Spinal cord disorder

This phase 3 trial tests whether an experimental drug called KP-100IT, injected into the spinal fluid, can help people with severe acute spinal cord injuries regain function. Participants, aged 18 to 89 with a complete loss of motor and sensory function (AIS grade A), receive fiv…

This trial tests a new recombinant polio vaccine (rPV) against the current standard IPOL vaccine in healthy adults aged 18 to 60. The goal is to see if the new vaccine is safe and triggers a strong immune response. It is a small, early-stage study to gather initial data.

This trial tests whether a powered leg exoskeleton called ZEPU AI9 can safely and effectively help people with walking difficulties caused by stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will be randomly assigned to receive either exoskeleton-assiste…

This study tests a laser treatment for tumors that have spread to the spine. The goal is to see if the laser can control tumor growth as well as traditional surgery, but with less risk. About 25 people with spine tumors will receive the laser treatment and be followed with MRI sc…

This trial tests whether robotic devices that guide arm and leg movements can safely improve strength, coordination, and daily function in adults with movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions. Participants will use the devices thre…

This trial tests whether adding robotic rehabilitation devices to standard physiotherapy can improve arm and leg function in adults with movement problems from stroke, spinal cord injury, traumatic brain injury, or orthopedic surgery. Participants will receive robotic-assisted se…

This trial is testing a robotic exoskeleton called ABLE Kids to see if it is safe and practical for children who have trouble walking due to conditions like cerebral palsy, spinal cord injury, or muscle weakness. Fifteen children will use the device in up to ten one-hour training…

This trial tests whether testosterone therapy can help men with spinal cord injury who have low testosterone and difficulty walking. The goal is to see if it increases muscle and bone in the legs, reduces body fat, and improves strength. Some participants also receive finasteride…

This study tests a precise, MRI-guided radiation treatment for people with cancer that has spread to the spine and is pressing on the spinal cord. The goal is to shrink the tumor enough to avoid surgery. About 24 adults with solid tumors like breast, prostate, or lung cancer will…

This early-stage trial is testing whether combining a robotic exoskeleton with spinal cord stimulation can help people with chronic spinal cord injury walk more easily. The study will include a small group of adults who already have a spinal stimulator implanted and have complete…

This study tests whether adding a mild electrical stimulation to the spinal cord (tSCS) during walking therapy can improve leg movement in people with recent spinal cord injury (within 6 months). Forty participants will receive either real or sham stimulation during 20 training s…

This pilot study tests whether a virtual-reality system controlled by muscle activity can help improve arm and hand movement in people recovering from stroke or spinal cord injury. Participants use a wearable device that detects muscle signals through sensors on the skin and prov…

This trial tests whether adding a robotic leg-training device (ZEPU-AI5) to standard rehab can safely improve walking, strength, and balance in adults aged 18–60 with lower-limb problems from stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will receive …

This study tests a robotic device called ZEPU-AI1 that helps people with leg weakness practice standing and walking. The trial includes adults aged 19 to 60 who have walking problems from stroke, spinal cord injury, or orthopedic surgery. Half of the participants will use the rob…

This trial is testing whether a single injection of stem cells from umbilical cord tissue, given into the spinal fluid, is safe and tolerable for people who have had a traumatic spinal cord injury within the past ten years. The study will monitor participants for side effects and…

This pilot trial asks whether adding a robotic hand-training device to standard rehabilitation is safe, practical, and helpful for people with arm and hand motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions. Participan…

This study looks back at medical records of children with spinal muscular atrophy (SMA) type 1 who received a one-time gene therapy called onasemnogene abeparvovec (Zolgensma). Researchers want to see if treated infants can sit independently for 30 seconds or more within a year. …

This early-stage trial is testing whether a single injection of XT-150, a gene therapy that produces an anti-inflammatory protein, is safe for people with ALS. Eight adults with ALS will receive one of two doses and be followed for six months. The goal is to check for side effect…

This trial tests whether adding a procedure called expansile duraplasty — opening and expanding the tough membrane around the spinal cord — to standard spinal surgery can improve neurological recovery in adults with acute severe spinal cord injury. Participants are randomly assig…

This early-phase trial is testing whether an experimental drug called NLG802, taken as a pill, can be safely combined with the chemotherapy drug temozolomide for children and young adults (ages 5 to 21) with progressive brain or spinal cord cancer. The study aims to find the high…

