Spinal cord disorder

This study tested whether injections of MYOBLOC (botulinum toxin type B) can safely reduce muscle tightness in the arm and hand of adults with spasticity caused by stroke, brain injury, multiple sclerosis, or other conditions. The trial planned to enroll about 300 participants bu…

This study tested an oral form of edaravone in 384 adults with ALS to see if it could slow the disease's progression over 48 weeks. Participants were randomly assigned to different dosing schedules. The trial was terminated early, and results are not yet fully available.

This study tested two doses of oral edaravone in 202 people with ALS to see if it could slow disease progression. Participants were followed for up to 48 weeks. The trial was terminated early, so the full results are not available.

This study aimed to see if a procedure called angiographic embolization (blocking blood vessels feeding spine tumors) before surgery could reduce blood loss during the operation. It included adults aged 18-75 with spine metastases that had moderate blood supply. The study was sto…

This phase 3 trial tested lithium carbonate against placebo in 88 people with ALS to see if it could improve survival and daily function. The study was terminated early, so the full results are not available. The trial aimed to find a treatment that slows the disease, but its ear…

This study tested whether the statin drug rosuvastatin, taken daily with supplements, could improve bone density and reduce heart disease risk in adults with long-term spinal cord injury. Only 8 people enrolled before the trial was stopped early. Participants received either rosu…

This phase 1 trial tested a gene therapy called AVXS-101 (Zolgensma) in 32 children with spinal muscular atrophy (SMA) who could sit but not stand or walk. The therapy delivers a working SMN gene via a spinal injection to help improve muscle function. The study focused on safety …

This study was designed to let people who had already taken latozinemab in an earlier study continue receiving the drug. Only 17 people took part, and the study was stopped early. The goal was to track safety and how long people stayed on treatment, not to test if the drug could …

This study tested a single dose of STR04, made from a patient's own bone marrow stem cells, for amyotrophic lateral sclerosis (ALS). Only one person enrolled before the study was stopped early. The goal was to see if the treatment was safe and could slow the disease, but no concl…

This study looked at the long-term safety and effectiveness of a daily oral medication called SPG302 in people with ALS who had already taken part in an earlier study. The trial was stopped early, and only 16 people were enrolled. Researchers tracked side effects, suicidal though…

This study tested a new drug called VRG50635 in 54 people with ALS (Lou Gehrig's disease). The main goal was to check if the drug is safe and how the body processes it. The trial was stopped early, but researchers were looking for side effects and changes in disease progression.

This study tested a blood product called immune globulin (Flebogamma) in 191 people with post-polio syndrome, a condition causing new muscle weakness years after polio. The goal was to see if it could improve walking distance and reduce pain. The trial was terminated early, so we…

This study tested an experimental drug called BIIB105 in adults with ALS, a progressive nerve disease. The trial had two parts: a 6-month placebo-controlled phase and a 3-year open-label extension where everyone received the drug. The goal was to check safety, how the body proces…

This early-stage trial tested an experimental drug called DNL747 in 15 people with ALS to see if it was safe and how the body processed it. The study was terminated before completion, so we don't have full results. It was a small, short-term safety study, not a test of whether th…

This study tested a special seat cushion (GASPARD®) that measures pressure and sends alerts to a smartphone to help prevent pressure sores in people with spinal cord injuries. The trial included 134 participants who used manual wheelchairs. Unfortunately, the study was terminated…

This study tested whether a digital platform (m-Rehab) could help people with ALS who use non-invasive ventilation. The platform included educational content, remote monitoring, and video consultations. The goal was to see if it could slow the loss of physical function and improv…

This study looked at whether a non-invasive brain stimulation method called tDCS, when added to standard physical therapy, could improve arm and hand function in people with recent spinal cord injuries. The trial included 13 participants with neck-level injuries who were between …

This study tested whether personalized fitness training could improve heart and lung fitness in people with incomplete spinal cord injury during early rehabilitation. Nineteen participants were assigned to either personalized training sessions or usual care for six weeks. The stu…

This study tested whether 12 weeks of rowing exercise with electrical stimulation to move paralyzed legs could reduce nerve pain and brain inflammation in people with spinal cord injury. The study enrolled 13 adults with recent spinal cord injury. Researchers measured pain, brain…

This small pilot study looked at whether adding functional electrical stimulation (FES) to reconstructive hand surgery can improve muscle strength and hand function in people with tetraplegia (paralysis of arms and legs). Fifteen adults with spinal cord injuries were enrolled. Th…

This study tested a device that sends electrical stimulation through the skin to the spinal cord, aiming to reduce muscle spasticity and improve movement in people with incomplete spinal cord injury. Twelve participants received repeated sessions of the stimulation. The goal was …

This study tested whether qigong, a practice of gentle movements and focused breathing, could reduce nerve pain in adults with spinal cord injury. About 23 people with chronic pain participated. The trial was stopped early, so the full effects are unclear.

This study tested whether two gut hormones, GIP and GLP-2, could reduce bone breakdown in children with spinal muscular atrophy, cerebral palsy, or Duchenne muscular dystrophy who use wheelchairs. Participants received a liquid meal and then either a hormone injection or a placeb…

This study was a registry that collected information from over 900 adults being treated for degenerative spine conditions. Researchers focused on the use of bone graft materials and how patients felt after treatment. The study did not test any new treatment and was stopped early.

This early-phase study tested whether breathing mild low-oxygen air (acute intermittent hypoxia) combined with hand exercise training could improve grip and pinch strength in people with chronic cervical spinal cord injury. The study also tested the drug D-cycloserine to see if i…

This study looked at how satisfied people with ALS (Lou Gehrig's disease) were when they had doctor visits by video from home, with a nurse or physiotherapist there to help. About 38 patients who used a breathing machine at home took part. The goal was to see if this kind of care…

This study looked at whether a non-invasive magnetic brain stimulation technique called iTMS, combined with hand exercises, could help people with spinal cord injury regain grasping ability. Researchers measured changes in brain signals and hand strength. The trial was terminated…

This study tested an experimental drug called BLZ945 in 28 people with ALS to see if it could reduce brain inflammation. Researchers used special PET scans to measure inflammation. The study was terminated early, so the full results are not available, but it aimed to gather safet…