Spinal cord disorder

This study looks at whether doing blood flow-restricted exercise two or three times per week makes a difference in muscle strength recovery for people with incomplete cervical spinal cord injury. Participants perform low-load muscle contractions while a cuff partially restricts b…

This early-stage trial tests whether injections of tiny particles from umbilical cord stem cells are safe for people with syringomyelia, a condition where fluid-filled cavities form in the spinal cord. The study will enroll 18 adults whose symptoms haven't improved after surgery …

This early-stage trial tests a single injection of ARO-ATXN2 in 36 adults with spinocerebellar ataxia type 2, a rare genetic disorder that affects movement and coordination. The main goal is to see if the drug is safe and how the body processes it. Participants are randomly assig…

This phase 2 trial tests whether the experimental drug VHB937 can slow the decline in function and delay the need for breathing support in people with early-stage ALS. About 251 participants will receive either VHB937 or a placebo for 40 weeks, followed by an open-label extension…

This study tests whether a robotic exoskeleton called ReWalk can help people with complete spinal cord injury below T4 walk and improve their health. Fifty participants will either use the exoskeleton or receive standard physical therapy. The goal is to see if the device improves…

This phase 3 trial tests whether the drug troriluzole can slow the progression of spinocerebellar ataxia, a rare genetic disorder that affects coordination and balance. About 300 adults with different types of SCA are randomly assigned to take either troriluzole or a placebo dail…

This study tests whether nerve transfer surgery can improve arm and hand function in people with complete spinal cord injuries who have no hand movement. Seventy participants will undergo surgery followed by 48 months of occupational therapy. The goal is to help them regain indep…

This study tests a liquid medicine called mirabegron in children aged 6 months to 3 years who have bladder problems due to nerve damage (neurogenic detrusor overactivity). The goal is to see if the medicine helps the bladder hold more urine safely, reducing leaks and pressure. Ch…

This study tests a gene therapy called vesemnogene lantuparvovec in about 20 people with spinal muscular atrophy (SMA), a genetic condition that causes muscle weakness. The therapy delivers a working copy of the SMN1 gene to help muscles work better. The main goal is to check saf…

This study tests whether a wearable suit that delivers small electrical pulses to leg muscles can improve walking speed in people with incomplete spinal cord injury. Participants first do standard treadmill training, then add the electrical stimulation suit for 20 sessions. The m…

This study tests a device that reads brain signals and sends them to the spinal cord to help people with chronic spinal cord injury move their legs. Three participants will use the system during rehabilitation to see if it is safe and can improve walking. The goal is to create a …

This study tests whether adding an experimental drug (RO7204239) to an existing SMA medicine (risdiplam) can help people with spinal muscular atrophy build stronger muscles and move better. The trial includes about 259 children and young adults, ages 2 to 25, who can walk. Resear…

This study looks at whether the drug troriluzole can slow the progression of spinocerebellar ataxia (SCA), a rare genetic disease that affects movement and balance. Researchers will compare 909 patients who took troriluzole for up to three years with similar patients who did not …

This study tests whether a surgically implanted device that sends electrical pulses to the spinal cord can help people with spinal cord injury regain voluntary leg movement. Only 2 participants with specific injury levels and MRI evidence of spared nerve fibers will be enrolled. …

This study tests whether stimulating the vagus nerve while doing rehabilitation exercises can help people with chronic spinal cord injury regain movement and sensation. Twenty participants who completed an earlier trial will receive active VNS paired with exercises targeting the …

This early study tests a single injection of a gene therapy called NTF001 in 12 people with ALS. The therapy aims to deliver a protein that supports nerve cell health. The main goal is to check safety, but researchers will also look for signs of benefit over 52 weeks.

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests whether adding taldefgrobep alfa to standard SMA treatments can improve muscle function in people with spinal muscular atrophy (SMA). About 269 participants, both walkers and non-walkers, will receive either the drug or a placebo for 48 weeks. The main goal is to…

This early-stage trial tests a new gene therapy called NKG001 in 21 children under 5 with spinal muscular atrophy (SMA). The therapy is given as a single dose, either through a vein or combined with a spinal injection. The main goal is to check safety and find the best dose, not …

This early-stage study tests the safety of acamprosate, a drug used for alcohol dependence, in 30 adults with ALS who have a specific mutation in the C9orf72 gene. Participants take the pill three times daily for 24 weeks and undergo regular checkups, breathing tests, and spinal …

This program gives eligible people with acute spinal cord injury early access to the investigational drug elezanumab before it is officially approved. A doctor must decide if the potential benefit outweighs the risks for each patient. The program is only available in certain terr…

This phase 2 trial tests whether adding the targeted drug abemaciclib to standard chemotherapy (temozolomide) helps children and young adults with newly diagnosed high-grade glioma live longer without their cancer growing. About 45 participants will receive either the combination…

