New drug VHB937 aims to slow ALS progression in Early-Stage patients

NCT ID NCT06643481

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This phase 2 trial tests whether the experimental drug VHB937 can slow the decline in function and delay the need for breathing support in people with early-stage ALS. About 251 participants will receive either VHB937 or a placebo for 40 weeks, followed by an open-label extension where everyone can get the drug. The study is currently active but no longer recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: VHB937 (a biologic drug given by infusion)
What this could lead to: If it works, this could point toward a treatment that slows the progression of ALS and delays the need for breathing support.
What could go wrong: This is a mid-stage trial with only 251 people, so results may not apply to all ALS patients. The drug may not show benefit over placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis motor neuron disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS (ALS)

Contacts and locations

Locations

AMR Knoxville

Knoxville, Tennessee, 37920, United States
Atrium Health

Charlotte, North Carolina, 28207, United States
Austin Neuromuscular Center

Austin, Texas, 78759, United States
Duke University Health System

Durham, North Carolina, 27710, United States
Emory University School of Medicine

Atlanta, Georgia, 30322, United States
Keck Medical Center USC

Los Angeles, California, 90033, United States
Lange Neurology PC

New York, New York, 10065, United States
Loma Linda University Health

Loma Linda, California, 92354, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Nerve and Muscle Center of Texas

Houston, Texas, 77030, United States
Novartis Investigative Site

North Ryde, New South Wales, 2109, Australia
Novartis Investigative Site

Herston, Queensland, 4029, Australia
Novartis Investigative Site

Caulfield South, Victoria, 3162, Australia
Novartis Investigative Site

Southport, 4215, Australia
Novartis Investigative Site

Leuven, Vlaams Brabant, 3000, Belgium
Novartis Investigative Site

Liège, 4000, Belgium
Novartis Investigative Site

Calgary, Alberta, T2N 4N1, Canada
Novartis Investigative Site

Montreal, Quebec, H4A 3T2, Canada
Novartis Investigative Site

Beijing, 100191, China
Novartis Investigative Site

Aalborg, 9000, Denmark
Novartis Investigative Site

Kobenhavn N V, 2400, Denmark
Novartis Investigative Site

Bron, 69677, France
Novartis Investigative Site

Lille, 59037, France
Novartis Investigative Site

Nice, 06001, France
Novartis Investigative Site

Paris, 75013, France
Novartis Investigative Site

Tours, 37044, France
Novartis Investigative Site

Mannheim, Baden-Wurttemberg, 68167, Germany
Novartis Investigative Site

Munich, Bavaria, 81675, Germany
Novartis Investigative Site

Würzburg, Bavaria, 97080, Germany
Novartis Investigative Site

Rostock, Mecklenburg-Vorpommern, 18057, Germany
Novartis Investigative Site

Berlin, 13353, Germany
Novartis Investigative Site

Hanover, 30559, Germany
Novartis Investigative Site

Lübeck, 23538, Germany
Novartis Investigative Site

Münster, 48149, Germany
Novartis Investigative Site

Ulm, 89081, Germany
Novartis Investigative Site

Dublin, DUBLIN 9, Ireland
Novartis Investigative Site

Milan, MI, 20138, Italy
Novartis Investigative Site

Modena, MO, 41126, Italy
Novartis Investigative Site

Pisa, PI, 56126, Italy
Novartis Investigative Site

Torino, TO, 10126, Italy
Novartis Investigative Site

Utrecht, 3584 CX, Netherlands
Novartis Investigative Site

Krakow, Poland, 31 531, Poland
Novartis Investigative Site

Bydgoszcz, 85-163, Poland
Novartis Investigative Site

Krakow, 30-721, Poland
Novartis Investigative Site

Warsaw, 01-684, Poland
Novartis Investigative Site

Warsaw, 02-473, Poland
Novartis Investigative Site

Yangsan, Gyeongsangnam-do, 50612, South Korea
Novartis Investigative Site

Seoul, 04763, South Korea
Novartis Investigative Site

Seoul, 05505, South Korea
Novartis Investigative Site

Santiago Compostela, A Coruna, 15706, Spain
Novartis Investigative Site

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Novartis Investigative Site

Barcelona, 08035, Spain
Novartis Investigative Site

Valencia, 46026, Spain
Novartis Investigative Site

Malmö, 214 28, Sweden
Novartis Investigative Site

Stockholm, 113 61, Sweden
Novartis Investigative Site

Umeå, SE-90185, Sweden
Novartis Investigative Site

Basel, 4031, Switzerland
Novartis Investigative Site

Sankt Gallen, 9007, Switzerland
Novartis Investigative Site

Sheffield, South Yorkshire, S10 2JF, United Kingdom
Novartis Investigative Site

Farnborough, BR6 8ND, United Kingdom
Novartis Investigative Site

London, SW17 0QT, United Kingdom
Novartis Investigative Site

London, WC1N 3BG, United Kingdom
Novartis Investigative Site

Stoke-on-Trent, ST4 6QG, United Kingdom
Orlando Health Clinical Trials

Orlando, Florida, 32806, United States
Temple University

Philadelphia, Pennsylvania, 19140, United States
The Ohio State University

Columbus, Ohio, 43210, United States
UC San Francisco Medical Center

San Francisco, California, 94143-0348, United States
Univ of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
University Of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of California San Diego

La Jolla, California, 92037, United States
University of Miami

Miami, Florida, 33136, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States

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