Respiratory failure

This study tests an experimental drug called centhaquine in 80 adults with moderate to severe ARDS, a life-threatening lung condition. The drug is added to standard care to see if it improves oxygen levels and reduces deaths. Participants must be in the ICU and start treatment wi…

This trial tests whether a newer ventilation method, called flow-controlled ventilation, keeps the lungs and diaphragm in better shape than the standard pressure-controlled method during elective heart bypass surgery. About 154 adults scheduled for on-pump coronary artery bypass …

This trial tests how different levels of spontaneous breathing during a ventilation mode called APRV affect lung function in adults with moderate-to-severe acute respiratory distress syndrome (ARDS). Each participant receives three breathing conditions in random order: low, high,…

This trial tests a new monitoring device, the Linshom CPRM, which fits into an oxygen mask or nasal cannula and alerts nurses when a patient's breathing starts to fail. Researchers will compare standard monitoring plus the Linshom alarm against standard monitoring alone in about …

This pilot trial tests a ventilator strategy that targets a specific measure of lung stress, called mechanical power, in adults with severe ARDS who are on VV ECMO. The goal is to see if this approach is feasible and safe compared to standard ultra-low tidal volume ventilation. R…

This trial tests whether an automated oxygen titration system, called FreeO2, can improve oxygen weaning in patients recovering from acute hypoxemic respiratory failure. The device continuously adjusts oxygen flow based on oxygen saturation levels, potentially reducing episodes o…

This trial tests whether two existing drugs, simvastatin and baricitinib, can help people with acute respiratory distress syndrome (ARDS), a severe lung condition that causes breathing failure. Participants are grouped by biological markers into subtypes, then randomly assigned t…

This phase III trial asks whether giving dexamethasone early to adults with severe influenza pneumonia and low blood oxygen can improve outcomes. Participants in intensive or intermediate care receive either the steroid or a placebo for up to 10 days, alongside standard flu treat…

This trial tests whether using electrical impedance tomography (EIT) to guide ventilator pressure settings improves lung function in patients with moderate-to-severe acute respiratory distress syndrome (ARDS) who are placed face down (prone positioning). Researchers will compare …

This trial tests whether a ventilator method called variable ventilation, which changes the size of each breath slightly, is safe and feasible for adults with acute respiratory distress syndrome (ARDS) who need breathing support. Participants receive 24 hours of variable ventilat…

This trial asks whether adding a device that removes carbon dioxide directly from the blood (ECCO2R) to standard noninvasive ventilation can help adults hospitalized with a severe COPD flare-up. Participants have high CO2 and acidic blood despite ventilation and cannot have a bre…

This trial tests whether epidural spinal cord stimulation can help people with severe brain injury breathe without a ventilator. Ten patients with stroke or traumatic brain injury who need mechanical ventilation will receive a surgically implanted electrode that delivers electric…

This study looks at whether a newer opioid painkiller, oliceridine, is less likely than the standard sufentanil to cause breathing problems after surgery in people at high risk of obstructive sleep apnea. About 851 adults with known or suspected sleep apnea will receive one of th…

This trial tests whether using a colorimetric carbon dioxide (CO₂) detector to guide non-invasive breathing support (ventilation) improves care for premature infants born before 32 weeks. The detector changes color to show how well the baby is exhaling CO₂, which may help doctors…

This study compares a new type of breathing device (biphasic cuirass ventilator) to standard non-invasive ventilation in 50 high-risk patients who are about to have their breathing tube removed. The goal is to see if the new device can reduce the number of patients who need to be…

This trial tests whether an AI system can help doctors choose better ventilator settings for children (ages 1 month to 18 years) in the pediatric ICU who need a breathing machine. Half of the children will receive standard care, while the other half will have their ventilator adj…

This trial compares two oxygen methods for tracheostomized patients who are being weaned off a mechanical ventilator. Half receive high-flow oxygen directly into the tracheostomy tube, while the other half receive conventional oxygen. The goal is to see if high-flow oxygen helps …

This trial compares two ways to humidify air for trauma patients on prolonged mechanical ventilation: active heated humidifiers and passive heat-and-moisture exchangers. The goal is to see which method reduces airway complications like mucus plugs and tube blockages, and improves…

