scans and complete tasks after taking either the drug or a placebo. T…

This study will test if a smart chatbot can help young adults (ages 18-29) who drink heavily to cut back. The chatbot will have personalized conversations to encourage healthier drinking habits. The main goal is to see if young adults find the chatbot easy and helpful to use, not…