This study tests a higher dose of nusinersen (Spinraza) in 45 teenagers and adults with spinal muscular atrophy (SMA) who cannot walk and have already taken risdiplam. Participants receive two 50 mg loading doses two weeks apart, then 28 mg every four months for about two years, …

This study compares a new, less invasive surgery to the standard open surgery for children with paralytic scoliosis (a curved spine) after a spinal cord injury. The minimally invasive approach uses smaller cuts and aims to correct the spine while causing less blood loss, fewer co…

This early-stage trial tests a gene therapy called PBFT02 for frontotemporal dementia (FTD) in people with specific genetic mutations. The therapy delivers a working copy of the GRN gene directly into the brain. The study involves 30 adults and primarily checks for safety and sid…

This early-stage study tests whether a new drug called QRL-201 is safe and tolerable for people with ALS (Lou Gehrig's disease). About 69 adults aged 18-80 with recent ALS symptoms will receive either the drug or a placebo. The main goal is to check for side effects, not to cure …

This trial tests a procedure called expansile duraplasty, where surgeons open the spinal cord's covering and sew in a patch to give the swollen cord more room. Researchers will compare recovery in 66 adults who receive this extra surgery versus those who get standard care alone. …

This was a planned phase 2 trial to test IC14, a monoclonal antibody, in 50 people with rapidly progressing ALS. Participants would have received intravenous IC14 or placebo twice weekly for 12 weeks. The study was withdrawn before any patients were enrolled, so no data on safety…

This study planned to test an experimental drug called IC14 in people with rapidly progressing ALS. The drug was given by IV over two weeks, and brain scans measured inflammation. However, the trial was withdrawn before enrolling any participants, so no data on safety or effectiv…

This study tests two ways to surgically repair spina bifida in the womb using a tiny camera. The goal is to close the spinal defect and reverse brain changes caused by the condition. About 110 pregnant women carrying babies with spina bifida will take part. The two methods are co…

This expanded access program provides apitegromab, an experimental drug that blocks myostatin to help maintain muscle strength, to eligible patients with spinal muscular atrophy (SMA) before it is officially approved. Participants must be at least 2 years old and have a confirmed…

This early-stage study tests whether a new drug, prosetin, is safe for people with ALS (Lou Gehrig's disease) and healthy volunteers. About 72 participants will receive either the drug or a placebo to check for side effects and how the drug moves through the body. The goal is to …

This study tests whether placing vancomycin powder directly into the wound during spine surgery can prevent infections in high-risk patients, such as those with spinal deformities or tumors. Half of the 76 adult participants will receive the powder, while the other half will not.…

This early trial tests whether a transplant of umbilical cord blood can help people with ALS, a fast-progressing nerve disease. Eight adults will receive the transplant after a mild chemotherapy-like prep. Researchers will check safety and whether the treatment slows decline in m…

This study follows 403 adults and children with spinal muscular atrophy who are already taking risdiplam (Evrysdi) as prescribed by their doctor. Researchers will track side effects and how well the drug works over about two years. The goal is to see if risdiplam remains safe and…

This study tests whether a two-step drug treatment can improve bone density in people with long-term spinal cord injury who have bone loss. Participants receive either romosozumab (a bone-building drug) or a placebo for 12 months, followed by denosumab (a bone-strengthening drug)…

This study tests whether combining two treatments—thermal ablation (using heat to destroy tumor cells) and stereotactic radiosurgery (precise, high-dose radiation)—can better control cancer that has spread to the spine and is pressing on the spinal cord. About 60 adults with vari…

This early-phase study tests whether a single, precise session of radiation (spine stereotactic radiosurgery) can safely treat spinal cord compression caused by cancer that has spread to the spine. The study includes 43 adults with inoperable tumors pressing on the spinal cord. R…

This study aimed to see if a mist-inhaled drug called RNS60 could help people with ALS, a nerve disease that weakens muscles. It planned to measure changes in daily function, breathing, and survival. However, the trial was withdrawn before enrolling any participants, so no result…

This study tests a minimally invasive fetoscopic surgery to repair spina bifida in unborn babies. The goal is to close the spinal defect and reverse brain herniation while reducing risks like uterine rupture and preterm birth that come with open fetal surgery. Thirty pregnant wom…

This study tested an experimental drug called ARGX-119 in 60 adults with ALS. The goal was to see if it was safe and could help with muscle function. The trial was stopped early because early results showed it was unlikely to make a meaningful difference. No safety concerns trigg…

This study tests the drug risdiplam (Evrysdi) in infants up to 6 weeks old who have a genetic diagnosis of spinal muscular atrophy (SMA) but no symptoms yet. The goal is to see if early treatment can help them reach motor milestones like sitting without support. The trial involve…

This program provides early access to an experimental drug called CNM-Au8 for people with amyotrophic lateral sclerosis (ALS), a progressive nerve disease. Participants must be 18 or older and have a confirmed ALS diagnosis. The goal is to offer treatment to those who cannot join…

This program provides CNM-Au8, a suspension of gold nanocrystals, to up to 300 people with ALS. The main goal is to give access to the drug and monitor safety, not to test if it works. Participants must have a confirmed ALS diagnosis and be at least 18 years old.