This study tests an experimental therapy called GKL-006RTU, made from a type of immune cell (iNKT cells), for people with moderate to severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. The trial has two parts: first, a small group receives the c…

This study tests a new way of using a breathing machine (ventilator) called time-controlled adaptive ventilation (TCAV) in people with severe lung injury from pneumonia. The goal is to see if TCAV reduces fluid buildup in the lungs compared to standard ventilation. The trial invo…

This study looks at whether adding a home telemonitoring system to standard nighttime breathing support (non-invasive ventilation) can help people with severe COPD and high carbon dioxide levels. About 92 participants will be split into two groups: one using standard home ventila…

This study aims to improve treatment for severe high altitude pulmonary edema (fluid in the lungs) and cerebral edema (brain swelling). Researchers will test breathing support devices and inhaled nitric oxide gas in over 3,000 patients in Tibet. The goal is to speed up recovery, …

This early-stage trial tests R-3750, a live biotherapeutic product, in 20 adults with late-stage acute respiratory distress syndrome (ARDS). The main goal is to see if it is safe and tolerable, while also checking for signs of improved lung function and less need for a ventilator…

This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucu…

This study tests whether a traditional Chinese herbal formula, Xuanbai Shengmai Decoction, can improve survival in adults with acute respiratory distress syndrome (ARDS), a severe lung condition often seen in the ICU. About 308 participants will receive either the herbal decoctio…

This study tests a new method for setting ventilators during abdominal surgery to prevent postoperative respiratory failure. The approach adjusts settings based on 'mechanical power,' a measure that combines several ventilator parameters. The trial will enroll 490 adults having a…

This study tests whether ondansetron, a drug typically used for nausea, can reduce the strong urge to breathe in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. By lowering this drive, the drug may prevent patients from overworking their lungs an…

This study looks at how to best give muscle relaxants to patients with severe lung failure (ARDS) who are on a breathing machine. It compares giving the drug as a steady drip versus as separate shots. The goal is to see which method is safer and works better, and to plan a larger…

This study tests a new way to use breathing machines for people with severe lung failure (ARDS). The goal is to reduce lung damage by using very gentle breaths and adding a machine that helps remove carbon dioxide from the blood. About 290 adults on breathing machines for less th…

This study tests a new treatment called JadiCell, made from stem cells from donated umbilical cords, for people with severe lung failure (ARDS). The goal is to see if a single IV dose can calm inflammation and help the lungs heal, so patients need less breathing support. About 12…

This study tests whether a Bag CPAP device, added to standard oxygen, can reduce the need for breathing tubes in adults with acute hypoxemic respiratory failure. Researchers in Rwanda will randomly assign 250 patients to receive either Bag CPAP plus oxygen or oxygen alone. The ma…

This study tests whether giving the steroid betamethasone to extremely premature babies (born before 28 weeks) helps them come off breathing machines more easily and lowers their risk of chronic lung disease. About 100 babies will receive either standard NICU care plus betamethas…

This study tests whether a new breathing support called Pressure Targeted High Flow works as well as standard CPAP in premature infants with breathing problems. About 78 babies born before 33 weeks will try each method for 24 hours. Researchers will monitor breathing, oxygen need…

This study tests whether using lung ultrasound to guide breathing treatments can help infants with respiratory failure leave the NICU sooner. About 64 newborns will be randomly assigned to either ultrasound-guided care or standard care. The goal is to see if this approach reduces…

This study tests whether the drug fostamatinib can safely help adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung injury. About 40 participants will receive either the drug or a placebo, and researchers will track serious side effects for 30 days. …

This study compares two types of high-frequency ventilators for premature babies born before 32 weeks who have breathing problems. The new mode, HFOV-VG, aims to deliver more stable breaths to reduce lung injury. Researchers will see if it lowers the chance of severe chronic lung…

This study looks at whether lying on the side at different angles can improve lung function in people with acute respiratory distress syndrome (ARDS), a serious lung condition. About 140 adult patients will be randomly placed in either the standard face-down position or a side-ly…

This study tests whether giving a special lung medicine (surfactant mixed with budesonide) to extremely premature babies who are still on a breathing machine at 7-14 days old is safe and can help prevent a serious lung condition called bronchopulmonary dysplasia. About 24 babies …

