Spinal injury

This study tested an experimental drug called NVG-291 in people with spinal cord injuries to see if it could help improve movement and strength. The trial was stopped early and included 24 adults with cervical spinal cord injuries. Participants received either the drug or a place…

This study tested whether a smartphone app could help people with incomplete spinal cord injury manage bladder issues. 88 adults were split into two groups: one received standard nursing, the other used a special app for 4 weeks that provided health education, bladder tracking, a…

This completed early-phase trial tested whether the drug 4-AP (dalfampridine), combined with special nerve stimulation and leg exercises, could improve muscle strength and control in people with spinal cord injury. 26 adults with injuries at or above the lower back took part. The…

This study tested a titanium implant called SPHEREPLAST in 37 people with spine fractures caused by osteoporosis or injury. The implant is placed during a procedure called balloon kyphoplasty to stabilize the broken bone and help it heal. Researchers looked at pain levels, disabi…

This pilot study tested a sleeve worn on the forearm that uses muscle signals to stimulate hand muscles, helping people with tetraplegia from spinal cord injury grasp and manipulate objects. Twelve adults with chronic cervical SCI completed a 12-week training program using the de…

This small pilot study tested two ways to stimulate the spinal cord—one with a surgically implanted device and one with surface electrodes—combined with a robotic exoskeleton to help people with spinal cord injury walk. Four men with complete paralysis below the chest took part. …

This study tested a freeze-dried plasma product that can be mixed with water in 6 minutes, avoiding the long thaw time of standard plasma. It included 42 trauma patients with severe bleeding who needed blood transfusions. The goal was to see if faster plasma delivery could improv…

This study looked at over 2,000 trauma patients who needed help breathing before arriving at the hospital. Half were given a supraglottic airway device (like an LMA or King tube) first, while the other half received standard care. The goal was to see which approach led to more pa…

This study tested a device called ExaStim that uses mild electrical stimulation on the skin over the spinal cord to help people with chronic cervical spinal cord injury improve arm and hand function. Thirty-three participants used the device at home for 4 weeks after a training p…

This study tested a special balance training program for people with incomplete spinal cord injury who are at high risk of falling. The training involved unexpected pushes or pulls to trigger a stepping response, with some participants also receiving electrical stimulation to hel…

This pilot study tested whether adding a special type of electrical stimulation to standard wound care helps heal chronic pressure injuries (bedsores) in people with spinal cord or brain injuries. Twenty adults with stage II-IV pressure sores that hadn't healed after four weeks o…

This study tested a new rehabilitation approach for people with spinal cord injury. Ten participants received a spinal cord stimulation implant and used a robotic exoskeleton to help them walk. The goal was to improve leg muscle strength and overall quality of life. The combinati…

This study tested a new therapy that combines two types of electrical stimulation with balance training (like video games) to help people with incomplete spinal cord injury improve their standing balance. Seventeen participants completed 12 sessions over 4 weeks. The goal was to …

People with spinal cord injury (SCI) face higher risks of heart disease and diabetes, partly due to chronic inflammation and poor blood vessel function. Exercise helps but is often not possible. This small study tested whether repeated passive heating (using a water-perfused suit…

This study tested whether a person with chronic paralysis from a spinal cord injury could control hand movements using only their thoughts. The participant, who already had a brain implant from the BrainGate study, used a computer to decode their intended grasp patterns. Those si…

This study tested whether combining a mild brain stimulation technique (tDCS) with a new mental and physical rehab method (NEUROM) can help people with chronic spinal cord injury regain leg movement and feeling. Fifty-six participants with paralysis below the lower back were rand…

This study tested an experimental drug called elezanumab in people with a recent cervical spinal cord injury. The goal was to see if the drug could improve arm and hand movement and was safe. About 60 adults aged 18-75 with severe neck-level injuries received either the drug or a…

This pilot study tested whether combining neuromuscular electrical stimulation with daily vitamin D could improve bone health in veterans with chronic spinal cord injury. Six participants underwent 9 months of treatment, with bone changes measured by MRI and DXA scans. The goal w…

This study tested a new gel-like product that helps stop bleeding during spinal surgery. It was compared to an existing product in 130 patients with spinal stenosis, tumors, or injuries. The goal was to see if the new product works just as well and is safe to use.

