New trial aims to treat both liver damage and alcohol addiction at once
NCT ID NCT07060638
First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times
Summary
This study tests whether adding alcohol use disorder treatments (acamprosate and counseling) to standard liver therapy improves outcomes for people with severe alcohol-associated hepatitis. It also compares a new drug, F-652, against prednisone for liver treatment. About 216 adults aged 18-70 with severe liver inflammation and heavy alcohol use will participate. The goal is to see if the combined approach reduces death, liver complications, and return to drinking over 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
F-652 (IL-22), prednisone, acamprosate, and motivational interviewing
What this could lead to
If successful, this could point toward a combined treatment approach that improves both liver health and alcohol abstinence in people with severe alcohol-associated hepatitis.
What could go wrong
This is an early phase 2 trial with 216 participants, so results may not apply to everyone. The treatments may not improve outcomes or could cause side effects like infections or liver complications.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ALCOHOL USE DISORDER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
Contact
-
Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact
-
Mayo Clinic
RECRUITINGRochester, Minnesota, 55902, United States
Contact
-
University of Louisville
RECRUITINGLouisville, Kentucky, 40292, United States
Contact
-
University of Texas Southwestern Medical School
RECRUITINGDallas, Texas, 15260, United States
Contact
-
Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23284, United States
Contact