This study tests whether giving steroids based on a patient's immune status can reduce deaths in severe pneumonia with respiratory failure. About 500 ICU patients will receive methylprednisolone, with doses adjusted according to their inflammatory profile. The goal is to find out…

This study tests whether adding inhaled nitric oxide (iNO) to standard care helps adults with moderate-to-severe acute respiratory distress syndrome (ARDS) survive longer. About 536 participants will be randomly assigned to receive iNO or a placebo through their ventilator. The m…

This study tests whether a combination of three inhaled drugs (furosemide, heparin, and hypertonic saline) can reduce lung injury in adults with acute respiratory distress syndrome (ARDS) who are on mechanical ventilators. The trial will involve 344 participants and measure daily…

This early-stage study tests a single dose of a new drug called AVM0703 in 16 adults with severe breathing failure (ARDS) caused by COVID-19 or the flu. The main goal is to check if the drug is safe and how the body processes it. Participants are randomly assigned to receive the …

This study tests whether giving high-flow nasal oxygen during the intubation procedure can prevent severe drops in oxygen levels in ICU patients with acute respiratory failure. 500 participants will be randomly assigned to receive either the extra oxygen or usual care. The goal i…

This study tests whether dexmedetomidine, a sedative that keeps patients more awake and has fewer side effects, can improve survival and reduce confusion in older adults (65+) on breathing machines in the ICU. Researchers will compare it to a placebo (salt water) in 300 patients …

Blunt chest trauma can lead to serious breathing problems, but current imaging tools have limits. This study tests whether adding a diaphragm ultrasound to the standard lung ultrasound helps doctors predict which patients will develop hypoxemic respiratory failure. Adults with is…

Researchers at Assiut University are testing whether lung ultrasound can diagnose pneumonia in newborns as reliably as the standard chest X-ray. The study will enroll 100 infants in the neonatal intensive care unit who have a clinical diagnosis of pneumonia within their first 28 …

This study tests whether paramedics can use a lung ultrasound to improve diagnosis of heart failure in patients with breathing trouble. About 1,000 adults with shortness of breath will receive the ultrasound during emergency care. Researchers will compare the paramedic's diagnosi…

This study is testing whether a simple, 1-minute heart recording (ECG) analyzed by a computer can help detect pulmonary embolism, a serious blood clot in the lungs. Researchers will enroll 500 adults who need to be checked for this condition. The goal is to see if this quick, non…

This study tests an AI system that helps doctors navigate a bronchoscope (a thin tube with a camera) into the lungs of patients with severe pneumonia. The AI provides real-time visual cues and voice prompts to guide the doctor to the right spot and describe what they see. About 1…

This study tests whether using a high-flow nasal cannula (a device that delivers warm, moist oxygen at high speeds) for 24 hours after major abdominal surgery can prevent lung complications like pneumonia or collapsed lungs. Researchers will compare this to standard oxygen therap…

This Phase 2 trial tests whether the drug ENA-001 can prevent respiratory depression (dangerously slow or shallow breathing) after major surgery under general anesthesia. About 200 adults having elective surgery will receive either ENA-001 or a placebo as an IV drip. The study is…

This study tests dexmedetomidine, a sedative that doesn't slow breathing, in 246 premature babies on ventilators. The goal is to see if it reduces the need for opioids, shortens time on the breathing machine, and improves long-term brain development. Babies will receive the drug …

This study tests a program called ICU-SUCCEED, designed to help survivors of acute respiratory failure and their family caregivers cope and manage recovery together. The program includes one in-person session and four follow-up sessions by phone or video, focusing on communicatio…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study tests whether adding a muscle relaxant (rocuronium) to standard painkiller (fentanyl) helps doctors place breathing tubes in newborns on the first try, without causing dangerous drops in oxygen or heart rate. About 102 premature or sick babies in a Brazilian NICU will …

This trial studies whether a slower inflation setting (long pressure rise time) on mechanical ventilators can improve oxygen levels in extremely preterm infants compared to the standard faster setting. About 68 babies born before 28 weeks will be randomly assigned to both setting…