This study tested whether a home exercise program using electrical stimulation to move the legs, combined with a personalized diet, could improve body composition and metabolism in adults with spinal cord injury. Twenty-six participants were assigned to either exercise plus diet …

This study tested a drug called MT-3921 (Unasnemab) in 72 people with recent severe neck spinal cord injuries. The goal was to see if it could improve arm and hand function better than a placebo. Participants received the drug or placebo by IV over 6 months, and their motor score…

This study tested whether adding functional electrical stimulation (FES) bicycle ergometry to robotic rehabilitation helps people with chronic incomplete spinal cord injury walk better. 38 participants completed 20 sessions over 4 weeks. The goal was to see if the combination imp…

This study tested whether a bone-building drug (teriparatide) and a vibrating platform, alone or together, could improve bone density in 60 adults with chronic spinal cord injury who had low bone mass. Participants received daily injections of teriparatide, used a vibration devic…

This early-stage trial tested a single dose of an experimental drug called ALMB-0166 in 24 people with acute spinal cord injury. The main goal was to check safety and how the drug moves through the body. Participants had moderate to severe injuries and were scheduled for surgery …

This small pilot study tested whether pairing vagus nerve stimulation with rehabilitation is safe and feasible for people with cervical spinal cord injury. Six participants received an implanted nerve stimulator and underwent rehab sessions. The study focused on safety and whethe…

This study tests whether a 12-week adaptive exercise program can reduce chronic inflammation in people with spinal cord injury (SCI). Chronic inflammation is linked to heart and lung disease, the top causes of death in SCI. Twenty-four adults with SCI will be randomly assigned to…

This study tested three different weight loss strategies in 110 adults with chronic spinal cord injury who were overweight. The strategies included portion-controlled meals, enhanced self-monitoring with technology, and a tailored lifestyle program called GLB-SCI. The goal was to…

This phase 2 trial tested whether combining testosterone therapy with a special type of electrical stimulation (long pulse width) could rebuild leg muscle in 12 people with spinal cord injury whose muscles no longer respond to standard electrical stimulation. Participants receive…

This pilot study tested whether a year of monthly romosozumab injections, followed by a year of weekly alendronate pills, can improve bone health in women with chronic spinal cord injury and osteoporosis. Twelve non-ambulatory women participated. The goal was to see if this two-s…

This early-phase trial tested a device called SC0806, which is surgically implanted into the spine. It releases a growth factor to encourage nerve repair in people with complete spinal cord injury. Ten participants were randomly assigned to receive either the device plus rehabili…

This study tested whether using the World Health Organization's trauma care checklist helps injured patients recover better. Sixty adults with trauma were randomly assigned to standard care or care with the checklist. Researchers measured pain, injury severity, complications, and…

This early study tested a wireless patch that uses a tiny electric current to push two drugs (neostigmine and glycopyrrolate) through the skin and into the blood. The goal is to help people with spinal cord injury have predictable bowel movements without needles. Only 2 healthy v…

This study tested whether a brain-computer interface (BCI) training program could improve hand and arm function in people with recent spinal cord injuries. Thirty participants used a system that reads brain signals during hand motor imagery exercises. The goal was to see if this …

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a simple, portable virtual reality balance test (called VETS) to see if it could help diagnose and track cervical spondylotic myelopathy (CSM), a spinal cord condition common in veterans. Eight participants with CSM and a control group performed balance tasks un…

This study tests whether a personalized nutrition plan can help people with a recent spinal cord injury avoid gaining unhealthy body fat and becoming obese. About 56 participants will receive tailored dietary advice for one year. The goal is to improve long-term health and preven…

This study tested whether a single dose of zoledronic acid, a drug already used for osteoporosis, can prevent the rapid bone loss that often follows a spinal cord injury. Researchers enrolled 60 adults who had recently lost the ability to walk due to injury. They measured changes…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This study tested a special exercise called blood flow-restricted resistance exercise (BFRE) in 10 people with incomplete spinal cord injury. Participants did arm exercises with a cuff that limits blood flow, plus electrical stimulation if needed, twice a week. The goal was to se…

This study tests whether dantrolene, a non-sedating muscle relaxant, can improve pain control and reduce agitation in adults undergoing lumbar fusion surgery. Participants receive either dantrolene or a placebo pill before and after surgery. The goal is to see if dantrolene impro…

This study tested a 20-minute neck-strengthening program in 50 amateur rugby players to see if it could speed up their neck muscle reactions to head impacts. The program used isometric contractions and stroboscopic glasses to improve visual processing and reflex force. Researcher…

This study tested a smart faucet that uses voice, motion, and remote controls to help people with spinal cord injury (SCI) get water for drinking, grooming, and washing without needing help. 40 participants with SCI and control subjects used the faucet in clinics and at home. The…

This completed study tested three different rehabilitation approaches—robotic rehabilitation, functional electrical stimulation (FES), and occupational therapy—to see which works best for improving hand and arm function in people with tetraplegia (paralysis of all four limbs) due…

This study tested whether adding core stability training to standard physical therapy improves trunk control and sitting balance in people with incomplete spinal cord injury. 46 participants aged 25-35 with injuries between T6 and T12 took part. The core training focused on exerc…

