ALCOHOL USE DISORDER

This study tests a culturally adapted counseling approach (CAMI) for Latino/a adults who drink heavily and may also use drugs. The program includes discussions about immigration-related stress and is delivered by trained community health workers in a primary care clinic. Research…

This study tests a behavioral program called contingency management for people who have had a liver transplant due to alcohol-related liver disease and have started drinking again. Thirty participants will be randomly assigned to either receive rewards (up to $80 per week) for pr…

This study looks at whether combining online sessions with in-person therapy helps people with alcohol use disorder stay in treatment and drink less. About 1800 adults in Denmark will take part. The goal is to see if this blended approach works better than standard face-to-face t…

This study looks at whether online mindfulness classes can help people with alcohol use disorder stay in recovery for the long haul. About 470 adults who want to cut back or stop drinking will either take video-based mindfulness classes or be referred to online support groups. Th…

This study tests a personalized program for low-income adults aged 35-64 who face higher risks of heart disease, heavy drinking, and HIV. The program includes patient outreach, individual health benefits, and help with healthcare costs. Researchers will measure changes in alcohol…

This study tests whether offering alcohol use disorder treatment in Black churches helps more people start and stay in treatment compared to traditional clinics. About 137 Black adults with alcohol problems will receive therapy either in a church or a specialty clinic. The goal i…

This study tests a drug called mazdutide to see if it can help people with alcohol use disorder drink less. About 300 adults with this condition will receive either the drug or a placebo for several weeks. The main goal is to measure changes in drinking behaviors using a standard…

This study looks at whether psilocybin, a hallucinogenic drug, can help people who have both major depression and alcohol use disorder. About 90 adults aged 21-65 will receive psilocybin in a controlled setting. Researchers will measure changes in depression symptoms and drinking…

This study tests whether citicoline, an over-the-counter supplement, can reduce brain inflammation and improve thinking skills in 56 adolescents aged 16 to 22 with alcohol use disorder. Participants receive either citicoline or a placebo pill for a set period. The goal is to see …

This study tests whether giving small monetary rewards for sober breathalyzer readings, collected remotely via a smartphone app, helps people with alcohol use disorder stay abstinent after detox. About 91 participants who recently completed detox will be monitored for several mon…

This study tests whether a smartphone app and breathalyzer can help people with alcohol use disorder stay sober by rewarding them with money for each day they don't drink. About 211 adults who want to quit drinking will use the app and breathalyzer at home. The goal is to make a …

This study tests a telehealth program for people with alcohol use disorder. Participants either receive the program—which includes medication, coaching, and a breathalyzer—or join a waitlist. The goal is to see if the program helps reduce heavy drinking over three months.

This study tests a program for couples to help adolescent girls and young women (ages 15-24) living with HIV in Uganda stay engaged in their HIV care. The approach works by reducing male partner alcohol use and the risk of intimate partner violence. About 80 participants will be …

This study tests a new drug called sunobinop to see if it can help people with moderate to severe alcohol use disorder drink less. About 200 adults who want treatment will receive either the drug or a placebo. The main goal is to see if the drug reduces the number of heavy drinki…

This study tests whether a medication normally used for other conditions can help people with HIV reduce their alcohol use. Researchers will enroll 30 adults with HIV and alcohol use disorder to see if the treatment is practical, safe, and acceptable. The approach combines the me…

This pilot study tests whether psilocybin (magic mushrooms) or ketamine, combined with talk therapy, can help men aged 25-65 with moderate to severe alcohol use disorder drink less. Twenty participants will receive one of the two treatments and be followed for changes in drinking…

This study tests a new type of brain stimulation, called deep rTMS, to help people with alcohol use disorder. The treatment targets brain areas involved in memory and decision-making. Researchers will measure if it reduces alcohol cravings and actual drinking in 44 participants.

This study looks at whether using existing medications in a new way can help people with HIV who also have alcohol use disorder drink less. About 30 participants will receive the medication along with counseling and check-ins from a pharmacist. The goal is to see if this approach…

This early-stage study tests whether apremilast, a drug currently used for arthritis, can help people with alcohol use disorder drink less. Ten adults will take the medication and have their alcohol intake measured during lab sessions. The goal is to gather initial data on whethe…

This early-phase study tests whether a non-invasive brain stimulation technique called accelerated rTMS can help older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. The goal is to see if the treatment can reduce heavy drinking and improve t…

This study tests a stepped alcohol treatment program delivered by phone or video for 180 adults with chronic liver disease who drink too much. Participants are randomly assigned to either the program or usual care. The goal is to see if the program helps reduce drinking and impro…

This study is developing and testing the first alcohol use disorder treatment designed specifically for transgender and gender non-conforming adults. About 30 participants will try an adapted form of interpersonal psychotherapy that addresses unique life experiences affecting dri…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter trainees. About 480 recruits will take part during their academy training. They will either receive the emotion-regulation workshop o…