This study tests whether electrical stimulation of the muscles used to breathe in (inspiratory) versus out (expiratory) can help patients on mechanical ventilators wean off the machine faster. The trial will include 48 adults aged 45-65 who have been on a ventilator for at least …

This study tests whether adding a special breathing exercise device (IMT Threshold) to standard rehab can help people recover faster after coronary artery bypass graft surgery. The goal is to reduce time in the hospital and prevent serious breathing complications like pneumonia. …

This study looks at whether adding a type of stretching called proprioceptive neuromuscular facilitation (PNF) to standard breathing exercises helps patients get off a breathing machine faster. About 93 adults in the ICU who are stable and awake will be split into three groups: o…

This study tests two types of nerve blocks for shoulder surgery to see which one is less likely to temporarily paralyze the diaphragm, the main muscle for breathing. About 70 adults having elective shoulder surgery will be randomly assigned to receive either a standard interscale…

This study tests a redesigned non-invasive ventilation mask that may help people with respiratory insufficiency breathe more easily. Sixty adults who are stable on NIV will wear their usual mask for one hour and then the new mask for one hour. Researchers will measure breathing r…

This study tests a procedure that freezes the nerves around broken ribs to see if it reduces pain and helps people breathe better. About 30 adults with at least two broken ribs and severe pain will either get the freezing treatment or standard pain medicine. Researchers will trac…

This study compares a new device called ADINA to standard high-flow nasal cannula for giving oxygen to premature babies with breathing distress. About 40 babies in the NICU will take part. The goal is to see if ADINA works as well as the usual method and to check for safety issue…

This study will test whether using special distraction cards or color-changing thermochromic cards can reduce pain, fear, and anxiety in children aged 4-6 who are receiving inhaler therapy for respiratory infections. About 90 children will be randomly assigned to use one type of …

This study tests two methods to train the breathing muscles of patients with respiratory failure who are on mechanical ventilators. One method slowly increases the effort needed to trigger a breath, while the other gradually reduces the machine's support. The goal is to see which…

This study tests whether a new type of home oxygen therapy, called high-flow nasal cannula (HFNC), can improve breathing comfort and quality of life for people with long-term lung or heart conditions. Participants will try both HFNC and standard oxygen therapy for two weeks each …

This study tests whether a nerve block in the neck (cervical erector spinae plane block) can reduce the feeling of shortness of breath in ICU patients with acute respiratory failure. Thirty participants will receive the block, and their breathing distress will be measured using p…

This study tests new breathing devices for people with breathing failure and high carbon dioxide levels. Standard masks can be uncomfortable, causing patients to stop treatment. The study compares a new nasal cannula and a redesigned mask to standard masks, measuring breathing ef…

Researchers at Assiut University Children Hospital are tracking 100 preterm infants who need invasive mechanical ventilation in the neonatal intensive care unit. The study aims to identify which early factors predict prolonged ventilation, defined as more than 7 days or frequent …

ARDS is a severe lung condition that damages the tiny air sacs and blood vessels in the lungs, leading to low oxygen and unstable circulation. Researchers at Hospices Civils de Lyon are measuring blood viscosity, or how thick and resistant to flow the blood is, in ICU patients wi…

Researchers at Radboud University Medical Center are studying whether the diaphragm, the main breathing muscle, enters a hibernation-like state in ICU patients who need a breathing machine. The study follows 112 adults on invasive mechanical ventilation for at least three days. S…

Researchers are studying whether repeated bedside ultrasound scans of the diaphragm can predict breathing failure in adults with septic shock. The study follows 120 patients in intensive care for up to 72 hours, measuring how far the diaphragm moves and how thick it is. The team …

This study aims to develop a new pain assessment scale, called EDEX, specifically for extremely premature infants born before 27 weeks. Current scales may not work well for these fragile babies, who show pain in subtle ways. Researchers will create the scale and then test it agai…

Researchers at Vanderbilt University Medical Center want to understand how immune cells use glucose, the body's main sugar, during critical illness. They give 25 adult ICU patients an intravenous infusion of a non-radioactive carbon-13 glucose tracer over a few hours. Then they c…

This international study follows about 565 patients who need advanced breathing support, such as high-flow oxygen or a ventilator, while being transported within or between hospitals. Researchers will track what happens during these trips, including any equipment problems or inte…