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This study tested whether a procedure called vertebroplasty (injecting cement into a broken spine bone) relieves pain better than a sham (fake) procedure in people with osteoporosis. 52 adults aged 50 and older with recent spine fractures took part. The main goal was to measure p…

This study tested a smart faucet that can be controlled by voice, eye gaze, or hand motion to help people with cervical spinal cord injury drink water and groom themselves. Twenty-eight participants tried the faucet to see if they could complete tasks like drinking, rinsing, and …

This small study tested whether a device that gently stimulates a nerve in the ear (called auricular vagus nerve stimulation) is safe for people with chronic spinal cord injuries. Sixteen participants received the stimulation over two visits. The main goal was to check for side e…

This study compared four minimally invasive procedures—vertebroplasty, kyphoplasty, stentoplasty, and thermal facet ablation—for treating pain from vertebral compression fractures. Researchers enrolled 1000 adults with chronic back pain due to these fractures. The goal was to see…

This completed Phase 2 trial tested a smart, hands-free faucet called Access-H2O for people with spinal cord injury. The faucet uses voice, motion, and remote controls to let users get water for drinking, grooming, and washing without help. Twenty-three participants with spinal c…

This study tested whether brief periods of breathing low-oxygen air (acute intermittent hypoxia) can improve arm, leg, and walking function in people with incomplete spinal cord injury. Sixty-eight participants received either the low-oxygen treatment or a sham (normal air) over …

This study tested a 'Digital Strolling' program where people with severe mobility impairment use a virtual reality headset to walk in a digital world. 24 participants either used the VR walking or watched walking videos for 10 days. The goal was to see if this approach could impr…

This small study tested whether training with a robotic exoskeleton (a wearable robot suit) can help improve bowel function in people with spinal cord injury. Ten adults with long-term spinal cord injury used the exoskeleton in a supervised program. Researchers measured changes i…

This study tested whether adding a special nerve stimulation treatment to standard exercise could improve neck disability in people with whiplash from a car accident. 44 adults with recent whiplash were split into two groups: one did only exercises, the other did exercises plus t…

This study tested a home-based program for people with spinal cord injury that combines leg cycling with electrical stimulation, arm exercise, and a hormone treatment. The goal was to see if this combination improves aerobic fitness, daily function, and overall health better than…

This study tested a low-cost elastic band device designed to help therapists assist people with spinal cord injury while walking on a treadmill. The device uses rubber bands to help move the legs forward during walking. Nineteen participants with spinal cord injury tried the devi…

This study tested whether a social robot could reduce fear and pain in children aged 5 to 10 during wound dressing. Sixty children were split into two groups: one interacted with the robot while getting their wound dressed, and the other received standard care. Researchers measur…

This study tested whether a virtual rehabilitation program called VIVA is feasible for people with spine fractures caused by osteoporosis. The program includes weekly online sessions to help reduce pain and improve movement and quality of life. The study involved 34 participants …

This completed study tested a 7-week, peer-led program for adults with spinal cord injury and chronic pain. The program combined education about pain neuroscience with body-based tools like red light therapy, massage, and guided movement. Twelve participants attended group sessio…

This study tested whether people with spinal cord injuries can reach a high-intensity heart rate while walking in a robotic exoskeleton. Eleven participants completed five training sessions using the Ekso device. Researchers measured heart rate, walking speed, and endurance befor…

This study tested whether a mild electrical stimulation (40 kHz) applied through the skin can safely reduce nerve pain in people with spinal cord injury. Thirty adults with paraplegia and chronic nerve pain received either real or placebo stimulation alongside their usual treatme…

This study tested whether wearing earplugs and an eye mask during an MRI scan can lower anxiety. 72 adults having their first MRI were split into two groups: one used the earplugs and eye mask, the other did not. Researchers measured changes in blood pressure, heart rate, breathi…

This study tested a special wheelchair that lets people with spinal cord injuries stand up and move around at the same time. The goal was to see if using this chair at home and in the community helps them stand more often and feel more satisfied with their daily activities. Twent…

This study tested two types of magnetic brain stimulation (TMS) to see if they can reduce nerve pain in people with spinal cord injury. 26 adults with long-term nerve pain that didn't respond to medication took part. The goal was to measure changes in pain severity, daily functio…

This pilot study tested whether a non-invasive treatment called extracorporeal shockwave therapy (ESWT) can safely reduce spasticity—muscle stiffness and spasms—in people with chronic spinal cord injury. Five participants received ESWT or a sham treatment, and researchers measure…

This study compared two pain relief methods for people undergoing lower back decompression surgery. One group received a nerve block (erector spinae plane block), while the other received ketamine through an IV. Researchers measured how well patients recovered using a quality-of-…

