ALCOHOL USE DISORDER

This study investigates whether a non-invasive brain stimulation technique called deep rTMS can help people with moderate to severe alcohol use disorder reduce their drinking. Participants stay in a research unit for about three weeks to receive the stimulation treatment while re…

This study is testing whether a culturally adapted form of talk therapy can help Latino adults who are heavy drinkers. The therapy is designed to address immigration-related stress and is delivered by trained community health workers in a primary care clinic. Researchers will mea…

This study is testing whether an investigational drug called mazdutide can help people with alcohol use disorder reduce their drinking. About 300 participants will receive either mazdutide or a placebo (inactive substance) for several months, and researchers will track their drin…

This study is testing whether mindfulness-based relapse prevention groups delivered over video calls are more effective than standard online support groups at helping people maintain long-term recovery from alcohol use disorder. It will involve 470 adults across the U.S. who want…

This small pilot study compares two different psychedelic-assisted therapies for alcohol use disorder. Twenty men with moderate to severe alcohol problems will receive either psilocybin (from magic mushrooms) or ketamine alongside psychotherapy sessions. Researchers will measure …

This study is testing whether an investigational drug called sunobinop can help people with moderate to severe alcohol use disorder drink less. About 200 adults who are actively seeking treatment and have a pattern of heavy drinking will take either sunobinop or a placebo pill. T…

This study aims to create and test a new talk therapy designed specifically for transgender and nonbinary people struggling with alcohol use disorder. Researchers will adapt an existing therapy to better address the unique life stresses and relationship challenges this group face…

This study is testing a telehealth program designed to help people with alcohol use disorder. Participants are assigned to either try the program immediately or be placed on a waitlist. The program includes medical assessment, prescription medications, coaching sessions, educatio…

This study is testing whether a special telehealth program can help people with advanced liver disease drink less alcohol. About 180 participants will be randomly assigned to either receive several motivational phone counseling sessions or to continue with their usual medical car…

This study is testing a new program for couples in Uganda where the young woman has HIV. The program aims to help her stay engaged with her HIV care and treatment. It works by helping her male partner reduce heavy alcohol use, which is linked to relationship violence, a major bar…

This small Yale University study is testing whether apremilast, a medication approved for psoriasis, might help people with alcohol use disorder drink less. Ten participants will take the medication daily and then complete lab sessions where researchers measure how much alcohol t…

This study is testing a non-invasive brain stimulation technique to see if it can help older adults with alcohol use disorder and mild memory problems. Researchers want to see if stimulating specific brain areas can reduce heavy drinking and improve thinking skills at the same ti…

This study is testing whether a non-invasive brain stimulation technique can help reduce alcohol cravings in veterans. The treatment, called repetitive Transcranial Magnetic Stimulation (rTMS), uses magnetic pulses to target specific brain areas. The goal is to see if this approa…

This early-stage study is testing the safety and initial effects of a single dose of the medication brexanolone in people who have both PTSD and alcohol use disorder. Researchers want to see if the drug can help reduce drinking triggered by stress. About 25 participants will rece…

This study is testing a 5-week behavioral therapy program designed for women who have experienced a sexual assault in the past year and are struggling with alcohol use. The goal is to see if this combined approach can help reduce symptoms of post-traumatic stress and control prob…

This study tested whether delivering alcohol treatment in Black churches helps more people than standard clinic care. Researchers compared how many Black adults with alcohol problems started treatment, stayed in it, and reduced their drinking in each setting. The goal was to see …

This study is testing whether a smartphone app and a connected breathalyzer can help people with alcohol use disorder stay sober. Participants use the system to remotely prove they haven't been drinking and can earn money for staying alcohol-free. The goal is to make a proven tre…

This study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' can help people who have both major depression and alcohol use disorder. Researchers at Johns Hopkins are comparing the effects of psilocybin to a placebo in 90 participants. The …

This study is testing if adding a remote support program helps people stay sober after leaving alcohol detox. Participants who recently finished detox use a smartphone app and a breathalyzer to prove they are not drinking. Some may earn small cash rewards for staying alcohol-free…

This study is testing whether a personalized support program can help prevent early deaths in low-income adults. The program provides health navigation, personalized benefits, and compensation for health-related costs to help participants reduce risks from heavy drinking, heart d…

This study is testing a special workshop, led by fellow firefighters, that teaches emotion regulation skills. It aims to prevent PTSD, depression, anxiety, and alcohol use problems in new firefighter recruits. Researchers will compare this workshop to standard mental health educa…

This study is testing two different talk therapies for insomnia in people who are also being treated for alcohol use disorder. Researchers want to see if improving sleep can help people drink less and feel less tired during the day. The study involves 134 participants who have bo…

This study aims to see if combining a brain stimulation technique (low-intensity focused ultrasound) with a mental exercise (thinking about positive future events) can help people who suffer from both chronic pain and alcohol use disorder. Ten participants will try different comb…

This study aims to better understand alcohol use disorder by testing a new assessment tool. Participants complete computer surveys and tasks that measure thinking, decision-making, and feelings about alcohol. The goal is to learn how brain function relates to drinking behavior an…

This study aims to understand how alcohol affects sleep differently in women and men. Researchers will monitor the sleep of 130 healthy adults after they receive a controlled dose of alcohol or a placebo. The main goal is to see if women's sleep is more sensitive to alcohol disru…

This study is observing 20 people in Portland, Oregon, who are voluntarily receiving state-regulated psilocybin services for alcohol use disorder. Researchers are not providing treatment but are tracking participants' experiences and drinking patterns over time to learn about rea…

This study aims to understand the long-term journey of recovery from alcohol use disorder by following 733 adults for up to 12 years. Researchers will track how people's brain function, life satisfaction, social relationships, and career engagement change over time, and what fact…

This study aims to better understand the journey of recovery from alcohol use disorder. Researchers are following 250 people who receive 12 weeks of therapy, tracking their progress closely during treatment and for up to 4.5 years afterward. The goal is to map out the different p…

This study aims to understand how alcohol use disorder affects inflammation in the brain and body. Researchers will use special PET/CT scans on a small group of people with the disorder and healthy volunteers to compare the results. The goal is to gather knowledge, not to test a …

This small lab study is checking if a single dose of the pain reliever diclofenac changes a specific brain chemical in people with alcohol use disorder. Twelve participants will take either the drug or a placebo pill once, and researchers will measure their blood. The goal is to …

This study aims to understand how common low sodium levels are in hospital patients and how the speed of correcting it affects recovery. Researchers will review the records of 10,000 patients to see if treatment follows guidelines and to measure the risk of a rare brain injury fr…