This study will closely monitor 180 adults with sepsis-related acute respiratory distress syndrome (ARDS) who are on breathing machines. Researchers will take fluid samples from the lungs and blood at several time points to measure inflammation and injury markers. The goal is to …

This study looks at elderly patients (60 and older) with COPD who need a breathing machine in the ICU. Researchers will check their nutritional status and measure the thickness of their diaphragm muscle using ultrasound. The goal is to see if these factors can predict how well pa…

This study looks at whether a simple, non-invasive ultrasound of the diaphragm can help predict which older adults (75+) with sudden shortness of breath will develop severe breathing failure. Researchers will measure diaphragm movement and thickness in 145 emergency patients and …

This study looks at whether three blood markers—sRAGE, CC16, and Syndecan-1—measured soon after a severe chest injury can predict who will develop acute respiratory distress syndrome (ARDS), a serious lung condition, and who might die in the hospital. Adults aged 18 to 60 with se…

This study looks at whether the amount of air a person breathes in on their own matches the amount they breathe when using a non-invasive ventilation (NIV) mask. It involves 30 adults with acute respiratory failure who are in intensive care. Researchers will measure tidal volume …

This study compares different bedside methods for choosing the optimal ventilator pressure (PEEP) in patients with moderate-to-severe acute respiratory distress syndrome (ARDS). The goal is to see if these methods give similar results and which one best balances keeping lungs ope…

This study looks at how a small opening in the heart, called a patent foramen ovale (PFO), affects blood flow and oxygen levels during exercise and simulated high altitude. About a third of people have this opening, which may allow oxygen-poor blood to mix with oxygen-rich blood,…

This observational study looks at whether inhaled sedation with isoflurane is a more cost-effective option than intravenous propofol for mechanically ventilated adults in the intensive care unit. Researchers will compare total care costs, duration of ventilation, ICU length of st…

This study looks at whether the force of mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) can damage the brain. Researchers will measure a protein called S100B in the blood, which is a sign of brain injury, and track thinking and memory problems …

This study looks at two bedside methods to measure how much of the lung can be reopened in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. It also compares four different ways to set the ventilator's positive end-expiratory pressure (PEEP). The g…

This pilot study investigates how standard changes to mechanical ventilator settings—such as breath size, flow rate, and pressure—affect shortness of breath in awake patients on ventilators. Many ICU patients experience breathlessness despite sedation, which may contribute to PTS…

This study follows 250 adults with severe COPD who use a breathing machine at home. Researchers collect data from sensors and regular check-ups to build a model that can warn of an upcoming flare-up. The goal is to catch problems early and reduce hospital visits.

This small pilot study will test two common blood pressure medicines—nicardipine and sodium nitroprusside—in 12 patients with acute respiratory failure and high blood pressure. Researchers will use a special imaging technique called electrical impedance tomography to see how thes…

This study looks at how two sedative drugs, dexmedetomidine and remifentanil, affect breathing effort in patients with acute hypoxemic respiratory failure who are receiving high-flow nasal oxygen. Researchers will measure changes in inspiratory effort and symptoms like shortness …

This study collects blood samples and health data from 1,200 adults with ARDS in intensive care. Researchers aim to identify biological markers that can group patients into subtypes and predict how they will respond to different treatments. The goal is to improve care for this li…

This study compares three types of nerve blocks used for pain relief during shoulder surgery. The goal is to see which block is least likely to temporarily paralyze the diaphragm, the main muscle used for breathing. Seventy-five adults having shoulder surgery will be randomly ass…

This study looks at whether the recruitment-to-inflation ratio (R/I ratio), a measurement used to guide ventilator settings in patients with acute respiratory distress syndrome (ARDS), gives the same result when repeated in the same patient. Researchers will measure it twice in 8…

This study looks at 88 ICU patients who are ready to try breathing on their own after being on a ventilator. Some patients will be taken off the ventilator completely (T-piece test), while others will breathe with a little machine help (PS-ZEEP test). The goal is to see which tes…

This study will collect data from 624 patients in respiratory intermediate care units (RICUs) across Catalonia to build a model that predicts 30-day survival. Researchers will also test an artificial intelligence approach and create a quick app for doctors. The goal is to better …