This phase 3 trial tests whether the drug tofersen can delay or prevent ALS in adults who carry a SOD1 gene mutation but have no symptoms yet. About 158 participants will receive either tofersen or a placebo, and researchers will track how many develop ALS within two years. The g…

This pilot study tests whether combining intensive hand-arm and leg therapy with strength training can improve motor function in children with spinal muscular atrophy (SMA). Five children will attend one 6-hour session each weekend for 15 weeks. Researchers will check if the ther…

This early-phase study tests whether combining noninvasive spinal cord stimulation with the drug buspirone can help people with severe spinal cord injury take steps overground. Fifteen participants who have been paralyzed for at least a year will undergo various training and meas…

This study tests a new treatment for ALS (Lou Gehrig's disease) using stem cells taken from the patient's own belly fat. The cells are injected into the fluid around the spine every 3 months for a year. The goal is to see if this treatment is safe and can slow down the disease. A…

This study tests whether adding non-invasive ventilation (a breathing machine) or the drug Buspar to a special rowing exercise program can improve heart and lung fitness in people with high-level spinal cord injury. Seventy participants will exercise for 6 months while receiving …

This clinical trial tests whether ibudilast (MN-166), a drug previously used for asthma, can slow the progression of amyotrophic lateral sclerosis (ALS). The study involves 234 adults with ALS, who will receive either ibudilast or a placebo for 12 months, followed by a 6-month op…

This study tests a new proton therapy machine called PROTEUS® PLUS in 47 adults with solid tumors. The goal is to see if it is safe and effective at controlling cancer. Researchers will measure tumor response and track side effects.

This small study tests a noninvasive method called transcutaneous spinal cord stimulation (scTS) to help children aged 7-12 with chronic cervical spinal cord injury regain hand function. Researchers will find the best placement and strength of stimulation on the neck and lower ba…

This study tests an experimental drug called ION363 in people with a rare, inherited form of ALS caused by FUS gene mutations. The goal is to see if the drug can slow the disease and help people live longer. About 89 participants will receive the drug via spinal injection. This i…

This long-term study is testing higher doses of nusinersen (Spinraza) in people with spinal muscular atrophy who already completed a previous nusinersen study. The main goal is to check safety over several years, including side effects, heart health, and growth. Participants rece…

This clinical trial is testing an oral drug called NUZ-001 in 160 people with ALS. Participants take the drug or a placebo daily for 36 weeks. The study measures how the disease progresses using a scale of physical function and survival. The goal is to see if NUZ-001 can slow ALS…

This trial provides expanded access to RAPA-501, a therapy made from a patient's own immune cells, for people with ALS. The goal is to control the disease and slow its progression. Participants must be 18 or older and have a confirmed ALS diagnosis.

This study tests whether the drug usnoflast can slow the progression of ALS, a severe nerve disease that causes muscle weakness and breathing problems. About 240 adults with ALS will receive either usnoflast or a placebo for 36 weeks. Researchers will measure changes in daily fun…

This study tests two minimally invasive fetal surgery techniques for repairing neural tube defects (spina bifida) in the womb. One method uses a Durepair patch to reinforce the repair, while the other does not. Researchers aim to see if the patch leads to a thicker repair and few…

This study tests a new proton therapy device, PROTEUS PLUS, in 47 adults with solid tumors. The goal is to see if it safely controls tumor growth. Participants receive targeted radiation, and researchers track side effects and disease response over time.

This study tests whether a combination of nicotinamide (a form of vitamin B3) and pterostilbene (a plant compound) can slow the progression of ALS, a fast-moving nerve disease. About 380 adults with ALS will take either the supplement or a placebo for a period of time. The goal i…

This study compares a high-tech, computer-controlled knee-ankle-foot brace (C-Brace) to traditional braces in 30 people with spinal cord injury. Participants will train with the device for up to 20 sessions and then use it at home for 3 months. The main goal is to see if the smar…

This study tests a new drug called NX210c in 80 adults with ALS, a nerve disease that weakens muscles over time. Participants receive multiple IV infusions of the drug or a placebo to see if it slows the disease and is safe. The main focus is on changes in blood markers that refl…

This study is an open-label extension for people with early amyotrophic lateral sclerosis (ALS) who completed a previous placebo-controlled trial. Participants will take a daily oral dose of CNM-Au8, a suspension of gold nanocrystals, to see if it safely slows disease progression…