This study tests whether a robotic device called ZEPU-AI3 can safely help people with lower limb weakness from stroke, spinal cord injury, or orthopedic surgery improve their walking. Participants receive either standard rehabilitation alone or standard rehab plus robot-assisted …

This study tests whether combining spinal cord stimulation with physical therapy can improve arm and hand movement in people with cervical spinal cord injury. Forty participants will receive either real stimulation or a sham version during 20 therapy sessions over 6-8 weeks. Rese…

This study will test a mobile brain-computer interface (iBCI) that lets people with severe paralysis control computers and mobile devices using only their thoughts. Two veterans with conditions like spinal cord injury or ALS will use the device at home. The goal is to see if the …

This study tests a device called the ReWire system, which is implanted to stimulate the vagus nerve during leg rehabilitation. The goal is to see if this paired stimulation can safely improve walking in people with chronic, incomplete spinal cord injury. The trial involves 20 par…

This trial tests whether an 8-week upper-limb resistance training program can improve cardiovascular autonomic function in adults with chronic spinal cord injury. Participants are randomly assigned to either supervised arm exercises three times per week or a control group. Resear…

This trial tests whether adding a posterior cervical fusion (using the CORUS PCSS 3D device) to the standard anterior cervical discectomy and fusion (ACDF) improves bone fusion success for people with two-level degenerative disc disease in the neck. About 225 adults with neck or …

This study will test whether combining exoskeleton-assisted walking with a mild electrical stimulation to the spinal cord can improve muscle size and bone strength in people with chronic spinal cord injury. Twenty-four participants who have been injured for more than three years …

People who have spine surgery for cancer that has spread are at high risk for dangerous blood clots in the legs or lungs. Currently, blood-thinning medicine is stopped when patients leave the hospital. This trial tests whether taking apixaban (Eliquis) by mouth for 30 days after …

This trial investigates whether combining high-frequency magnetic stimulation of the sacral nerve roots with ultrasound therapy to the bladder can reduce involuntary bladder contractions in people with spinal cord injury. Participants receive daily treatments for three weeks, and…

This study tests a fully wireless brain-computer interface (BCI) that aims to decode attempted speech in real time for people with locked-in syndrome (LIS), often caused by ALS or stroke. The implant records brain signals from areas controlling the mouth and throat, then translat…

This study tracks the safety and effectiveness of a stent graft device used to treat aneurysms, dissections, or trauma in the aortic arch (the curved part of the main artery from the heart). Researchers will follow 75 patients in Japan who receive the device, monitoring for compl…

This study tests whether a special arm-crank exercise (eccentric training) can improve upper body strength and daily function better than standard strength training for people recovering from a spinal cord injury. Twenty participants will do 20 sessions of one type of training ov…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This trial investigates whether injecting Q-Cells—specialized human cells that support nerve function—into the spinal cord is safe for people with ALS. Up to 30 participants receive injections in the lower or upper spinal cord, with some receiving higher doses. Researchers monito…

This study tests whether a nasal spray called foralumab is safe and tolerable for people with ALS, a disease that damages nerve cells controlling movement. Foralumab is designed to calm inflammation and immune activity thought to contribute to ALS. About 44 adults aged 18 to 75 w…

This study tests whether two common heart medications—atorvastatin (a statin) and lisinopril (an ACE inhibitor)—can prevent or reduce heart damage caused by radiation therapy for chest cancers like breast, lung, and esophageal cancer. About 60 adults receiving chest radiation wil…

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This early study tests a new cell therapy called QH101 for people with solid tumors that have spread to the brain, spinal cord, or surrounding membranes. The therapy uses specially engineered immune cells designed to better recognize and attack cancer cells. The main goals are to…

This early-phase trial tests a gene therapy called SKG0201 in 11 infants with spinal muscular atrophy (SMA) type I, a severe muscle-weakening disease. The therapy uses a harmless virus to deliver a working copy of the missing SMN1 gene. The study aims to see if it is safe and can…

This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucu…

This study will follow 36 people with spinal muscular atrophy (SMA) who receive a gene therapy called onasemnogene abeparvovec (ITVISMA) injected into the spinal fluid. The goal is to see how well it works and how safe it is in everyday medical practice. Participants must be at l…

This study tests an oral traditional Chinese medicine made from the fungus C. cicadae in people with ALS who have high levels of certain fats (sphingolipids) in their blood. About 84 participants will receive either the medicine or a placebo for 6 months, with follow-up for 9 mon…