This pilot study tests whether a simple tip sheet can help ICU doctors have better conversations with families of patients on breathing machines, especially families from different racial backgrounds. About 106 doctors and their patients' families will take part. The goal is to s…

This study looks at whether a standard step-by-step plan can help adults on high-flow oxygen therapy stop it more quickly and safely. About 2,000 patients across 8 hospitals will be involved. The goal is to see if the plan leads to more patients successfully coming off oxygen wit…

This study looks at how a gas called nitric oxide, given through a mask or nasal tubes, changes the way air and blood flow match in the lungs of people with ARDS (a serious lung injury). Researchers will use a special imaging technique (EIT) to see these changes right away. The g…

This study looks at whether ventilating only one lung during heart-lung bypass surgery can reduce fluid buildup and lung damage in high-risk patients. Forty-five older adults having major elective heart surgery will take part. The goal is to see if this approach leads to better l…

This study will test whether using higher or standard pressure on a ventilator during surgery helps patients breathe better after waking up. About 360 adults having planned non-chest, non-heart surgery will be randomly assigned to one of two pressure levels. The main goal is to s…

This study checks if a Turkish version of a questionnaire called S3-NIV is reliable and accurate for people with chronic breathing failure who use a home breathing machine. Researchers will ask 120 stable patients to fill out the questionnaire to see how well it measures their di…

This study looks at how inhaled nitric oxide affects oxygen levels and lung function in severely obese patients who have severe breathing failure and are on a ventilator. Researchers will compare these patients to those with normal weight to see if obesity changes how the gas wor…

Hispanic patients are twice as likely to die from respiratory failure as non-Hispanic patients, partly due to deeper sedation and less physical therapy. This pilot study will test a 'safer sedation bundle'—a set of tools and practices to help ICU staff follow guidelines more clos…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study will compare two non-invasive breathing support methods—a face mask that pushes air in and a special nasal tube that delivers high-flow oxygen—for adults in the emergency room with dangerously low blood oxygen. About 500 participants will be randomly assigned to one me…

This study will observe 40 adults with acute respiratory distress syndrome (ARDS) on ventilators. Researchers will adjust the ventilator's pressure settings and use ultrasound to measure vein congestion, checking if certain settings are linked to better kidney outcomes. The goal …

This study looks at whether a bedside lung ultrasound can help doctors see how well the lungs of obese patients are opening during a breathing machine procedure. The goal is to find the best air pressure to keep lungs open and improve oxygen levels. About 45 adults with a BMI of …

This pilot study will enroll 80 ICU patients with acute hypoxemic respiratory failure to compare two ventilator strategies: one that allows patients to breathe spontaneously and one that fully controls their breathing. The goal is to see if a larger trial is possible and to gathe…

This study looks at how different levels of breathing support (PEEP) affect blood flow congestion in the veins of patients with acute respiratory distress syndrome (ARDS). Researchers will use ultrasound to grade congestion in the liver, kidney, and portal veins as absent, modera…

This study will compare a new, shorter lung ultrasound method (using 6 checkpoints) to the standard longer method (12 checkpoints) in 20 ICU patients with acute respiratory failure. The goal is to see if the quicker method gives the same information about lung function and patien…

This study tests whether measuring jaw movements can accurately assess breathing effort in intensive care patients with acute respiratory failure. Researchers will compare jaw movement signals to the standard invasive method (esophageal pressure) in 50 adults during weaning from …

This study looks at how different levels of ventilator pressure affect the heart and lungs in 20 patients with moderate-to-severe ARDS. Researchers will test three pressure settings to see which one best balances lung collapse and overstretching while keeping the heart pumping we…

This study looks at a new way to close the belly wall during large hernia surgery to prevent breathing problems right after the operation. Doctors will use standard breathing measurements during surgery to decide the best closure method. The study will include 50 adults who are a…

This study looks at whether using a special imaging technique called Electrical Impedance Tomography (EIT) can help doctors perform safer lung recruitment maneuvers in children with acute respiratory distress syndrome (ARDS). The researchers will enroll 8 children on ventilators …