This study tests whether taking a probiotic supplement for four weeks can reduce alcohol cravings and improve thinking, mood, and gut health in people with alcohol use disorder. 38 participants are randomly assigned to receive either the probiotic or a placebo, and neither they n…

This study tests a cognitive behavioral therapy (CBT) group designed specifically for women veterans who have alcohol use disorder. About 162 women will take part, and the therapy focuses on changing thoughts and behaviors around drinking. The goal is to help them drink less and …

This study tests whether a ketone supplement called Kenetik can reduce alcohol withdrawal symptoms and the need for sedative medication during a 5-day detox program. About 50 adults with alcohol use disorder will receive either the ketone drink or a placebo three times daily. Res…

This early study tests whether a drug called brexanolone is safe and feasible for people who have both PTSD and alcohol use disorder. The goal is to see if it can help reduce stress-related drinking. The study involves 25 adults aged 21 to 55.

This pilot study tests whether a non-invasive brain stimulation technique called rTMS can reduce alcohol cravings in veterans who also have mild traumatic brain injury or PTSD. Twenty veterans will receive either real or placebo rTMS over 10 sessions in 2 weeks. The goal is to se…

This study looks at whether a 6-session phone therapy called Acceptance and Commitment Therapy (ACT) can help young adults (ages 18-25) in Hong Kong who drink heavily. 60 participants will be split into two groups: one gets the ACT phone calls, the other gets supportive chats. Re…

This study looks at whether adding oxytocin (a natural hormone) to a special talk therapy helps veterans with both PTSD and alcohol use disorder. About 175 veterans will get either oxytocin or a placebo before therapy sessions. Researchers will track changes in drinking habits an…

This study tests a smartphone-based program called LDART that provides social support to help adults with alcohol use disorder cut down on drinking. About 80 participants in Connecticut will use the app for 28 days and report their drinking habits. The goal is to see if the progr…

This study looks at how alcohol use disorder and mild traumatic brain injury together affect the brain in veterans. Researchers want to find the right brain area to stimulate with a non-invasive technique called rTMS to help improve daily functioning. About 100 veterans will take…

This study looks at how being a woman or a man, and changes in sex hormones during the menstrual cycle, affect the way alcohol disrupts sleep. Healthy adults aged 21-45 who drink regularly will have their sleep monitored in a lab after receiving alcohol or a placebo. The goal is …

This early-stage study looks at whether a single dose of diclofenac, a common pain reliever, can change certain brain chemicals in people with alcohol use disorder. The study involves 12 adults who will receive either diclofenac or a placebo in a random, double-blind manner. The …

This study follows 250 adults with Alcohol Use Disorder who receive 12 weeks of therapy. Researchers track their drinking habits, dependence severity, and quality of life for a year after treatment to understand different recovery patterns. The goal is to better define what recov…

This study follows 733 adults with alcohol use disorder to learn what helps people recover and what leads to relapse. Researchers measure thinking, social life, and drinking patterns over time. The goal is to find new ways to prevent relapse and support long-term recovery.

This study looks at why many veterans with PTSD, depression, or alcohol/opioid problems don't get proven treatments. It tests a method called Participatory System Dynamics, where patients, doctors, and leaders work together to improve care. The goal is to see if this approach wor…

This study explores two experimental methods—Episodic Future Thinking (imagining positive future events) and Low-intensity Focused Ultrasound (using sound waves on the brain)—to see if they can reduce pain and alcohol cravings in people with both chronic pain and alcohol use diso…

This study looks at different methods to help primary care clinics better screen patients for substance use disorders. Researchers will compare approaches like practice coaching, group learning, and financial rewards. The goal is to find the best way to increase screening rates a…

This study is testing a new assessment tool called the ANA to better understand how brain function relates to alcohol use disorder (AUD). Researchers will have 1,400 adults complete computer surveys and tasks that measure thinking, decision-making, and emotions related to drinkin…

This study uses a special PET/CT scan to measure inflammation in the brain and body of people with alcohol use disorder (AUD) compared to healthy volunteers. Up to 90 participants (60 with AUD, 30 healthy) will receive one scan with an investigational tracer. The goal is to under…

This study looks at how alcohol changes the way our brains work together during social interactions. Researchers will monitor brain activity in pairs of people while they drink alcohol. The goal is to understand the brain mechanisms behind alcohol's rewarding effects in social se…

This study watches 20 adults in Portland, Oregon, who are already receiving psilocybin services for alcohol use disorder. Researchers do not provide treatment—they only observe and collect data through surveys and questionnaires. The goal is to see if psilocybin-assisted care red…

This study tests new technology-driven programs to help people manage their alcohol use and overall well-being. Researchers are looking at whether these virtual programs can improve access to treatment and help people start and stick with therapy. The study involves 362 adults wi…

This study looks back at 10,000 hospital patients to understand how often low sodium levels occur, how they are treated, and what complications arise. Researchers will examine factors like how quickly sodium levels are corrected and whether that affects patient outcomes such as b…