This early-stage trial tests whether transplanting a patient's own nose cells into the spinal cord, combined with intensive exercise, is safe and possible for people with chronic spinal cord injury. About 30 participants will receive the cell transplant and a 32-week rehab progra…

This study tests giving radiation therapy (SBRT) to the spine soon after surgery, while patients are still in the hospital, instead of waiting 2-4 weeks. The goal is to see if this faster approach is safe and helps control cancer growth in the spine. About 50 adults with cancer t…

This study tests a surgery called selective dorsal rhizotomy to reduce severe muscle stiffness (spasticity) caused by traumatic brain or spinal cord injury. The surgery involves cutting specific nerve rootlets in the spine to relax overactive muscles. Researchers will enroll 32 p…

This early-stage trial tests whether a daily supplement called HMB (beta-hydroxy-beta-methylbutyrate) is safe and can lower certain blood markers linked to ALS. One hundred adults with ALS will take 3 grams of HMB daily. Researchers will track changes in blood markers and functio…

This study tests a brain-computer interface (BCI) implant in 10 people with tetraplegia (paralysis of all four limbs) from brainstem or spinal cord injury. The implant reads brain signals to control a pneumatic hand glove, helping patients grasp objects like cups or phones. The t…

This Phase 2 trial tests whether umbilical cord stem cells can safely improve movement and coordination in people with spinocerebellar ataxia (types 1, 2, 3, and 6). Forty-five participants will receive the cells through an IV and a spinal injection. The main goal is to see if sy…

This study will follow 130 people who had surgery for cancer that spread to the spine. Half will get radiation after surgery, half will not. Researchers want to see if radiation helps keep the cancer from coming back and improves how long patients live. The goal is to help doctor…

This study tests whether a drug called istradefylline can boost the walking improvements seen with low-oxygen therapy in people with chronic, incomplete spinal cord injury. About 40 adults aged 18-75 with injuries at least one year old will receive the drug or a placebo before wa…

This study tests a new drug, PLL001, in 153 people with ALS. It is given as a daily injection under the skin. The trial is split into two parts: first to check safety, then to see if it slows the disease and helps people live longer. Participants are randomly assigned to get eith…

This study tests whether the experimental drug tazbentetol can slow the progression of ALS, a disease that weakens muscles and affects movement. About 430 adults with ALS will receive either the drug or a placebo. The main goal is to see if tazbentetol helps maintain daily functi…

This study tests a custom-made drug designed for one person with ALS caused by a specific gene mutation (CHCHD10). The drug aims to slow disease progression by targeting the genetic root cause. The participant will be closely monitored for changes in muscle strength, breathing, a…

This study tests whether combining spinal cord stimulation with physical therapy can help people with non-traumatic spinal cord injury regain leg movement and the ability to stand or step. Ten adults who have had a spinal cord injury for at least one year and cannot walk independ…

This study tests a new device called SSMD, which uses non-invasive stimulation to help people with movement problems after stroke, traumatic brain injury, spinal cord injury, or peripheral nerve damage. 120 adults aged 18-80 with moderate to severe arm impairment will receive eit…

This early-phase trial tests an oral drug, Kamlanoflast, in 40 people with ALS. Over 24 weeks, researchers will check safety, tolerability, and whether the drug reduces inflammation and slows decline in function. It is not yet recruiting.

This early-stage trial tests whether a single dose of CRIS100 is safe for people with a recent spinal cord injury in the upper back. Only 5 adults with severe injuries will receive the drug directly at the injury site within 72 hours. The study focuses on side effects and lab cha…

This early-phase trial tests a nasal spray called NEO100 (a purified natural compound) in 12 children with certain aggressive brain tumors. The goal is to see if it's safe, find the best dose, and check if the drug reaches the tumor. Participants will receive increasing doses, an…

This study tests whether walking in a robotic exoskeleton combined with mild electrical stimulation of the spinal cord can improve muscle and bone health in people with chronic spinal cord injury. About 24 participants will be assigned to either active or sham stimulation during …

This study tests whether combining two drugs (galunisertib and nerandomilast) can slow the progression of ALS in 60 people who have high levels of a protein called GREM2. The drugs aim to reduce brain inflammation and nerve cell damage. Participants will receive either the drug c…