This study tests whether metformin, a widely used diabetes drug, is safe for people with a specific genetic form of ALS (C9orf72). Over 24 weeks, 41 participants will take metformin to see if it reduces toxic proteins linked to the disease. The goal is to determine if metformin c…

This study follows 20 adults with spinal muscular atrophy (SMA) type II who are already taking SPINRAZA. Researchers will measure motor function using a 32-point scale over 27 months to see if the drug helps maintain or improve movement. The goal is to better understand how SPINR…

This early-stage trial tests a single injection of RJK002, a gene therapy, into the spinal fluid of 9 people with ALS. The main goal is to see if it is safe and to find the best dose for future studies. Researchers will also track changes in daily function, but the trial is too s…

This study tests a new gene therapy called SKG0201 in 12 infants with spinal muscular atrophy type 1, a severe muscle-weakening disease. The treatment aims to improve survival and motor skills by delivering a working gene. Researchers are checking safety and how well the therapy …

This early-phase trial tested whether giving a second, single dose of highly focused radiation is safe for people with spine tumors that have grown back after previous radiation. Nine adults with certain types of cancer took part. The goal was to find the highest safe dose and wa…

This study tests a device called PCSS used alongside standard neck fusion surgery to treat degenerative disc disease in the neck. About 236 adults aged 18-80 who need surgery on three neck levels will be enrolled. The goal is to see if the device helps bones fuse better and safel…

This study tests whether short, mild low-oxygen breathing sessions can improve walking and leg strength in people with a recent spinal cord injury. Over 10 sessions, participants breathe either low-oxygen air or normal air through a mask. The goal is to see if this simple approac…

This study tests whether digoxin, a heart medication, is safe and tolerable for people with ALS. It also looks at whether digoxin can slow nerve damage. About 40 adults with early-stage ALS will take digoxin for 24 weeks. The goal is to find a new way to manage this disease.

This early-stage trial tests a gene therapy called AMT-162 in 20 adults with a specific genetic form of ALS (SOD1-ALS). The treatment is given as a single injection into the spinal fluid. The main goal is to check safety and tolerability, while also looking for early signs that i…

This study tests if stem cells taken from a patient's own belly fat and injected into the spine can safely help restore movement and feeling after a spinal cord injury. About 40 adults with paralysis will receive the treatment. The goal is to see if this approach can improve func…

This study tests an implanted stimulator and sensor that helps people with cervical spinal cord injury regain hand and arm function. Ten participants will use the device to perform everyday tasks like grasping objects. The goal is to improve independence and quality of life.

This early-stage trial tests a single injection of gene therapy for people with SMARD1 or CMT2S, rare diseases caused by mutations in the IGHMBP2 gene. The therapy delivers a working copy of the gene directly into the spinal fluid. Ten participants, ranging from infants to childr…

This expanded access program gives one patient with a spinal cord injury at the C5-C7 level a single infusion of their own stem cells (HB-adMSCs). The stem cells are taken from the patient's fat tissue and grown in a lab before being given back. The goal is to see if this approac…

This study tested a stem cell treatment for amyotrophic lateral sclerosis (ALS), a progressive nerve disease. It involved one patient who received their own fat-derived stem cells to try to control the disease. The treatment is no longer available.

This study tested a stem cell treatment for people with long-term spinal cord injuries. It involved three patients who received their own fat-derived stem cells through an IV. The goal was to see if the treatment could safely restore nerve signals and improve sensation or movemen…

This pilot study tests an 8-week program called REACH-SCI designed to help people with spinal cord injury (paraplegia) reduce the time they spend sitting. The program includes a wearable activity tracker, education, goal setting, one-on-one coaching, a peer support chat, and exer…

This phase 4 trial tests whether starting with romosozumab for 12 months and then switching to denosumab for another 12 months can better maintain bone density around the knee in people with recent spinal cord injury, compared to using denosumab alone. The study involves 40 adult…

This early-phase trial tests a substance made from stem cells from baby teeth (SHED-CM) in 10 people with ALS. The goal is to see if it is safe and if it might slow the disease. Participants receive the treatment intravenously over 12 weeks, with follow-up for 4 more weeks.

This study planned to test whether donated umbilical cord blood could help adults with stroke or spinal cord injury. However, the trial was withdrawn before enrolling any participants, so no data or results are available.