This study will test 20 adults with moderate-to-severe ARDS to see whether a controlled breathing machine (with or without muscle paralysis) or a machine that lets them breathe on their own is better at preventing lung injury. Each patient will try four different ventilation sett…

This study follows 40 adults with serious burn injuries to collect blood, tissue samples, and medical record data. Researchers will look for patterns that could help predict who will develop sepsis or other complications. The goal is to build a computer-based 'digital twin' model…

This study will test a new, non-invasive method called EIT Pulse Wave to measure blood flow to the lungs and predict heart stroke volume in critically ill patients. Researchers will compare it to the standard Swan-Ganz catheter, which is invasive. The study involves 19 adults in …

This observational study will analyze blood and sputum samples from 411 adults with acute respiratory distress syndrome (ARDS) who are on ventilators. Researchers will look for patterns in microbes, metabolites, and gene activity to see if they can predict how well patients respo…

This study follows 80 adults with serious burns to understand how their bodies respond to injury and treatment. Researchers collect blood and tissue samples and review medical records to find patterns that might predict sepsis and other complications. The goal is to build compute…

This study tests whether a special ultrasound technique, called VExUS, can predict which ICU patients will have trouble breathing on their own after being on a ventilator. Researchers will scan the veins of 350 patients just before a breathing trial. The goal is to see if signs o…

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This study will use a new 3D imaging device (3D-EIT) to see if it can detect a pattern called 'cyclic on-off switching' of blood flow in the lungs of 40 adults with moderate to severe ARDS who are on mechanical ventilation. The goal is to validate whether this non-invasive, bedsi…

This study tests whether an AI model (ChatGPT-5) can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults admitted to the ICU will be randomly assigned to standard care or care where the AI provides diagnostic and trea…

This study will observe 184 adults with acute respiratory distress syndrome (ARDS) who are on a breathing machine. Researchers want to see how different machine settings affect lung injury and survival. The goal is to find safer ways to use ventilators for these critically ill pa…

This study looks at whether a chest CT scan gives important new information beyond a simple chest X-ray for ICU patients with respiratory failure. Researchers will review records of 50 patients to see if CT findings changed their treatment. The goal is to find out if some CT scan…

This study will enroll 60 adults with acute hypoxemic respiratory failure (low oxygen levels) to compare three noninvasive breathing supports: CPAP, NIV, and high-flow nasal oxygen. Researchers will use electrical impedance tomography to measure lung strain in real time. The goal…

This study will test two different ways of using a breathing machine (CPAP) in 60 severely obese adults after they wake up from anesthesia. The goal is to see which setting better supports heart and lung function. Participants will be monitored with special sensors to measure lun…

This study will follow 800 adults with acute respiratory distress syndrome (ARDS) in a Korean hospital to learn about their symptoms, treatments, and outcomes. Researchers will collect data from medical records and monitor how different ventilator settings affect recovery. The go…

This study will create a registry of up to 1,000 ICU patients who are monitored with a non-invasive lung imaging device called Electrical Impedance Tomography (EIT). The device helps doctors see how well the lungs are working and guide breathing support. Researchers will track ou…

This study compares two scoring systems—the Silverman-Andersen score and the Downes score—to see which better predicts when a newborn with breathing problems will need a breathing tube. Researchers will follow 220 preterm and term infants receiving noninvasive breathing support. …

This study will compare two ways of measuring pressure inside the heart during heart surgery: the gold standard (direct left atrial pressure) and a more common indirect method (pulmonary capillary wedge pressure). Researchers want to see if the indirect method is accurate enough …

This study looks at patients who needed a breathing machine for more than 48 hours in the ICU between 2021 and 2023. Researchers will interview 90 adults in 2025 to see if they still have physical, mental, or thinking problems (called post-ICU syndrome) and how it affects their q…

This study looks for proteins in the blood that could signal transfusion-related acute lung injury (TRALI), a rare but dangerous complication in ICU patients. Researchers will compare blood samples from 210 people, including ICU patients with and without lung injury, and healthy …

This study will look at 70 children aged 1 month to 18 years who come to the emergency room with severe breathing problems. Researchers at Assiut University Children Hospital want to find out how common these cases are, what causes them, and which children are most at risk. The g…