This study looks at whether it is safe to avoid antibiotics before bladder Botox injections in people with multiple sclerosis or spinal cord injury who have bacteria in their urine but no symptoms. About 526 participants will be randomly assigned to receive either antibiotics or …

This study tests a custom 3D-printed implant designed to rebuild the spine after removing a tumor. The implant is less rigid than traditional ones, which may help bone grow better and reduce sinking. Researchers will follow 18 adults for safety and how well the implant fuses with…

This study tests whether metformin, a common diabetes medicine, can help people recover after a spinal cord injury. The drug may reduce scar tissue that blocks nerve healing. Researchers will give metformin or a placebo to 34 adults with recent thoraco-lumbar spinal cord injury a…

This early-phase study tests whether a concentrated form of the patient's own growth factors can improve motor function after a spinal cord injury. Ten adults with moderate to severe traumatic spinal cord injury will receive the treatment. The goal is to see if this approach can …

This study tests a new stem cell therapy called XS228 for people with recent spinal cord injuries. The treatment uses lab-made nerve cells injected into the spinal fluid to help repair damage. About 60 adults with incomplete paralysis will receive either XS228 or a placebo and be…

This study follows 16 people who already received EG110A, a gene therapy that uses a modified herpes virus to deliver a botulinum toxin-like protein to relax bladder muscles. Researchers will track side effects and how well the treatment works over five years. The goal is to see …

This phase 3 trial tests whether adding masitinib to standard ALS treatment (riluzole) can slow the disease better than placebo plus riluzole. About 412 adults with ALS will take the drug or placebo for 48 weeks. The main goal is to measure changes in daily function and breathing…

This early-stage trial is testing a new gene therapy called SNUG01 for people with ALS, a disease that damages nerves controlling movement. The study will involve 21 adults and aims to check if the treatment is safe and tolerable. Researchers will also look for early signs that i…

This study investigates whether measuring a protein called neurofilament light chain (NfL) in the blood can help doctors diagnose amyotrophic lateral sclerosis (ALS) more quickly and accurately. ALS is often hard to distinguish from other neurological diseases, leading to delays …

This study tests a wearable microwave sensor that monitors bladder fullness without needles or catheters. About 40 adults with spinal cord injury who use self-catheterization will wear the sensor while their bladder fills and empties. The goal is to see if the device can accurate…

This study aims to find specific markers in blood platelets that can help doctors diagnose ALS (Lou Gehrig's disease) more accurately and earlier. Researchers will compare 60 participants—30 with newly diagnosed ALS and 30 with other motor neuron diseases—to see if platelet tests…

This phase 2 trial tests whether a nitric oxide spray (glyceryl trinitrate) can prevent dangerous blood pressure spikes during bowel care in people with spinal cord injury. 26 participants will receive either the active spray or a placebo during two at-home bowel care sessions. T…

This study tests a small ear device that gently stimulates a nerve (taVNS) in people who recently had a spinal cord injury. The goal is to see if it is safe and comfortable, and whether adding it to walking therapy might help improve mobility. About 50 adults will take part in tw…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This study tests a patient empowerment program for veterans with spinal cord injury and neurogenic bladder who have had at least one urinary tract infection in the past year. The program provides training and tools to help them recognize when antibiotics are not needed and advoca…

This trial tests whether a mild electrical current applied to the brain during spine tumor surgery can lower anxiety afterward. Adults aged 18 to 65 scheduled for elective intraspinal tumor removal will receive either real or sham stimulation for 20 minutes right after anesthesia…

This study tests whether applying myofascial release—a manual therapy that relaxes tight muscles—to the arms can improve sprint speed in wheelchair rugby players with spinal cord injury. Twelve athletes will complete a 20-meter sprint test with and without the therapy on separate…

This study tests whether adding Kinesio Taping to a standard bowel program can improve bowel function in adults with spinal cord injury. Thirty participants will be randomly assigned to receive either the bowel program alone or the bowel program plus Kinesio Taping applied to the…

This early-phase trial tests a wearable device that delivers mild electrical stimulation to a nerve near the genitals, aiming to improve bladder control in men with spinal cord injury. The study will enroll 12 participants and measure changes in bladder capacity and device usabil…

This study will test whether walking on an antigravity treadmill can boost heart and lung fitness and improve leg function in 60 people with incomplete spinal cord injury. Participants will do gait training on the treadmill or between parallel bars. The goal is to see if this spe…

