ALCOHOL USE DISORDER

This study is testing if a medication called semaglutide, which is already used for weight loss and diabetes, can help people with obesity and fatty liver disease drink less alcohol or stop drinking altogether. Over 16 weeks, researchers will compare people who receive the drug p…

This small Yale University study will test if the medication semaglutide (a drug used for weight loss and diabetes) is practical and acceptable for treating alcohol use disorder in adults who have had weight loss surgery. The researchers want to see if the drug might help reduce …

This study is testing whether a medication called tirzepatide, currently used for weight management, can help people who struggle with heavy alcohol use and the related liver damage it causes. About 120 adults with alcohol use disorder and a specific type of metabolic liver disea…

This study is testing whether a new, non-invasive brain stimulation technique can help people with alcohol use disorder. Researchers will use a device to target a deep brain area involved in cravings and emotions. They will measure changes in alcohol cravings, relapse rates, and …

This study aims to adapt and test a phone-delivered support program designed to prevent suicide among people with alcohol use disorder in Tanzania. Researchers will work with 30 participants from an emergency department to see if the culturally adapted program is practical and ac…

This study is testing whether a financial reward program can help people with alcohol-related liver disease reduce or stop drinking. Participants will be randomly assigned to either receive escalating cash payments for clean blood tests that show reduced alcohol use, or receive s…

This study is testing whether adding a special brain training program helps people being treated for alcohol use disorder. The program aims to improve thinking skills, self-awareness, and the feeling of being capable of managing recovery. Researchers will compare outcomes for 130…

This study is testing whether Emotional Brain Training (EBT), a method that teaches skills to shift from negative to positive emotional states, can help people in addiction recovery. Researchers will compare standard addiction treatment alone to standard treatment plus 8 weeks of…

This study aims to see if combining two medications, semaglutide (a drug also used for weight loss) and naltrexone (an existing treatment for alcohol use disorder), is safe and more effective than naltrexone alone. It will involve 45 adults already enrolled in a 4-week inpatient …

This study is testing whether a single dose of a nutritional ketone supplement can affect how the brain uses energy and influence drinking behavior in people with mild to moderate alcohol use disorder. Participants will receive the supplement or a placebo and then have brain scan…

This study is testing if apremilast, a medication already used for psoriasis, can help people with alcohol use disorder drink less. Researchers will give 120 adults either a 60mg or 90mg daily dose of the drug or a placebo pill and measure their alcohol consumption in lab session…

This study is testing whether a non-invasive brain stimulation technique, called Transcranial Magnetic Stimulation (TMS), can help people with opioid or alcohol addiction. It will see if adding TMS to standard rehab therapy helps people stay engaged in treatment, reduces cravings…

This study will test a coordinated care program for men with drinking problems in Goa, India. Over 1,000 men will be randomly assigned to receive either the new program or standard care. The program offers different support—like mobile messages, counseling, or supervised home det…

This study is testing whether a chatbot powered by AI (like ChatGPT) can be a helpful and acceptable tool for young adults (ages 18-29) who drink at risky levels. Researchers want to see if people will use the chatbot and find it easy and helpful, as a first step before larger st…

This study aims to see if two different doses of a pill called apremilast can help reduce alcohol cravings and drinking in people with moderate to severe alcohol use disorder. It will involve about 100 adults who are seeking treatment and will take the medication daily for two we…

This study is testing whether adding daily fiber-rich snacks to standard hospital care helps people going through alcohol withdrawal. Researchers want to see if the fiber improves gut health, reduces cravings and anxiety, and supports liver function. About 138 adults with alcohol…

This study aims to see if taking a daily full-spectrum CBD product can help people who regularly drink alcohol to reduce their drinking and improve related problems. Researchers will enroll 180 adults who drink alcohol and have tried CBD or cannabis before. Participants will take…

This study tests whether connecting liver transplant recipients who had alcohol-related liver disease with trained peer support specialists improves their recovery. The peer specialists have personal experience with similar challenges and will provide regular support between medi…

This is a small pilot study to see if a digital program called 'Let's Do Addiction Recovery Together!' (LDART) is practical, acceptable, and shows early signs of helping adults with alcohol use disorder. The study will enroll 80 adults in Connecticut who report heavy drinking and…

This study is testing if semaglutide, a medication currently used for diabetes and weight loss, can help U.S. veterans with moderate to severe alcohol use disorder. About 440 veterans will receive either the real medication or a placebo injection weekly for 28 weeks to see if it …

This study is testing whether a single dose of the medication methylphenidate (Ritalin) can help young adults who misuse alcohol by reducing their cravings and brain reactions to alcohol-related pictures. Researchers will give participants either the medication or a placebo and u…

This study is testing whether therapy sessions combined with the drug MDMA can help military veterans who struggle with both post-traumatic stress disorder (PTSD) and alcohol use disorder. Researchers will compare the full MDMA-assisted therapy to a similar therapy with a very lo…

This small Yale study is testing whether nimodipine, a blood pressure medication, can reduce alcohol drinking in people with alcohol use disorder. Five non-treatment-seeking adults will stay overnight in a hospital, receive the drug, and then participate in a lab session where th…

This study is testing whether therapy combined with the psychedelic compound psilocybin can help people with severe alcohol use disorder reduce their heavy drinking. Thirty-six adults who recently completed detox will receive therapy and be randomly assigned to get either a highe…

This study aims to find the best way to help people living with HIV in Kenya quit smoking and cut back on heavy drinking. It will test a combination of intensive counseling and a medication called cytisine. The goal is to improve long-term health outcomes for 300 participants who…

This study is testing whether a small, wearable device that gently stimulates nerves in the ear can help people with alcohol use disorder get through detox. Participants will wear the device for five days while staying at a clinic to see if it reduces withdrawal symptoms, craving…

This study aims to understand how alcohol changes the way the liver handles fat. Researchers will take two small samples of liver tissue from people with alcohol use disorder who are entering a detox program—one sample early on and another a few weeks later. By comparing these sa…

This study aims to understand how inflammation in the body affects mood and alcohol cravings in people with alcohol use disorder (AUD). Researchers will give 64 participants (half with AUD, half without) a single, low-dose IV infusion that triggers a temporary inflammatory respon…

This study aims to understand if recent federal policy changes made it easier for veterans to get and stay in treatment for opioid addiction. Researchers will compare health records from before and after the policy changes for over 185,000 veterans with opioid or alcohol use diso…

This study aims to understand how severe alcohol use disorder affects a person's ability to read social cues and interact with others. Researchers will use brain scans (MRI) and track daily social interactions via smartphone to see how these social difficulties are linked to brai…