This completed Phase 3 trial tested whether brivaracetam, a drug used for seizures, can reduce chronic nerve pain in people with spinal cord injury. 44 adults with persistent pain took part. The study compared brivaracetam to a placebo and measured changes in pain intensity and d…

This study tested a device that combines mild electrical muscle stimulation with a balance-board video game to help people with spinal cord injury or stroke improve their balance and reduce fall risk. 18 adults who were at least one year past their injury took part. The goal was …

This study tested two types of magnetic brain stimulation (iTBS and rTMS) combined with robotic walking therapy in 30 people with chronic spinal cord injury. The goal was to see if these treatments could improve leg strength, walking ability, and daily independence. All participa…

This study tested two 8-week home exercise programs for 96 adults with spinal cord injury. One program used movement to music, the other standard exercises. Researchers measured physical activity levels and pain to see which approach worked better.

This study tested a lightweight robotic suit called the Myosuit in 34 people with incomplete spinal cord injury. Participants used the suit during walking exercises and then took it home for six weeks to see if it improved their daily walking. The goal was to measure changes in w…

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…

This small study tested whether functional electrical stimulation (FES) arm cycling could improve arm strength and function in people with recent spinal cord injury. Six participants with cervical-level injuries cycled with electrical stimulation 3 times a week for 6 weeks. The s…

This study tested a combination of three procedures—spinal fixation, nerve heat treatment, and anti-inflammatory injections—for people with ongoing back and leg pain after disc surgery. 63 participants were split into two groups to see if the triple approach worked better than sp…

This study looked at whether a type of talk therapy called prolonged exposure therapy can help reduce PTSD symptoms in people with spinal cord injuries. Thirty adults with both conditions were randomly assigned to receive the therapy or continue their usual care. The main goal wa…

This study tested a new online program to help people with spinal cord injury cope better and improve their mental health. Twelve adults with spinal cord injury and mild anxiety or depression took part in eight weekly online group sessions led by a nurse. The main goal was to see…

This study looked at whether high-intensity walking training is better than lower-intensity walking exercise for people with chronic, motor incomplete spinal cord injury. Researchers measured walking speed and distance in 53 participants. The goal was to find a more effective way…

This study tested a new approach to help people with spinal cord injury walk better. Participants received brief sessions of mild low-oxygen air (acute intermittent hypoxia) combined with gentle electrical stimulation on the back, plus walking practice. The goal was to see if thi…

This study tested an intensive motor rehabilitation program that uses advanced technology to help adults with chronic stroke or spinal cord injury improve their daily functioning. 102 participants were randomly assigned to either the tech-enhanced rehab or a control group. The go…

This study tested a computer game-based exercise program to help people with stroke or spinal cord injury improve hand and arm function. Thirty-five adults who were at least six months post-injury used a special mouse-like device to play games designed to practice hand movements.…

This study tested a new approach to help people with cervical spinal cord injury improve arm and hand function. Participants received non-invasive brain stimulation combined with upper limb training over several weeks. The goal was to see if this combination could strengthen musc…

This study tested whether combining two drugs—dextromethorphan (taken by mouth) and lidocaine (given through a vein)—can reduce central neuropathic pain in people with spinal cord injury. 26 adults with moderate or worse pain for at least 3 months took part. Each person received …

This study tested three doses of dextromethorphan (a common cough medicine) against a placebo to see if it could reduce nerve pain in people with spinal cord injuries. 26 adults with chronic central neuropathic pain took part. The goal was to measure pain relief and satisfaction …

This completed Phase 1 trial tested whether three FDA-approved drugs (cyproheptadine, carbidopa-levodopa, and atomoxetine) could improve hand function when combined with hand training exercises in 25 people with chronic spinal cord injury. Participants took a single dose of one d…

This study tested a special talking therapy (values-based cognitive behavioral therapy) for 6 adults with spinal cord injury from road accidents. The goal was to see if it helps reduce daily pain and improve living according to personal values. Participants attended 10 therapy se…

This early-phase study tested whether short bursts of low-oxygen breathing (acute intermittent hypoxia) combined with high-intensity arm training could improve hand and arm function in 58 people with chronic spinal cord injury. Participants had injuries between neck levels C1 and…

This study tested whether starting gentle leg cycling in bed within 48 hours after spinal surgery is safe and doable for people with severe spinal cord injuries. Forty-five adults took part, cycling for 30 minutes daily for two weeks. Researchers checked for safety, how many sess…

This study tested whether daily electrical stimulation of the buttock muscles can help people with chronic spinal cord injury. Thirty participants used a device for 35 minutes each day over six months. Researchers measured muscle volume and sitting pressure to see if the stimulat…