This study tests whether eating at least 6 servings of fermented foods daily for 10 weeks can improve bowel function and gut health in adults with chronic spinal cord injury. Participants will be randomly assigned to either a high-fermented-food diet or a control diet. The resear…

This study tests a robotic device designed to help people with stroke, Parkinson's disease, ALS, or mild cognitive impairment improve their arm and hand function. Thirty adults will receive standard rehabilitation, and half will also use the robot for up to 30 minutes per session…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This pilot study tests a non-invasive device that stimulates a nerve in the neck to see if it can increase how often people with ALS swallow and their urge to swallow. Up to 5 participants will receive supervised treatment sessions and be monitored with swallowing tests. The goal…

This study tests whether adding brain stimulation to spinal cord stimulation can improve leg strength and walking in adults with chronic incomplete spinal cord injury. 24 participants will receive either combined therapy or spinal stimulation alone over 16 weeks. The goal is to s…

This study tests whether adding Functional Electrical Stimulation (FES) to standard rehab can reduce leg stiffness, build muscle strength, and improve walking in people with paraplegia. Forty adults with spinal cord injury will be split into two groups: one gets rehab alone, the …

This pilot study tests whether combining two types of non-invasive stimulation—one on the brain and one on the spine—can improve arm and hand function in people with chronic incomplete cervical spinal cord injury. 24 adults will receive either both stimulations plus rehabilitatio…

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. 32 adults will use the device at home for 30 days. The main goal is to see if the treatment is practical and well-tolerated, whi…

This study tests whether a self-balancing exoskeleton called XoMotion-R can help people with spinal cord injury (SCI) walk hands-free during rehab. Researchers will recruit 16 participants (8 inpatients and 8 outpatients) with specific levels of SCI to try the device. The goal is…

This study will test a special moving platform combined with virtual reality to help people with neurological disorders like Parkinson's disease, stroke, ALS, or mild cognitive impairment improve their balance and movement. The platform moves in three directions and adapts exerci…

This study tests whether a home-based virtual reality guided breathing program can reduce anxiety and improve quality of life in people with ALS. Sixty participants will use a VR headset to follow breathing exercises. The goal is to see if this simple, immersive tool can help man…

This study looks at whether giving people with ALS and their caregivers video recordings of their clinic visits helps them feel better and manage care more easily. About 800 participants (400 patient-caregiver pairs) from eight U.S. sites will be split into two groups: one gets s…

This study tests whether a gentle electrical current applied to the spinal cord (transcutaneous spinal cord stimulation) during assisted cycling can improve leg movement, reduce muscle spasms, and help bladder/bowel control in adults with incomplete spinal cord injury. Forty part…

This study tests a new AI system that adjusts electrical stimulation to the spine in real time while people with spinal cord injury walk. The goal is to improve muscle activation and walking ability compared to standard stimulation. The study involves 7 participants and focuses o…

This study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…

This study tests a home-based digital rehabilitation program combined with a non-invasive spinal cord stimulation device to improve upper limb function in people with chronic tetraplegia. Nine participants will use a mobile app-guided exercise program with daily stimulation over …

This pilot study tests whether combining non-invasive brain stimulation (over the cerebellum) with spinal cord stimulation can improve arm and hand function in people with chronic cervical spinal cord injury. Twenty-four participants will receive either both stimulations, spinal …

Chronic pain affects over 60% of people with spinal cord injuries, and standard treatments often fall short. The EmpowerSpine program is a 10-week online course that teaches pain biology, daily activity strategies, and resilience skills. This study will test 100 participants to f…

This study tests whether an AI-powered mobile app can help people with spinal cord injury manage bowel dysfunction. About 34 adults will use the app for 12 weeks to see if it reduces bowel problem scores, shortens bathroom time, and improves quality of life. The goal is to make d…

This study tests whether a multicomponent support group can improve the confidence (self-efficacy) of primary caregivers of children with Duchenne muscular dystrophy or spinal muscular atrophy in Pakistan. Thirty caregivers will join group sessions with doctors, therapists, and o…

This study tests whether a special type of horseback physiotherapy can improve movement, posture, breathing, and quality of life in children with spinal muscular atrophy (SMA). Twenty children aged 2 to 9 years will receive both the horse therapy and standard physiotherapy in ran…

This study compares two needle-based treatments—electrolysis and dry needling—against standard physiotherapy for whiplash pain from car accidents. Thirty-six adults with neck pain and active trigger points will receive one of the three approaches. The goal is to see which method …