This study tests a device called the RISES-T System, which uses mild electrical stimulation through the skin to help people with chronic spinal cord injury improve their mobility and reduce muscle stiffness. Ten participants will try different stimulation techniques while researc…

This study tests a new way to repair spina bifida before birth using a tiny camera and a patch made from donated human umbilical cord tissue. The patch is placed over the spinal cord to create a watertight seal, which may reduce problems after birth. The trial includes 50 pregnan…

This program gives ALS patients who cannot join other clinical trials access to an experimental drug called trehalose (SLS-005). Trehalose is a sugar solution given once a week through a vein. The goal is to see if it can help control the disease. The program is no longer availab…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study compares a new ultra-high resolution PET/CT scanner, the NeuroEXPLORER, with standard clinical PET/CT scanners for imaging the head and neck. Researchers aim to see if the new device provides more detailed images to improve diagnosis of conditions like dementia, Parkin…

This study is testing whether a simple saliva sample can help diagnose amyotrophic lateral sclerosis (ALS). Researchers will analyze RNA in the saliva of 653 people, including ALS patients and healthy volunteers. If the test works, it could offer a faster, less invasive way to di…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study aims to create a simple test battery to determine fall risk in people with neuromuscular disorders, such as muscular dystrophy or ALS. Researchers will assess 108 participants using several physical tests like walking, standing, and rising from a chair. The goal is to …

This study tests whether injecting bone cement into the spine can prevent fractures after high-dose radiation treatment for cancer that has spread to the backbone. About 87 patients with solid tumors and spinal metastases will receive either standard radiation alone or radiation …

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study tests whether a non-invasive electrical stimulation applied to the back can boost the benefits of walking therapy for people with incomplete spinal cord injury. 18 adults with chronic spinal cord injury will receive either real or fake stimulation during their walking …

Many people with spinal cord injury struggle with slow bowel emptying and constipation. This study tests whether a small device that delivers gentle electrical pulses to the belly can speed up bowel movements and improve stool consistency. Twelve participants will use the stimula…

This small early-phase trial tests whether a single oral dose of a hemp-derived CBD/CBD-A extract can reduce neuropathic pain and change brain activity in people with spinal cord injury. Six participants with moderate to severe nerve pain for at least three months will receive ei…

This study tests whether an implanted spinal cord stimulator can reduce chronic pain and improve rehabilitation outcomes in people with thoracic spinal cord injury. Twenty-five participants will either have the device turned on or off for three months, while both groups continue …

This study looks at whether time-restricted eating (a form of intermittent fasting) is a practical way for veterans with spinal cord injury and obesity to lose weight. Fifteen veterans with paraplegia will try eating all their daily calories within a set window of time for 6 week…

This pilot study tests a program called ALIGN, designed to help adults with spina bifida improve how they manage health tasks like coordinating care and handling medications. The program includes six virtual group sessions and one individual session with a clinician. Researchers …

This study tests whether robotic-assisted walking training (using a device called Lokomat) can improve balance and walking smoothness in people with incomplete spinal cord injury. Thirty participants will be randomly assigned to either robotic training or standard physiotherapy. …

This study aimed to see if a simple mindfulness breathing exercise could improve health and quality of life in people with spinal cord injury. Participants would have done a 10-15 minute guided breathing session three times a week for a month. However, the trial was withdrawn bef…

This study tests a treatment called Hypnosis Enhanced Cognitive Therapy (HYPCT) for people with new spinal cord injuries who are in rehab. It compares HYPCT to standard pain education to see if it can lower pain intensity and prevent chronic pain. Participants will attend four se…

This study tests whether walking with a robotic exoskeleton three times a week for 12 weeks can reduce nerve pain in people with spinal cord injury. Forty adults with traumatic spinal injury and persistent nerve pain will be randomly assigned to either robotic walking or a relaxa…

This small pilot study is testing whether a daily low dose of naltrexone (4.5 mg) can reduce central neuropathic pain and improve quality of life in 10 adults with traumatic spinal cord injury. Participants take the drug for 12 weeks, and researchers measure pain scores and daily…

This study tests a 12-week online program for mothers of infants (12-36 months old) with SMA Type 1. The program aims to teach mothers how to support their baby's development and improve their own knowledge. Thirteen mothers will take part, with 10 receiving the program and 3 rec…

This trial tests whether a 10-week online health program called DRIV can help adults with long-term spinal cord injury adopt healthier habits and feel better. Participants attend weekly video group sessions covering exercise, nutrition, stress, and goal-setting. Researchers compa…

This study tests a new way to use deep brain stimulation for people with severe, treatment-resistant chronic pain from stroke, spinal cord injury, or phantom limb pain. Instead of constant stimulation, the device delivers electrical pulses only when the brain senses high pain sig…

This study tests whether using a mechanical insufflation device (BiWaze Cough) twice daily for 6 months can slow the decline in cough strength in 20 people with early ALS. Participants will use a facemask or mouthpiece to help inflate their lungs fully before coughing. Researcher…

This study tests whether combining motor skill training with a non-invasive spinal stimulation can improve walking, balance, and strength while reducing muscle spasticity in people with incomplete spinal cord injury. Twenty-eight participants will do a series of standing exercise…

This study tests whether a drug called istradefylline, combined with short periods of breathing low-oxygen air (acute intermittent hypoxia), can improve breathing in people with ALS. About 40 adults with ALS and healthy volunteers will take part. The goal is to see if this combin…

