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ALS drug trial halted early: what we know about oral edaravone

NCT ID NCT05151471

Terminated Disease control Sponsor: Tanabe Pharma America, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two doses of oral edaravone in 202 people with ALS to see if it could slow disease progression. Participants were followed for up to 48 weeks. The trial was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
oral edaravone
What this could lead to
If successful, this could confirm that oral edaravone helps slow functional decline in people with ALS.
What could go wrong
The study was terminated early, so results may be incomplete. ALS is a complex disease, and even if edaravone helps, it is not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALS

Contacts and locations

Locations

  • CHU de Quebec-Hopital-Enfant-Jesus

    Québec, Quebec, G1J 1Z4, Canada

  • Chefarzt Muskelzentrum/ALS Clinic Kantonsspital St.Gallen Muskelzentrum/ALS Clinic

    Sankt Gallen, 9007, Switzerland

  • Emory University - School of Medicine

    Atlanta, Georgia, 30317-2819, United States

  • Fukushima Medical University Hospital

    Fukushima, Fukushima, 960-1295, Japan

  • Hanyang University Medical Center

    Wangsimni-ro, Seongdong-gu, 04763, South Korea

  • Health Science Center Mcmaster University

    Hamilton, Ontario, L8P 1H1, Canada

  • Hiroshima University Hospital

    Hiroshima, Hiroshima, 734-8551, Japan

  • Johns Hopkins University

    Baltimore, Maryland, 21205, United States

  • Kagawa University Hospital

    Kita-gun, Kagawa-ken, 761-0793, Japan

  • Kansai Electric Power Hospital

    Osaka, Osaka, 553-0003, Japan

  • London Health Sciences Centre - University Hospital

    London, Ontario, N6A 5A5, Canada

  • Murakami Karindoh Hospital

    Fukuoka, Fukuoka, 819-8585, Japan

  • Nagoya University Hospital

    Nagoya, Aichi-ken, 466-8560, Japan

  • National Hospital Organization Chibahigashi National Hospital

    Chiba, Chiba, 260-8712, Japan

  • National Hospital Organization Higashinagoya National Hospital

    Nagoya, Aichi-ken, 465-8620, Japan

  • National Hospital Organization Iou National Hospital

    Kanazawa, Ishikawa-ken, 920-0192, Japan

  • National Hospital Organization Kumamoto Saishun Medical Center

    Kōshi, Kumamoto, 861-1196, Japan

  • National Hospital Organization Osaka Toneyama Medical Center

    Toyonaka, Osaka, 560-8552, Japan

  • National Hospital Organization Shizuoka Institute of Epilepsy and Neurological Disorders

    Shizuoka, Shizuoka, 420-8688, Japan

  • National Hospital Organization Utano National Hospital

    Kyoto, Kyoto, 616-8255, Japan

  • Nerve And Muscle Center Of Texas

    Houston, Texas, 77019, United States

  • Neurology Associates, P.C - Lincoln

    Lincoln, Nebraska, 68506, United States

  • Niigata University Medical & Dental Hospital

    Niigata, Niigata, 951-8520, Japan

  • Northwestern University Feinberg School of Medicine

    Chicago, Illinois, 60611-2605, United States

  • Saitama Neuropsychiatric Institute

    Saitama, 338-8577, Japan

  • Teikyo University Hospital

    Itabashi-ku, Tokyo, 173-8606, Japan

  • Toho University Omori Medical Center

    Ōta-ku, Tokyo, 143-8541, Japan

  • Tohoku University Hospital

    Sendai, Miyagi, 980-8574, Japan

  • Tokyo Metropolitan Neurological Hospital

    Fuchū, Tokyo, 183-0042, Japan

  • UF Health Cancer Center/Clinical Trials Office

    Gainesville, Florida, 32610-3633, United States

  • Universitaetsklinikum Wuerzburg

    Würzburg, 97080, Germany

  • University Of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Alberta - Walter C Mackenzie Health Sciences Centre (WCM)

    Edmonton, Alberta, T6G 2B7, Canada

  • University of Washington Medical Center

    Seattle, Washington, 98195, United States

  • West Virginia University School of Medicine (WVUSoM) - Movement Disorder Clinic

    Morgantown, West Virginia, 26506-9180, United States

  • Woodland Research Northwest, LLC

    Rogers, Arkansas, 72758, United States

  • Yokohama City University Hospital

    Yokohama, Kanagawa, 236-0004, Japan

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