This study tests a new approach to reduce nerve pain in people with spinal cord injury. Ten participants will receive ten sessions combining mild brain stimulation (tDCS) with virtual reality walking and muscle vibration. The goal is to see if this drug-free combo can lower pain …

This study tests a mind-body program designed to help people recently diagnosed with ALS and their caregivers manage emotional distress. About 20 patient-caregiver pairs will try a 6-session coping intervention. The main goal is to see if the program is practical and well-liked, …

This study tests whether combining loud sounds and mild electrical stimulation with walking practice can improve walking speed and leg strength in people with chronic spinal cord injury. About 20 adults with incomplete spinal injuries who can stand and have some ankle movement wi…

This study will test a new device that combines a brain-sensing headband with Apple's Vision Pro goggles to help people with ALS, brain injury, or spinal cord injury communicate. Up to 10 participants will use the system for 3-4 months to see how well they can type and control a …

This early study tests whether delivering small electrical pulses over the skin above the spinal cord, alongside standard therapy, can help people with a recent spinal cord injury regain arm and hand function. Twenty participants will receive either active or sham stimulation dur…

This study tests whether a short form of therapy called Focused Acceptance and Commitment Therapy (FACT) can help people with spinal cord injuries improve their mental health and quality of life while still in the hospital. Eight participants will complete questionnaires before a…

This study tests a robotic exoskeleton called CLINICAL EXPLORER in 60 children aged 2 to 17 with neurodevelopmental disorders like cerebral palsy. The device supports walking during 8 therapy sessions. Researchers will check if it is safe, easy to use, and helps improve movement …

This study looks at whether electrical pudendal nerve stimulation (EPNS), delivered through thin needles near the tailbone, can improve bladder function in children who have nerve-related bladder issues after tethered cord surgery. Fifty children will receive EPNS three times a w…

This study follows 80 people with spinal muscular atrophy (SMA) in Japan who receive Zolgensma (onasemnogene abeparvovec) as an intrathecal injection. The goal is to track safety issues, such as liver problems or blood clotting abnormalities, and to measure changes in motor funct…

This study will enroll 35 Spanish-speaking adults with ALS and a similar group without ALS to see if a smartphone app can reliably measure changes in speech and breathing over time. Participants will use the app to record speaking and breathing tasks, and researchers will compare…

ALS is a progressive nerve disease with no simple test for early diagnosis or tracking. This study is collecting blood samples and medical data from 200 people with ALS to look for patterns in proteins, genes, and immune markers. The goal is to build a biomarker panel that could …

This observational study screens 500 people with early-stage ALS to see if they qualify for specific early-phase clinical trials. Participants undergo tests, genetic analysis, and biomarker checks to match them with the right trial. The study also builds a research database for f…

This study uses questionnaires and focus groups to understand the challenges children with spinal muscular atrophy (SMA) and their families face when moving between schools or starting a new educational stage. Researchers aim to identify barriers to inclusion and support, and to …

This study uses advanced MRI to examine whether a deformity in the upper spinal canal is linked to syringomyelia (fluid-filled cavities in the spinal cord) in people with Chiari malformation type I. Researchers will compare MRI scans from 50 adults with Chiari malformation, with …

This study looks at 40 veterans with chronic spinal cord injury to find any remaining nerve connections below their injury. Researchers will use MRI scans and non-invasive stimulation to measure these connections. The goal is to understand who might benefit from future treatments…

This study investigates whether increased muscle tone in the legs can predict neurogenic detrusor overactivity (NDO)—a condition where the bladder contracts involuntarily—in adults with upper sacral spinal cord injury. Researchers will compare medical records of 300 patients with…

This pilot study will test whether temporarily stimulating nerves in the lower spine can improve movement and bladder function in one person with a spinal cord injury. The participant will have small electrodes placed near the spinal nerves and undergo 10 days of rehabilitation s…

This study will interview 15 parents or guardians of children with spinal muscular atrophy type 1 to learn about their daily challenges with feeding and communication. Even though newer treatments have improved survival, their impact on swallowing and speech is not well understoo…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This study tests whether a new real-time imaging method can make radiation therapy more accurate for cancer patients. About 40 adults with various cancers will receive their normal radiation treatment while the new imaging tracks the tumor in real time. The goal is to see if the …