This study looks at whether using a powered exoskeleton to walk can improve quality of life for people with spinal cord injury. Eighteen participants will either use the device at home or in a clinic over 24 months. Researchers will measure changes in well-being and compare costs…

This study tests whether brief periods of breathing low oxygen can improve leg strength and walking in people with chronic spinal cord injury. Thirty adults with incomplete spinal cord injury will inhale low oxygen for short sessions over time. Researchers will measure walking en…

This study looks at whether nutrition education and one-on-one counseling can reduce chronic pain in people with spinal cord injury. Thirty adults will attend monthly sessions for four months, either in person or online. Researchers will measure changes in pain intensity and nerv…

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study tests a device that stimulates the vagus nerve during arm rehabilitation exercises to see if it helps people with spinal cord injuries regain upper limb function. Twenty adults with chronic cervical spinal cord injury will receive either active or placebo stimulation d…

This study tests whether a single large dose of spine radiosurgery works better than three smaller doses for people whose spinal tumors have come back after previous radiation. About 80 adults with solid tumors that spread to the spine will be randomly assigned to one of the two …

This early study tests a simple idea: temporarily numbing non-paralyzed arm muscles with an over-the-counter lidocaine cream while exercising paralyzed muscles. Researchers hope this will improve strength, function, and sensation in people with spinal cord injury. About 30 adults…

This study tests whether an 8-week group exercise class done over video can improve psychological and social well-being in people with spinal cord injury. The class is tailored for wheelchair users and co-led by someone with lived experience. Researchers will measure changes in m…

This pilot study tests whether using a robotic glove for 20 minutes a day, 5 days a week, can improve quality of life, grip strength, and fine motor control in people with ALS. Five participants will use the glove at home over 8 weeks, with some in-person and telehealth check-ins…

This early study tests whether combining a spinal cord stimulator with the drug buspirone can improve arm and hand movement in people with cervical spinal cord injury. Twelve participants will receive both the device and the drug, and their motor function will be formally assesse…

This study tests whether 8 weeks of acceptance and commitment therapy (ACT) delivered via Zoom can help reduce depression in people with spinal cord injuries. 140 participants with mild or worse depressive symptoms will be randomly assigned to either ACT or a wait-list that conti…

This study is testing a device called MemorEM, which is a cap that sends low-level electromagnetic waves to the head. The goal is to get feedback from 1,000 patients with neurological diseases like Alzheimer's or Parkinson's, and their caregivers, on how easy the device is to use…

This study tests whether adding mild electrical stimulation to the spinal cord (TSCS) to exoskeleton training helps people with incomplete spinal cord injury walk better. 30 participants within a year of injury will receive 24 training sessions. Researchers will measure walking s…

This study tests whether a short form of talk therapy, called brief prolonged exposure therapy, can help prevent post-traumatic stress disorder (PTSD) in people who have had a spinal cord injury. The therapy involves three one-hour sessions during inpatient rehabilitation. Resear…

This study tests a highly precise radiation system (CT-on-Rails or Trilogy) to treat spine tumors that have spread from other cancers. About 150 participants will receive three radiation sessions over two weeks. Researchers will track pain relief and side effects using patient qu…

This study is testing whether a robotic exoskeleton called Atalante can safely help people with ALS maintain their ability to walk. The idea is that the suit provides natural leg movements and feedback to the brain, which may slow down walking decline. About 20 adults with slow-p…

This study tests whether a gentle electrical current (TENS) applied to the lower back can reduce muscle stiffness and improve movement in people with spinal cord injuries. Forty adults with injuries between the neck and mid-back will either receive TENS for two months or wait two…

This study tests whether a non-invasive device that delivers pulsed electromagnetic fields can improve bladder function in 40 children aged 4-12 with myelomeningocele (a form of spina bifida). The treatment aims to stimulate nerves controlling the bladder, potentially reducing in…

This study tests a new, team-based rehabilitation program for 125 working-age adults with persistent physical symptoms and chronic fatigue. The program includes doctors, therapists, and counselors who work together to help patients manage their symptoms and improve daily function…

This study tests a method called conditioning open-label placebo (COLP) to help patients with spinal cord injury, multiple injuries, or burns use fewer opioids while still getting the same pain relief. About 66 adults in intensive rehab will receive a placebo alongside their regu…

This study tests a wearable robotic exoskeleton called EXPLORER in 15 children with movement problems from conditions like cerebral palsy. The goal is to see if it helps them walk better in their everyday environments, such as home and the community. The study focuses on safety, …

This study planned to test whether training on a rowing machine that uses electrical stimulation to move the legs could improve fitness in adults with traumatic paraplegia. Participants would have trained for 6 months, but the trial was withdrawn before anyone enrolled, so no res…

This study tests a training program that teaches children with physical disabilities how to use their manual wheelchairs better. The goal is to help them move around on their own instead of relying on others, which can improve their confidence and social life. Four children aged …