This study tested whether therapy sessions delivered via iPad FaceTime could help people with spinal cord injury who feel depressed. 75 adults with recent spinal cord injury and mild to moderate depression received cognitive behavior therapy from a psychologist. The goal was to r…

This study tested whether using a device that electrically stimulates the abdominal muscles can help people with spinal cord injury manage their bowel movements more quickly and comfortably. 36 adults with injuries at or above T12 were randomly assigned to receive real or low-dos…

This small study tested whether combining virtual walking (watching a first-person walk video) with mild brain stimulation (tDCS) could help ease chronic nerve pain in people with spinal cord injury. Four participants tried the 2-week program, keeping pain diaries and reporting h…

This study looked at whether walking with a therapy dog helps adult trauma patients move more during their hospital stay. Sixty-four patients each took two walks—one with a dog and one without—and reported their pain, anxiety, and motivation. The goal was to see if animal-assiste…

This study tested a new, non-invasive treatment for people with cervical spinal cord injury who have difficulty using their hands and arms. Fifteen participants received either electrical stimulation of the spinal cord combined with physical therapy, or physical therapy alone. Th…

This study tested whether a high-intensity exercise program, run by physical therapy students, can help people with neurologic disabilities move better in everyday life. Fifteen participants with conditions like cerebral palsy, stroke, or spinal cord injury completed the program.…

This pilot study tested whether brivaracetam, a drug used for seizures, can reduce severe nerve pain in people with chronic spinal cord injury. 24 participants received either brivaracetam or a placebo for 3 months. The study aimed to see if a larger trial is possible and measure…

This study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…

This study looked at two methods of injecting bone cement into fractured vertebrae in elderly patients with osteoporosis. 196 patients were randomly assigned to receive either a one-sided or two-sided injection. The goal was to see which approach better reduces pain and improves …

This study tested prefabricated carbon fiber ankle-foot orthoses (AFOs) in 65 children and teenagers with conditions like cerebral palsy, spina bifida, or spinal cord injuries that affect walking. Researchers measured stride length, walking speed, and user satisfaction by compari…

This study tested whether virtual reality (VR) games could help people with tetraplegia (paralysis of all four limbs) improve arm and hand function during hospital rehabilitation. Twelve participants either received standard therapy or added VR games to their routine for 12 weeks…

This study tested whether applying mild electrical stimulation to the skin over the spinal cord could help regulate blood pressure in veterans with spinal cord injury who have chronically low blood pressure. Ten participants with injuries at or above T6 received stimulation at di…

This completed study tested whether a new type of electrical stimulation, called spatially distributed sequential stimulation, works better than standard stimulation for people with upper motor neuron disease. Ten adults with stable symptoms used both methods while cycling. Resea…

This phase 2 trial tested whether buspirone, a drug usually used for anxiety, can improve breathing capacity in people with chronic high-level spinal cord injuries. Thirteen participants took either buspirone or a placebo for 14 days. Researchers measured lung function, breathing…

This Phase 2 trial tested whether KAI-1678, given as a single injection under the skin, can reduce pain in people with spinal cord injury. Only 5 adults with long-term spinal cord injury and chronic pain took part. The study compared KAI-1678 to a placebo to see if it improved pa…

This study tested whether walking training overground with body weight support helps people with chronic spinal cord injury walk better. Fourteen participants were randomly assigned to either overground or treadmill training for four weeks. The goal was to see if the overground a…

This study tested two different robotic exoskeletons—one that balances itself and one that requires the user to balance—in 6 people with spinal cord injury. Researchers measured how fast and far participants could walk with each device, along with muscle activity and user feedbac…

This study gathered information from 193 adults who had surgery or orthopedic treatment for spine problems. Researchers collected clinical, functional, and social data to create a detailed database. The goal was to better understand patient outcomes and standardize how data is co…

This completed study from France reviewed the long-term results of a surgery called continent cutaneous urinary diversion in 70 spinal cord injury patients. The surgery creates a new way to drain urine through the belly when patients cannot use a catheter normally. Researchers co…

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This study aims to create a simple bedside tool that helps doctors quickly identify motorcycle accident victims with chest injuries who are at high risk of dying. Researchers will analyze data from 1250 patients to build and test the tool, focusing on factors like helmet use and …

This completed study looked at 510 trauma patients who had no signs of nerve damage. Researchers wanted to see if getting a full-body CT scan actually changed how doctors managed their care. The goal is to find out if these scans are truly helpful or just add cost and time.

