High altitude pulmonary edema

This study tests whether using a real-time lung imaging tool (EIT) to guide breathing therapy helps people who have been on a breathing machine for a long time. The goal is to see if this personalized approach helps them breathe on their own sooner compared to standard therapy. T…

This study is testing a small device called the MiniLung petite kit, which helps oxygenate blood and remove carbon dioxide in newborns and children weighing 2 to 8 kilograms who have severe breathing or heart failure. The device works with a console to temporarily take over the w…

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to…

This study tests whether the asthma inhaler Advair HFA can prevent high altitude pulmonary edema (HAPE), a dangerous buildup of fluid in the lungs at high altitudes. Researchers will give the drug or a placebo to 60 healthy volunteers and people prone to HAPE, then measure their …

This study tests if a special high-flow oxygen mask works better than standard oxygen for people with high-altitude pulmonary edema (fluid in the lungs from climbing too high too fast). About 200 adults who develop symptoms within 7 days of reaching high altitude will be randomly…

This study is testing whether a special breathing tube called a supraglottic airway can be used to help premature babies breathe right after birth. The study will include 20 premature infants born between 29 and 33 weeks who need breathing support. The goal is to see if this devi…

This study is testing whether two non-invasive tools—ultrasound and electrical impedance tomography (EIT)—can help doctors monitor breathing muscles in patients with acute respiratory failure who are using non-invasive breathing support. Up to 100 adults will be enrolled, with me…

This observational study looks at 30 adults with acute respiratory failure on mechanical ventilation. Researchers want to see if a bedside device called electrical impedance tomography (EIT) can reliably guide ventilator pressure settings, compared to the current gold standard (C…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

This study looks at how the right side of the heart works when there is less oxygen, like at high altitudes. It involves 18 adults who have had HAPE (high-altitude pulmonary edema) in the past. Participants breathe special gas mixtures to mimic altitudes of 2,500 and 4,000 meters…

This study observes 325 adults with acute breathing failure who are using non-invasive breathing support like high-flow oxygen or a mask ventilator. Researchers want to find out which patients end up needing a breathing tube. The goal is to better predict and prevent treatment fa…

This study follows 100 adults who needed ECMO support for severe heart or lung failure. Researchers will track muscle size, strength, and quality of life over time to understand why some patients develop lasting weakness. No new treatments are being tested; the goal is to gather …

This study looks back at medical records of about 59 ICU patients who used a low-flow carbon dioxide removal (ECCO2R) machine for breathing failure. The goal is to describe how the device was used and what happened to patients, including survival and side effects. It does not tes…

This study involves 60 critically ill patients in the ICU who are on breathing machines (ventilators). Researchers want to see if a new scoring system can automatically detect when a patient is struggling to breathe. The goal is to improve how doctors monitor and care for these p…