This early-stage trial tests the drug dalfampridine (Ampyra), already used for multiple sclerosis, in 35 adults with primary lateral sclerosis or upper motor neuron ALS. The main goal is to see if it safely improves walking speed, measured by a timed 25-foot walk. Researchers wil…

This study tests a robotic feeding device called Obi for people who cannot use their arms to eat on their own. About 50 participants, including patients, caregivers, and healthcare providers, will use the device at home or in care settings for one week. Afterward, they will fill …

This study looks at two new ways to stage amyotrophic lateral sclerosis (ALS) based on key disease milestones. Researchers will check how well these systems work in 50 patients and see if adding a blood marker called neurofilament can improve tracking of the disease. The goal is …

This study is observing 217 people with ALS and related conditions like frontotemporal dementia and hereditary spastic paraplegia. Researchers aim to connect each person's genetic makeup with their symptoms and find biological markers in blood and spinal fluid. No new treatments …

This study looks at people with ALS and similar diseases like frontotemporal dementia and hereditary spastic paraplegia. Researchers want to understand how genes affect the disease and find biological markers (biomarkers) to help develop future treatments. About 708 participants,…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study enrolls people with ALS and related disorders, as well as healthy volunteers, to track biological markers (biomarkers) in urine, blood, and spinal fluid. The goal is to better understand how these markers change over time, which could help design more effective future …

This study planned to see if mindfulness meditation using virtual reality could help people with ALS feel better emotionally and improve their quality of life. It was designed for adults with ALS who speak French. However, the study was withdrawn before enrolling any participants…

This study follows 113 people who recently had a spinal cord injury to understand how feelings of injustice (like blaming others or feeling cheated) change over time and affect their mental health, pain, and quality of life. Researchers will interview some participants and use su…

This study looks at whether the immune system mistakenly makes antibodies that attack the body's own nerves and muscles in people with multiple sclerosis, myasthenia gravis, and similar conditions. Researchers will collect blood samples (and sometimes cheek swabs) from 120 adults…

This study looks at whether doing MRI scans in the same position used for radiation treatment helps doctors plan more accurate therapy for spinal tumors. About 21 adults with cancer that has spread to the spine will have two MRI scans—one with a special immobilization device and …

This study tests a new, low-cost device that creates controlled slips while people with incomplete spinal cord injuries walk on it. The goal is to measure how their balance changes, both standing still and moving. Ten participants who can walk without aids will be observed to bet…

This study tests whether advanced MRI techniques can measure brain changes in people with ALS (Lou Gehrig's disease). Researchers will scan 119 participants three times over 8 months to see if these scans can track the disease and help diagnose it earlier. The goal is to create b…

This study is a registry that collects medical records, quality-of-life questionnaires, and tissue samples from 900 people with spine tumors or other spine disorders. The goal is to learn more about these conditions to guide better treatment in the future. Participants must be be…

This study uses advanced MRI scans and genetic tests to track how neurodegenerative diseases like frontotemporal dementia and ALS spread across the brain's network. Researchers will follow 645 participants, including patients, family members, and healthy controls, for up to 2 yea…

This study tests an 8-week online group program called Living Longer and Stronger with SCI, designed to help people with spinal cord injury improve their physical, mental, and social health as they age. Participants set health goals and make weekly action plans with support from …

This study asks 30 adults with spinal cord injury about their exercise habits and what they would want in a physical activity program. Researchers will use surveys and interviews to learn what helps people start and keep exercising. The goal is to design better exercise programs …

This study follows 9 people with transverse myelitis who previously received an experimental cell therapy called Q-Cells®. Researchers will monitor them for 10 years to check for side effects and see if the treatment continues to have any effect. Participants will have regular ex…

This study was designed to test experimental nano-based painkillers on nerve cells taken from people having surgery for spinal tumors. The goal was to see how well these treatments might work for pain. However, the study was withdrawn before any participants were enrolled, so no …

This study compares immune responses to flu and COVID-19 vaccines between people with chronic spinal cord injuries and healthy individuals. Researchers will analyze blood samples to see if gene activity and antibody levels differ between the groups. The goal is to understand why …

This study compares three different therapy approaches to help people with cervical spinal cord injury improve arm, hand, and trunk control. Ninety-nine participants will complete 40 therapy sessions over 8 weeks, with follow-up at 12 weeks. The goal is to find which method works…

This study looks at three ways surgeons place screws in the spine during surgery: using a robot, using a navigation system, or doing it by hand. The goal is to see which method leads to fewer screws needing to be fixed in a second surgery within the first year. About 932 adults w…

This study looks back at 50 people who had surgery for rare spinal cord tumors between 2022 and 2024. Researchers want to see how the surgery changed their nerve function, movement, and daily life. They also track complications like infections or bleeding. The goal is to learn wh…