This study looked at 55 adults with arm or leg injuries to see if using a tourniquet before reaching the hospital made a difference. Researchers compared those who had a tourniquet placed to those who did not, checking for shock, blood transfusions, and other complications. The g…

This study looked at 265 severely injured adults in France to see if getting them to the hospital within the recommended 60 minutes (the 'golden hour') improves their chances of survival. Researchers checked if following these time guidelines helped patients live at least 24 hour…

Researchers looked at records from over 58,000 adults who had fall injuries to build a simple scoring system that estimates the chance of dying within 30 days. The tool uses age, sex, and vital signs taken in the emergency room. This study did not test any treatment—it only aimed…

This completed trial tested how quickly paramedics can stabilize a patient's spine using a scoop stretcher versus a vacuum mattress. Fifteen emergency medical workers participated in a simulated emergency. The goal was to see which device is faster and whether the quality of stab…

This study looked at how the interaction between a physical therapist and a patient affects recovery during robot-assisted walking training for people with spinal cord injury. 55 participants were split into two groups: one with high therapist interaction and one with minimal int…

This pilot study tested whether a personalized nutrition plan using up to three Ensure shakes a day is practical for older adults (60+) recovering from a serious injury. Forty participants were randomly assigned to either the nutrition plan or standard care. The study did not mea…

This study looked at whether slow, yogic-style breathing can affect heart rate and blood pressure in people with spinal cord injuries. Seventeen wheelchair users completed breathing exercises while their heart and blood pressure were measured. The goal was to learn more about how…

This study looked back at the medical records of 137 severely injured trauma patients who needed large blood transfusions between 2020 and 2025. Researchers analyzed how different transfusion strategies, such as balanced ratios and whole blood use, affected 30-day survival and ot…

This study checks whether a simple six-minute pegboard and ring test is a valid and reliable way to measure upper body exercise capacity in people with spinal cord injury. Researchers will compare the pegboard results with standard strength and function tests in 34 adults who use…

This study tested a new robotic device called REACTION that combines an exoskeleton and a gait trainer to help people with stroke or spinal cord injury improve walking and balance. Seven participants completed two sessions of walking and balance tasks, followed by an interview. T…

This study looked at whether robotic gait training helps people with spinal cord injury walk better compared to standard walking therapy. 115 patients in inpatient rehab took part. The goal was to measure improvements in walking ability and speed.

This study looked at how spinal cord epidural stimulation affects bladder, bowel, and blood pressure control in 61 adults with spinal cord injury. Researchers monitored participants in a lab and at home to understand autonomic dysreflexia and test stimulation as a therapy. The go…

This study tested whether a special ultrasound with a contrast agent (DEFINITY®) can measure blood flow in the spinal cord during surgery for acute spinal cord injury. 27 patients received the contrast agent while surgeons performed routine decompression. The goal was to see if t…

This study looked at 22 adults with spinal cord injury to understand whether anxiety or physical discomfort causes changes in heart rate and blood pressure during bladder catheterization. Participants either did the procedure themselves or had a nurse do it, with some not knowing…

This study tested a new lightweight device called PYTHEAS ODYSSEE that helps surgeons place screws in the spine more accurately. Fourteen adults having spine surgery used the device to guide screw placement. The goal was to see if the device reduces screw misplacement and is safe…

This study looked back at 170 adults with chronic neck pain from whiplash injuries to compare two treatments: radiofrequency (a nerve-blocking procedure) and neck fusion surgery. Researchers reviewed medical records from a 20-year period to see which treatment provided better pai…

This study looked at three different ways to close surgical wounds after spine surgery. Researchers measured blood flow around the wound to see if one method was better. The study involved 50 adults with spinal stenosis who had back surgery at Mayo Clinic.

This study involved over 22,000 children who experienced blunt trauma (like car crashes or falls) to develop a tool that helps doctors decide which kids truly need neck immobilization and imaging. The goal is to avoid unnecessary X-rays and CT scans, which expose children to radi…

This study tested whether a gentle electrical stimulation on the ear (taVNS) can improve how the heart and nervous system respond during exercise in people with chronic spinal cord injury. 35 adults completed two exercise sessions—one with real stimulation and one with a sham (fa…

This study looked at how parents cope emotionally after their child is hospitalized in intensive care for a severe injury. Researchers checked for signs of anxiety, depression, and post-traumatic stress in 62 parents, 3 to 6 months after the child left the ICU. The goal was to un…

This study looked at whether using regular CT scans (already done for other reasons) can better predict the risk of spine fractures in people over 50, compared to the standard FRAX risk score. Researchers analyzed CT images from nearly 2,800 adults taken five years apart. The goa…

This completed study surveyed 70 women with spinal cord injury to learn about their experiences with fertility, contraception, and pregnancy. Researchers asked closed- and open-ended questions to understand how the injury affects decisions about having children and choosing birth…

This study tested a simple frailty score (TSFI) to see if it can predict complications and death in trauma patients aged 65 and older. Researchers enrolled 500 patients across multiple hospitals. The goal was to improve care by identifying high-risk patients early, not to provide…