This study is testing a robot named Alter-Ego to see if it can safely help doctors, nurses, and therapists care for people with ALS. The robot can be controlled remotely or work on its own to do tasks like guiding remote medical visits, delivering supplies, and reminding patients…

This study looks at bone health in children with spinal muscular atrophy (SMA), a condition that causes muscle weakness. Researchers want to find out how common fractures are and whether newer SMA treatments affect bone strength. They will review medical records from about 550 ch…

This observational study will look at how fear of movement (kinesiophobia) relates to independence, fear of falling, pain, and mood in 70 adults with paraplegic spinal cord injury. Participants will fill out questionnaires during one visit. The goal is to better understand these …

This study looks at how quickly people with paraplegic spinal cord injury can mentally picture moving their hands or feet compared to healthy individuals. Researchers will use a computer task where participants identify left or right hand/foot images. The goal is to understand ho…

This study tests a driving simulator designed to help people with neurological conditions like stroke, Parkinson's, ALS, or mild cognitive impairment improve their motor and thinking skills. About 60 participants (including healthy volunteers) will use the simulator to see if it …

This study follows 150 adults with paralysis from spinal tumors who undergo surgery to relieve pressure on the spinal cord. Researchers track how well patients recover movement, bladder and bowel function, and quality of life over one year. The goal is to identify factors that he…

This early-phase study tests a special dye called [11C]CPPC used in PET scans to see if it can safely detect brain inflammation in people with ALS. Researchers will compare scans from 20 ALS patients and healthy volunteers to check if the dye highlights areas of inflammation and …

This study looks at whether people with long-term spinal cord injury who also have a condition called autonomic dysreflexia (sudden high blood pressure) have changes in their heart structure. Researchers will use MRI scans to compare two groups: 24 people with high-level injury a…

This observational study will follow 100 children in Denmark who receive a stem cell transplant for blood cancer or other serious blood disorders. Researchers will test their thinking skills, physical abilities, and daily activity before the transplant and for one year after. The…

This study will look back at the medical records of 50 people with spinal cord injuries treated over the last five years. Researchers want to understand common causes of injury, levels of paralysis, and what complications patients faced, such as pressure sores or infections. The …

This study aims to understand how care for people with Motor Neurone Disease (MND) is coordinated between specialist clinics and local community services. Researchers will talk to patients, carers, and healthcare professionals, and observe how care is transferred. The goal is to …

This exploratory study will use an upright MRI scanner to take 3D images of the bladder in 20 people—some with spinal cord injury who use catheters, and some healthy volunteers. The goal is to understand how the bladder and surrounding structures change shape during catheter use …

This pilot study aims to see if a larger trial comparing two standard treatments for mild degenerative cervical myelopathy (spinal cord compression) is possible. 56 adults with mild symptoms will be randomly assigned to either decompressive surgery or a structured conservative ca…

This study follows 600 Chinese children who received standard vaccines against polio, measles, mumps, rubella, and hepatitis A. Researchers will test their blood to see if protective antibodies remain 5 years after vaccination. The goal is to understand how long vaccine protectio…

This study will compare how well an AI program (Blings) measures speech clarity in 40 adults with speech disorders from stroke or other neurological conditions. Two speech therapists will also rate the same speech samples. The goal is to see if the AI can reliably replace or assi…

This study looks at children with spinal dysraphism, a birth defect where the spine doesn't close properly. The goal is to better understand bladder and bowel problems in these children, especially those with less obvious forms. By studying 210 children treated at one hospital ov…

This study looks at how parents feel after their newborn is screened for spinal muscular atrophy (SMA). Researchers will interview 36 parents in two French regions to understand their anxiety, stress, and support needs. The goal is to improve how screening results are shared and …

This study tests a Polish version of a questionnaire called DALS-15, which measures how severe breathing difficulty (dyspnea) is in people with ALS. About 120 Polish-speaking ALS patients who have trouble breathing will fill out the questionnaire along with other breathing tests.…

This pilot study will use ultrasound to measure diaphragm movement in 20 ALS patients, both while they breathe on their own and while using non-invasive ventilation (NIV). The goal is to see if ultrasound can detect changes in how the diaphragm works with and without the breathin…

This study will follow 175 children and young adults who had a bone marrow transplant before age 18. Researchers will test their thinking, memory, and attention skills, and check for links to physical health issues like metabolism and fitness. The goal is to find early warning si…