This early-phase study at the Cleveland Clinic is testing whether combining a type of brain stimulation (paired neurostimulation) with hand training on one side can improve hand movement and dexterity on both sides in people with cervical spinal cord injury. Seventeen participant…

This study looks at people with early ALS who still have some unaffected body areas. Researchers want to find the very first signs of the disease spreading. By observing 100 participants over time, they hope to learn how ALS starts and progresses, which could help with earlier di…

This study is observing 328 adults who receive a Neuro-Patch during brain or spine surgery to repair the protective lining around the brain or spinal cord. Researchers are tracking complications and how easy the patch is for surgeons to use. The goal is to gather real-world data …

This study looks at whether non-invasive spinal cord stimulation, combined with breathing, arm, or trunk training, can improve lung and breathing muscle function in people with spinal cord injuries. 36 adults with injuries at or above the T5 level are participating. The goal is t…

This study examines whether removing the breathing tube (extubation) in the operating room versus later in the intensive care unit improves outcomes for newborns undergoing surgery for myelomeningocele, a type of spina bifida. Researchers will review records of 60 babies to compa…

This study aimed to create a self-management program to help veterans with AIS D spinal cord injury improve their well-being. It was designed for veterans who have some movement and sensation but often struggle with emotional and social challenges. However, the study was withdraw…

This study follows 50 adults with incomplete cervical spinal cord injuries to see how well certain tests capture their recovery over 6 months. Researchers will track things like movement, sensation, and balance to find the best ways to measure improvement. The goal is to make fut…

This study is a registry that gathers detailed information from about 960 adults with metastatic spine tumors (cancer that has spread to the spine from elsewhere). Researchers collect data on patients' health, treatments, symptoms, and quality of life over time. The goal is to be…

This study looks at whether common balance tests can tell doctors why a person is having trouble with balance. Researchers will test 330 people, including healthy volunteers and patients with stroke, vision problems, inner ear issues, spine problems, or spinal cord damage. The go…

This study uses interviews and focus groups to understand how transcutaneous tibial nerve stimulation (TTNS) impacts quality of life and daily activities in 75 people with neurogenic bladder from spinal cord injuries. Researchers aim to identify key themes about bladder function …

This study follows 150 people with rare neuroimmunologic disorders like neuromyelitis optica and transverse myelitis. Researchers collect medical data and blood samples over time to learn what causes inflammation and why some patients respond to treatments while others do not. Th…

This study is testing a new, comfortable headset that reads brain signals to help people with ALS type on a virtual keyboard. The goal is to improve the device so it can be used in daily life. Five people with ALS will try the headset, and researchers will measure how easy it is …

This study aimed to test whether high-frequency electrical stimulation could improve bladder control in people with spinal cord injury who already have a special device implanted. Researchers planned to compare high-frequency versus low-frequency stimulation in 5 to 10 participan…

This study follows 100 people with brain or spinal cord injuries to see how their ability to judge their own memory (metacognition) changes over time. Researchers want to know if better self-awareness helps people stick with rehabilitation. Participants complete computer memory t…

This study looks at early factors that might predict how well people recover after a traumatic spinal cord injury. Researchers will examine blood pressure management, pain medications, and biological markers from 800 patients. The goal is to find patterns that help doctors person…

This study is creating a large, long-term collection of blood samples and health information from over 3,200 people with multiple sclerosis and related demyelinating diseases, as well as healthy volunteers. The goal is to provide scientists with a shared resource to better unders…

This study is creating a new tool for children with spina bifida and their doctors to work together on setting personal goals for managing bladder and bowel leakage. The goal is to improve the child's quality of life by focusing on what matters most to them, rather than just medi…

This study follows 75 manual wheelchair users with spinal cord injuries over 3 to 5 years to see when and why shoulder problems start. Researchers use yearly MRIs and motion tracking to link daily activities to shoulder damage. The goal is to find ways to prevent shoulder pain an…

This study looks at whether a power wheelchair that can lift a child from sitting to standing is practical for kids with conditions like cerebral palsy, spinal cord injuries, or genetic diseases. Only 4 children aged 5-17 are taking part. The goal is to see if the chair helps the…

This study follows 35 infants with spinal muscular atrophy (SMA) who are receiving gene therapy or other advanced treatments. Researchers use small wearable motion sensors to measure how well the babies move their arms and legs over two years. The goal is to create a more precise…

This study looks at 80 people with ALS to see if electrical tests (EMG) and ultrasound scans of breathing muscles can predict when they will need breathing support. The goal is to start noninvasive ventilation at the right time. Researchers will also check for links between muscl…

This study is a registry that collects information on up to 600 children in China with spinal muscular atrophy (SMA). It aims to describe how the disease progresses and how treatments are used in everyday medical practice. The study does not test a new drug but gathers data to be…