This study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…

This study looked at what resilience means for people living with a spinal cord injury. Researchers interviewed 28 adults who had their injury at least one year ago, asking about their experiences and having them fill out surveys. The goal was to find common themes among people a…

This study tested whether a special type of MRI (called DBSI) can predict how well people recover after surgery for a compressed spinal cord. 71 patients with cervical spondylotic myelopathy had this MRI before surgery and again 2 years later. Researchers looked for imaging marke…

This study tested a new training device called an eccentric arm-crank in 12 athletes with spinal cord injury. Over 20 training sessions, participants used the device to build upper body strength and endurance. The goal was to see if the device is practical and effective for impro…

This small study tested whether it is safe and practical to use two devices together in people with recent spinal cord injury. Eight participants received both a mild electrical stimulator placed on the back and leg, and a low-level laser. The main goal was to see if the equipmen…

This study looked at whether a structured regional health system, where trauma centers are organized by level of care, reduces deaths within 28 days after severe injury. Researchers compared outcomes for 2193 severely injured patients treated in a structured system versus a non-s…

This study looked at how the calf muscle and Achilles tendon work together during walking in people who have had a stroke or spinal cord injury, compared to healthy individuals. Researchers used ultrasound and motion analysis to measure muscle and tendon lengths in 64 adults. The…

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and their mood to understand why weight gain happens. The goal is to use this information to design better programs that help people wi…

This study looked back at medical records and conducted phone surveys of 70 patients who were treated for vertebral compression fractures with integrative Korean medicine at four hospitals. The goal was to see how well the treatment worked for pain and disability, both during the…

This study checked how well the Trauma and Injury Severity Score (TRISS) predicts survival and the need for intensive care or surgery in 204 trauma patients at one hospital in Iraq. Researchers measured the score within 6 hours of arrival and tracked outcomes. The goal is to see …

This completed study looked at how the brain controls muscles after a spinal cord injury. Researchers tested 120 people with chronic neck-level injuries to measure nerve signals and motor function. The goal was to better understand how to improve hand and arm movement for daily t…

This study looked at how different amounts of numbing medicine given around the collarbone affect pain relief and side effects during arm surgery. Researchers also used ultrasound to measure the nerve behind the eye to see if it relates to brain pressure. 64 patients aged 18 to 5…

This study looked at how walking with a robot (Lokomat) helps people with spinal cord injuries recover movement. Ten patients were assessed before, during, and after training, plus one month later. The goal was to understand how gait improves over time, not to test a new drug or …

This study tested a new way to control a robotic arm mounted on a power wheelchair. The arm uses a camera to help guide movements, making tasks like grabbing a drink easier. 21 adults who use power wheelchairs and have trouble with everyday tasks took part. They compared the new …

This study looked at whether ultrasound can measure bladder wall thickness in people with spinal cord injury and how it relates to standard bladder function tests. Researchers studied 116 adults to see if this non-invasive method could help assess bladder health. The goal is to f…

Researchers studied 407 children under 18 who had whole-body CT scans after trauma. They looked at injury details, physical exams, and lab results to create a scoring system called WHOLE. The goal is to help emergency doctors decide when a full-body scan is truly needed, reducing…

This completed study surveyed 56 adults with spinal cord injury in Türkiye to find out which everyday activities—like eating, bathing, or using a wheelchair—they value most and how independent they hope to become. Participants rated each activity on a 0–10 scale and stated their …

This study analyzed blood and other samples from 106 adults with recent spinal cord injuries to find molecules linked to better recovery. Researchers measured changes in these molecules before and after rehabilitation and one year after injury. The goal is to identify biological …

This study looked at 263 severely injured trauma patients to find out how often they develop early blood clotting problems (called trauma-induced coagulopathy) and excessive clot breakdown (hyperfibrinolysis) within the first hour of arriving at the emergency room. Researchers us…

This pilot study tested a wearable robotic exoskeleton called EksoNR in 5 people with stroke, spinal cord injury, cerebellar ataxia, or spastic paraplegia. The goal was to see if using the device for gait training in an outpatient setting is safe, tolerable, and feasible. Researc…

This study looked at 94 adults with a recent spinal cord injury to see if keeping their blood pressure at a higher or lower target helped them heal better. Participants were split into two groups: one with a standard blood pressure goal and one with a higher goal, maintained for …

This study collected information from over 8,000 people who had spine surgery for conditions like degeneration, deformity, or trauma. Researchers gathered X-ray and health data to learn which treatments work best for different patients. The goal was to build a database to answer …

This study tested whether using ultrasound to guide the placement of catheters in the femoral artery and vein (in the groin) reduces complications in severely injured patients in the intensive care unit. The trial involved 136 adults with severe trauma who needed these catheters.…

This study tested whether a brain-spinal cord-muscle training program can strengthen connections that control movement in people with spinal cord injury. Twenty-one participants completed four months of training using brain stimulation and muscle monitoring. The goal was to see i…

This completed study looked at 80 people with spinal cord injuries to understand how arm, shoulder, and wrist problems relate to their daily lives. Researchers used ultrasound to examine these areas and compared the findings with pain levels and physical exams. The goal was to id…

This study tested whether personalized walking training based on detailed 3D movement analysis works better than standard walking therapy. 63 people with spinal cord damage from injury or multiple sclerosis took part. The goal was to see if customizing exercises to each person's …

This study involved 32 adults with arm weakness from stroke, multiple sclerosis, or spinal cord injury. Researchers measured how much force patients could voluntarily produce in their arms and used that data to build mathematical models. The goal is to use these models to improve…

This completed study looked at 150 adults with thoraco-lumbar spine injuries to see if adding an emergency MRI to a standard CT scan changes how doctors treat them. The researchers compared treatment plans before and after the MRI, including options like rest, minimally invasive …

This completed study used MRI scans to see how thinking difficulties appear in the brains of people with spinal cord injury. Fifty-four participants completed cognitive tasks while their brain activity was measured. The goal was to better understand non-motor challenges that ofte…

This small study tested whether mild nerve stimulation could increase vaginal blood flow in women with sexual problems, spinal cord injury, or no issues at all. Nine women had a small sensor placed in the vagina to measure blood flow changes during stimulation. The goal was to un…

This study tested a mobile app called SCI-Lynx designed to help people with spinal cord injury connect with others who have similar exercise goals. Over one month, 33 participants used the app to find exercise buddies, set goals, and track progress. The goal was to see if the app…

This small study tested whether briefly restricting blood flow to one arm (called remote ischemic conditioning, or RIC) could improve hand function in people with spinal cord injury or ALS. Participants did hand exercises while receiving either active RIC or a sham version. The g…

This completed study looked at 40 adults with certain types of spine fractures in the chest or lower back that did not cause nerve problems. Researchers compared outcomes between patients who had surgery (spinal fusion) and those who received conservative care like bracing and ex…

This study looked at 15,000 trauma patients treated at a Swedish hospital over 10 years. Researchers focused on those with serious neck or face injuries to understand what causes deadly bleeding and how it is managed. The goal is to improve care for future patients with these inj…

This study looked at 43 adults with incomplete spinal cord injury to see how their own views on safe walking matched their therapists' views and actual walking ability. Researchers measured walking independence, leg strength, balance, and fall risk. The goal is to improve dischar…

This study looked at 80 adults with specific types of spine fractures (A3 and A4) that had a certain injury score (4 or 5). Patients were randomly assigned to receive either surgery or non-surgical care. The researchers measured pain, bone healing, and spine shape to see which ap…

This study from the University of Zurich looked at how people with different neurological conditions walk. Researchers measured walking patterns in 208 adults, including those with stroke, Parkinson's, multiple sclerosis, and spinal cord injury, as well as healthy volunteers. The…

This early-phase trial in 13 healthy volunteers measures how two drugs, neostigmine and glycopyrrolate, enter the bloodstream when given through a skin patch using a mild electric current (iontophoresis) compared to an IV. The goal is to see if this needle-free method could one d…

This study followed 35 men with spinal cord injuries over 18 months to see how their sperm quality changes and what factors might cause problems. Researchers measured sperm health, inflammation, and infections from ejaculates collected every 6 months. The goal is to find ways to …

This study looked at two community-based wellness programs for adults with disabilities like spina bifida, cerebral palsy, spinal cord injury, and traumatic brain injury. Researchers measured changes in health, mood, quality of life, and healthcare costs over up to 24 months. The…

This study looked at how sleep apnea and low oxygen levels affect muscle strength and breathing in people with chronic spinal cord injury. Thirty adults with neck-level spinal cord injuries were tested using hand grip strength and muscle activity measurements. The goal was to und…

This study tested whether robotic training that adjusts errors based on each person's abilities can improve motor learning in healthy adults and people with neurological conditions like stroke. Over 250 participants performed arm tasks with robotic devices while researchers measu…

This study looks at how a robotic body-weight support system called FLOAT affects the way people with incomplete spinal cord injury perform everyday tasks like walking, standing up, and climbing stairs. Researchers measure movement and muscle activity with and without the robot's…

This study tested whether a single session of high-intensity interval training (three 20-second all-out efforts on an arm bike) could improve heart and brain function in 30 people with spinal cord injury compared to uninjured controls. The goal was to see if this type of exercise…